Amino acid dipepetide frequency for Intoshia linei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.66AlaAla: 1.66 ± 0.031	0.801AlaCys: 0.801 ± 0.024	1.708AlaAsp: 1.708 ± 0.023	1.846AlaGlu: 1.846 ± 0.028	1.721AlaPhe: 1.721 ± 0.026	1.402AlaGly: 1.402 ± 0.049	0.738AlaHis: 0.738 ± 0.014	3.414AlaIle: 3.414 ± 0.036	2.962AlaLys: 2.962 ± 0.032	3.199AlaLeu: 3.199 ± 0.036	0.9AlaMet: 0.9 ± 0.016	2.366AlaAsn: 2.366 ± 0.027	0.973AlaPro: 0.973 ± 0.02	1.097AlaGln: 1.097 ± 0.019	1.253AlaArg: 1.253 ± 0.025	2.636AlaSer: 2.636 ± 0.032	1.961AlaThr: 1.961 ± 0.025	1.999AlaVal: 1.999 ± 0.029	0.28AlaTrp: 0.28 ± 0.009	1.47AlaTyr: 1.47 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.778CysAla: 0.778 ± 0.019	0.469CysCys: 0.469 ± 0.012	1.412CysAsp: 1.412 ± 0.034	1.292CysGlu: 1.292 ± 0.028	1.087CysPhe: 1.087 ± 0.019	1.04CysGly: 1.04 ± 0.021	0.581CysHis: 0.581 ± 0.015	2.136CysIle: 2.136 ± 0.037	1.965CysLys: 1.965 ± 0.039	2.106CysLeu: 2.106 ± 0.037	0.479CysMet: 0.479 ± 0.015	1.703CysAsn: 1.703 ± 0.031	0.948CysPro: 0.948 ± 0.089	0.919CysGln: 0.919 ± 0.023	0.856CysArg: 0.856 ± 0.018	1.813CysSer: 1.813 ± 0.039	1.308CysThr: 1.308 ± 0.038	1.231CysVal: 1.231 ± 0.023	0.191CysTrp: 0.191 ± 0.008	0.887CysTyr: 0.887 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	2.08AspAla: 2.08 ± 0.025	1.265AspCys: 1.265 ± 0.034	3.359AspAsp: 3.359 ± 0.043	4.174AspGlu: 4.174 ± 0.047	2.629AspPhe: 2.629 ± 0.03	2.211AspGly: 2.211 ± 0.041	0.934AspHis: 0.934 ± 0.018	5.109AspIle: 5.109 ± 0.043	4.948AspLys: 4.948 ± 0.035	4.609AspLeu: 4.609 ± 0.037	1.337AspMet: 1.337 ± 0.021	4.109AspAsn: 4.109 ± 0.034	1.372AspPro: 1.372 ± 0.022	1.752AspGln: 1.752 ± 0.026	1.865AspArg: 1.865 ± 0.027	4.47AspSer: 4.47 ± 0.04	2.914AspThr: 2.914 ± 0.033	3.366AspVal: 3.366 ± 0.033	0.502AspTrp: 0.502 ± 0.013	2.607AspTyr: 2.607 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	1.978GluAla: 1.978 ± 0.027	1.325GluCys: 1.325 ± 0.027	2.688GluAsp: 2.688 ± 0.034	3.498GluGlu: 3.498 ± 0.051	2.687GluPhe: 2.687 ± 0.034	1.561GluGly: 1.561 ± 0.027	1.068GluHis: 1.068 ± 0.017	6.048GluIle: 6.048 ± 0.058	7.069GluLys: 7.069 ± 0.079	4.984GluLeu: 4.984 ± 0.046	1.816GluMet: 1.816 ± 0.026	6.504GluAsn: 6.504 ± 0.056	1.564GluPro: 1.564 ± 0.024	1.73GluGln: 1.73 ± 0.027	2.178GluArg: 2.178 ± 0.035	4.892GluSer: 4.892 ± 0.044	3.443GluThr: 3.443 ± 0.031	1.956GluVal: 1.956 ± 0.028	0.524GluTrp: 0.524 ± 0.015	2.72GluTyr: 2.72 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	1.64PheAla: 1.64 ± 0.024	1.127PheCys: 1.127 ± 0.024	3.382PheAsp: 3.382 ± 0.033	3.067PheGlu: 3.067 ± 0.032	2.201PhePhe: 2.201 ± 0.032	2.1PheGly: 2.1 ± 0.028	1.034PheHis: 1.034 ± 0.021	4.323PheIle: 4.323 ± 0.041	4.268PheLys: 4.268 ± 0.04	4.042PheLeu: 4.042 ± 0.04	1.163PheMet: 1.163 ± 0.02	4.128PheAsn: 4.128 ± 0.039	1.328PhePro: 1.328 ± 0.022	1.683PheGln: 1.683 ± 0.023	1.542PheArg: 1.542 ± 0.022	4.184PheSer: 4.184 ± 0.038	2.606PheThr: 2.606 ± 0.03	2.714PheVal: 2.714 ± 0.026	0.409PheTrp: 0.409 ± 0.012	2.297PheTyr: 2.297 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	1.391GlyAla: 1.391 ± 0.027	0.794GlyCys: 0.794 ± 0.017	1.754GlyAsp: 1.754 ± 0.027	1.825GlyGlu: 1.825 ± 0.032	1.851GlyPhe: 1.851 ± 0.033	1.686GlyGly: 1.686 ± 0.034	0.86GlyHis: 0.86 ± 0.02	3.332GlyIle: 3.332 ± 0.046	3.116GlyLys: 3.116 ± 0.042	3.017GlyLeu: 3.017 ± 0.044	0.89GlyMet: 0.89 ± 0.02	2.534GlyAsn: 2.534 ± 0.036	0.921GlyPro: 0.921 ± 0.024	1.156GlyGln: 1.156 ± 0.025	1.501GlyArg: 1.501 ± 0.04	2.776GlySer: 2.776 ± 0.053	1.986GlyThr: 1.986 ± 0.044	1.999GlyVal: 1.999 ± 0.028	0.365GlyTrp: 0.365 ± 0.012	1.871GlyTyr: 1.871 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	0.721HisAla: 0.721 ± 0.016	0.532HisCys: 0.532 ± 0.013	1.127HisAsp: 1.127 ± 0.022	1.25HisGlu: 1.25 ± 0.019	1.271HisPhe: 1.271 ± 0.02	0.849HisGly: 0.849 ± 0.02	0.56HisHis: 0.56 ± 0.018	1.881HisIle: 1.881 ± 0.023	1.623HisLys: 1.623 ± 0.024	2.201HisLeu: 2.201 ± 0.026	0.491HisMet: 0.491 ± 0.012	1.504HisAsn: 1.504 ± 0.023	0.725HisPro: 0.725 ± 0.016	0.833HisGln: 0.833 ± 0.017	0.888HisArg: 0.888 ± 0.02	1.673HisSer: 1.673 ± 0.022	1.066HisThr: 1.066 ± 0.02	1.349HisVal: 1.349 ± 0.022	0.201HisTrp: 0.201 ± 0.007	1.08HisTyr: 1.08 ± 0.022	0.001HisXaa: 0.001 ± 0.0
Ile	3.14IleAla: 3.14 ± 0.032	2.158IleCys: 2.158 ± 0.037	5.705IleAsp: 5.705 ± 0.042	5.943IleGlu: 5.943 ± 0.055	4.594IlePhe: 4.594 ± 0.047	3.447IleGly: 3.447 ± 0.049	2.021IleHis: 2.021 ± 0.025	7.771IleIle: 7.771 ± 0.065	8.413IleLys: 8.413 ± 0.06	8.138IleLeu: 8.138 ± 0.066	2.09IleMet: 2.09 ± 0.026	7.368IleAsn: 7.368 ± 0.06	3.021IlePro: 3.021 ± 0.033	3.219IleGln: 3.219 ± 0.032	3.035IleArg: 3.035 ± 0.035	7.666IleSer: 7.666 ± 0.053	4.296IleThr: 4.296 ± 0.035	4.688IleVal: 4.688 ± 0.047	0.763IleTrp: 0.763 ± 0.018	3.99IleTyr: 3.99 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	2.422LysAla: 2.422 ± 0.031	2.51LysCys: 2.51 ± 0.05	4.286LysAsp: 4.286 ± 0.041	5.042LysGlu: 5.042 ± 0.054	4.533LysPhe: 4.533 ± 0.041	2.268LysGly: 2.268 ± 0.062	1.964LysHis: 1.964 ± 0.026	9.189LysIle: 9.189 ± 0.065	9.455LysLys: 9.455 ± 0.088	8.806LysLeu: 8.806 ± 0.054	2.675LysMet: 2.675 ± 0.031	8.876LysAsn: 8.876 ± 0.072	2.835LysPro: 2.835 ± 0.034	2.905LysGln: 2.905 ± 0.034	3.798LysArg: 3.798 ± 0.038	7.759LysSer: 7.759 ± 0.069	4.817LysThr: 4.817 ± 0.041	3.65LysVal: 3.65 ± 0.036	0.762LysTrp: 0.762 ± 0.015	4.531LysTyr: 4.531 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	3.208LeuAla: 3.208 ± 0.038	1.891LeuCys: 1.891 ± 0.032	4.664LeuAsp: 4.664 ± 0.038	5.148LeuGlu: 5.148 ± 0.049	4.203LeuPhe: 4.203 ± 0.037	2.715LeuGly: 2.715 ± 0.034	2.039LeuHis: 2.039 ± 0.026	7.617LeuIle: 7.617 ± 0.052	9.168LeuLys: 9.168 ± 0.068	7.732LeuLeu: 7.732 ± 0.064	2.18LeuMet: 2.18 ± 0.029	8.133LeuAsn: 8.133 ± 0.058	3.047LeuPro: 3.047 ± 0.038	3.13LeuGln: 3.13 ± 0.036	3.181LeuArg: 3.181 ± 0.035	7.353LeuSer: 7.353 ± 0.049	4.614LeuThr: 4.614 ± 0.038	4.089LeuVal: 4.089 ± 0.037	0.713LeuTrp: 0.713 ± 0.015	3.701LeuTyr: 3.701 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	1.033MetAla: 1.033 ± 0.018	0.554MetCys: 0.554 ± 0.015	1.576MetAsp: 1.576 ± 0.023	1.686MetGlu: 1.686 ± 0.024	1.066MetPhe: 1.066 ± 0.018	0.954MetGly: 0.954 ± 0.02	0.555MetHis: 0.555 ± 0.013	1.874MetIle: 1.874 ± 0.022	2.379MetLys: 2.379 ± 0.03	1.912MetLeu: 1.912 ± 0.026	0.622MetMet: 0.622 ± 0.014	2.13MetAsn: 2.13 ± 0.029	0.712MetPro: 0.712 ± 0.016	0.873MetGln: 0.873 ± 0.017	0.856MetArg: 0.856 ± 0.017	2.018MetSer: 2.018 ± 0.027	1.297MetThr: 1.297 ± 0.021	1.137MetVal: 1.137 ± 0.017	0.213MetTrp: 0.213 ± 0.007	1.121MetTyr: 1.121 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.686AsnAla: 2.686 ± 0.026	2.014AsnCys: 2.014 ± 0.034	4.926AsnAsp: 4.926 ± 0.045	5.812AsnGlu: 5.812 ± 0.053	4.544AsnPhe: 4.544 ± 0.042	3.049AsnGly: 3.049 ± 0.037	1.685AsnHis: 1.685 ± 0.029	7.928AsnIle: 7.928 ± 0.063	6.684AsnLys: 6.684 ± 0.056	7.874AsnLeu: 7.874 ± 0.067	2.027AsnMet: 2.027 ± 0.026	6.17AsnAsn: 6.17 ± 0.056	2.261AsnPro: 2.261 ± 0.028	3.166AsnGln: 3.166 ± 0.038	2.775AsnArg: 2.775 ± 0.032	6.629AsnSer: 6.629 ± 0.046	4.034AsnThr: 4.034 ± 0.035	5.44AsnVal: 5.44 ± 0.05	0.666AsnTrp: 0.666 ± 0.015	4.047AsnTyr: 4.047 ± 0.04	0.001AsnXaa: 0.001 ± 0.001
Pro	0.933ProAla: 0.933 ± 0.023	0.609ProCys: 0.609 ± 0.028	1.458ProAsp: 1.458 ± 0.02	1.782ProGlu: 1.782 ± 0.026	1.491ProPhe: 1.491 ± 0.025	1.061ProGly: 1.061 ± 0.032	0.717ProHis: 0.717 ± 0.018	3.091ProIle: 3.091 ± 0.041	2.792ProLys: 2.792 ± 0.033	2.557ProLeu: 2.557 ± 0.028	0.636ProMet: 0.636 ± 0.015	2.489ProAsn: 2.489 ± 0.031	1.227ProPro: 1.227 ± 0.025	1.072ProGln: 1.072 ± 0.02	1.026ProArg: 1.026 ± 0.021	2.351ProSer: 2.351 ± 0.033	1.872ProThr: 1.872 ± 0.035	1.642ProVal: 1.642 ± 0.027	0.226ProTrp: 0.226 ± 0.012	1.28ProTyr: 1.28 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	0.964GlnAla: 0.964 ± 0.017	0.823GlnCys: 0.823 ± 0.02	1.711GlnAsp: 1.711 ± 0.026	1.88GlnGlu: 1.88 ± 0.028	1.831GlnPhe: 1.831 ± 0.026	0.882GlnGly: 0.882 ± 0.015	0.821GlnHis: 0.821 ± 0.016	3.265GlnIle: 3.265 ± 0.036	3.211GlnLys: 3.211 ± 0.037	3.234GlnLeu: 3.234 ± 0.032	0.924GlnMet: 0.924 ± 0.016	3.532GlnAsn: 3.532 ± 0.042	0.967GlnPro: 0.967 ± 0.021	1.261GlnGln: 1.261 ± 0.024	1.265GlnArg: 1.265 ± 0.023	2.665GlnSer: 2.665 ± 0.028	1.755GlnThr: 1.755 ± 0.024	1.576GlnVal: 1.576 ± 0.027	0.258GlnTrp: 0.258 ± 0.008	1.619GlnTyr: 1.619 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	1.195ArgAla: 1.195 ± 0.02	0.793ArgCys: 0.793 ± 0.019	1.807ArgAsp: 1.807 ± 0.027	1.955ArgGlu: 1.955 ± 0.031	1.761ArgPhe: 1.761 ± 0.025	1.306ArgGly: 1.306 ± 0.034	0.981ArgHis: 0.981 ± 0.016	3.214ArgIle: 3.214 ± 0.035	3.76ArgLys: 3.76 ± 0.041	3.418ArgLeu: 3.418 ± 0.039	0.93ArgMet: 0.93 ± 0.018	3.058ArgAsn: 3.058 ± 0.037	1.023ArgPro: 1.023 ± 0.017	1.411ArgGln: 1.411 ± 0.023	1.867ArgArg: 1.867 ± 0.027	2.534ArgSer: 2.534 ± 0.038	1.612ArgThr: 1.612 ± 0.023	1.704ArgVal: 1.704 ± 0.026	0.334ArgTrp: 0.334 ± 0.012	1.67ArgTyr: 1.67 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	2.67SerAla: 2.67 ± 0.031	1.658SerCys: 1.658 ± 0.032	4.624SerAsp: 4.624 ± 0.04	4.631SerGlu: 4.631 ± 0.045	3.907SerPhe: 3.907 ± 0.037	2.92SerGly: 2.92 ± 0.044	1.807SerHis: 1.807 ± 0.02	7.7SerIle: 7.7 ± 0.058	7.512SerLys: 7.512 ± 0.053	7.07SerLeu: 7.07 ± 0.048	1.817SerMet: 1.817 ± 0.024	7.038SerAsn: 7.038 ± 0.051	2.236SerPro: 2.236 ± 0.042	2.877SerGln: 2.877 ± 0.031	2.854SerArg: 2.854 ± 0.04	6.328SerSer: 6.328 ± 0.053	4.591SerThr: 4.591 ± 0.044	4.267SerVal: 4.267 ± 0.038	0.577SerTrp: 0.577 ± 0.016	2.986SerTyr: 2.986 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	1.9ThrAla: 1.9 ± 0.029	1.334ThrCys: 1.334 ± 0.035	2.929ThrAsp: 2.929 ± 0.034	3.134ThrGlu: 3.134 ± 0.03	2.8ThrPhe: 2.8 ± 0.028	2.085ThrGly: 2.085 ± 0.054	1.13ThrHis: 1.13 ± 0.02	4.796ThrIle: 4.796 ± 0.037	4.701ThrLys: 4.701 ± 0.04	4.693ThrLeu: 4.693 ± 0.041	1.146ThrMet: 1.146 ± 0.02	4.301ThrAsn: 4.301 ± 0.039	1.916ThrPro: 1.916 ± 0.034	1.696ThrGln: 1.696 ± 0.022	1.754ThrArg: 1.754 ± 0.022	4.109ThrSer: 4.109 ± 0.043	3.082ThrThr: 3.082 ± 0.071	2.831ThrVal: 2.831 ± 0.028	0.398ThrTrp: 0.398 ± 0.012	1.963ThrTyr: 1.963 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	2.071ValAla: 2.071 ± 0.026	1.196ValCys: 1.196 ± 0.023	3.375ValAsp: 3.375 ± 0.036	3.272ValGlu: 3.272 ± 0.03	2.339ValPhe: 2.339 ± 0.03	1.997ValGly: 1.997 ± 0.031	1.142ValHis: 1.142 ± 0.019	4.083ValIle: 4.083 ± 0.039	4.508ValLys: 4.508 ± 0.042	4.282ValLeu: 4.282 ± 0.035	1.163ValMet: 1.163 ± 0.018	4.167ValAsn: 4.167 ± 0.042	1.653ValPro: 1.653 ± 0.025	1.709ValGln: 1.709 ± 0.026	1.735ValArg: 1.735 ± 0.027	4.12ValSer: 4.12 ± 0.04	2.57ValThr: 2.57 ± 0.028	2.828ValVal: 2.828 ± 0.034	0.447ValTrp: 0.447 ± 0.012	2.387ValTyr: 2.387 ± 0.028	0.001ValXaa: 0.001 ± 0.001
Trp	0.292TrpAla: 0.292 ± 0.011	0.189TrpCys: 0.189 ± 0.009	0.475TrpAsp: 0.475 ± 0.014	0.372TrpGlu: 0.372 ± 0.01	0.389TrpPhe: 0.389 ± 0.012	0.272TrpGly: 0.272 ± 0.011	0.184TrpHis: 0.184 ± 0.007	0.811TrpIle: 0.811 ± 0.016	0.827TrpLys: 0.827 ± 0.017	0.744TrpLeu: 0.744 ± 0.017	0.221TrpMet: 0.221 ± 0.008	0.772TrpAsn: 0.772 ± 0.018	0.245TrpPro: 0.245 ± 0.009	0.249TrpGln: 0.249 ± 0.008	0.356TrpArg: 0.356 ± 0.01	0.671TrpSer: 0.671 ± 0.014	0.456TrpThr: 0.456 ± 0.011	0.378TrpVal: 0.378 ± 0.011	0.094TrpTrp: 0.094 ± 0.005	0.32TrpTyr: 0.32 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.625TyrAla: 1.625 ± 0.022	1.159TyrCys: 1.159 ± 0.059	2.646TyrAsp: 2.646 ± 0.028	2.621TyrGlu: 2.621 ± 0.031	2.331TyrPhe: 2.331 ± 0.026	1.819TyrGly: 1.819 ± 0.028	1.006TyrHis: 1.006 ± 0.02	3.885TyrIle: 3.885 ± 0.04	3.722TyrLys: 3.722 ± 0.036	3.91TyrLeu: 3.91 ± 0.041	1.063TyrMet: 1.063 ± 0.019	3.536TyrAsn: 3.536 ± 0.035	1.339TyrPro: 1.339 ± 0.018	1.708TyrGln: 1.708 ± 0.025	1.746TyrArg: 1.746 ± 0.024	3.423TyrSer: 3.423 ± 0.034	2.419TyrThr: 2.419 ± 0.029	2.202TyrVal: 2.202 ± 0.028	0.39TyrTrp: 0.39 ± 0.011	2.043TyrTyr: 2.043 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 8720 proteins (3312867 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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