Amino acid dipepetide frequency for Brenneria salicis ATCC 15712 = DSM 30166

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.241AlaAla: 10.241 ± 0.135
1.138AlaCys: 1.138 ± 0.034
5.253AlaAsp: 5.253 ± 0.083
5.789AlaGlu: 5.789 ± 0.071
3.58AlaPhe: 3.58 ± 0.052
7.544AlaGly: 7.544 ± 0.101
1.852AlaHis: 1.852 ± 0.043
5.901AlaIle: 5.901 ± 0.075
3.505AlaLys: 3.505 ± 0.073
12.068AlaLeu: 12.068 ± 0.121
2.864AlaMet: 2.864 ± 0.057
3.068AlaAsn: 3.068 ± 0.055
3.639AlaPro: 3.639 ± 0.068
4.792AlaGln: 4.792 ± 0.074
5.747AlaArg: 5.747 ± 0.081
5.584AlaSer: 5.584 ± 0.087
4.682AlaThr: 4.682 ± 0.083
6.604AlaVal: 6.604 ± 0.08
1.2AlaTrp: 1.2 ± 0.035
2.356AlaTyr: 2.356 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.986CysAla: 0.986 ± 0.031
0.18CysCys: 0.18 ± 0.013
0.57CysAsp: 0.57 ± 0.022
0.586CysGlu: 0.586 ± 0.03
0.438CysPhe: 0.438 ± 0.02
1.023CysGly: 1.023 ± 0.028
0.316CysHis: 0.316 ± 0.02
0.603CysIle: 0.603 ± 0.025
0.286CysLys: 0.286 ± 0.016
1.11CysLeu: 1.11 ± 0.03
0.246CysMet: 0.246 ± 0.015
0.333CysAsn: 0.333 ± 0.017
0.497CysPro: 0.497 ± 0.027
0.428CysGln: 0.428 ± 0.021
0.732CysArg: 0.732 ± 0.026
0.635CysSer: 0.635 ± 0.026
0.453CysThr: 0.453 ± 0.019
0.741CysVal: 0.741 ± 0.025
0.184CysTrp: 0.184 ± 0.012
0.374CysTyr: 0.374 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
5.334AspAla: 5.334 ± 0.085
0.526AspCys: 0.526 ± 0.019
3.157AspAsp: 3.157 ± 0.061
3.65AspGlu: 3.65 ± 0.058
2.103AspPhe: 2.103 ± 0.038
3.97AspGly: 3.97 ± 0.097
1.054AspHis: 1.054 ± 0.032
3.799AspIle: 3.799 ± 0.068
2.275AspLys: 2.275 ± 0.053
4.884AspLeu: 4.884 ± 0.072
1.393AspMet: 1.393 ± 0.038
2.264AspAsn: 2.264 ± 0.046
2.187AspPro: 2.187 ± 0.051
1.769AspGln: 1.769 ± 0.042
2.795AspArg: 2.795 ± 0.051
2.866AspSer: 2.866 ± 0.054
2.551AspThr: 2.551 ± 0.056
3.784AspVal: 3.784 ± 0.062
0.886AspTrp: 0.886 ± 0.03
1.891AspTyr: 1.891 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
5.02GluAla: 5.02 ± 0.079
0.495GluCys: 0.495 ± 0.022
2.334GluAsp: 2.334 ± 0.049
3.099GluGlu: 3.099 ± 0.063
1.795GluPhe: 1.795 ± 0.04
3.197GluGly: 3.197 ± 0.058
1.395GluHis: 1.395 ± 0.037
3.418GluIle: 3.418 ± 0.059
3.1GluLys: 3.1 ± 0.059
5.899GluLeu: 5.899 ± 0.082
1.766GluMet: 1.766 ± 0.044
2.418GluAsn: 2.418 ± 0.049
2.093GluPro: 2.093 ± 0.043
3.749GluGln: 3.749 ± 0.077
3.98GluArg: 3.98 ± 0.072
3.025GluSer: 3.025 ± 0.05
2.896GluThr: 2.896 ± 0.056
3.601GluVal: 3.601 ± 0.062
0.703GluTrp: 0.703 ± 0.027
1.456GluTyr: 1.456 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.448PheAla: 3.448 ± 0.06
0.475PheCys: 0.475 ± 0.021
2.282PheAsp: 2.282 ± 0.049
1.643PheGlu: 1.643 ± 0.039
1.576PhePhe: 1.576 ± 0.04
3.02PheGly: 3.02 ± 0.05
0.805PheHis: 0.805 ± 0.027
2.614PheIle: 2.614 ± 0.051
1.245PheLys: 1.245 ± 0.037
3.258PheLeu: 3.258 ± 0.061
0.942PheMet: 0.942 ± 0.03
1.707PheAsn: 1.707 ± 0.042
1.522PhePro: 1.522 ± 0.036
1.267PheGln: 1.267 ± 0.034
1.949PheArg: 1.949 ± 0.042
3.159PheSer: 3.159 ± 0.052
2.187PheThr: 2.187 ± 0.048
2.387PheVal: 2.387 ± 0.048
0.55PheTrp: 0.55 ± 0.023
1.179PheTyr: 1.179 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
6.206GlyAla: 6.206 ± 0.092
1.042GlyCys: 1.042 ± 0.03
3.728GlyAsp: 3.728 ± 0.063
4.518GlyGlu: 4.518 ± 0.063
3.126GlyPhe: 3.126 ± 0.055
5.4GlyGly: 5.4 ± 0.094
1.564GlyHis: 1.564 ± 0.036
4.973GlyIle: 4.973 ± 0.069
3.91GlyLys: 3.91 ± 0.07
7.407GlyLeu: 7.407 ± 0.096
2.351GlyMet: 2.351 ± 0.049
2.763GlyAsn: 2.763 ± 0.056
2.0GlyPro: 2.0 ± 0.049
2.949GlyGln: 2.949 ± 0.063
4.01GlyArg: 4.01 ± 0.065
4.08GlySer: 4.08 ± 0.066
3.405GlyThr: 3.405 ± 0.063
5.663GlyVal: 5.663 ± 0.079
1.139GlyTrp: 1.139 ± 0.034
2.537GlyTyr: 2.537 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.974HisAla: 1.974 ± 0.046
0.337HisCys: 0.337 ± 0.019
1.229HisAsp: 1.229 ± 0.036
1.108HisGlu: 1.108 ± 0.031
0.996HisPhe: 0.996 ± 0.035
1.681HisGly: 1.681 ± 0.042
0.786HisHis: 0.786 ± 0.028
1.363HisIle: 1.363 ± 0.035
0.741HisLys: 0.741 ± 0.027
2.351HisLeu: 2.351 ± 0.05
0.491HisMet: 0.491 ± 0.025
0.854HisAsn: 0.854 ± 0.032
1.323HisPro: 1.323 ± 0.037
1.376HisGln: 1.376 ± 0.041
1.37HisArg: 1.37 ± 0.035
1.226HisSer: 1.226 ± 0.032
1.058HisThr: 1.058 ± 0.029
1.244HisVal: 1.244 ± 0.039
0.395HisTrp: 0.395 ± 0.019
0.892HisTyr: 0.892 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.67IleAla: 6.67 ± 0.089
0.683IleCys: 0.683 ± 0.023
3.704IleAsp: 3.704 ± 0.063
3.605IleGlu: 3.605 ± 0.066
2.05IlePhe: 2.05 ± 0.053
4.872IleGly: 4.872 ± 0.08
1.227IleHis: 1.227 ± 0.029
3.528IleIle: 3.528 ± 0.07
2.508IleLys: 2.508 ± 0.053
5.233IleLeu: 5.233 ± 0.085
1.338IleMet: 1.338 ± 0.031
2.595IleAsn: 2.595 ± 0.046
2.777IlePro: 2.777 ± 0.057
2.097IleGln: 2.097 ± 0.048
3.389IleArg: 3.389 ± 0.049
4.038IleSer: 4.038 ± 0.06
3.612IleThr: 3.612 ± 0.054
4.08IleVal: 4.08 ± 0.064
0.664IleTrp: 0.664 ± 0.028
1.576IleTyr: 1.576 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
3.797LysAla: 3.797 ± 0.072
0.262LysCys: 0.262 ± 0.018
1.972LysAsp: 1.972 ± 0.053
2.202LysGlu: 2.202 ± 0.058
1.027LysPhe: 1.027 ± 0.033
2.607LysGly: 2.607 ± 0.049
0.876LysHis: 0.876 ± 0.027
2.468LysIle: 2.468 ± 0.054
2.051LysLys: 2.051 ± 0.055
4.225LysLeu: 4.225 ± 0.078
1.089LysMet: 1.089 ± 0.035
1.698LysAsn: 1.698 ± 0.046
2.062LysPro: 2.062 ± 0.049
2.069LysGln: 2.069 ± 0.043
2.516LysArg: 2.516 ± 0.052
2.317LysSer: 2.317 ± 0.049
2.571LysThr: 2.571 ± 0.055
2.713LysVal: 2.713 ± 0.055
0.37LysTrp: 0.37 ± 0.019
1.023LysTyr: 1.023 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
11.768LeuAla: 11.768 ± 0.112
1.269LeuCys: 1.269 ± 0.037
5.78LeuAsp: 5.78 ± 0.084
5.378LeuGlu: 5.378 ± 0.089
4.116LeuPhe: 4.116 ± 0.079
7.393LeuGly: 7.393 ± 0.104
2.344LeuHis: 2.344 ± 0.053
6.186LeuIle: 6.186 ± 0.092
4.398LeuLys: 4.398 ± 0.059
12.417LeuLeu: 12.417 ± 0.163
2.923LeuMet: 2.923 ± 0.058
4.346LeuAsn: 4.346 ± 0.07
5.77LeuPro: 5.77 ± 0.073
4.478LeuGln: 4.478 ± 0.077
6.454LeuArg: 6.454 ± 0.084
7.923LeuSer: 7.923 ± 0.111
6.542LeuThr: 6.542 ± 0.097
6.911LeuVal: 6.911 ± 0.083
1.257LeuTrp: 1.257 ± 0.033
2.645LeuTyr: 2.645 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.791MetAla: 2.791 ± 0.051
0.184MetCys: 0.184 ± 0.013
1.23MetAsp: 1.23 ± 0.031
1.214MetGlu: 1.214 ± 0.033
0.828MetPhe: 0.828 ± 0.028
1.768MetGly: 1.768 ± 0.042
0.503MetHis: 0.503 ± 0.02
1.564MetIle: 1.564 ± 0.039
1.278MetLys: 1.278 ± 0.036
3.223MetLeu: 3.223 ± 0.058
0.871MetMet: 0.871 ± 0.03
1.061MetAsn: 1.061 ± 0.035
1.356MetPro: 1.356 ± 0.037
1.233MetGln: 1.233 ± 0.035
1.513MetArg: 1.513 ± 0.036
1.824MetSer: 1.824 ± 0.042
1.717MetThr: 1.717 ± 0.032
1.926MetVal: 1.926 ± 0.044
0.207MetTrp: 0.207 ± 0.015
0.497MetTyr: 0.497 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.651AsnAla: 3.651 ± 0.064
0.322AsnCys: 0.322 ± 0.016
2.008AsnAsp: 2.008 ± 0.042
1.916AsnGlu: 1.916 ± 0.038
1.266AsnPhe: 1.266 ± 0.033
2.907AsnGly: 2.907 ± 0.062
0.887AsnHis: 0.887 ± 0.033
2.416AsnIle: 2.416 ± 0.05
1.526AsnLys: 1.526 ± 0.038
3.596AsnLeu: 3.596 ± 0.057
0.931AsnMet: 0.931 ± 0.032
1.644AsnAsn: 1.644 ± 0.039
2.075AsnPro: 2.075 ± 0.046
1.72AsnGln: 1.72 ± 0.037
2.161AsnArg: 2.161 ± 0.05
2.074AsnSer: 2.074 ± 0.048
2.0AsnThr: 2.0 ± 0.045
2.538AsnVal: 2.538 ± 0.05
0.526AsnTrp: 0.526 ± 0.024
1.135AsnTyr: 1.135 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
4.572ProAla: 4.572 ± 0.078
0.393ProCys: 0.393 ± 0.02
2.898ProAsp: 2.898 ± 0.049
3.061ProGlu: 3.061 ± 0.047
1.722ProPhe: 1.722 ± 0.039
3.281ProGly: 3.281 ± 0.055
1.094ProHis: 1.094 ± 0.036
2.202ProIle: 2.202 ± 0.051
1.444ProLys: 1.444 ± 0.042
5.228ProLeu: 5.228 ± 0.076
1.065ProMet: 1.065 ± 0.029
1.306ProAsn: 1.306 ± 0.042
1.759ProPro: 1.759 ± 0.045
2.217ProGln: 2.217 ± 0.047
2.067ProArg: 2.067 ± 0.047
2.359ProSer: 2.359 ± 0.053
2.226ProThr: 2.226 ± 0.05
3.613ProVal: 3.613 ± 0.06
0.649ProTrp: 0.649 ± 0.024
1.334ProTyr: 1.334 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
5.178GlnAla: 5.178 ± 0.085
0.428GlnCys: 0.428 ± 0.021
2.101GlnAsp: 2.101 ± 0.043
2.354GlnGlu: 2.354 ± 0.053
1.477GlnPhe: 1.477 ± 0.037
3.291GlnGly: 3.291 ± 0.064
1.266GlnHis: 1.266 ± 0.038
2.496GlnIle: 2.496 ± 0.048
1.683GlnLys: 1.683 ± 0.043
5.286GlnLeu: 5.286 ± 0.087
1.144GlnMet: 1.144 ± 0.032
1.457GlnAsn: 1.457 ± 0.032
2.366GlnPro: 2.366 ± 0.057
3.796GlnGln: 3.796 ± 0.102
3.663GlnArg: 3.663 ± 0.067
2.583GlnSer: 2.583 ± 0.05
2.406GlnThr: 2.406 ± 0.046
3.211GlnVal: 3.211 ± 0.059
0.685GlnTrp: 0.685 ± 0.026
1.204GlnTyr: 1.204 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
4.763ArgAla: 4.763 ± 0.063
0.678ArgCys: 0.678 ± 0.029
3.183ArgAsp: 3.183 ± 0.053
3.705ArgGlu: 3.705 ± 0.07
2.617ArgPhe: 2.617 ± 0.048
3.459ArgGly: 3.459 ± 0.056
1.786ArgHis: 1.786 ± 0.049
3.697ArgIle: 3.697 ± 0.064
2.342ArgLys: 2.342 ± 0.052
7.093ArgLeu: 7.093 ± 0.091
1.685ArgMet: 1.685 ± 0.039
2.112ArgAsn: 2.112 ± 0.05
2.325ArgPro: 2.325 ± 0.038
3.84ArgGln: 3.84 ± 0.065
3.927ArgArg: 3.927 ± 0.062
2.871ArgSer: 2.871 ± 0.051
2.586ArgThr: 2.586 ± 0.046
3.885ArgVal: 3.885 ± 0.061
1.008ArgTrp: 1.008 ± 0.03
2.274ArgTyr: 2.274 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.956SerAla: 5.956 ± 0.091
0.529SerCys: 0.529 ± 0.028
3.163SerAsp: 3.163 ± 0.069
3.211SerGlu: 3.211 ± 0.06
2.263SerPhe: 2.263 ± 0.048
5.536SerGly: 5.536 ± 0.093
1.433SerHis: 1.433 ± 0.035
3.25SerIle: 3.25 ± 0.069
1.958SerLys: 1.958 ± 0.045
7.008SerLeu: 7.008 ± 0.087
1.5SerMet: 1.5 ± 0.037
1.961SerAsn: 1.961 ± 0.046
2.732SerPro: 2.732 ± 0.052
2.745SerGln: 2.745 ± 0.051
3.539SerArg: 3.539 ± 0.059
3.763SerSer: 3.763 ± 0.069
2.94SerThr: 2.94 ± 0.056
4.264SerVal: 4.264 ± 0.062
0.882SerTrp: 0.882 ± 0.031
1.677SerTyr: 1.677 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
4.976ThrAla: 4.976 ± 0.081
0.441ThrCys: 0.441 ± 0.023
2.703ThrAsp: 2.703 ± 0.051
2.725ThrGlu: 2.725 ± 0.05
1.917ThrPhe: 1.917 ± 0.048
4.13ThrGly: 4.13 ± 0.07
1.175ThrHis: 1.175 ± 0.031
2.996ThrIle: 2.996 ± 0.061
1.411ThrLys: 1.411 ± 0.037
7.362ThrLeu: 7.362 ± 0.109
1.122ThrMet: 1.122 ± 0.033
1.599ThrAsn: 1.599 ± 0.037
3.135ThrPro: 3.135 ± 0.067
2.305ThrGln: 2.305 ± 0.049
3.049ThrArg: 3.049 ± 0.052
2.94ThrSer: 2.94 ± 0.054
2.871ThrThr: 2.871 ± 0.062
3.873ThrVal: 3.873 ± 0.077
0.637ThrTrp: 0.637 ± 0.023
1.265ThrTyr: 1.265 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
6.753ValAla: 6.753 ± 0.088
0.789ValCys: 0.789 ± 0.025
3.683ValAsp: 3.683 ± 0.064
3.926ValGlu: 3.926 ± 0.069
2.53ValPhe: 2.53 ± 0.052
4.722ValGly: 4.722 ± 0.071
1.231ValHis: 1.231 ± 0.036
4.641ValIle: 4.641 ± 0.074
2.949ValLys: 2.949 ± 0.057
7.264ValLeu: 7.264 ± 0.086
2.14ValMet: 2.14 ± 0.047
2.757ValAsn: 2.757 ± 0.054
2.774ValPro: 2.774 ± 0.054
2.331ValGln: 2.331 ± 0.052
3.789ValArg: 3.789 ± 0.06
4.565ValSer: 4.565 ± 0.071
4.078ValThr: 4.078 ± 0.071
5.259ValVal: 5.259 ± 0.083
0.868ValTrp: 0.868 ± 0.03
1.758ValTyr: 1.758 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.896TrpAla: 0.896 ± 0.026
0.171TrpCys: 0.171 ± 0.012
0.576TrpAsp: 0.576 ± 0.028
0.549TrpGlu: 0.549 ± 0.021
0.592TrpPhe: 0.592 ± 0.024
0.833TrpGly: 0.833 ± 0.026
0.4TrpHis: 0.4 ± 0.023
0.685TrpIle: 0.685 ± 0.024
0.434TrpLys: 0.434 ± 0.021
2.141TrpLeu: 2.141 ± 0.053
0.347TrpMet: 0.347 ± 0.018
0.431TrpAsn: 0.431 ± 0.02
0.617TrpPro: 0.617 ± 0.025
1.085TrpGln: 1.085 ± 0.036
1.092TrpArg: 1.092 ± 0.038
0.765TrpSer: 0.765 ± 0.029
0.468TrpThr: 0.468 ± 0.02
0.815TrpVal: 0.815 ± 0.026
0.221TrpTrp: 0.221 ± 0.016
0.356TrpTyr: 0.356 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.426TyrAla: 2.426 ± 0.052
0.381TyrCys: 0.381 ± 0.019
1.583TyrAsp: 1.583 ± 0.041
1.202TyrGlu: 1.202 ± 0.032
1.194TyrPhe: 1.194 ± 0.034
2.135TyrGly: 2.135 ± 0.046
0.798TyrHis: 0.798 ± 0.031
1.445TyrIle: 1.445 ± 0.037
0.871TyrLys: 0.871 ± 0.034
3.244TyrLeu: 3.244 ± 0.058
0.581TyrMet: 0.581 ± 0.025
0.924TyrAsn: 0.924 ± 0.033
1.483TyrPro: 1.483 ± 0.034
1.828TyrGln: 1.828 ± 0.039
2.097TyrArg: 2.097 ± 0.051
1.714TyrSer: 1.714 ± 0.036
1.386TyrThr: 1.386 ± 0.043
1.692TyrVal: 1.692 ± 0.046
0.444TyrTrp: 0.444 ± 0.021
0.917TyrTyr: 0.917 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3611 proteins (1120221 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski