Amino acid dipepetide frequency for Achromobacter phage vB_AxyP_19-32_Axy11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.238AlaAla: 10.238 ± 1.793
0.618AlaCys: 0.618 ± 0.192
4.369AlaAsp: 4.369 ± 0.67
6.575AlaGlu: 6.575 ± 0.751
2.604AlaPhe: 2.604 ± 0.372
6.752AlaGly: 6.752 ± 0.771
1.368AlaHis: 1.368 ± 0.244
4.457AlaIle: 4.457 ± 0.477
5.472AlaLys: 5.472 ± 0.756
8.031AlaLeu: 8.031 ± 0.758
2.824AlaMet: 2.824 ± 0.461
4.766AlaAsn: 4.766 ± 0.553
3.795AlaPro: 3.795 ± 0.472
4.81AlaGln: 4.81 ± 0.725
4.854AlaArg: 4.854 ± 0.625
4.942AlaSer: 4.942 ± 0.553
5.251AlaThr: 5.251 ± 0.534
6.752AlaVal: 6.752 ± 1.263
1.236AlaTrp: 1.236 ± 0.233
3.177AlaTyr: 3.177 ± 0.372
0.0AlaXaa: 0.0 ± 0.0
Cys
0.485CysAla: 0.485 ± 0.168
0.132CysCys: 0.132 ± 0.07
0.309CysAsp: 0.309 ± 0.125
0.485CysGlu: 0.485 ± 0.17
0.265CysPhe: 0.265 ± 0.108
0.574CysGly: 0.574 ± 0.166
0.353CysHis: 0.353 ± 0.126
0.397CysIle: 0.397 ± 0.166
0.53CysLys: 0.53 ± 0.169
0.662CysLeu: 0.662 ± 0.23
0.177CysMet: 0.177 ± 0.121
0.485CysAsn: 0.485 ± 0.169
0.353CysPro: 0.353 ± 0.152
0.132CysGln: 0.132 ± 0.077
0.485CysArg: 0.485 ± 0.167
0.53CysSer: 0.53 ± 0.189
0.53CysThr: 0.53 ± 0.146
0.221CysVal: 0.221 ± 0.108
0.177CysTrp: 0.177 ± 0.086
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
5.737AspAla: 5.737 ± 0.862
0.309AspCys: 0.309 ± 0.139
3.045AspAsp: 3.045 ± 0.5
3.045AspGlu: 3.045 ± 0.44
2.515AspPhe: 2.515 ± 0.367
4.28AspGly: 4.28 ± 0.476
1.545AspHis: 1.545 ± 0.263
3.221AspIle: 3.221 ± 0.413
3.045AspLys: 3.045 ± 0.329
5.693AspLeu: 5.693 ± 0.44
1.809AspMet: 1.809 ± 0.263
1.853AspAsn: 1.853 ± 0.377
3.927AspPro: 3.927 ± 0.45
2.78AspGln: 2.78 ± 0.405
2.868AspArg: 2.868 ± 0.301
2.957AspSer: 2.957 ± 0.41
2.824AspThr: 2.824 ± 0.374
3.619AspVal: 3.619 ± 0.377
0.927AspTrp: 0.927 ± 0.242
2.295AspTyr: 2.295 ± 0.405
0.0AspXaa: 0.0 ± 0.0
Glu
7.237GluAla: 7.237 ± 0.978
0.309GluCys: 0.309 ± 0.11
3.927GluAsp: 3.927 ± 0.406
5.472GluGlu: 5.472 ± 0.687
2.471GluPhe: 2.471 ± 0.302
4.28GluGly: 4.28 ± 0.407
1.412GluHis: 1.412 ± 0.264
3.707GluIle: 3.707 ± 0.416
3.795GluLys: 3.795 ± 0.555
5.384GluLeu: 5.384 ± 0.521
1.986GluMet: 1.986 ± 0.326
2.339GluAsn: 2.339 ± 0.318
2.515GluPro: 2.515 ± 0.353
3.574GluGln: 3.574 ± 0.385
2.604GluArg: 2.604 ± 0.35
3.133GluSer: 3.133 ± 0.337
2.868GluThr: 2.868 ± 0.341
4.634GluVal: 4.634 ± 0.451
0.838GluTrp: 0.838 ± 0.187
2.074GluTyr: 2.074 ± 0.364
0.0GluXaa: 0.0 ± 0.0
Phe
2.559PheAla: 2.559 ± 0.319
0.441PheCys: 0.441 ± 0.171
2.383PheAsp: 2.383 ± 0.3
1.809PheGlu: 1.809 ± 0.319
1.191PhePhe: 1.191 ± 0.202
2.824PheGly: 2.824 ± 0.327
0.485PheHis: 0.485 ± 0.17
1.942PheIle: 1.942 ± 0.301
2.118PheLys: 2.118 ± 0.403
2.074PheLeu: 2.074 ± 0.341
1.412PheMet: 1.412 ± 0.25
1.765PheAsn: 1.765 ± 0.293
0.927PhePro: 0.927 ± 0.243
1.545PheGln: 1.545 ± 0.214
2.515PheArg: 2.515 ± 0.387
2.295PheSer: 2.295 ± 0.317
2.648PheThr: 2.648 ± 0.441
2.78PheVal: 2.78 ± 0.385
0.574PheTrp: 0.574 ± 0.218
1.191PheTyr: 1.191 ± 0.248
0.0PheXaa: 0.0 ± 0.0
Gly
5.516GlyAla: 5.516 ± 0.632
0.574GlyCys: 0.574 ± 0.173
4.06GlyAsp: 4.06 ± 0.371
4.369GlyGlu: 4.369 ± 0.406
2.648GlyPhe: 2.648 ± 0.428
4.104GlyGly: 4.104 ± 0.563
0.838GlyHis: 0.838 ± 0.265
4.06GlyIle: 4.06 ± 0.424
4.589GlyLys: 4.589 ± 0.598
5.604GlyLeu: 5.604 ± 0.582
3.089GlyMet: 3.089 ± 0.368
4.06GlyAsn: 4.06 ± 0.475
2.03GlyPro: 2.03 ± 0.315
2.604GlyGln: 2.604 ± 0.339
4.325GlyArg: 4.325 ± 0.517
4.457GlySer: 4.457 ± 0.527
4.854GlyThr: 4.854 ± 0.502
4.413GlyVal: 4.413 ± 0.479
1.147GlyTrp: 1.147 ± 0.284
2.912GlyTyr: 2.912 ± 0.301
0.0GlyXaa: 0.0 ± 0.0
His
1.633HisAla: 1.633 ± 0.264
0.353HisCys: 0.353 ± 0.126
0.883HisAsp: 0.883 ± 0.17
1.368HisGlu: 1.368 ± 0.315
0.75HisPhe: 0.75 ± 0.192
1.191HisGly: 1.191 ± 0.362
0.397HisHis: 0.397 ± 0.156
1.103HisIle: 1.103 ± 0.293
1.191HisLys: 1.191 ± 0.269
2.118HisLeu: 2.118 ± 0.36
0.618HisMet: 0.618 ± 0.141
0.662HisAsn: 0.662 ± 0.13
0.927HisPro: 0.927 ± 0.246
0.927HisGln: 0.927 ± 0.218
1.015HisArg: 1.015 ± 0.357
0.883HisSer: 0.883 ± 0.222
0.838HisThr: 0.838 ± 0.208
1.28HisVal: 1.28 ± 0.261
0.353HisTrp: 0.353 ± 0.127
1.236HisTyr: 1.236 ± 0.251
0.0HisXaa: 0.0 ± 0.0
Ile
4.766IleAla: 4.766 ± 0.415
0.441IleCys: 0.441 ± 0.134
3.574IleAsp: 3.574 ± 0.351
3.354IleGlu: 3.354 ± 0.445
1.721IlePhe: 1.721 ± 0.265
3.354IleGly: 3.354 ± 0.459
1.324IleHis: 1.324 ± 0.25
2.912IleIle: 2.912 ± 0.513
3.927IleLys: 3.927 ± 0.506
4.06IleLeu: 4.06 ± 0.464
1.589IleMet: 1.589 ± 0.272
2.604IleAsn: 2.604 ± 0.382
2.957IlePro: 2.957 ± 0.394
2.78IleGln: 2.78 ± 0.359
2.559IleArg: 2.559 ± 0.306
2.648IleSer: 2.648 ± 0.302
3.266IleThr: 3.266 ± 0.346
3.221IleVal: 3.221 ± 0.437
0.706IleTrp: 0.706 ± 0.196
1.898IleTyr: 1.898 ± 0.284
0.0IleXaa: 0.0 ± 0.0
Lys
6.663LysAla: 6.663 ± 0.694
0.132LysCys: 0.132 ± 0.077
3.972LysAsp: 3.972 ± 0.525
4.325LysGlu: 4.325 ± 0.458
1.853LysPhe: 1.853 ± 0.265
3.266LysGly: 3.266 ± 0.444
1.236LysHis: 1.236 ± 0.277
2.912LysIle: 2.912 ± 0.381
4.457LysLys: 4.457 ± 0.56
5.516LysLeu: 5.516 ± 0.57
2.074LysMet: 2.074 ± 0.314
2.604LysAsn: 2.604 ± 0.39
2.824LysPro: 2.824 ± 0.543
2.957LysGln: 2.957 ± 0.337
2.868LysArg: 2.868 ± 0.375
3.221LysSer: 3.221 ± 0.369
3.354LysThr: 3.354 ± 0.374
4.81LysVal: 4.81 ± 0.443
0.838LysTrp: 0.838 ± 0.222
1.765LysTyr: 1.765 ± 0.374
0.0LysXaa: 0.0 ± 0.0
Leu
7.678LeuAla: 7.678 ± 0.836
0.53LeuCys: 0.53 ± 0.174
5.34LeuAsp: 5.34 ± 0.438
5.163LeuGlu: 5.163 ± 0.395
3.486LeuPhe: 3.486 ± 0.42
6.443LeuGly: 6.443 ± 0.628
1.898LeuHis: 1.898 ± 0.347
3.839LeuIle: 3.839 ± 0.33
4.987LeuLys: 4.987 ± 0.6
5.913LeuLeu: 5.913 ± 0.634
2.383LeuMet: 2.383 ± 0.283
4.942LeuAsn: 4.942 ± 0.457
4.413LeuPro: 4.413 ± 0.501
3.177LeuGln: 3.177 ± 0.337
4.06LeuArg: 4.06 ± 0.367
4.589LeuSer: 4.589 ± 0.536
4.987LeuThr: 4.987 ± 0.51
5.295LeuVal: 5.295 ± 0.438
0.883LeuTrp: 0.883 ± 0.192
2.295LeuTyr: 2.295 ± 0.296
0.0LeuXaa: 0.0 ± 0.0
Met
3.221MetAla: 3.221 ± 0.398
0.132MetCys: 0.132 ± 0.073
2.251MetAsp: 2.251 ± 0.259
2.295MetGlu: 2.295 ± 0.315
0.971MetPhe: 0.971 ± 0.234
1.942MetGly: 1.942 ± 0.327
0.662MetHis: 0.662 ± 0.216
1.5MetIle: 1.5 ± 0.203
1.986MetLys: 1.986 ± 0.405
2.868MetLeu: 2.868 ± 0.383
0.927MetMet: 0.927 ± 0.174
1.324MetAsn: 1.324 ± 0.247
1.765MetPro: 1.765 ± 0.243
2.206MetGln: 2.206 ± 0.331
1.633MetArg: 1.633 ± 0.257
2.559MetSer: 2.559 ± 0.275
1.853MetThr: 1.853 ± 0.248
1.942MetVal: 1.942 ± 0.257
0.309MetTrp: 0.309 ± 0.135
0.574MetTyr: 0.574 ± 0.158
0.0MetXaa: 0.0 ± 0.0
Asn
4.236AsnAla: 4.236 ± 0.421
0.574AsnCys: 0.574 ± 0.223
1.942AsnAsp: 1.942 ± 0.352
3.133AsnGlu: 3.133 ± 0.477
1.853AsnPhe: 1.853 ± 0.322
3.266AsnGly: 3.266 ± 0.416
0.883AsnHis: 0.883 ± 0.254
2.427AsnIle: 2.427 ± 0.307
2.471AsnLys: 2.471 ± 0.375
4.192AsnLeu: 4.192 ± 0.528
1.589AsnMet: 1.589 ± 0.285
2.736AsnAsn: 2.736 ± 0.515
3.442AsnPro: 3.442 ± 0.498
2.912AsnGln: 2.912 ± 0.351
2.251AsnArg: 2.251 ± 0.302
2.912AsnSer: 2.912 ± 0.303
2.912AsnThr: 2.912 ± 0.311
2.912AsnVal: 2.912 ± 0.399
0.838AsnTrp: 0.838 ± 0.229
1.633AsnTyr: 1.633 ± 0.236
0.0AsnXaa: 0.0 ± 0.0
Pro
4.148ProAla: 4.148 ± 0.598
0.397ProCys: 0.397 ± 0.124
2.78ProAsp: 2.78 ± 0.393
3.795ProGlu: 3.795 ± 0.419
1.545ProPhe: 1.545 ± 0.288
3.751ProGly: 3.751 ± 0.525
0.397ProHis: 0.397 ± 0.153
2.251ProIle: 2.251 ± 0.375
2.912ProLys: 2.912 ± 0.419
3.31ProLeu: 3.31 ± 0.357
1.456ProMet: 1.456 ± 0.255
1.986ProAsn: 1.986 ± 0.311
1.898ProPro: 1.898 ± 0.322
1.589ProGln: 1.589 ± 0.233
1.853ProArg: 1.853 ± 0.342
2.957ProSer: 2.957 ± 0.322
2.648ProThr: 2.648 ± 0.296
3.972ProVal: 3.972 ± 0.399
0.662ProTrp: 0.662 ± 0.175
1.677ProTyr: 1.677 ± 0.342
0.0ProXaa: 0.0 ± 0.0
Gln
5.295GlnAla: 5.295 ± 0.737
0.088GlnCys: 0.088 ± 0.063
2.427GlnAsp: 2.427 ± 0.339
3.486GlnGlu: 3.486 ± 0.401
1.677GlnPhe: 1.677 ± 0.31
3.31GlnGly: 3.31 ± 0.416
1.103GlnHis: 1.103 ± 0.232
3.045GlnIle: 3.045 ± 0.592
2.736GlnLys: 2.736 ± 0.295
3.045GlnLeu: 3.045 ± 0.349
1.986GlnMet: 1.986 ± 0.384
2.427GlnAsn: 2.427 ± 0.32
1.456GlnPro: 1.456 ± 0.208
2.339GlnGln: 2.339 ± 0.282
2.251GlnArg: 2.251 ± 0.292
2.559GlnSer: 2.559 ± 0.346
2.427GlnThr: 2.427 ± 0.236
3.001GlnVal: 3.001 ± 0.337
0.75GlnTrp: 0.75 ± 0.164
1.721GlnTyr: 1.721 ± 0.251
0.0GlnXaa: 0.0 ± 0.0
Arg
3.795ArgAla: 3.795 ± 0.414
0.353ArgCys: 0.353 ± 0.139
2.868ArgAsp: 2.868 ± 0.454
3.31ArgGlu: 3.31 ± 0.389
1.809ArgPhe: 1.809 ± 0.286
2.957ArgGly: 2.957 ± 0.298
0.75ArgHis: 0.75 ± 0.196
2.427ArgIle: 2.427 ± 0.358
3.221ArgLys: 3.221 ± 0.342
4.589ArgLeu: 4.589 ± 0.518
1.765ArgMet: 1.765 ± 0.251
2.515ArgAsn: 2.515 ± 0.323
1.633ArgPro: 1.633 ± 0.393
2.471ArgGln: 2.471 ± 0.329
2.604ArgArg: 2.604 ± 0.446
3.31ArgSer: 3.31 ± 0.396
2.912ArgThr: 2.912 ± 0.298
3.619ArgVal: 3.619 ± 0.363
0.838ArgTrp: 0.838 ± 0.23
1.368ArgTyr: 1.368 ± 0.245
0.0ArgXaa: 0.0 ± 0.0
Ser
4.722SerAla: 4.722 ± 0.389
0.485SerCys: 0.485 ± 0.177
3.619SerAsp: 3.619 ± 0.485
2.604SerGlu: 2.604 ± 0.349
1.898SerPhe: 1.898 ± 0.274
4.104SerGly: 4.104 ± 0.646
0.971SerHis: 0.971 ± 0.221
3.177SerIle: 3.177 ± 0.321
3.133SerLys: 3.133 ± 0.367
4.942SerLeu: 4.942 ± 0.453
1.721SerMet: 1.721 ± 0.309
3.133SerAsn: 3.133 ± 0.468
2.559SerPro: 2.559 ± 0.348
2.251SerGln: 2.251 ± 0.309
2.471SerArg: 2.471 ± 0.315
3.045SerSer: 3.045 ± 0.436
3.795SerThr: 3.795 ± 0.383
4.06SerVal: 4.06 ± 0.321
1.015SerTrp: 1.015 ± 0.214
2.206SerTyr: 2.206 ± 0.395
0.0SerXaa: 0.0 ± 0.0
Thr
5.957ThrAla: 5.957 ± 0.642
0.485ThrCys: 0.485 ± 0.187
3.354ThrAsp: 3.354 ± 0.339
3.398ThrGlu: 3.398 ± 0.339
2.295ThrPhe: 2.295 ± 0.378
4.854ThrGly: 4.854 ± 0.422
1.103ThrHis: 1.103 ± 0.302
3.266ThrIle: 3.266 ± 0.464
3.839ThrLys: 3.839 ± 0.537
4.457ThrLeu: 4.457 ± 0.554
1.456ThrMet: 1.456 ± 0.25
2.604ThrAsn: 2.604 ± 0.358
3.133ThrPro: 3.133 ± 0.289
2.824ThrGln: 2.824 ± 0.318
2.604ThrArg: 2.604 ± 0.337
3.089ThrSer: 3.089 ± 0.371
3.001ThrThr: 3.001 ± 0.437
3.795ThrVal: 3.795 ± 0.347
0.75ThrTrp: 0.75 ± 0.299
1.324ThrTyr: 1.324 ± 0.384
0.0ThrXaa: 0.0 ± 0.0
Val
5.957ValAla: 5.957 ± 0.569
0.574ValCys: 0.574 ± 0.234
3.707ValAsp: 3.707 ± 0.339
4.148ValGlu: 4.148 ± 0.382
2.03ValPhe: 2.03 ± 0.317
4.854ValGly: 4.854 ± 0.756
1.456ValHis: 1.456 ± 0.286
4.016ValIle: 4.016 ± 0.523
4.28ValLys: 4.28 ± 0.518
5.648ValLeu: 5.648 ± 0.4
2.736ValMet: 2.736 ± 0.328
3.53ValAsn: 3.53 ± 0.368
3.442ValPro: 3.442 ± 0.46
2.912ValGln: 2.912 ± 0.387
3.089ValArg: 3.089 ± 0.336
3.795ValSer: 3.795 ± 0.337
4.28ValThr: 4.28 ± 0.371
4.854ValVal: 4.854 ± 0.698
1.015ValTrp: 1.015 ± 0.274
2.251ValTyr: 2.251 ± 0.333
0.0ValXaa: 0.0 ± 0.0
Trp
1.015TrpAla: 1.015 ± 0.311
0.177TrpCys: 0.177 ± 0.089
1.059TrpAsp: 1.059 ± 0.367
0.971TrpGlu: 0.971 ± 0.268
0.53TrpPhe: 0.53 ± 0.139
1.368TrpGly: 1.368 ± 0.448
0.309TrpHis: 0.309 ± 0.107
0.971TrpIle: 0.971 ± 0.237
1.059TrpLys: 1.059 ± 0.186
1.236TrpLeu: 1.236 ± 0.321
0.265TrpMet: 0.265 ± 0.13
0.838TrpAsn: 0.838 ± 0.197
0.485TrpPro: 0.485 ± 0.157
0.53TrpGln: 0.53 ± 0.135
0.838TrpArg: 0.838 ± 0.247
0.618TrpSer: 0.618 ± 0.132
0.485TrpThr: 0.485 ± 0.216
1.015TrpVal: 1.015 ± 0.156
0.309TrpTrp: 0.309 ± 0.204
0.53TrpTyr: 0.53 ± 0.178
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.03TyrAla: 2.03 ± 0.253
0.177TyrCys: 0.177 ± 0.094
2.427TyrAsp: 2.427 ± 0.275
1.456TyrGlu: 1.456 ± 0.276
1.368TyrPhe: 1.368 ± 0.257
2.78TyrGly: 2.78 ± 0.44
1.236TyrHis: 1.236 ± 0.328
2.03TyrIle: 2.03 ± 0.356
1.898TyrLys: 1.898 ± 0.346
2.957TyrLeu: 2.957 ± 0.505
1.015TyrMet: 1.015 ± 0.2
1.942TyrAsn: 1.942 ± 0.206
1.5TyrPro: 1.5 ± 0.33
1.809TyrGln: 1.809 ± 0.3
1.368TyrArg: 1.368 ± 0.284
1.412TyrSer: 1.412 ± 0.238
1.853TyrThr: 1.853 ± 0.295
2.427TyrVal: 2.427 ± 0.29
0.441TyrTrp: 0.441 ± 0.125
0.838TyrTyr: 0.838 ± 0.2
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 81 proteins (22662 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski