Amino acid dipepetide frequency for Aequorivita sublithincola (strain DSM 14238 / LMG 21431 / ACAM 643 / 9-3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.548AlaAla: 4.548 ± 0.086	0.547AlaCys: 0.547 ± 0.025	3.42AlaAsp: 3.42 ± 0.063	4.603AlaGlu: 4.603 ± 0.076	3.368AlaPhe: 3.368 ± 0.065	4.408AlaGly: 4.408 ± 0.085	1.018AlaHis: 1.018 ± 0.034	5.391AlaIle: 5.391 ± 0.09	4.62AlaLys: 4.62 ± 0.083	6.127AlaLeu: 6.127 ± 0.087	1.651AlaMet: 1.651 ± 0.048	3.395AlaAsn: 3.395 ± 0.062	1.919AlaPro: 1.919 ± 0.045	2.396AlaGln: 2.396 ± 0.049	1.955AlaArg: 1.955 ± 0.053	4.31AlaSer: 4.31 ± 0.074	3.738AlaThr: 3.738 ± 0.068	4.199AlaVal: 4.199 ± 0.078	0.579AlaTrp: 0.579 ± 0.025	2.344AlaTyr: 2.344 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.455CysAla: 0.455 ± 0.021	0.087CysCys: 0.087 ± 0.01	0.422CysAsp: 0.422 ± 0.028	0.489CysGlu: 0.489 ± 0.025	0.4CysPhe: 0.4 ± 0.02	0.68CysGly: 0.68 ± 0.03	0.145CysHis: 0.145 ± 0.014	0.546CysIle: 0.546 ± 0.024	0.424CysLys: 0.424 ± 0.021	0.605CysLeu: 0.605 ± 0.024	0.134CysMet: 0.134 ± 0.012	0.407CysAsn: 0.407 ± 0.022	0.298CysPro: 0.298 ± 0.022	0.216CysGln: 0.216 ± 0.025	0.194CysArg: 0.194 ± 0.013	0.557CysSer: 0.557 ± 0.026	0.415CysThr: 0.415 ± 0.024	0.443CysVal: 0.443 ± 0.019	0.059CysTrp: 0.059 ± 0.007	0.266CysTyr: 0.266 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.669AspAla: 3.669 ± 0.06	0.427AspCys: 0.427 ± 0.022	3.017AspAsp: 3.017 ± 0.071	3.928AspGlu: 3.928 ± 0.078	3.684AspPhe: 3.684 ± 0.071	4.14AspGly: 4.14 ± 0.115	0.826AspHis: 0.826 ± 0.031	4.159AspIle: 4.159 ± 0.074	3.885AspLys: 3.885 ± 0.073	5.011AspLeu: 5.011 ± 0.075	1.072AspMet: 1.072 ± 0.033	3.022AspAsn: 3.022 ± 0.062	1.903AspPro: 1.903 ± 0.062	1.332AspGln: 1.332 ± 0.037	1.825AspArg: 1.825 ± 0.045	3.39AspSer: 3.39 ± 0.067	2.724AspThr: 2.724 ± 0.06	3.685AspVal: 3.685 ± 0.07	0.744AspTrp: 0.744 ± 0.03	2.741AspTyr: 2.741 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.71GluAla: 4.71 ± 0.069	0.335GluCys: 0.335 ± 0.018	3.664GluAsp: 3.664 ± 0.071	5.237GluGlu: 5.237 ± 0.099	2.957GluPhe: 2.957 ± 0.058	3.875GluGly: 3.875 ± 0.056	1.017GluHis: 1.017 ± 0.035	6.072GluIle: 6.072 ± 0.085	6.669GluLys: 6.669 ± 0.108	5.887GluLeu: 5.887 ± 0.093	1.845GluMet: 1.845 ± 0.046	5.497GluAsn: 5.497 ± 0.087	1.568GluPro: 1.568 ± 0.041	2.022GluGln: 2.022 ± 0.04	2.569GluArg: 2.569 ± 0.059	3.334GluSer: 3.334 ± 0.052	4.263GluThr: 4.263 ± 0.075	4.374GluVal: 4.374 ± 0.069	0.597GluTrp: 0.597 ± 0.026	2.554GluTyr: 2.554 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.141PheAla: 3.141 ± 0.059	0.438PheCys: 0.438 ± 0.024	3.163PheAsp: 3.163 ± 0.06	3.696PheGlu: 3.696 ± 0.072	2.788PhePhe: 2.788 ± 0.071	3.746PheGly: 3.746 ± 0.072	0.804PheHis: 0.804 ± 0.03	3.954PheIle: 3.954 ± 0.073	3.773PheLys: 3.773 ± 0.065	4.903PheLeu: 4.903 ± 0.081	1.105PheMet: 1.105 ± 0.034	3.16PheAsn: 3.16 ± 0.062	1.872PhePro: 1.872 ± 0.04	1.744PheGln: 1.744 ± 0.046	1.685PheArg: 1.685 ± 0.043	4.313PheSer: 4.313 ± 0.077	3.178PheThr: 3.178 ± 0.061	3.048PheVal: 3.048 ± 0.061	0.554PheTrp: 0.554 ± 0.025	2.262PheTyr: 2.262 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	4.249GlyAla: 4.249 ± 0.089	0.565GlyCys: 0.565 ± 0.032	3.591GlyAsp: 3.591 ± 0.092	3.798GlyGlu: 3.798 ± 0.057	3.707GlyPhe: 3.707 ± 0.064	5.056GlyGly: 5.056 ± 0.201	1.048GlyHis: 1.048 ± 0.032	5.469GlyIle: 5.469 ± 0.087	4.967GlyLys: 4.967 ± 0.084	5.599GlyLeu: 5.599 ± 0.09	1.691GlyMet: 1.691 ± 0.051	4.16GlyAsn: 4.16 ± 0.104	1.448GlyPro: 1.448 ± 0.047	1.849GlyGln: 1.849 ± 0.04	2.107GlyArg: 2.107 ± 0.053	4.139GlySer: 4.139 ± 0.083	4.166GlyThr: 4.166 ± 0.116	4.151GlyVal: 4.151 ± 0.073	0.767GlyTrp: 0.767 ± 0.031	2.694GlyTyr: 2.694 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	0.789HisAla: 0.789 ± 0.029	0.162HisCys: 0.162 ± 0.014	0.749HisAsp: 0.749 ± 0.026	0.859HisGlu: 0.859 ± 0.029	1.101HisPhe: 1.101 ± 0.032	0.998HisGly: 0.998 ± 0.032	0.41HisHis: 0.41 ± 0.022	1.295HisIle: 1.295 ± 0.04	1.136HisLys: 1.136 ± 0.037	1.566HisLeu: 1.566 ± 0.042	0.247HisMet: 0.247 ± 0.014	0.901HisAsn: 0.901 ± 0.031	0.81HisPro: 0.81 ± 0.03	0.588HisGln: 0.588 ± 0.024	0.633HisArg: 0.633 ± 0.024	1.076HisSer: 1.076 ± 0.035	0.885HisThr: 0.885 ± 0.028	0.793HisVal: 0.793 ± 0.029	0.22HisTrp: 0.22 ± 0.015	0.777HisTyr: 0.777 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.809IleAla: 5.809 ± 0.101	0.604IleCys: 0.604 ± 0.026	4.713IleAsp: 4.713 ± 0.08	5.297IleGlu: 5.297 ± 0.091	4.011IlePhe: 4.011 ± 0.077	4.971IleGly: 4.971 ± 0.085	1.249IleHis: 1.249 ± 0.038	6.162IleIle: 6.162 ± 0.101	5.386IleLys: 5.386 ± 0.083	7.31IleLeu: 7.31 ± 0.101	1.427IleMet: 1.427 ± 0.046	4.483IleAsn: 4.483 ± 0.077	3.34IlePro: 3.34 ± 0.062	2.448IleGln: 2.448 ± 0.05	2.464IleArg: 2.464 ± 0.051	6.111IleSer: 6.111 ± 0.088	4.805IleThr: 4.805 ± 0.088	4.786IleVal: 4.786 ± 0.071	0.661IleTrp: 0.661 ± 0.024	2.927IleTyr: 2.927 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.779LysAla: 4.779 ± 0.084	0.313LysCys: 0.313 ± 0.018	4.483LysAsp: 4.483 ± 0.08	6.158LysGlu: 6.158 ± 0.109	3.078LysPhe: 3.078 ± 0.053	4.208LysGly: 4.208 ± 0.072	1.224LysHis: 1.224 ± 0.035	6.43LysIle: 6.43 ± 0.094	7.113LysLys: 7.113 ± 0.114	6.685LysLeu: 6.685 ± 0.105	2.276LysMet: 2.276 ± 0.052	5.686LysAsn: 5.686 ± 0.083	2.507LysPro: 2.507 ± 0.056	2.719LysGln: 2.719 ± 0.06	2.829LysArg: 2.829 ± 0.06	4.326LysSer: 4.326 ± 0.083	5.014LysThr: 5.014 ± 0.081	4.402LysVal: 4.402 ± 0.078	0.738LysTrp: 0.738 ± 0.026	3.05LysTyr: 3.05 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	5.908LeuAla: 5.908 ± 0.082	0.653LeuCys: 0.653 ± 0.033	5.001LeuAsp: 5.001 ± 0.079	6.153LeuGlu: 6.153 ± 0.095	4.935LeuPhe: 4.935 ± 0.088	5.65LeuGly: 5.65 ± 0.098	1.537LeuHis: 1.537 ± 0.044	6.622LeuIle: 6.622 ± 0.103	8.086LeuLys: 8.086 ± 0.113	9.114LeuLeu: 9.114 ± 0.132	2.032LeuMet: 2.032 ± 0.053	5.537LeuAsn: 5.537 ± 0.081	3.495LeuPro: 3.495 ± 0.066	3.442LeuGln: 3.442 ± 0.07	3.244LeuArg: 3.244 ± 0.057	6.6LeuSer: 6.6 ± 0.084	4.896LeuThr: 4.896 ± 0.086	5.319LeuVal: 5.319 ± 0.08	0.833LeuTrp: 0.833 ± 0.032	3.162LeuTyr: 3.162 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.767MetAla: 1.767 ± 0.045	0.133MetCys: 0.133 ± 0.012	1.299MetAsp: 1.299 ± 0.04	1.515MetGlu: 1.515 ± 0.041	0.81MetPhe: 0.81 ± 0.03	1.47MetGly: 1.47 ± 0.043	0.358MetHis: 0.358 ± 0.02	1.555MetIle: 1.555 ± 0.046	2.43MetLys: 2.43 ± 0.049	2.102MetLeu: 2.102 ± 0.053	0.619MetMet: 0.619 ± 0.027	1.359MetAsn: 1.359 ± 0.039	0.831MetPro: 0.831 ± 0.03	0.864MetGln: 0.864 ± 0.025	0.811MetArg: 0.811 ± 0.034	1.264MetSer: 1.264 ± 0.036	1.132MetThr: 1.132 ± 0.034	1.379MetVal: 1.379 ± 0.038	0.169MetTrp: 0.169 ± 0.013	0.675MetTyr: 0.675 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.734AsnAla: 3.734 ± 0.066	0.506AsnCys: 0.506 ± 0.024	3.39AsnAsp: 3.39 ± 0.065	3.926AsnGlu: 3.926 ± 0.068	3.387AsnPhe: 3.387 ± 0.068	4.257AsnGly: 4.257 ± 0.118	0.991AsnHis: 0.991 ± 0.031	4.863AsnIle: 4.863 ± 0.071	4.104AsnLys: 4.104 ± 0.073	5.67AsnLeu: 5.67 ± 0.085	1.25AsnMet: 1.25 ± 0.032	3.914AsnAsn: 3.914 ± 0.097	3.054AsnPro: 3.054 ± 0.063	2.026AsnGln: 2.026 ± 0.053	2.144AsnArg: 2.144 ± 0.047	4.136AsnSer: 4.136 ± 0.078	3.648AsnThr: 3.648 ± 0.075	3.623AsnVal: 3.623 ± 0.066	0.695AsnTrp: 0.695 ± 0.029	2.917AsnTyr: 2.917 ± 0.065	0.0AsnXaa: 0.0 ± 0.0
Pro	2.013ProAla: 2.013 ± 0.056	0.211ProCys: 0.211 ± 0.015	1.978ProAsp: 1.978 ± 0.052	2.883ProGlu: 2.883 ± 0.052	1.998ProPhe: 1.998 ± 0.047	2.012ProGly: 2.012 ± 0.049	0.562ProHis: 0.562 ± 0.02	2.684ProIle: 2.684 ± 0.047	2.693ProLys: 2.693 ± 0.059	2.99ProLeu: 2.99 ± 0.059	0.742ProMet: 0.742 ± 0.031	2.402ProAsn: 2.402 ± 0.053	0.956ProPro: 0.956 ± 0.04	1.237ProGln: 1.237 ± 0.036	0.932ProArg: 0.932 ± 0.03	2.233ProSer: 2.233 ± 0.047	2.034ProThr: 2.034 ± 0.07	2.262ProVal: 2.262 ± 0.047	0.336ProTrp: 0.336 ± 0.02	1.389ProTyr: 1.389 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.019GlnAla: 2.019 ± 0.051	0.176GlnCys: 0.176 ± 0.013	1.584GlnAsp: 1.584 ± 0.043	2.12GlnGlu: 2.12 ± 0.049	1.662GlnPhe: 1.662 ± 0.042	1.761GlnGly: 1.761 ± 0.048	0.554GlnHis: 0.554 ± 0.026	2.515GlnIle: 2.515 ± 0.048	2.938GlnLys: 2.938 ± 0.058	3.392GlnLeu: 3.392 ± 0.066	0.878GlnMet: 0.878 ± 0.029	2.286GlnAsn: 2.286 ± 0.05	1.057GlnPro: 1.057 ± 0.037	1.467GlnGln: 1.467 ± 0.041	1.209GlnArg: 1.209 ± 0.036	1.793GlnSer: 1.793 ± 0.042	1.919GlnThr: 1.919 ± 0.049	1.832GlnVal: 1.832 ± 0.048	0.337GlnTrp: 0.337 ± 0.018	1.269GlnTyr: 1.269 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.005ArgAla: 2.005 ± 0.046	0.198ArgCys: 0.198 ± 0.018	1.851ArgAsp: 1.851 ± 0.048	2.334ArgGlu: 2.334 ± 0.053	1.852ArgPhe: 1.852 ± 0.047	2.021ArgGly: 2.021 ± 0.041	0.542ArgHis: 0.542 ± 0.024	2.764ArgIle: 2.764 ± 0.057	2.819ArgLys: 2.819 ± 0.066	3.097ArgLeu: 3.097 ± 0.062	0.898ArgMet: 0.898 ± 0.03	2.223ArgAsn: 2.223 ± 0.052	1.079ArgPro: 1.079 ± 0.034	0.978ArgGln: 0.978 ± 0.029	1.304ArgArg: 1.304 ± 0.042	1.892ArgSer: 1.892 ± 0.047	1.814ArgThr: 1.814 ± 0.039	2.011ArgVal: 2.011 ± 0.052	0.368ArgTrp: 0.368 ± 0.018	1.453ArgTyr: 1.453 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.996SerAla: 3.996 ± 0.066	0.621SerCys: 0.621 ± 0.025	3.275SerAsp: 3.275 ± 0.058	5.244SerGlu: 5.244 ± 0.086	3.851SerPhe: 3.851 ± 0.075	4.736SerGly: 4.736 ± 0.096	0.964SerHis: 0.964 ± 0.031	5.173SerIle: 5.173 ± 0.077	5.102SerLys: 5.102 ± 0.083	6.101SerLeu: 6.101 ± 0.084	1.185SerMet: 1.185 ± 0.035	3.841SerAsn: 3.841 ± 0.081	2.132SerPro: 2.132 ± 0.051	2.194SerGln: 2.194 ± 0.053	2.032SerArg: 2.032 ± 0.045	4.21SerSer: 4.21 ± 0.073	3.446SerThr: 3.446 ± 0.058	4.046SerVal: 4.046 ± 0.067	0.656SerTrp: 0.656 ± 0.027	2.561SerTyr: 2.561 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	3.863ThrAla: 3.863 ± 0.082	0.368ThrCys: 0.368 ± 0.024	3.357ThrAsp: 3.357 ± 0.074	3.628ThrGlu: 3.628 ± 0.065	3.167ThrPhe: 3.167 ± 0.058	4.064ThrGly: 4.064 ± 0.107	0.917ThrHis: 0.917 ± 0.032	4.973ThrIle: 4.973 ± 0.083	3.711ThrLys: 3.711 ± 0.063	5.487ThrLeu: 5.487 ± 0.084	1.036ThrMet: 1.036 ± 0.03	3.257ThrAsn: 3.257 ± 0.074	2.347ThrPro: 2.347 ± 0.07	1.766ThrGln: 1.766 ± 0.049	1.646ThrArg: 1.646 ± 0.046	3.853ThrSer: 3.853 ± 0.067	3.489ThrThr: 3.489 ± 0.08	4.144ThrVal: 4.144 ± 0.098	0.574ThrTrp: 0.574 ± 0.025	2.265ThrTyr: 2.265 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	4.157ValAla: 4.157 ± 0.069	0.511ValCys: 0.511 ± 0.021	3.423ValAsp: 3.423 ± 0.066	4.161ValGlu: 4.161 ± 0.059	3.397ValPhe: 3.397 ± 0.067	3.936ValGly: 3.936 ± 0.069	0.923ValHis: 0.923 ± 0.03	4.767ValIle: 4.767 ± 0.082	4.308ValLys: 4.308 ± 0.076	5.822ValLeu: 5.822 ± 0.082	1.435ValMet: 1.435 ± 0.046	3.448ValAsn: 3.448 ± 0.069	2.187ValPro: 2.187 ± 0.046	1.741ValGln: 1.741 ± 0.046	1.977ValArg: 1.977 ± 0.044	4.57ValSer: 4.57 ± 0.067	3.561ValThr: 3.561 ± 0.125	4.035ValVal: 4.035 ± 0.095	0.635ValTrp: 0.635 ± 0.031	2.347ValTyr: 2.347 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.584TrpAla: 0.584 ± 0.022	0.088TrpCys: 0.088 ± 0.008	0.54TrpAsp: 0.54 ± 0.023	0.676TrpGlu: 0.676 ± 0.027	0.576TrpPhe: 0.576 ± 0.023	0.602TrpGly: 0.602 ± 0.027	0.224TrpHis: 0.224 ± 0.013	0.723TrpIle: 0.723 ± 0.028	0.804TrpLys: 0.804 ± 0.029	0.988TrpLeu: 0.988 ± 0.035	0.302TrpMet: 0.302 ± 0.019	0.677TrpAsn: 0.677 ± 0.03	0.257TrpPro: 0.257 ± 0.015	0.435TrpGln: 0.435 ± 0.024	0.396TrpArg: 0.396 ± 0.019	0.566TrpSer: 0.566 ± 0.029	0.502TrpThr: 0.502 ± 0.026	0.628TrpVal: 0.628 ± 0.024	0.12TrpTrp: 0.12 ± 0.012	0.433TrpTyr: 0.433 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.341TyrAla: 2.341 ± 0.047	0.297TyrCys: 0.297 ± 0.018	2.261TyrAsp: 2.261 ± 0.056	2.342TyrGlu: 2.342 ± 0.05	2.596TyrPhe: 2.596 ± 0.054	2.632TyrGly: 2.632 ± 0.055	0.683TyrHis: 0.683 ± 0.027	2.847TyrIle: 2.847 ± 0.056	3.052TyrLys: 3.052 ± 0.057	3.766TyrLeu: 3.766 ± 0.067	0.718TyrMet: 0.718 ± 0.026	2.577TyrAsn: 2.577 ± 0.058	1.488TyrPro: 1.488 ± 0.037	1.303TyrGln: 1.303 ± 0.039	1.547TyrArg: 1.547 ± 0.039	2.694TyrSer: 2.694 ± 0.068	2.282TyrThr: 2.282 ± 0.079	2.181TyrVal: 2.181 ± 0.043	0.477TyrTrp: 0.477 ± 0.022	1.83TyrTyr: 1.83 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3134 proteins (1040270 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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