Amino acid dipepetide frequency for Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.896AlaAla: 7.896 ± 1.607
0.948AlaCys: 0.948 ± 1.793
1.895AlaAsp: 1.895 ± 0.753
4.106AlaGlu: 4.106 ± 1.19
3.79AlaPhe: 3.79 ± 1.464
5.685AlaGly: 5.685 ± 2.168
1.579AlaHis: 1.579 ± 0.688
5.054AlaIle: 5.054 ± 1.209
1.263AlaLys: 1.263 ± 0.616
6.949AlaLeu: 6.949 ± 1.368
1.263AlaMet: 1.263 ± 0.302
4.738AlaAsn: 4.738 ± 1.145
5.37AlaPro: 5.37 ± 1.283
4.106AlaGln: 4.106 ± 1.222
4.106AlaArg: 4.106 ± 0.983
4.738AlaSer: 4.738 ± 0.89
6.633AlaThr: 6.633 ± 1.441
6.633AlaVal: 6.633 ± 0.966
3.79AlaTrp: 3.79 ± 0.527
1.895AlaTyr: 1.895 ± 1.02
0.0AlaXaa: 0.0 ± 0.0
Cys
0.948CysAla: 0.948 ± 0.308
0.316CysCys: 0.316 ± 0.937
0.948CysAsp: 0.948 ± 0.51
0.948CysGlu: 0.948 ± 0.51
1.263CysPhe: 1.263 ± 0.302
2.211CysGly: 2.211 ± 0.604
0.0CysHis: 0.0 ± 0.0
0.316CysIle: 0.316 ± 0.17
0.316CysLys: 0.316 ± 0.17
1.263CysLeu: 1.263 ± 0.83
0.632CysMet: 0.632 ± 0.34
0.0CysAsn: 0.0 ± 0.0
1.263CysPro: 1.263 ± 0.807
0.316CysGln: 0.316 ± 0.17
0.0CysArg: 0.0 ± 0.0
0.948CysSer: 0.948 ± 0.955
0.632CysThr: 0.632 ± 0.34
0.0CysVal: 0.0 ± 0.0
0.632CysTrp: 0.632 ± 0.395
0.316CysTyr: 0.316 ± 0.17
0.0CysXaa: 0.0 ± 0.0
Asp
2.843AspAla: 2.843 ± 0.598
0.948AspCys: 0.948 ± 0.51
1.579AspAsp: 1.579 ± 0.85
4.106AspGlu: 4.106 ± 1.744
3.79AspPhe: 3.79 ± 0.907
2.843AspGly: 2.843 ± 0.924
0.632AspHis: 0.632 ± 0.34
1.895AspIle: 1.895 ± 0.508
1.579AspLys: 1.579 ± 0.382
3.474AspLeu: 3.474 ± 1.202
0.632AspMet: 0.632 ± 0.34
0.316AspAsn: 0.316 ± 0.17
3.159AspPro: 3.159 ± 1.376
0.632AspGln: 0.632 ± 0.34
1.895AspArg: 1.895 ± 0.512
2.843AspSer: 2.843 ± 1.084
3.159AspThr: 3.159 ± 0.886
3.474AspVal: 3.474 ± 0.531
0.316AspTrp: 0.316 ± 0.17
1.579AspTyr: 1.579 ± 0.382
0.0AspXaa: 0.0 ± 0.0
Glu
2.843GluAla: 2.843 ± 0.598
0.316GluCys: 0.316 ± 0.17
0.632GluAsp: 0.632 ± 0.34
2.843GluGlu: 2.843 ± 1.53
1.579GluPhe: 1.579 ± 0.85
4.106GluGly: 4.106 ± 1.158
0.632GluHis: 0.632 ± 0.395
1.263GluIle: 1.263 ± 0.302
0.632GluLys: 0.632 ± 0.651
5.054GluLeu: 5.054 ± 1.23
1.895GluMet: 1.895 ± 0.508
2.843GluAsn: 2.843 ± 0.924
3.474GluPro: 3.474 ± 1.295
2.527GluGln: 2.527 ± 0.809
3.474GluArg: 3.474 ± 0.531
0.316GluSer: 0.316 ± 0.17
5.37GluThr: 5.37 ± 0.857
2.843GluVal: 2.843 ± 0.598
0.948GluTrp: 0.948 ± 0.51
1.263GluTyr: 1.263 ± 0.302
0.0GluXaa: 0.0 ± 0.0
Phe
4.106PheAla: 4.106 ± 1.677
1.579PheCys: 1.579 ± 0.382
3.159PheAsp: 3.159 ± 0.531
1.895PheGlu: 1.895 ± 0.508
0.316PhePhe: 0.316 ± 0.17
3.474PheGly: 3.474 ± 1.066
0.948PheHis: 0.948 ± 0.51
0.632PheIle: 0.632 ± 0.863
1.895PheLys: 1.895 ± 0.753
2.527PheLeu: 2.527 ± 1.492
0.948PheMet: 0.948 ± 0.308
1.579PheAsn: 1.579 ± 0.688
2.211PhePro: 2.211 ± 0.586
4.106PheGln: 4.106 ± 1.677
1.263PheArg: 1.263 ± 0.302
1.895PheSer: 1.895 ± 0.508
3.79PheThr: 3.79 ± 1.464
3.79PheVal: 3.79 ± 0.991
0.632PheTrp: 0.632 ± 0.395
1.263PheTyr: 1.263 ± 0.68
0.0PheXaa: 0.0 ± 0.0
Gly
6.633GlyAla: 6.633 ± 1.485
1.263GlyCys: 1.263 ± 1.725
3.474GlyAsp: 3.474 ± 0.882
2.211GlyGlu: 2.211 ± 0.864
2.211GlyPhe: 2.211 ± 0.794
6.001GlyGly: 6.001 ± 1.058
1.895GlyHis: 1.895 ± 0.512
5.054GlyIle: 5.054 ± 1.209
2.527GlyLys: 2.527 ± 0.992
5.685GlyLeu: 5.685 ± 1.3
2.843GlyMet: 2.843 ± 0.667
3.474GlyAsn: 3.474 ± 0.87
5.685GlyPro: 5.685 ± 1.413
1.579GlyGln: 1.579 ± 0.688
3.474GlyArg: 3.474 ± 0.87
5.685GlySer: 5.685 ± 2.247
8.528GlyThr: 8.528 ± 1.789
7.896GlyVal: 7.896 ± 1.221
2.211GlyTrp: 2.211 ± 0.586
3.474GlyTyr: 3.474 ± 0.494
0.0GlyXaa: 0.0 ± 0.0
His
3.79HisAla: 3.79 ± 0.583
0.0HisCys: 0.0 ± 0.0
0.316HisAsp: 0.316 ± 0.17
0.316HisGlu: 0.316 ± 0.17
1.579HisPhe: 1.579 ± 0.688
1.263HisGly: 1.263 ± 0.68
1.263HisHis: 1.263 ± 0.68
1.263HisIle: 1.263 ± 0.68
1.579HisLys: 1.579 ± 0.382
1.895HisLeu: 1.895 ± 0.512
0.948HisMet: 0.948 ± 0.51
0.632HisAsn: 0.632 ± 0.651
1.579HisPro: 1.579 ± 0.723
1.263HisGln: 1.263 ± 0.83
1.579HisArg: 1.579 ± 0.382
1.579HisSer: 1.579 ± 1.214
0.632HisThr: 0.632 ± 0.34
1.579HisVal: 1.579 ± 0.382
0.316HisTrp: 0.316 ± 0.17
0.632HisTyr: 0.632 ± 0.34
0.0HisXaa: 0.0 ± 0.0
Ile
4.106IleAla: 4.106 ± 1.138
0.948IleCys: 0.948 ± 0.51
0.316IleAsp: 0.316 ± 0.17
1.895IleGlu: 1.895 ± 1.02
0.948IlePhe: 0.948 ± 0.51
5.37IleGly: 5.37 ± 0.857
0.948IleHis: 0.948 ± 0.51
2.211IleIle: 2.211 ± 0.654
1.579IleLys: 1.579 ± 0.85
3.474IleLeu: 3.474 ± 0.882
0.632IleMet: 0.632 ± 0.651
3.79IleAsn: 3.79 ± 0.78
4.422IlePro: 4.422 ± 1.661
1.263IleGln: 1.263 ± 0.302
4.106IleArg: 4.106 ± 1.442
3.474IleSer: 3.474 ± 1.295
4.422IleThr: 4.422 ± 1.294
4.422IleVal: 4.422 ± 0.697
0.632IleTrp: 0.632 ± 0.651
0.316IleTyr: 0.316 ± 0.17
0.0IleXaa: 0.0 ± 0.0
Lys
2.527LysAla: 2.527 ± 1.36
0.0LysCys: 0.0 ± 0.0
1.263LysAsp: 1.263 ± 0.68
0.632LysGlu: 0.632 ± 0.34
0.632LysPhe: 0.632 ± 0.34
3.79LysGly: 3.79 ± 1.464
0.948LysHis: 0.948 ± 0.51
1.895LysIle: 1.895 ± 1.02
0.948LysLys: 0.948 ± 0.51
1.579LysLeu: 1.579 ± 0.85
0.632LysMet: 0.632 ± 0.34
1.263LysAsn: 1.263 ± 0.698
2.843LysPro: 2.843 ± 0.598
1.895LysGln: 1.895 ± 1.656
1.895LysArg: 1.895 ± 1.02
1.579LysSer: 1.579 ± 1.251
2.527LysThr: 2.527 ± 1.36
0.948LysVal: 0.948 ± 0.51
0.316LysTrp: 0.316 ± 0.17
0.632LysTyr: 0.632 ± 0.34
0.0LysXaa: 0.0 ± 0.0
Leu
7.581LeuAla: 7.581 ± 2.152
0.316LeuCys: 0.316 ± 0.17
3.159LeuAsp: 3.159 ± 2.107
4.738LeuGlu: 4.738 ± 0.714
2.211LeuPhe: 2.211 ± 0.604
4.738LeuGly: 4.738 ± 2.451
1.895LeuHis: 1.895 ± 0.508
3.159LeuIle: 3.159 ± 1.663
4.422LeuLys: 4.422 ± 2.38
7.581LeuLeu: 7.581 ± 7.48
2.211LeuMet: 2.211 ± 1.013
1.263LeuAsn: 1.263 ± 0.302
4.422LeuPro: 4.422 ± 0.553
3.474LeuGln: 3.474 ± 1.464
3.79LeuArg: 3.79 ± 1.399
8.212LeuSer: 8.212 ± 3.479
5.054LeuThr: 5.054 ± 3.23
6.949LeuVal: 6.949 ± 0.887
1.263LeuTrp: 1.263 ± 0.302
1.895LeuTyr: 1.895 ± 0.644
0.0LeuXaa: 0.0 ± 0.0
Met
2.527MetAla: 2.527 ± 0.701
0.0MetCys: 0.0 ± 0.0
1.895MetAsp: 1.895 ± 0.928
2.211MetGlu: 2.211 ± 1.522
1.263MetPhe: 1.263 ± 0.302
1.263MetGly: 1.263 ± 0.83
0.632MetHis: 0.632 ± 0.651
1.579MetIle: 1.579 ± 0.382
0.0MetLys: 0.0 ± 0.0
1.895MetLeu: 1.895 ± 0.644
0.0MetMet: 0.0 ± 0.0
0.948MetAsn: 0.948 ± 0.611
1.263MetPro: 1.263 ± 0.302
0.632MetGln: 0.632 ± 0.34
0.948MetArg: 0.948 ± 0.51
2.527MetSer: 2.527 ± 1.154
1.579MetThr: 1.579 ± 0.85
2.527MetVal: 2.527 ± 0.99
1.579MetTrp: 1.579 ± 0.382
1.895MetTyr: 1.895 ± 0.508
0.0MetXaa: 0.0 ± 0.0
Asn
1.579AsnAla: 1.579 ± 0.85
0.948AsnCys: 0.948 ± 0.308
4.106AsnAsp: 4.106 ± 1.677
0.316AsnGlu: 0.316 ± 0.73
0.316AsnPhe: 0.316 ± 0.17
4.738AsnGly: 4.738 ± 1.464
1.263AsnHis: 1.263 ± 0.302
2.527AsnIle: 2.527 ± 0.676
2.211AsnLys: 2.211 ± 0.486
1.895AsnLeu: 1.895 ± 0.753
1.263AsnMet: 1.263 ± 0.302
2.211AsnAsn: 2.211 ± 1.079
7.581AsnPro: 7.581 ± 2.125
1.263AsnGln: 1.263 ± 0.79
2.527AsnArg: 2.527 ± 0.604
4.106AsnSer: 4.106 ± 1.677
2.527AsnThr: 2.527 ± 0.809
3.474AsnVal: 3.474 ± 1.295
0.0AsnTrp: 0.0 ± 0.0
1.263AsnTyr: 1.263 ± 0.302
0.0AsnXaa: 0.0 ± 0.0
Pro
4.422ProAla: 4.422 ± 0.972
0.0ProCys: 0.0 ± 0.0
4.422ProAsp: 4.422 ± 1.044
4.738ProGlu: 4.738 ± 2.063
2.843ProPhe: 2.843 ± 0.598
6.317ProGly: 6.317 ± 1.634
2.211ProHis: 2.211 ± 1.562
1.579ProIle: 1.579 ± 0.666
1.263ProLys: 1.263 ± 0.302
5.685ProLeu: 5.685 ± 1.139
2.843ProMet: 2.843 ± 1.902
2.527ProAsn: 2.527 ± 0.99
3.79ProPro: 3.79 ± 0.78
1.263ProGln: 1.263 ± 0.616
3.474ProArg: 3.474 ± 1.392
3.79ProSer: 3.79 ± 1.257
7.265ProThr: 7.265 ± 1.778
5.054ProVal: 5.054 ± 1.619
0.0ProTrp: 0.0 ± 0.0
2.527ProTyr: 2.527 ± 0.809
0.0ProXaa: 0.0 ± 0.0
Gln
5.054GlnAla: 5.054 ± 0.97
0.0GlnCys: 0.0 ± 0.0
1.263GlnAsp: 1.263 ± 0.68
1.579GlnGlu: 1.579 ± 0.588
1.263GlnPhe: 1.263 ± 0.807
3.159GlnGly: 3.159 ± 1.326
0.948GlnHis: 0.948 ± 0.51
2.527GlnIle: 2.527 ± 0.676
0.948GlnLys: 0.948 ± 0.611
2.527GlnLeu: 2.527 ± 0.518
2.211GlnMet: 2.211 ± 1.144
3.159GlnAsn: 3.159 ± 0.981
1.895GlnPro: 1.895 ± 0.616
2.843GlnGln: 2.843 ± 0.779
1.895GlnArg: 1.895 ± 0.512
3.159GlnSer: 3.159 ± 3.853
1.579GlnThr: 1.579 ± 1.251
3.79GlnVal: 3.79 ± 0.527
0.316GlnTrp: 0.316 ± 0.17
1.895GlnTyr: 1.895 ± 0.644
0.0GlnXaa: 0.0 ± 0.0
Arg
4.422ArgAla: 4.422 ± 0.719
0.632ArgCys: 0.632 ± 0.34
2.527ArgAsp: 2.527 ± 0.518
2.211ArgGlu: 2.211 ± 0.972
1.895ArgPhe: 1.895 ± 0.644
3.474ArgGly: 3.474 ± 0.882
2.211ArgHis: 2.211 ± 0.794
2.527ArgIle: 2.527 ± 1.244
0.316ArgLys: 0.316 ± 0.17
4.106ArgLeu: 4.106 ± 0.602
2.211ArgMet: 2.211 ± 1.079
1.263ArgAsn: 1.263 ± 0.302
4.422ArgPro: 4.422 ± 2.202
3.159ArgGln: 3.159 ± 1.465
4.422ArgArg: 4.422 ± 0.792
3.159ArgSer: 3.159 ± 2.43
5.37ArgThr: 5.37 ± 1.144
5.37ArgVal: 5.37 ± 1.106
0.632ArgTrp: 0.632 ± 0.863
0.948ArgTyr: 0.948 ± 0.51
0.0ArgXaa: 0.0 ± 0.0
Ser
4.738SerAla: 4.738 ± 1.033
1.263SerCys: 1.263 ± 0.302
1.579SerAsp: 1.579 ± 0.85
0.948SerGlu: 0.948 ± 0.51
2.843SerPhe: 2.843 ± 1.7
7.896SerGly: 7.896 ± 3.053
1.895SerHis: 1.895 ± 0.512
6.949SerIle: 6.949 ± 1.74
0.948SerLys: 0.948 ± 0.51
7.581SerLeu: 7.581 ± 7.7
1.263SerMet: 1.263 ± 0.649
6.001SerAsn: 6.001 ± 1.75
2.843SerPro: 2.843 ± 0.97
3.474SerGln: 3.474 ± 1.57
2.527SerArg: 2.527 ± 0.701
2.527SerSer: 2.527 ± 0.604
6.001SerThr: 6.001 ± 2.355
5.37SerVal: 5.37 ± 0.937
1.263SerTrp: 1.263 ± 1.354
1.895SerTyr: 1.895 ± 0.644
0.0SerXaa: 0.0 ± 0.0
Thr
7.896ThrAla: 7.896 ± 0.515
1.263ThrCys: 1.263 ± 0.79
0.632ThrAsp: 0.632 ± 0.34
3.159ThrGlu: 3.159 ± 1.133
5.685ThrPhe: 5.685 ± 1.167
7.581ThrGly: 7.581 ± 2.265
1.895ThrHis: 1.895 ± 1.02
4.422ThrIle: 4.422 ± 1.294
3.159ThrLys: 3.159 ± 1.133
4.422ThrLeu: 4.422 ± 3.106
1.579ThrMet: 1.579 ± 0.666
4.106ThrAsn: 4.106 ± 1.677
5.37ThrPro: 5.37 ± 1.222
3.159ThrGln: 3.159 ± 1.663
6.317ThrArg: 6.317 ± 2.444
9.16ThrSer: 9.16 ± 0.749
6.949ThrThr: 6.949 ± 0.924
3.159ThrVal: 3.159 ± 1.278
0.948ThrTrp: 0.948 ± 0.611
2.211ThrTyr: 2.211 ± 0.654
0.0ThrXaa: 0.0 ± 0.0
Val
6.633ValAla: 6.633 ± 1.093
2.211ValCys: 2.211 ± 0.654
5.054ValAsp: 5.054 ± 1.209
3.79ValGlu: 3.79 ± 1.015
5.054ValPhe: 5.054 ± 1.209
5.37ValGly: 5.37 ± 0.937
0.632ValHis: 0.632 ± 0.34
3.79ValIle: 3.79 ± 0.987
1.895ValLys: 1.895 ± 1.02
6.001ValLeu: 6.001 ± 1.878
1.263ValMet: 1.263 ± 0.554
4.738ValAsn: 4.738 ± 1.145
3.474ValPro: 3.474 ± 0.882
3.159ValGln: 3.159 ± 0.731
4.422ValArg: 4.422 ± 0.553
6.317ValSer: 6.317 ± 0.967
5.37ValThr: 5.37 ± 1.262
7.581ValVal: 7.581 ± 1.237
0.316ValTrp: 0.316 ± 0.17
2.211ValTyr: 2.211 ± 0.794
0.0ValXaa: 0.0 ± 0.0
Trp
0.948TrpAla: 0.948 ± 0.308
0.0TrpCys: 0.0 ± 0.0
1.579TrpAsp: 1.579 ± 0.85
0.632TrpGlu: 0.632 ± 0.395
0.316TrpPhe: 0.316 ± 0.17
1.579TrpGly: 1.579 ± 0.588
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.948TrpLys: 0.948 ± 0.51
3.474TrpLeu: 3.474 ± 0.721
0.316TrpMet: 0.316 ± 0.73
0.632TrpAsn: 0.632 ± 0.395
0.316TrpPro: 0.316 ± 0.17
0.948TrpGln: 0.948 ± 0.308
1.579TrpArg: 1.579 ± 0.85
1.579TrpSer: 1.579 ± 1.742
0.316TrpThr: 0.316 ± 0.17
1.579TrpVal: 1.579 ± 0.688
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.948TyrAla: 0.948 ± 0.818
0.316TyrCys: 0.316 ± 0.17
1.895TyrAsp: 1.895 ± 0.616
1.579TyrGlu: 1.579 ± 0.382
2.211TyrPhe: 2.211 ± 0.654
0.948TyrGly: 0.948 ± 0.51
1.579TyrHis: 1.579 ± 0.723
0.632TyrIle: 0.632 ± 0.34
0.316TyrLys: 0.316 ± 0.17
1.263TyrLeu: 1.263 ± 0.68
1.263TyrMet: 1.263 ± 0.302
0.632TyrAsn: 0.632 ± 0.34
0.632TyrPro: 0.632 ± 0.34
1.263TyrGln: 1.263 ± 0.698
1.579TyrArg: 1.579 ± 1.672
2.211TyrSer: 2.211 ± 0.586
5.37TyrThr: 5.37 ± 1.387
2.843TyrVal: 2.843 ± 0.97
0.632TyrTrp: 0.632 ± 0.34
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3167 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski