Amino acid dipepetide frequency for Lysobacter psychrotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.035AlaAla: 18.035 ± 0.204	1.285AlaCys: 1.285 ± 0.038	7.398AlaAsp: 7.398 ± 0.096	6.207AlaGlu: 6.207 ± 0.122	4.302AlaPhe: 4.302 ± 0.065	11.356AlaGly: 11.356 ± 0.129	2.736AlaHis: 2.736 ± 0.051	5.652AlaIle: 5.652 ± 0.078	3.096AlaLys: 3.096 ± 0.067	15.002AlaLeu: 15.002 ± 0.158	3.398AlaMet: 3.398 ± 0.07	3.029AlaAsn: 3.029 ± 0.059	6.71AlaPro: 6.71 ± 0.11	5.363AlaGln: 5.363 ± 0.079	10.135AlaArg: 10.135 ± 0.13	7.182AlaSer: 7.182 ± 0.091	7.023AlaThr: 7.023 ± 0.103	8.93AlaVal: 8.93 ± 0.1	2.021AlaTrp: 2.021 ± 0.05	2.532AlaTyr: 2.532 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.101CysAla: 1.101 ± 0.035	0.111CysCys: 0.111 ± 0.011	0.523CysAsp: 0.523 ± 0.022	0.448CysGlu: 0.448 ± 0.02	0.287CysPhe: 0.287 ± 0.016	0.939CysGly: 0.939 ± 0.03	0.238CysHis: 0.238 ± 0.014	0.34CysIle: 0.34 ± 0.016	0.189CysLys: 0.189 ± 0.014	0.786CysLeu: 0.786 ± 0.026	0.144CysMet: 0.144 ± 0.011	0.259CysAsn: 0.259 ± 0.017	0.451CysPro: 0.451 ± 0.022	0.239CysGln: 0.239 ± 0.014	0.624CysArg: 0.624 ± 0.023	0.495CysSer: 0.495 ± 0.021	0.491CysThr: 0.491 ± 0.021	0.681CysVal: 0.681 ± 0.025	0.138CysTrp: 0.138 ± 0.011	0.191CysTyr: 0.191 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	9.29AspAla: 9.29 ± 0.122	0.483AspCys: 0.483 ± 0.019	3.843AspAsp: 3.843 ± 0.071	3.348AspGlu: 3.348 ± 0.065	1.979AspPhe: 1.979 ± 0.046	6.512AspGly: 6.512 ± 0.098	1.243AspHis: 1.243 ± 0.034	2.29AspIle: 2.29 ± 0.045	1.337AspLys: 1.337 ± 0.04	5.484AspLeu: 5.484 ± 0.077	1.048AspMet: 1.048 ± 0.03	1.45AspAsn: 1.45 ± 0.04	3.544AspPro: 3.544 ± 0.064	1.662AspGln: 1.662 ± 0.036	4.359AspArg: 4.359 ± 0.074	2.783AspSer: 2.783 ± 0.055	2.893AspThr: 2.893 ± 0.051	4.439AspVal: 4.439 ± 0.067	1.039AspTrp: 1.039 ± 0.03	1.751AspTyr: 1.751 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.483GluAla: 6.483 ± 0.101	0.366GluCys: 0.366 ± 0.018	2.309GluAsp: 2.309 ± 0.05	2.115GluGlu: 2.115 ± 0.056	1.76GluPhe: 1.76 ± 0.039	3.823GluGly: 3.823 ± 0.054	1.51GluHis: 1.51 ± 0.036	2.385GluIle: 2.385 ± 0.048	1.286GluLys: 1.286 ± 0.04	6.106GluLeu: 6.106 ± 0.096	1.021GluMet: 1.021 ± 0.033	1.118GluAsn: 1.118 ± 0.031	2.62GluPro: 2.62 ± 0.053	2.35GluGln: 2.35 ± 0.053	5.127GluArg: 5.127 ± 0.109	2.666GluSer: 2.666 ± 0.053	2.518GluThr: 2.518 ± 0.055	3.72GluVal: 3.72 ± 0.064	0.682GluTrp: 0.682 ± 0.024	1.101GluTyr: 1.101 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.405PheAla: 4.405 ± 0.067	0.319PheCys: 0.319 ± 0.019	2.978PheAsp: 2.978 ± 0.051	2.113PheGlu: 2.113 ± 0.045	1.071PhePhe: 1.071 ± 0.034	3.361PheGly: 3.361 ± 0.061	0.763PheHis: 0.763 ± 0.029	1.13PheIle: 1.13 ± 0.034	0.853PheLys: 0.853 ± 0.03	2.8PheLeu: 2.8 ± 0.055	0.584PheMet: 0.584 ± 0.023	1.053PheAsn: 1.053 ± 0.035	1.386PhePro: 1.386 ± 0.035	0.903PheGln: 0.903 ± 0.025	2.122PheArg: 2.122 ± 0.047	1.877PheSer: 1.877 ± 0.046	1.73PheThr: 1.73 ± 0.056	2.692PheVal: 2.692 ± 0.044	0.467PheTrp: 0.467 ± 0.02	0.778PheTyr: 0.778 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.397GlyAla: 9.397 ± 0.094	0.883GlyCys: 0.883 ± 0.028	5.384GlyAsp: 5.384 ± 0.076	4.927GlyGlu: 4.927 ± 0.074	3.39GlyPhe: 3.39 ± 0.057	7.667GlyGly: 7.667 ± 0.127	2.138GlyHis: 2.138 ± 0.048	3.78GlyIle: 3.78 ± 0.059	2.857GlyLys: 2.857 ± 0.054	8.631GlyLeu: 8.631 ± 0.103	2.119GlyMet: 2.119 ± 0.044	2.799GlyAsn: 2.799 ± 0.076	3.211GlyPro: 3.211 ± 0.06	3.162GlyGln: 3.162 ± 0.067	6.593GlyArg: 6.593 ± 0.092	5.084GlySer: 5.084 ± 0.088	4.634GlyThr: 4.634 ± 0.116	6.592GlyVal: 6.592 ± 0.082	1.639GlyTrp: 1.639 ± 0.043	2.447GlyTyr: 2.447 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	3.217HisAla: 3.217 ± 0.059	0.291HisCys: 0.291 ± 0.016	1.475HisAsp: 1.475 ± 0.041	1.232HisGlu: 1.232 ± 0.032	0.83HisPhe: 0.83 ± 0.025	2.415HisGly: 2.415 ± 0.052	0.657HisHis: 0.657 ± 0.029	0.698HisIle: 0.698 ± 0.025	0.415HisLys: 0.415 ± 0.022	2.236HisLeu: 2.236 ± 0.052	0.407HisMet: 0.407 ± 0.018	0.504HisAsn: 0.504 ± 0.022	1.498HisPro: 1.498 ± 0.036	0.68HisGln: 0.68 ± 0.024	1.847HisArg: 1.847 ± 0.043	1.0HisSer: 1.0 ± 0.03	1.035HisThr: 1.035 ± 0.033	1.757HisVal: 1.757 ± 0.041	0.463HisTrp: 0.463 ± 0.02	0.65HisTyr: 0.65 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.548IleAla: 6.548 ± 0.086	0.347IleCys: 0.347 ± 0.018	3.416IleAsp: 3.416 ± 0.057	3.245IleGlu: 3.245 ± 0.057	0.923IlePhe: 0.923 ± 0.033	4.358IleGly: 4.358 ± 0.065	0.84IleHis: 0.84 ± 0.025	1.048IleIle: 1.048 ± 0.039	1.02IleLys: 1.02 ± 0.035	2.59IleLeu: 2.59 ± 0.057	0.417IleMet: 0.417 ± 0.02	1.172IleAsn: 1.172 ± 0.038	1.849IlePro: 1.849 ± 0.045	0.958IleGln: 0.958 ± 0.032	2.539IleArg: 2.539 ± 0.046	2.04IleSer: 2.04 ± 0.043	2.093IleThr: 2.093 ± 0.051	3.217IleVal: 3.217 ± 0.056	0.401IleTrp: 0.401 ± 0.021	0.752IleTyr: 0.752 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.036LysAla: 3.036 ± 0.068	0.144LysCys: 0.144 ± 0.011	1.226LysAsp: 1.226 ± 0.04	0.951LysGlu: 0.951 ± 0.04	0.729LysPhe: 0.729 ± 0.028	1.797LysGly: 1.797 ± 0.047	0.574LysHis: 0.574 ± 0.023	1.078LysIle: 1.078 ± 0.038	0.876LysLys: 0.876 ± 0.055	2.83LysLeu: 2.83 ± 0.053	0.525LysMet: 0.525 ± 0.025	0.527LysAsn: 0.527 ± 0.024	1.77LysPro: 1.77 ± 0.047	1.052LysGln: 1.052 ± 0.034	1.944LysArg: 1.944 ± 0.045	1.316LysSer: 1.316 ± 0.038	1.323LysThr: 1.323 ± 0.043	2.054LysVal: 2.054 ± 0.051	0.267LysTrp: 0.267 ± 0.016	0.567LysTyr: 0.567 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.327LeuAla: 15.327 ± 0.158	0.918LeuCys: 0.918 ± 0.028	6.857LeuAsp: 6.857 ± 0.084	4.981LeuGlu: 4.981 ± 0.092	3.257LeuPhe: 3.257 ± 0.065	8.64LeuGly: 8.64 ± 0.106	2.471LeuHis: 2.471 ± 0.054	3.613LeuIle: 3.613 ± 0.064	2.695LeuLys: 2.695 ± 0.045	11.396LeuLeu: 11.396 ± 0.154	2.041LeuMet: 2.041 ± 0.046	2.297LeuAsn: 2.297 ± 0.05	6.428LeuPro: 6.428 ± 0.093	3.745LeuGln: 3.745 ± 0.054	9.011LeuArg: 9.011 ± 0.132	5.953LeuSer: 5.953 ± 0.082	4.732LeuThr: 4.732 ± 0.068	7.9LeuVal: 7.9 ± 0.092	1.402LeuTrp: 1.402 ± 0.042	2.06LeuTyr: 2.06 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.63MetAla: 2.63 ± 0.045	0.127MetCys: 0.127 ± 0.012	1.009MetAsp: 1.009 ± 0.034	0.817MetGlu: 0.817 ± 0.031	0.619MetPhe: 0.619 ± 0.023	1.425MetGly: 1.425 ± 0.04	0.514MetHis: 0.514 ± 0.019	0.767MetIle: 0.767 ± 0.025	0.711MetLys: 0.711 ± 0.027	2.315MetLeu: 2.315 ± 0.051	0.415MetMet: 0.415 ± 0.021	0.636MetAsn: 0.636 ± 0.024	1.446MetPro: 1.446 ± 0.037	0.908MetGln: 0.908 ± 0.026	1.687MetArg: 1.687 ± 0.04	1.43MetSer: 1.43 ± 0.035	1.324MetThr: 1.324 ± 0.034	1.477MetVal: 1.477 ± 0.034	0.17MetTrp: 0.17 ± 0.013	0.357MetTyr: 0.357 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.406AsnAla: 3.406 ± 0.059	0.253AsnCys: 0.253 ± 0.017	1.486AsnAsp: 1.486 ± 0.04	1.172AsnGlu: 1.172 ± 0.029	0.85AsnPhe: 0.85 ± 0.034	2.596AsnGly: 2.596 ± 0.066	0.514AsnHis: 0.514 ± 0.023	0.956AsnIle: 0.956 ± 0.032	0.576AsnLys: 0.576 ± 0.023	2.497AsnLeu: 2.497 ± 0.047	0.379AsnMet: 0.379 ± 0.019	0.718AsnAsn: 0.718 ± 0.034	1.801AsnPro: 1.801 ± 0.043	0.774AsnGln: 0.774 ± 0.025	1.858AsnArg: 1.858 ± 0.04	1.133AsnSer: 1.133 ± 0.043	1.346AsnThr: 1.346 ± 0.039	1.904AsnVal: 1.904 ± 0.041	0.414AsnTrp: 0.414 ± 0.02	0.667AsnTyr: 0.667 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.51ProAla: 7.51 ± 0.104	0.334ProCys: 0.334 ± 0.018	3.663ProAsp: 3.663 ± 0.065	3.029ProGlu: 3.029 ± 0.055	1.603ProPhe: 1.603 ± 0.042	5.077ProGly: 5.077 ± 0.076	1.158ProHis: 1.158 ± 0.032	1.933ProIle: 1.933 ± 0.04	1.185ProLys: 1.185 ± 0.034	5.343ProLeu: 5.343 ± 0.077	1.31ProMet: 1.31 ± 0.04	1.222ProAsn: 1.222 ± 0.035	2.958ProPro: 2.958 ± 0.067	2.003ProGln: 2.003 ± 0.051	3.715ProArg: 3.715 ± 0.058	2.973ProSer: 2.973 ± 0.056	2.825ProThr: 2.825 ± 0.057	4.397ProVal: 4.397 ± 0.076	0.831ProTrp: 0.831 ± 0.022	1.106ProTyr: 1.106 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.14GlnAla: 5.14 ± 0.075	0.272GlnCys: 0.272 ± 0.017	1.426GlnAsp: 1.426 ± 0.039	1.245GlnGlu: 1.245 ± 0.035	1.197GlnPhe: 1.197 ± 0.035	2.605GlnGly: 2.605 ± 0.053	0.893GlnHis: 0.893 ± 0.03	1.419GlnIle: 1.419 ± 0.038	0.791GlnLys: 0.791 ± 0.029	4.301GlnLeu: 4.301 ± 0.058	0.757GlnMet: 0.757 ± 0.027	0.671GlnAsn: 0.671 ± 0.028	2.239GlnPro: 2.239 ± 0.05	1.732GlnGln: 1.732 ± 0.049	3.666GlnArg: 3.666 ± 0.07	1.726GlnSer: 1.726 ± 0.046	1.623GlnThr: 1.623 ± 0.046	3.0GlnVal: 3.0 ± 0.049	0.68GlnTrp: 0.68 ± 0.026	0.797GlnTyr: 0.797 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.847ArgAla: 8.847 ± 0.113	0.644ArgCys: 0.644 ± 0.023	4.9ArgAsp: 4.9 ± 0.078	4.595ArgGlu: 4.595 ± 0.076	3.025ArgPhe: 3.025 ± 0.06	5.762ArgGly: 5.762 ± 0.078	2.209ArgHis: 2.209 ± 0.045	3.904ArgIle: 3.904 ± 0.057	1.884ArgLys: 1.884 ± 0.045	8.714ArgLeu: 8.714 ± 0.132	1.908ArgMet: 1.908 ± 0.04	2.068ArgAsn: 2.068 ± 0.046	3.737ArgPro: 3.737 ± 0.064	2.857ArgGln: 2.857 ± 0.056	6.322ArgArg: 6.322 ± 0.092	3.911ArgSer: 3.911 ± 0.064	3.521ArgThr: 3.521 ± 0.063	5.831ArgVal: 5.831 ± 0.084	1.478ArgTrp: 1.478 ± 0.04	2.266ArgTyr: 2.266 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.567SerAla: 6.567 ± 0.094	0.436SerCys: 0.436 ± 0.02	3.014SerAsp: 3.014 ± 0.054	2.465SerGlu: 2.465 ± 0.049	1.878SerPhe: 1.878 ± 0.043	5.429SerGly: 5.429 ± 0.102	1.219SerHis: 1.219 ± 0.029	2.156SerIle: 2.156 ± 0.044	1.299SerLys: 1.299 ± 0.041	5.557SerLeu: 5.557 ± 0.079	1.051SerMet: 1.051 ± 0.038	1.6SerAsn: 1.6 ± 0.046	2.998SerPro: 2.998 ± 0.052	1.929SerGln: 1.929 ± 0.04	3.912SerArg: 3.912 ± 0.066	3.039SerSer: 3.039 ± 0.077	3.053SerThr: 3.053 ± 0.06	3.905SerVal: 3.905 ± 0.071	0.83SerTrp: 0.83 ± 0.027	1.344SerTyr: 1.344 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.261ThrAla: 6.261 ± 0.112	0.42ThrCys: 0.42 ± 0.022	2.782ThrAsp: 2.782 ± 0.057	2.106ThrGlu: 2.106 ± 0.042	1.643ThrPhe: 1.643 ± 0.047	4.869ThrGly: 4.869 ± 0.082	1.076ThrHis: 1.076 ± 0.032	2.054ThrIle: 2.054 ± 0.05	0.894ThrLys: 0.894 ± 0.03	5.847ThrLeu: 5.847 ± 0.085	0.953ThrMet: 0.953 ± 0.028	1.147ThrAsn: 1.147 ± 0.042	3.536ThrPro: 3.536 ± 0.058	1.714ThrGln: 1.714 ± 0.042	3.773ThrArg: 3.773 ± 0.063	2.731ThrSer: 2.731 ± 0.055	3.018ThrThr: 3.018 ± 0.078	4.309ThrVal: 4.309 ± 0.083	0.748ThrTrp: 0.748 ± 0.032	1.182ThrTyr: 1.182 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	10.078ValAla: 10.078 ± 0.109	0.684ValCys: 0.684 ± 0.026	4.907ValAsp: 4.907 ± 0.074	4.458ValGlu: 4.458 ± 0.075	2.602ValPhe: 2.602 ± 0.054	5.694ValGly: 5.694 ± 0.082	1.681ValHis: 1.681 ± 0.04	3.209ValIle: 3.209 ± 0.064	1.672ValLys: 1.672 ± 0.044	8.623ValLeu: 8.623 ± 0.103	1.515ValMet: 1.515 ± 0.038	1.896ValAsn: 1.896 ± 0.042	4.012ValPro: 4.012 ± 0.059	2.498ValGln: 2.498 ± 0.049	5.522ValArg: 5.522 ± 0.083	4.177ValSer: 4.177 ± 0.072	3.888ValThr: 3.888 ± 0.076	6.533ValVal: 6.533 ± 0.091	0.946ValTrp: 0.946 ± 0.029	1.485ValTyr: 1.485 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.29TrpAla: 1.29 ± 0.038	0.145TrpCys: 0.145 ± 0.012	0.688TrpAsp: 0.688 ± 0.025	0.548TrpGlu: 0.548 ± 0.023	0.583TrpPhe: 0.583 ± 0.021	0.932TrpGly: 0.932 ± 0.032	0.398TrpHis: 0.398 ± 0.02	0.69TrpIle: 0.69 ± 0.03	0.442TrpLys: 0.442 ± 0.02	2.256TrpLeu: 2.256 ± 0.061	0.407TrpMet: 0.407 ± 0.019	0.49TrpAsn: 0.49 ± 0.024	0.833TrpPro: 0.833 ± 0.031	0.828TrpGln: 0.828 ± 0.03	1.454TrpArg: 1.454 ± 0.046	0.918TrpSer: 0.918 ± 0.031	0.782TrpThr: 0.782 ± 0.031	1.006TrpVal: 1.006 ± 0.027	0.351TrpTrp: 0.351 ± 0.02	0.328TrpTyr: 0.328 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.825TyrAla: 2.825 ± 0.057	0.213TyrCys: 0.213 ± 0.013	1.489TyrAsp: 1.489 ± 0.053	1.064TyrGlu: 1.064 ± 0.03	0.858TyrPhe: 0.858 ± 0.028	2.08TyrGly: 2.08 ± 0.051	0.475TyrHis: 0.475 ± 0.02	0.672TyrIle: 0.672 ± 0.025	0.51TyrLys: 0.51 ± 0.023	2.409TyrLeu: 2.409 ± 0.045	0.387TyrMet: 0.387 ± 0.024	0.645TyrAsn: 0.645 ± 0.03	1.149TyrPro: 1.149 ± 0.035	0.821TyrGln: 0.821 ± 0.027	2.17TyrArg: 2.17 ± 0.052	1.249TyrSer: 1.249 ± 0.043	1.212TyrThr: 1.212 ± 0.047	1.737TyrVal: 1.737 ± 0.044	0.398TyrTrp: 0.398 ± 0.019	0.601TyrTyr: 0.601 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3253 proteins (1113829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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