Amino acid dipepetide frequency for Hydrocarboniclastica marina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.272AlaAla: 11.272 ± 0.106	1.071AlaCys: 1.071 ± 0.034	5.89AlaAsp: 5.89 ± 0.08	7.217AlaGlu: 7.217 ± 0.099	3.719AlaPhe: 3.719 ± 0.067	8.786AlaGly: 8.786 ± 0.1	2.049AlaHis: 2.049 ± 0.042	5.224AlaIle: 5.224 ± 0.072	2.981AlaLys: 2.981 ± 0.055	12.112AlaLeu: 12.112 ± 0.119	2.785AlaMet: 2.785 ± 0.052	2.766AlaAsn: 2.766 ± 0.047	4.12AlaPro: 4.12 ± 0.077	4.165AlaGln: 4.165 ± 0.059	7.127AlaArg: 7.127 ± 0.086	6.047AlaSer: 6.047 ± 0.074	4.857AlaThr: 4.857 ± 0.071	7.661AlaVal: 7.661 ± 0.079	1.424AlaTrp: 1.424 ± 0.041	2.397AlaTyr: 2.397 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.87CysAla: 0.87 ± 0.031	0.132CysCys: 0.132 ± 0.011	0.54CysAsp: 0.54 ± 0.023	0.531CysGlu: 0.531 ± 0.021	0.362CysPhe: 0.362 ± 0.019	0.901CysGly: 0.901 ± 0.027	0.278CysHis: 0.278 ± 0.015	0.415CysIle: 0.415 ± 0.018	0.278CysLys: 0.278 ± 0.015	0.995CysLeu: 0.995 ± 0.03	0.19CysMet: 0.19 ± 0.011	0.271CysAsn: 0.271 ± 0.017	0.488CysPro: 0.488 ± 0.022	0.401CysGln: 0.401 ± 0.016	0.705CysArg: 0.705 ± 0.023	0.601CysSer: 0.601 ± 0.019	0.438CysThr: 0.438 ± 0.018	0.636CysVal: 0.636 ± 0.023	0.136CysTrp: 0.136 ± 0.011	0.241CysTyr: 0.241 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.41AspAla: 5.41 ± 0.075	0.475AspCys: 0.475 ± 0.022	3.218AspAsp: 3.218 ± 0.067	4.093AspGlu: 4.093 ± 0.071	2.255AspPhe: 2.255 ± 0.04	4.471AspGly: 4.471 ± 0.099	1.305AspHis: 1.305 ± 0.033	3.003AspIle: 3.003 ± 0.057	1.892AspLys: 1.892 ± 0.043	6.013AspLeu: 6.013 ± 0.079	1.324AspMet: 1.324 ± 0.033	1.761AspAsn: 1.761 ± 0.036	2.967AspPro: 2.967 ± 0.049	2.491AspGln: 2.491 ± 0.045	3.924AspArg: 3.924 ± 0.058	3.113AspSer: 3.113 ± 0.061	2.64AspThr: 2.64 ± 0.055	3.885AspVal: 3.885 ± 0.061	0.956AspTrp: 0.956 ± 0.027	1.787AspTyr: 1.787 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.972GluAla: 6.972 ± 0.087	0.455GluCys: 0.455 ± 0.018	3.294GluAsp: 3.294 ± 0.061	3.873GluGlu: 3.873 ± 0.084	2.063GluPhe: 2.063 ± 0.037	4.404GluGly: 4.404 ± 0.071	1.571GluHis: 1.571 ± 0.034	3.314GluIle: 3.314 ± 0.06	2.671GluLys: 2.671 ± 0.056	7.097GluLeu: 7.097 ± 0.098	1.586GluMet: 1.586 ± 0.038	2.12GluAsn: 2.12 ± 0.043	3.112GluPro: 3.112 ± 0.076	3.536GluGln: 3.536 ± 0.067	4.919GluArg: 4.919 ± 0.074	3.583GluSer: 3.583 ± 0.056	3.497GluThr: 3.497 ± 0.063	4.554GluVal: 4.554 ± 0.072	0.728GluTrp: 0.728 ± 0.024	1.388GluTyr: 1.388 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.571PheAla: 3.571 ± 0.059	0.452PheCys: 0.452 ± 0.017	2.424PheAsp: 2.424 ± 0.044	2.352PheGlu: 2.352 ± 0.045	1.603PhePhe: 1.603 ± 0.042	3.201PheGly: 3.201 ± 0.06	0.802PheHis: 0.802 ± 0.029	1.898PheIle: 1.898 ± 0.042	1.111PheLys: 1.111 ± 0.031	3.554PheLeu: 3.554 ± 0.057	0.878PheMet: 0.878 ± 0.031	1.288PheAsn: 1.288 ± 0.034	1.577PhePro: 1.577 ± 0.035	1.255PheGln: 1.255 ± 0.03	2.361PheArg: 2.361 ± 0.047	2.761PheSer: 2.761 ± 0.058	2.014PheThr: 2.014 ± 0.047	2.572PheVal: 2.572 ± 0.05	0.562PheTrp: 0.562 ± 0.026	1.137PheTyr: 1.137 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	7.271GlyAla: 7.271 ± 0.106	0.891GlyCys: 0.891 ± 0.027	4.295GlyAsp: 4.295 ± 0.083	4.989GlyGlu: 4.989 ± 0.07	3.452GlyPhe: 3.452 ± 0.054	5.869GlyGly: 5.869 ± 0.085	1.901GlyHis: 1.901 ± 0.042	4.334GlyIle: 4.334 ± 0.069	3.171GlyLys: 3.171 ± 0.055	8.623GlyLeu: 8.623 ± 0.094	2.249GlyMet: 2.249 ± 0.043	2.431GlyAsn: 2.431 ± 0.06	2.709GlyPro: 2.709 ± 0.046	3.408GlyGln: 3.408 ± 0.06	5.108GlyArg: 5.108 ± 0.068	4.794GlySer: 4.794 ± 0.082	4.16GlyThr: 4.16 ± 0.086	5.662GlyVal: 5.662 ± 0.076	1.24GlyTrp: 1.24 ± 0.035	2.411GlyTyr: 2.411 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.944HisAla: 1.944 ± 0.046	0.299HisCys: 0.299 ± 0.015	1.131HisAsp: 1.131 ± 0.028	1.282HisGlu: 1.282 ± 0.038	0.968HisPhe: 0.968 ± 0.027	1.852HisGly: 1.852 ± 0.042	0.667HisHis: 0.667 ± 0.025	1.003HisIle: 1.003 ± 0.031	0.621HisLys: 0.621 ± 0.022	2.386HisLeu: 2.386 ± 0.049	0.478HisMet: 0.478 ± 0.019	0.655HisAsn: 0.655 ± 0.023	1.337HisPro: 1.337 ± 0.035	0.963HisGln: 0.963 ± 0.032	1.573HisArg: 1.573 ± 0.037	1.323HisSer: 1.323 ± 0.034	0.971HisThr: 0.971 ± 0.029	1.392HisVal: 1.392 ± 0.035	0.428HisTrp: 0.428 ± 0.02	0.76HisTyr: 0.76 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.615IleAla: 5.615 ± 0.076	0.49IleCys: 0.49 ± 0.019	3.28IleAsp: 3.28 ± 0.055	3.522IleGlu: 3.522 ± 0.064	1.632IlePhe: 1.632 ± 0.036	4.152IleGly: 4.152 ± 0.064	1.012IleHis: 1.012 ± 0.027	2.327IleIle: 2.327 ± 0.059	1.673IleLys: 1.673 ± 0.037	4.589IleLeu: 4.589 ± 0.061	0.917IleMet: 0.917 ± 0.029	1.889IleAsn: 1.889 ± 0.043	2.385IlePro: 2.385 ± 0.041	1.688IleGln: 1.688 ± 0.036	3.299IleArg: 3.299 ± 0.052	3.243IleSer: 3.243 ± 0.06	2.656IleThr: 2.656 ± 0.049	3.541IleVal: 3.541 ± 0.056	0.534IleTrp: 0.534 ± 0.021	1.179IleTyr: 1.179 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.663LysAla: 3.663 ± 0.059	0.205LysCys: 0.205 ± 0.012	1.752LysAsp: 1.752 ± 0.044	1.875LysGlu: 1.875 ± 0.043	0.872LysPhe: 0.872 ± 0.027	2.567LysGly: 2.567 ± 0.054	0.745LysHis: 0.745 ± 0.025	1.526LysIle: 1.526 ± 0.038	1.545LysLys: 1.545 ± 0.05	3.638LysLeu: 3.638 ± 0.061	0.771LysMet: 0.771 ± 0.025	1.027LysAsn: 1.027 ± 0.031	2.0LysPro: 2.0 ± 0.049	1.449LysGln: 1.449 ± 0.037	2.35LysArg: 2.35 ± 0.047	1.974LysSer: 1.974 ± 0.044	1.919LysThr: 1.919 ± 0.044	2.545LysVal: 2.545 ± 0.051	0.369LysTrp: 0.369 ± 0.018	0.725LysTyr: 0.725 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.623LeuAla: 12.623 ± 0.132	1.05LeuCys: 1.05 ± 0.029	6.4LeuAsp: 6.4 ± 0.079	7.118LeuGlu: 7.118 ± 0.096	4.012LeuPhe: 4.012 ± 0.067	8.484LeuGly: 8.484 ± 0.101	2.09LeuHis: 2.09 ± 0.047	5.412LeuIle: 5.412 ± 0.077	3.971LeuLys: 3.971 ± 0.067	11.344LeuLeu: 11.344 ± 0.15	2.51LeuMet: 2.51 ± 0.052	3.352LeuAsn: 3.352 ± 0.057	5.445LeuPro: 5.445 ± 0.065	4.038LeuGln: 4.038 ± 0.066	6.949LeuArg: 6.949 ± 0.082	7.091LeuSer: 7.091 ± 0.099	5.645LeuThr: 5.645 ± 0.085	7.935LeuVal: 7.935 ± 0.09	1.31LeuTrp: 1.31 ± 0.038	2.435LeuTyr: 2.435 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.903MetAla: 2.903 ± 0.056	0.155MetCys: 0.155 ± 0.01	1.234MetAsp: 1.234 ± 0.033	1.22MetGlu: 1.22 ± 0.03	0.666MetPhe: 0.666 ± 0.026	1.832MetGly: 1.832 ± 0.046	0.489MetHis: 0.489 ± 0.021	1.139MetIle: 1.139 ± 0.031	0.955MetLys: 0.955 ± 0.028	2.593MetLeu: 2.593 ± 0.051	0.594MetMet: 0.594 ± 0.023	0.853MetAsn: 0.853 ± 0.026	1.334MetPro: 1.334 ± 0.035	0.906MetGln: 0.906 ± 0.026	1.482MetArg: 1.482 ± 0.035	1.648MetSer: 1.648 ± 0.042	1.557MetThr: 1.557 ± 0.032	1.705MetVal: 1.705 ± 0.041	0.155MetTrp: 0.155 ± 0.011	0.415MetTyr: 0.415 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.079AsnAla: 3.079 ± 0.058	0.283AsnCys: 0.283 ± 0.014	1.691AsnAsp: 1.691 ± 0.038	1.791AsnGlu: 1.791 ± 0.039	1.046AsnPhe: 1.046 ± 0.027	2.453AsnGly: 2.453 ± 0.06	0.697AsnHis: 0.697 ± 0.025	1.619AsnIle: 1.619 ± 0.037	0.94AsnLys: 0.94 ± 0.027	3.227AsnLeu: 3.227 ± 0.057	0.679AsnMet: 0.679 ± 0.024	1.003AsnAsn: 1.003 ± 0.034	1.947AsnPro: 1.947 ± 0.035	1.238AsnGln: 1.238 ± 0.033	2.327AsnArg: 2.327 ± 0.042	1.735AsnSer: 1.735 ± 0.043	1.525AsnThr: 1.525 ± 0.038	2.028AsnVal: 2.028 ± 0.043	0.447AsnTrp: 0.447 ± 0.019	0.819AsnTyr: 0.819 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.143ProAla: 5.143 ± 0.075	0.326ProCys: 0.326 ± 0.018	3.516ProAsp: 3.516 ± 0.057	4.097ProGlu: 4.097 ± 0.073	1.767ProPhe: 1.767 ± 0.04	4.401ProGly: 4.401 ± 0.061	0.945ProHis: 0.945 ± 0.029	1.994ProIle: 1.994 ± 0.039	1.391ProLys: 1.391 ± 0.038	4.853ProLeu: 4.853 ± 0.07	1.07ProMet: 1.07 ± 0.028	1.305ProAsn: 1.305 ± 0.034	1.961ProPro: 1.961 ± 0.045	1.763ProGln: 1.763 ± 0.04	2.524ProArg: 2.524 ± 0.049	2.573ProSer: 2.573 ± 0.047	2.116ProThr: 2.116 ± 0.044	4.071ProVal: 4.071 ± 0.064	0.655ProTrp: 0.655 ± 0.026	1.189ProTyr: 1.189 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.889GlnAla: 4.889 ± 0.063	0.334GlnCys: 0.334 ± 0.018	1.892GlnAsp: 1.892 ± 0.036	2.304GlnGlu: 2.304 ± 0.049	1.394GlnPhe: 1.394 ± 0.037	3.121GlnGly: 3.121 ± 0.055	0.907GlnHis: 0.907 ± 0.031	1.959GlnIle: 1.959 ± 0.045	1.428GlnLys: 1.428 ± 0.036	4.479GlnLeu: 4.479 ± 0.073	0.98GlnMet: 0.98 ± 0.027	1.174GlnAsn: 1.174 ± 0.03	2.079GlnPro: 2.079 ± 0.042	2.191GlnGln: 2.191 ± 0.052	3.182GlnArg: 3.182 ± 0.059	2.518GlnSer: 2.518 ± 0.044	1.991GlnThr: 1.991 ± 0.041	3.12GlnVal: 3.12 ± 0.055	0.647GlnTrp: 0.647 ± 0.023	0.978GlnTyr: 0.978 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	5.977ArgAla: 5.977 ± 0.078	0.633ArgCys: 0.633 ± 0.024	3.788ArgAsp: 3.788 ± 0.053	4.698ArgGlu: 4.698 ± 0.073	2.988ArgPhe: 2.988 ± 0.055	3.999ArgGly: 3.999 ± 0.058	1.683ArgHis: 1.683 ± 0.039	3.611ArgIle: 3.611 ± 0.052	2.647ArgLys: 2.647 ± 0.05	8.123ArgLeu: 8.123 ± 0.082	1.668ArgMet: 1.668 ± 0.038	2.156ArgAsn: 2.156 ± 0.045	2.934ArgPro: 2.934 ± 0.052	3.339ArgGln: 3.339 ± 0.065	4.917ArgArg: 4.917 ± 0.084	3.805ArgSer: 3.805 ± 0.056	2.985ArgThr: 2.985 ± 0.045	4.723ArgVal: 4.723 ± 0.064	1.113ArgTrp: 1.113 ± 0.033	2.177ArgTyr: 2.177 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.214SerAla: 6.214 ± 0.089	0.54SerCys: 0.54 ± 0.023	3.375SerAsp: 3.375 ± 0.06	3.697SerGlu: 3.697 ± 0.054	2.339SerPhe: 2.339 ± 0.04	5.599SerGly: 5.599 ± 0.076	1.392SerHis: 1.392 ± 0.035	2.749SerIle: 2.749 ± 0.047	1.758SerLys: 1.758 ± 0.043	6.626SerLeu: 6.626 ± 0.073	1.488SerMet: 1.488 ± 0.033	1.679SerAsn: 1.679 ± 0.041	2.976SerPro: 2.976 ± 0.05	2.396SerGln: 2.396 ± 0.048	4.235SerArg: 4.235 ± 0.062	3.788SerSer: 3.788 ± 0.068	2.919SerThr: 2.919 ± 0.053	4.353SerVal: 4.353 ± 0.068	0.846SerTrp: 0.846 ± 0.026	1.467SerTyr: 1.467 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.262ThrAla: 5.262 ± 0.081	0.446ThrCys: 0.446 ± 0.022	2.96ThrAsp: 2.96 ± 0.055	3.031ThrGlu: 3.031 ± 0.05	1.794ThrPhe: 1.794 ± 0.041	4.656ThrGly: 4.656 ± 0.08	1.098ThrHis: 1.098 ± 0.03	2.282ThrIle: 2.282 ± 0.049	1.152ThrLys: 1.152 ± 0.03	6.225ThrLeu: 6.225 ± 0.09	0.983ThrMet: 0.983 ± 0.029	1.298ThrAsn: 1.298 ± 0.033	2.811ThrPro: 2.811 ± 0.051	1.794ThrGln: 1.794 ± 0.036	3.269ThrArg: 3.269 ± 0.056	2.807ThrSer: 2.807 ± 0.064	2.623ThrThr: 2.623 ± 0.054	4.12ThrVal: 4.12 ± 0.069	0.667ThrTrp: 0.667 ± 0.023	1.181ThrTyr: 1.181 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.773ValAla: 7.773 ± 0.089	0.723ValCys: 0.723 ± 0.026	4.244ValAsp: 4.244 ± 0.062	4.857ValGlu: 4.857 ± 0.064	2.814ValPhe: 2.814 ± 0.061	5.218ValGly: 5.218 ± 0.077	1.417ValHis: 1.417 ± 0.032	4.064ValIle: 4.064 ± 0.063	2.264ValLys: 2.264 ± 0.051	7.702ValLeu: 7.702 ± 0.095	1.835ValMet: 1.835 ± 0.04	2.367ValAsn: 2.367 ± 0.051	3.512ValPro: 3.512 ± 0.049	2.49ValGln: 2.49 ± 0.042	4.508ValArg: 4.508 ± 0.06	4.658ValSer: 4.658 ± 0.062	4.09ValThr: 4.09 ± 0.073	5.76ValVal: 5.76 ± 0.078	0.878ValTrp: 0.878 ± 0.026	1.68ValTyr: 1.68 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.057TrpAla: 1.057 ± 0.029	0.156TrpCys: 0.156 ± 0.012	0.617TrpAsp: 0.617 ± 0.024	0.649TrpGlu: 0.649 ± 0.025	0.556TrpPhe: 0.556 ± 0.021	0.896TrpGly: 0.896 ± 0.028	0.396TrpHis: 0.396 ± 0.018	0.653TrpIle: 0.653 ± 0.025	0.39TrpLys: 0.39 ± 0.019	2.023TrpLeu: 2.023 ± 0.048	0.348TrpMet: 0.348 ± 0.017	0.398TrpAsn: 0.398 ± 0.017	0.682TrpPro: 0.682 ± 0.025	0.84TrpGln: 0.84 ± 0.03	1.059TrpArg: 1.059 ± 0.032	0.82TrpSer: 0.82 ± 0.027	0.652TrpThr: 0.652 ± 0.021	0.969TrpVal: 0.969 ± 0.032	0.21TrpTrp: 0.21 ± 0.016	0.328TrpTyr: 0.328 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.166TyrAla: 2.166 ± 0.047	0.293TyrCys: 0.293 ± 0.016	1.444TyrAsp: 1.444 ± 0.04	1.539TyrGlu: 1.539 ± 0.037	1.069TyrPhe: 1.069 ± 0.03	2.107TyrGly: 2.107 ± 0.047	0.588TyrHis: 0.588 ± 0.026	1.099TyrIle: 1.099 ± 0.028	0.678TyrLys: 0.678 ± 0.024	3.012TyrLeu: 3.012 ± 0.051	0.5TyrMet: 0.5 ± 0.022	0.782TyrAsn: 0.782 ± 0.028	1.283TyrPro: 1.283 ± 0.033	1.216TyrGln: 1.216 ± 0.031	2.147TyrArg: 2.147 ± 0.048	1.557TyrSer: 1.557 ± 0.035	1.203TyrThr: 1.203 ± 0.035	1.62TyrVal: 1.62 ± 0.043	0.394TyrTrp: 0.394 ± 0.016	0.723TyrTyr: 0.723 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3673 proteins (1223267 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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