Amino acid dipepetide frequency for Bifidobacterium psychraerophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.036AlaAla: 12.036 ± 0.165	1.026AlaCys: 1.026 ± 0.038	6.433AlaAsp: 6.433 ± 0.089	5.494AlaGlu: 5.494 ± 0.094	3.781AlaPhe: 3.781 ± 0.071	8.788AlaGly: 8.788 ± 0.125	2.14AlaHis: 2.14 ± 0.055	5.685AlaIle: 5.685 ± 0.097	4.174AlaLys: 4.174 ± 0.085	10.989AlaLeu: 10.989 ± 0.138	2.737AlaMet: 2.737 ± 0.057	2.879AlaAsn: 2.879 ± 0.075	3.81AlaPro: 3.81 ± 0.078	4.594AlaGln: 4.594 ± 0.08	5.812AlaArg: 5.812 ± 0.104	8.044AlaSer: 8.044 ± 0.139	5.585AlaThr: 5.585 ± 0.107	8.485AlaVal: 8.485 ± 0.118	1.361AlaTrp: 1.361 ± 0.042	2.602AlaTyr: 2.602 ± 0.076	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.042	0.129CysCys: 0.129 ± 0.016	0.515CysAsp: 0.515 ± 0.027	0.403CysGlu: 0.403 ± 0.024	0.316CysPhe: 0.316 ± 0.022	0.875CysGly: 0.875 ± 0.035	0.181CysHis: 0.181 ± 0.015	0.468CysIle: 0.468 ± 0.025	0.188CysLys: 0.188 ± 0.016	0.766CysLeu: 0.766 ± 0.034	0.215CysMet: 0.215 ± 0.018	0.176CysAsn: 0.176 ± 0.015	0.428CysPro: 0.428 ± 0.026	0.189CysGln: 0.189 ± 0.015	0.458CysArg: 0.458 ± 0.028	0.57CysSer: 0.57 ± 0.03	0.532CysThr: 0.532 ± 0.033	0.685CysVal: 0.685 ± 0.032	0.102CysTrp: 0.102 ± 0.013	0.172CysTyr: 0.172 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.397AspAla: 7.397 ± 0.124	0.414AspCys: 0.414 ± 0.024	4.413AspAsp: 4.413 ± 0.102	4.452AspGlu: 4.452 ± 0.093	2.224AspPhe: 2.224 ± 0.054	5.537AspGly: 5.537 ± 0.111	1.349AspHis: 1.349 ± 0.042	3.361AspIle: 3.361 ± 0.069	1.908AspLys: 1.908 ± 0.056	5.206AspLeu: 5.206 ± 0.1	1.483AspMet: 1.483 ± 0.044	1.584AspAsn: 1.584 ± 0.044	3.326AspPro: 3.326 ± 0.07	1.909AspGln: 1.909 ± 0.056	3.281AspArg: 3.281 ± 0.075	3.996AspSer: 3.996 ± 0.075	3.318AspThr: 3.318 ± 0.083	4.835AspVal: 4.835 ± 0.087	0.868AspTrp: 0.868 ± 0.037	1.696AspTyr: 1.696 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.877GluAla: 5.877 ± 0.107	0.37GluCys: 0.37 ± 0.025	3.349GluAsp: 3.349 ± 0.075	3.408GluGlu: 3.408 ± 0.075	1.624GluPhe: 1.624 ± 0.047	4.368GluGly: 4.368 ± 0.096	1.957GluHis: 1.957 ± 0.053	2.729GluIle: 2.729 ± 0.062	1.819GluLys: 1.819 ± 0.062	5.134GluLeu: 5.134 ± 0.103	1.338GluMet: 1.338 ± 0.045	1.652GluAsn: 1.652 ± 0.047	1.996GluPro: 1.996 ± 0.053	2.854GluGln: 2.854 ± 0.063	4.077GluArg: 4.077 ± 0.087	4.11GluSer: 4.11 ± 0.082	2.618GluThr: 2.618 ± 0.065	3.494GluVal: 3.494 ± 0.073	0.656GluTrp: 0.656 ± 0.033	1.561GluTyr: 1.561 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.831PheAla: 3.831 ± 0.08	0.302PheCys: 0.302 ± 0.021	2.439PheAsp: 2.439 ± 0.066	1.79PheGlu: 1.79 ± 0.049	1.267PhePhe: 1.267 ± 0.054	3.283PheGly: 3.283 ± 0.067	0.696PheHis: 0.696 ± 0.031	1.958PheIle: 1.958 ± 0.071	1.039PheLys: 1.039 ± 0.036	2.893PheLeu: 2.893 ± 0.07	0.793PheMet: 0.793 ± 0.036	1.231PheAsn: 1.231 ± 0.037	1.435PhePro: 1.435 ± 0.041	0.894PheGln: 0.894 ± 0.035	1.592PheArg: 1.592 ± 0.047	2.685PheSer: 2.685 ± 0.058	2.371PheThr: 2.371 ± 0.065	2.624PheVal: 2.624 ± 0.063	0.489PheTrp: 0.489 ± 0.025	0.807PheTyr: 0.807 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	7.818GlyAla: 7.818 ± 0.129	0.645GlyCys: 0.645 ± 0.032	4.607GlyAsp: 4.607 ± 0.097	4.334GlyGlu: 4.334 ± 0.085	3.265GlyPhe: 3.265 ± 0.069	6.283GlyGly: 6.283 ± 0.112	1.909GlyHis: 1.909 ± 0.057	5.487GlyIle: 5.487 ± 0.106	3.644GlyLys: 3.644 ± 0.072	7.393GlyLeu: 7.393 ± 0.101	2.254GlyMet: 2.254 ± 0.05	2.759GlyAsn: 2.759 ± 0.061	2.627GlyPro: 2.627 ± 0.064	2.837GlyGln: 2.837 ± 0.068	4.65GlyArg: 4.65 ± 0.088	6.329GlySer: 6.329 ± 0.119	5.129GlyThr: 5.129 ± 0.095	6.28GlyVal: 6.28 ± 0.098	1.165GlyTrp: 1.165 ± 0.037	2.641GlyTyr: 2.641 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	2.344HisAla: 2.344 ± 0.061	0.205HisCys: 0.205 ± 0.016	1.688HisAsp: 1.688 ± 0.051	1.309HisGlu: 1.309 ± 0.044	0.694HisPhe: 0.694 ± 0.03	2.039HisGly: 2.039 ± 0.062	0.647HisHis: 0.647 ± 0.034	1.196HisIle: 1.196 ± 0.04	0.523HisLys: 0.523 ± 0.025	1.818HisLeu: 1.818 ± 0.054	0.636HisMet: 0.636 ± 0.032	0.567HisAsn: 0.567 ± 0.029	1.427HisPro: 1.427 ± 0.043	0.839HisGln: 0.839 ± 0.032	1.534HisArg: 1.534 ± 0.048	1.403HisSer: 1.403 ± 0.043	1.314HisThr: 1.314 ± 0.046	1.681HisVal: 1.681 ± 0.039	0.338HisTrp: 0.338 ± 0.023	0.601HisTyr: 0.601 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.894IleAla: 6.894 ± 0.103	0.585IleCys: 0.585 ± 0.03	3.769IleAsp: 3.769 ± 0.079	3.242IleGlu: 3.242 ± 0.087	1.684IlePhe: 1.684 ± 0.054	4.763IleGly: 4.763 ± 0.08	1.057IleHis: 1.057 ± 0.036	3.161IleIle: 3.161 ± 0.077	1.515IleLys: 1.515 ± 0.055	4.4IleLeu: 4.4 ± 0.098	1.189IleMet: 1.189 ± 0.04	1.756IleAsn: 1.756 ± 0.054	2.936IlePro: 2.936 ± 0.068	1.444IleGln: 1.444 ± 0.045	3.165IleArg: 3.165 ± 0.065	4.046IleSer: 4.046 ± 0.081	3.635IleThr: 3.635 ± 0.071	4.778IleVal: 4.778 ± 0.107	0.594IleTrp: 0.594 ± 0.027	1.188IleTyr: 1.188 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.349LysAla: 4.349 ± 0.085	0.117LysCys: 0.117 ± 0.011	2.396LysAsp: 2.396 ± 0.063	2.001LysGlu: 2.001 ± 0.056	0.753LysPhe: 0.753 ± 0.035	2.716LysGly: 2.716 ± 0.061	0.876LysHis: 0.876 ± 0.035	1.668LysIle: 1.668 ± 0.051	1.42LysLys: 1.42 ± 0.054	2.94LysLeu: 2.94 ± 0.071	0.69LysMet: 0.69 ± 0.031	1.085LysAsn: 1.085 ± 0.043	1.732LysPro: 1.732 ± 0.052	1.563LysGln: 1.563 ± 0.05	2.254LysArg: 2.254 ± 0.049	2.38LysSer: 2.38 ± 0.067	2.201LysThr: 2.201 ± 0.063	2.538LysVal: 2.538 ± 0.065	0.361LysTrp: 0.361 ± 0.021	0.779LysTyr: 0.779 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	10.031LeuAla: 10.031 ± 0.134	0.917LeuCys: 0.917 ± 0.038	5.863LeuAsp: 5.863 ± 0.104	4.363LeuGlu: 4.363 ± 0.095	3.199LeuPhe: 3.199 ± 0.084	7.655LeuGly: 7.655 ± 0.097	2.066LeuHis: 2.066 ± 0.054	5.195LeuIle: 5.195 ± 0.108	3.1LeuLys: 3.1 ± 0.071	9.267LeuLeu: 9.267 ± 0.166	2.303LeuMet: 2.303 ± 0.063	3.007LeuAsn: 3.007 ± 0.065	4.598LeuPro: 4.598 ± 0.078	2.919LeuGln: 2.919 ± 0.06	5.776LeuArg: 5.776 ± 0.105	7.259LeuSer: 7.259 ± 0.119	5.178LeuThr: 5.178 ± 0.092	6.669LeuVal: 6.669 ± 0.118	1.116LeuTrp: 1.116 ± 0.046	1.988LeuTyr: 1.988 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.472MetAla: 2.472 ± 0.058	0.226MetCys: 0.226 ± 0.017	1.326MetAsp: 1.326 ± 0.042	1.029MetGlu: 1.029 ± 0.037	0.776MetPhe: 0.776 ± 0.036	1.773MetGly: 1.773 ± 0.05	0.577MetHis: 0.577 ± 0.031	1.334MetIle: 1.334 ± 0.044	0.949MetLys: 0.949 ± 0.034	2.511MetLeu: 2.511 ± 0.059	0.72MetMet: 0.72 ± 0.032	0.888MetAsn: 0.888 ± 0.034	1.378MetPro: 1.378 ± 0.041	0.925MetGln: 0.925 ± 0.035	1.656MetArg: 1.656 ± 0.051	1.996MetSer: 1.996 ± 0.056	1.794MetThr: 1.794 ± 0.045	1.831MetVal: 1.831 ± 0.051	0.29MetTrp: 0.29 ± 0.018	0.497MetTyr: 0.497 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.45AsnAla: 3.45 ± 0.068	0.198AsnCys: 0.198 ± 0.016	1.87AsnAsp: 1.87 ± 0.049	1.66AsnGlu: 1.66 ± 0.05	0.893AsnPhe: 0.893 ± 0.038	2.692AsnGly: 2.692 ± 0.062	0.597AsnHis: 0.597 ± 0.028	1.701AsnIle: 1.701 ± 0.048	0.999AsnLys: 0.999 ± 0.04	2.539AsnLeu: 2.539 ± 0.068	0.721AsnMet: 0.721 ± 0.036	0.981AsnAsn: 0.981 ± 0.041	2.18AsnPro: 2.18 ± 0.051	0.989AsnGln: 0.989 ± 0.037	1.728AsnArg: 1.728 ± 0.047	1.829AsnSer: 1.829 ± 0.052	2.173AsnThr: 2.173 ± 0.066	2.093AsnVal: 2.093 ± 0.054	0.467AsnTrp: 0.467 ± 0.024	0.782AsnTyr: 0.782 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.214ProAla: 4.214 ± 0.081	0.312ProCys: 0.312 ± 0.021	3.222ProAsp: 3.222 ± 0.064	3.318ProGlu: 3.318 ± 0.073	1.605ProPhe: 1.605 ± 0.042	3.698ProGly: 3.698 ± 0.073	0.985ProHis: 0.985 ± 0.037	2.126ProIle: 2.126 ± 0.056	1.629ProLys: 1.629 ± 0.043	3.841ProLeu: 3.841 ± 0.082	0.942ProMet: 0.942 ± 0.035	1.269ProAsn: 1.269 ± 0.041	1.218ProPro: 1.218 ± 0.046	1.902ProGln: 1.902 ± 0.051	2.338ProArg: 2.338 ± 0.052	3.495ProSer: 3.495 ± 0.073	2.607ProThr: 2.607 ± 0.059	3.668ProVal: 3.668 ± 0.08	0.716ProTrp: 0.716 ± 0.039	1.255ProTyr: 1.255 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	4.206GlnAla: 4.206 ± 0.076	0.258GlnCys: 0.258 ± 0.023	2.033GlnAsp: 2.033 ± 0.052	2.178GlnGlu: 2.178 ± 0.055	0.99GlnPhe: 0.99 ± 0.036	3.06GlnGly: 3.06 ± 0.066	1.044GlnHis: 1.044 ± 0.039	1.947GlnIle: 1.947 ± 0.049	1.092GlnLys: 1.092 ± 0.04	3.347GlnLeu: 3.347 ± 0.066	0.976GlnMet: 0.976 ± 0.035	0.993GlnAsn: 0.993 ± 0.038	1.411GlnPro: 1.411 ± 0.048	2.087GlnGln: 2.087 ± 0.068	2.632GlnArg: 2.632 ± 0.058	2.796GlnSer: 2.796 ± 0.068	2.131GlnThr: 2.131 ± 0.053	2.509GlnVal: 2.509 ± 0.061	0.656GlnTrp: 0.656 ± 0.032	1.039GlnTyr: 1.039 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	4.907ArgAla: 4.907 ± 0.082	0.462ArgCys: 0.462 ± 0.028	3.314ArgAsp: 3.314 ± 0.08	3.441ArgGlu: 3.441 ± 0.073	2.299ArgPhe: 2.299 ± 0.058	3.7ArgGly: 3.7 ± 0.077	1.595ArgHis: 1.595 ± 0.048	3.852ArgIle: 3.852 ± 0.071	2.3ArgLys: 2.3 ± 0.064	5.481ArgLeu: 5.481 ± 0.091	1.774ArgMet: 1.774 ± 0.051	2.072ArgAsn: 2.072 ± 0.062	2.483ArgPro: 2.483 ± 0.06	2.514ArgGln: 2.514 ± 0.062	4.632ArgArg: 4.632 ± 0.094	4.455ArgSer: 4.455 ± 0.084	3.141ArgThr: 3.141 ± 0.067	3.999ArgVal: 3.999 ± 0.074	0.849ArgTrp: 0.849 ± 0.034	1.865ArgTyr: 1.865 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	7.589SerAla: 7.589 ± 0.123	0.573SerCys: 0.573 ± 0.028	4.896SerAsp: 4.896 ± 0.094	3.65SerGlu: 3.65 ± 0.07	2.637SerPhe: 2.637 ± 0.06	6.945SerGly: 6.945 ± 0.103	1.527SerHis: 1.527 ± 0.05	3.946SerIle: 3.946 ± 0.073	2.578SerLys: 2.578 ± 0.065	6.603SerLeu: 6.603 ± 0.117	1.836SerMet: 1.836 ± 0.042	2.248SerAsn: 2.248 ± 0.053	3.007SerPro: 3.007 ± 0.063	2.733SerGln: 2.733 ± 0.064	4.1SerArg: 4.1 ± 0.08	6.315SerSer: 6.315 ± 0.154	4.751SerThr: 4.751 ± 0.097	5.522SerVal: 5.522 ± 0.086	1.086SerTrp: 1.086 ± 0.043	1.93SerTyr: 1.93 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	6.391ThrAla: 6.391 ± 0.111	0.388ThrCys: 0.388 ± 0.026	3.165ThrAsp: 3.165 ± 0.071	2.595ThrGlu: 2.595 ± 0.06	1.911ThrPhe: 1.911 ± 0.054	5.199ThrGly: 5.199 ± 0.103	1.263ThrHis: 1.263 ± 0.041	3.439ThrIle: 3.439 ± 0.082	1.916ThrLys: 1.916 ± 0.059	5.765ThrLeu: 5.765 ± 0.093	1.386ThrMet: 1.386 ± 0.044	1.688ThrAsn: 1.688 ± 0.054	3.138ThrPro: 3.138 ± 0.067	2.13ThrGln: 2.13 ± 0.055	3.022ThrArg: 3.022 ± 0.062	4.207ThrSer: 4.207 ± 0.095	3.679ThrThr: 3.679 ± 0.088	5.482ThrVal: 5.482 ± 0.092	0.804ThrTrp: 0.804 ± 0.036	1.456ThrTyr: 1.456 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	7.723ValAla: 7.723 ± 0.103	0.786ValCys: 0.786 ± 0.036	4.812ValAsp: 4.812 ± 0.084	4.211ValGlu: 4.211 ± 0.084	2.943ValPhe: 2.943 ± 0.077	5.454ValGly: 5.454 ± 0.094	1.52ValHis: 1.52 ± 0.044	4.616ValIle: 4.616 ± 0.085	2.645ValLys: 2.645 ± 0.063	7.807ValLeu: 7.807 ± 0.118	2.01ValMet: 2.01 ± 0.056	2.399ValAsn: 2.399 ± 0.058	3.479ValPro: 3.479 ± 0.064	2.388ValGln: 2.388 ± 0.053	3.945ValArg: 3.945 ± 0.079	5.861ValSer: 5.861 ± 0.093	4.623ValThr: 4.623 ± 0.085	6.286ValVal: 6.286 ± 0.117	0.952ValTrp: 0.952 ± 0.033	1.717ValTyr: 1.717 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.104TrpAla: 1.104 ± 0.042	0.156TrpCys: 0.156 ± 0.016	0.787TrpAsp: 0.787 ± 0.033	0.619TrpGlu: 0.619 ± 0.033	0.531TrpPhe: 0.531 ± 0.029	0.957TrpGly: 0.957 ± 0.037	0.334TrpHis: 0.334 ± 0.023	0.741TrpIle: 0.741 ± 0.033	0.597TrpLys: 0.597 ± 0.029	1.411TrpLeu: 1.411 ± 0.044	0.413TrpMet: 0.413 ± 0.023	0.616TrpAsn: 0.616 ± 0.026	0.485TrpPro: 0.485 ± 0.027	0.61TrpGln: 0.61 ± 0.028	0.829TrpArg: 0.829 ± 0.037	1.006TrpSer: 1.006 ± 0.04	0.766TrpThr: 0.766 ± 0.033	0.892TrpVal: 0.892 ± 0.036	0.295TrpTrp: 0.295 ± 0.019	0.384TrpTyr: 0.384 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.889TyrAla: 2.889 ± 0.067	0.233TyrCys: 0.233 ± 0.019	1.663TyrAsp: 1.663 ± 0.054	1.491TyrGlu: 1.491 ± 0.049	1.027TyrPhe: 1.027 ± 0.039	2.273TyrGly: 2.273 ± 0.06	0.483TyrHis: 0.483 ± 0.024	1.191TyrIle: 1.191 ± 0.042	0.782TyrLys: 0.782 ± 0.034	2.358TyrLeu: 2.358 ± 0.056	0.53TyrMet: 0.53 ± 0.029	0.694TyrAsn: 0.694 ± 0.035	1.267TyrPro: 1.267 ± 0.044	1.065TyrGln: 1.065 ± 0.036	1.651TyrArg: 1.651 ± 0.048	1.69TyrSer: 1.69 ± 0.048	1.475TyrThr: 1.475 ± 0.052	1.827TyrVal: 1.827 ± 0.046	0.37TyrTrp: 0.37 ± 0.024	0.796TyrTyr: 0.796 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2122 proteins (762520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---