Amino acid dipepetide frequency for Urechidicola croceus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.134AlaAla: 3.134 ± 0.082	0.436AlaCys: 0.436 ± 0.025	3.041AlaAsp: 3.041 ± 0.063	3.4AlaGlu: 3.4 ± 0.065	2.745AlaPhe: 2.745 ± 0.052	3.478AlaGly: 3.478 ± 0.071	0.974AlaHis: 0.974 ± 0.029	5.235AlaIle: 5.235 ± 0.096	4.254AlaLys: 4.254 ± 0.082	5.011AlaLeu: 5.011 ± 0.09	1.239AlaMet: 1.239 ± 0.037	3.25AlaAsn: 3.25 ± 0.105	1.582AlaPro: 1.582 ± 0.042	2.079AlaGln: 2.079 ± 0.043	1.647AlaArg: 1.647 ± 0.048	3.679AlaSer: 3.679 ± 0.066	3.401AlaThr: 3.401 ± 0.117	3.507AlaVal: 3.507 ± 0.073	0.507AlaTrp: 0.507 ± 0.025	1.998AlaTyr: 1.998 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.404CysAla: 0.404 ± 0.021	0.102CysCys: 0.102 ± 0.01	0.606CysAsp: 0.606 ± 0.089	0.458CysGlu: 0.458 ± 0.024	0.36CysPhe: 0.36 ± 0.019	0.548CysGly: 0.548 ± 0.029	0.166CysHis: 0.166 ± 0.014	0.526CysIle: 0.526 ± 0.026	0.507CysLys: 0.507 ± 0.026	0.588CysLeu: 0.588 ± 0.026	0.13CysMet: 0.13 ± 0.012	0.457CysAsn: 0.457 ± 0.04	0.317CysPro: 0.317 ± 0.021	0.186CysGln: 0.186 ± 0.015	0.169CysArg: 0.169 ± 0.013	0.51CysSer: 0.51 ± 0.026	0.41CysThr: 0.41 ± 0.022	0.388CysVal: 0.388 ± 0.022	0.062CysTrp: 0.062 ± 0.008	0.261CysTyr: 0.261 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.543AspAla: 3.543 ± 0.101	0.503AspCys: 0.503 ± 0.062	3.494AspAsp: 3.494 ± 0.213	4.197AspGlu: 4.197 ± 0.08	3.74AspPhe: 3.74 ± 0.068	4.11AspGly: 4.11 ± 0.249	0.734AspHis: 0.734 ± 0.031	5.127AspIle: 5.127 ± 0.094	4.549AspLys: 4.549 ± 0.09	5.331AspLeu: 5.331 ± 0.097	1.062AspMet: 1.062 ± 0.036	3.599AspAsn: 3.599 ± 0.086	1.581AspPro: 1.581 ± 0.103	1.246AspGln: 1.246 ± 0.04	1.68AspArg: 1.68 ± 0.048	3.628AspSer: 3.628 ± 0.074	3.132AspThr: 3.132 ± 0.223	3.658AspVal: 3.658 ± 0.067	0.754AspTrp: 0.754 ± 0.03	2.894AspTyr: 2.894 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	3.307GluAla: 3.307 ± 0.073	0.35GluCys: 0.35 ± 0.019	3.63GluAsp: 3.63 ± 0.071	4.848GluGlu: 4.848 ± 0.094	3.304GluPhe: 3.304 ± 0.068	3.519GluGly: 3.519 ± 0.055	1.057GluHis: 1.057 ± 0.036	6.475GluIle: 6.475 ± 0.077	6.267GluLys: 6.267 ± 0.112	6.603GluLeu: 6.603 ± 0.098	1.565GluMet: 1.565 ± 0.047	5.341GluAsn: 5.341 ± 0.086	1.471GluPro: 1.471 ± 0.041	2.163GluGln: 2.163 ± 0.06	2.244GluArg: 2.244 ± 0.055	3.806GluSer: 3.806 ± 0.071	3.706GluThr: 3.706 ± 0.069	4.43GluVal: 4.43 ± 0.068	0.584GluTrp: 0.584 ± 0.026	2.682GluTyr: 2.682 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	2.639PheAla: 2.639 ± 0.061	0.404PheCys: 0.404 ± 0.022	3.514PheAsp: 3.514 ± 0.063	3.697PheGlu: 3.697 ± 0.069	2.738PhePhe: 2.738 ± 0.064	3.65PheGly: 3.65 ± 0.063	0.813PheHis: 0.813 ± 0.027	4.398PheIle: 4.398 ± 0.088	4.038PheLys: 4.038 ± 0.088	4.522PheLeu: 4.522 ± 0.096	1.049PheMet: 1.049 ± 0.036	3.674PheAsn: 3.674 ± 0.075	1.646PhePro: 1.646 ± 0.047	1.458PheGln: 1.458 ± 0.043	1.462PheArg: 1.462 ± 0.041	4.12PheSer: 4.12 ± 0.07	3.03PheThr: 3.03 ± 0.065	2.944PheVal: 2.944 ± 0.059	0.578PheTrp: 0.578 ± 0.024	2.277PheTyr: 2.277 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	3.568GlyAla: 3.568 ± 0.075	0.535GlyCys: 0.535 ± 0.024	3.452GlyAsp: 3.452 ± 0.091	3.659GlyGlu: 3.659 ± 0.067	3.638GlyPhe: 3.638 ± 0.067	4.447GlyGly: 4.447 ± 0.098	1.08GlyHis: 1.08 ± 0.037	5.639GlyIle: 5.639 ± 0.093	4.912GlyLys: 4.912 ± 0.08	5.516GlyLeu: 5.516 ± 0.08	1.481GlyMet: 1.481 ± 0.043	3.726GlyAsn: 3.726 ± 0.078	1.205GlyPro: 1.205 ± 0.053	1.755GlyGln: 1.755 ± 0.063	1.942GlyArg: 1.942 ± 0.048	3.964GlySer: 3.964 ± 0.08	4.17GlyThr: 4.17 ± 0.169	4.273GlyVal: 4.273 ± 0.075	0.72GlyTrp: 0.72 ± 0.025	2.734GlyTyr: 2.734 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	0.785HisAla: 0.785 ± 0.029	0.169HisCys: 0.169 ± 0.014	0.739HisAsp: 0.739 ± 0.027	0.933HisGlu: 0.933 ± 0.03	1.099HisPhe: 1.099 ± 0.036	0.933HisGly: 0.933 ± 0.03	0.427HisHis: 0.427 ± 0.023	1.436HisIle: 1.436 ± 0.041	1.242HisLys: 1.242 ± 0.036	1.659HisLeu: 1.659 ± 0.039	0.318HisMet: 0.318 ± 0.017	1.077HisAsn: 1.077 ± 0.036	0.83HisPro: 0.83 ± 0.033	0.678HisGln: 0.678 ± 0.028	0.615HisArg: 0.615 ± 0.024	1.086HisSer: 1.086 ± 0.034	0.88HisThr: 0.88 ± 0.028	0.856HisVal: 0.856 ± 0.027	0.206HisTrp: 0.206 ± 0.014	0.79HisTyr: 0.79 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.376IleAla: 5.376 ± 0.087	0.575IleCys: 0.575 ± 0.023	5.92IleAsp: 5.92 ± 0.135	6.36IleGlu: 6.36 ± 0.094	4.042IlePhe: 4.042 ± 0.079	5.537IleGly: 5.537 ± 0.091	1.471IleHis: 1.471 ± 0.045	7.17IleIle: 7.17 ± 0.128	6.57IleLys: 6.57 ± 0.109	7.711IleLeu: 7.711 ± 0.115	1.422IleMet: 1.422 ± 0.037	5.669IleAsn: 5.669 ± 0.078	3.589IlePro: 3.589 ± 0.071	2.808IleGln: 2.808 ± 0.059	2.494IleArg: 2.494 ± 0.052	6.576IleSer: 6.576 ± 0.096	5.102IleThr: 5.102 ± 0.08	5.133IleVal: 5.133 ± 0.079	0.729IleTrp: 0.729 ± 0.03	3.16IleTyr: 3.16 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	4.054LysAla: 4.054 ± 0.09	0.399LysCys: 0.399 ± 0.02	4.362LysAsp: 4.362 ± 0.073	6.304LysGlu: 6.304 ± 0.113	3.428LysPhe: 3.428 ± 0.078	4.549LysGly: 4.549 ± 0.086	1.383LysHis: 1.383 ± 0.035	7.34LysIle: 7.34 ± 0.109	7.781LysLys: 7.781 ± 0.145	7.201LysLeu: 7.201 ± 0.11	2.133LysMet: 2.133 ± 0.049	6.213LysAsn: 6.213 ± 0.118	2.405LysPro: 2.405 ± 0.05	2.588LysGln: 2.588 ± 0.062	2.833LysArg: 2.833 ± 0.068	5.054LysSer: 5.054 ± 0.077	4.623LysThr: 4.623 ± 0.085	5.007LysVal: 5.007 ± 0.09	0.81LysTrp: 0.81 ± 0.027	3.493LysTyr: 3.493 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	4.775LeuAla: 4.775 ± 0.075	0.592LeuCys: 0.592 ± 0.028	5.29LeuAsp: 5.29 ± 0.102	5.964LeuGlu: 5.964 ± 0.107	4.876LeuPhe: 4.876 ± 0.091	5.634LeuGly: 5.634 ± 0.096	1.352LeuHis: 1.352 ± 0.038	7.828LeuIle: 7.828 ± 0.118	8.14LeuLys: 8.14 ± 0.122	8.294LeuLeu: 8.294 ± 0.154	1.853LeuMet: 1.853 ± 0.049	6.425LeuAsn: 6.425 ± 0.101	3.203LeuPro: 3.203 ± 0.065	2.745LeuGln: 2.745 ± 0.06	2.909LeuArg: 2.909 ± 0.059	6.518LeuSer: 6.518 ± 0.102	5.197LeuThr: 5.197 ± 0.127	5.102LeuVal: 5.102 ± 0.07	0.769LeuTrp: 0.769 ± 0.032	3.126LeuTyr: 3.126 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.41MetAla: 1.41 ± 0.04	0.138MetCys: 0.138 ± 0.012	1.014MetAsp: 1.014 ± 0.036	1.163MetGlu: 1.163 ± 0.036	0.811MetPhe: 0.811 ± 0.028	1.183MetGly: 1.183 ± 0.038	0.376MetHis: 0.376 ± 0.019	1.678MetIle: 1.678 ± 0.046	2.256MetLys: 2.256 ± 0.047	1.829MetLeu: 1.829 ± 0.045	0.554MetMet: 0.554 ± 0.028	1.428MetAsn: 1.428 ± 0.039	0.726MetPro: 0.726 ± 0.026	0.692MetGln: 0.692 ± 0.025	0.772MetArg: 0.772 ± 0.028	1.501MetSer: 1.501 ± 0.04	1.111MetThr: 1.111 ± 0.034	1.225MetVal: 1.225 ± 0.036	0.164MetTrp: 0.164 ± 0.013	0.679MetTyr: 0.679 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.479AsnAla: 3.479 ± 0.07	0.489AsnCys: 0.489 ± 0.028	4.126AsnAsp: 4.126 ± 0.222	4.32AsnGlu: 4.32 ± 0.071	3.517AsnPhe: 3.517 ± 0.083	4.465AsnGly: 4.465 ± 0.129	1.184AsnHis: 1.184 ± 0.037	5.695AsnIle: 5.695 ± 0.08	5.183AsnLys: 5.183 ± 0.092	5.872AsnLeu: 5.872 ± 0.102	1.256AsnMet: 1.256 ± 0.035	4.701AsnAsn: 4.701 ± 0.099	2.917AsnPro: 2.917 ± 0.083	2.4AsnGln: 2.4 ± 0.049	2.098AsnArg: 2.098 ± 0.052	4.727AsnSer: 4.727 ± 0.084	3.889AsnThr: 3.889 ± 0.072	3.618AsnVal: 3.618 ± 0.062	0.852AsnTrp: 0.852 ± 0.034	3.195AsnTyr: 3.195 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.591ProAla: 1.591 ± 0.053	0.203ProCys: 0.203 ± 0.013	1.959ProAsp: 1.959 ± 0.078	2.49ProGlu: 2.49 ± 0.057	1.768ProPhe: 1.768 ± 0.05	1.555ProGly: 1.555 ± 0.044	0.579ProHis: 0.579 ± 0.025	2.896ProIle: 2.896 ± 0.055	2.63ProLys: 2.63 ± 0.062	2.705ProLeu: 2.705 ± 0.055	0.693ProMet: 0.693 ± 0.026	2.335ProAsn: 2.335 ± 0.055	0.832ProPro: 0.832 ± 0.048	1.007ProGln: 1.007 ± 0.036	0.852ProArg: 0.852 ± 0.031	2.066ProSer: 2.066 ± 0.042	2.243ProThr: 2.243 ± 0.136	2.034ProVal: 2.034 ± 0.077	0.332ProTrp: 0.332 ± 0.02	1.315ProTyr: 1.315 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	1.557GlnAla: 1.557 ± 0.036	0.203GlnCys: 0.203 ± 0.041	1.614GlnAsp: 1.614 ± 0.04	2.263GlnGlu: 2.263 ± 0.059	1.618GlnPhe: 1.618 ± 0.04	1.7GlnGly: 1.7 ± 0.042	0.55GlnHis: 0.55 ± 0.026	2.617GlnIle: 2.617 ± 0.054	2.756GlnLys: 2.756 ± 0.065	3.294GlnLeu: 3.294 ± 0.067	0.738GlnMet: 0.738 ± 0.027	2.335GlnAsn: 2.335 ± 0.055	0.901GlnPro: 0.901 ± 0.027	1.225GlnGln: 1.225 ± 0.044	1.098GlnArg: 1.098 ± 0.034	1.937GlnSer: 1.937 ± 0.047	1.686GlnThr: 1.686 ± 0.042	1.855GlnVal: 1.855 ± 0.052	0.295GlnTrp: 0.295 ± 0.019	1.296GlnTyr: 1.296 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	1.748ArgAla: 1.748 ± 0.047	0.184ArgCys: 0.184 ± 0.015	1.642ArgAsp: 1.642 ± 0.045	1.986ArgGlu: 1.986 ± 0.047	1.746ArgPhe: 1.746 ± 0.045	1.792ArgGly: 1.792 ± 0.048	0.529ArgHis: 0.529 ± 0.024	2.82ArgIle: 2.82 ± 0.058	2.816ArgLys: 2.816 ± 0.064	2.914ArgLeu: 2.914 ± 0.066	0.77ArgMet: 0.77 ± 0.031	2.13ArgAsn: 2.13 ± 0.053	0.984ArgPro: 0.984 ± 0.031	0.934ArgGln: 0.934 ± 0.032	1.139ArgArg: 1.139 ± 0.042	1.657ArgSer: 1.657 ± 0.046	1.771ArgThr: 1.771 ± 0.052	1.939ArgVal: 1.939 ± 0.057	0.322ArgTrp: 0.322 ± 0.02	1.303ArgTyr: 1.303 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.412SerAla: 3.412 ± 0.073	0.626SerCys: 0.626 ± 0.024	3.83SerAsp: 3.83 ± 0.069	4.495SerGlu: 4.495 ± 0.076	3.828SerPhe: 3.828 ± 0.063	4.462SerGly: 4.462 ± 0.081	1.113SerHis: 1.113 ± 0.036	6.168SerIle: 6.168 ± 0.095	5.516SerLys: 5.516 ± 0.093	5.999SerLeu: 5.999 ± 0.093	1.351SerMet: 1.351 ± 0.038	4.529SerAsn: 4.529 ± 0.084	1.979SerPro: 1.979 ± 0.051	2.214SerGln: 2.214 ± 0.051	1.993SerArg: 1.993 ± 0.05	4.504SerSer: 4.504 ± 0.073	3.854SerThr: 3.854 ± 0.064	3.942SerVal: 3.942 ± 0.072	0.713SerTrp: 0.713 ± 0.031	2.684SerTyr: 2.684 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.404ThrAla: 3.404 ± 0.11	0.34ThrCys: 0.34 ± 0.022	3.602ThrAsp: 3.602 ± 0.158	3.676ThrGlu: 3.676 ± 0.079	3.064ThrPhe: 3.064 ± 0.058	3.842ThrGly: 3.842 ± 0.093	1.055ThrHis: 1.055 ± 0.03	5.523ThrIle: 5.523 ± 0.121	3.918ThrLys: 3.918 ± 0.063	5.196ThrLeu: 5.196 ± 0.1	0.963ThrMet: 0.963 ± 0.036	3.638ThrAsn: 3.638 ± 0.08	2.346ThrPro: 2.346 ± 0.105	1.799ThrGln: 1.799 ± 0.058	1.565ThrArg: 1.565 ± 0.038	4.082ThrSer: 4.082 ± 0.07	3.747ThrThr: 3.747 ± 0.121	3.915ThrVal: 3.915 ± 0.184	0.521ThrTrp: 0.521 ± 0.023	2.361ThrTyr: 2.361 ± 0.073	0.0ThrXaa: 0.0 ± 0.0
Val	3.718ValAla: 3.718 ± 0.108	0.488ValCys: 0.488 ± 0.045	3.757ValAsp: 3.757 ± 0.082	4.085ValGlu: 4.085 ± 0.07	3.256ValPhe: 3.256 ± 0.062	3.814ValGly: 3.814 ± 0.061	0.944ValHis: 0.944 ± 0.033	5.032ValIle: 5.032 ± 0.077	4.5ValLys: 4.5 ± 0.082	5.636ValLeu: 5.636 ± 0.071	1.202ValMet: 1.202 ± 0.039	3.826ValAsn: 3.826 ± 0.088	1.98ValPro: 1.98 ± 0.045	1.694ValGln: 1.694 ± 0.042	1.801ValArg: 1.801 ± 0.048	4.31ValSer: 4.31 ± 0.076	3.632ValThr: 3.632 ± 0.198	3.975ValVal: 3.975 ± 0.083	0.558ValTrp: 0.558 ± 0.024	2.244ValTyr: 2.244 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.568TrpAla: 0.568 ± 0.027	0.087TrpCys: 0.087 ± 0.009	0.536TrpAsp: 0.536 ± 0.022	0.645TrpGlu: 0.645 ± 0.028	0.555TrpPhe: 0.555 ± 0.027	0.62TrpGly: 0.62 ± 0.026	0.202TrpHis: 0.202 ± 0.014	0.798TrpIle: 0.798 ± 0.029	0.857TrpLys: 0.857 ± 0.03	0.907TrpLeu: 0.907 ± 0.035	0.273TrpMet: 0.273 ± 0.016	0.777TrpAsn: 0.777 ± 0.028	0.204TrpPro: 0.204 ± 0.016	0.342TrpGln: 0.342 ± 0.021	0.393TrpArg: 0.393 ± 0.02	0.664TrpSer: 0.664 ± 0.029	0.527TrpThr: 0.527 ± 0.023	0.573TrpVal: 0.573 ± 0.021	0.15TrpTrp: 0.15 ± 0.014	0.434TrpTyr: 0.434 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.127TyrAla: 2.127 ± 0.054	0.333TyrCys: 0.333 ± 0.018	2.434TyrAsp: 2.434 ± 0.06	2.41TyrGlu: 2.41 ± 0.052	2.518TyrPhe: 2.518 ± 0.053	2.576TyrGly: 2.576 ± 0.051	0.769TyrHis: 0.769 ± 0.027	3.014TyrIle: 3.014 ± 0.062	3.268TyrLys: 3.268 ± 0.067	3.806TyrLeu: 3.806 ± 0.069	0.654TyrMet: 0.654 ± 0.025	2.856TyrAsn: 2.856 ± 0.059	1.386TyrPro: 1.386 ± 0.043	1.527TyrGln: 1.527 ± 0.052	1.416TyrArg: 1.416 ± 0.044	2.824TyrSer: 2.824 ± 0.058	2.444TyrThr: 2.444 ± 0.067	2.079TyrVal: 2.079 ± 0.05	0.486TyrTrp: 0.486 ± 0.022	1.84TyrTyr: 1.84 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2946 proteins (1027031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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