Amino acid dipepetide frequency for Vibrio phage vB_VspS_VS-ABTNL-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.129AlaAla: 9.129 ± 1.472
0.989AlaCys: 0.989 ± 0.289
5.63AlaAsp: 5.63 ± 0.575
7.607AlaGlu: 7.607 ± 0.852
2.434AlaPhe: 2.434 ± 0.387
7.531AlaGly: 7.531 ± 1.179
1.293AlaHis: 1.293 ± 0.321
4.793AlaIle: 4.793 ± 0.601
5.173AlaLys: 5.173 ± 0.802
6.999AlaLeu: 6.999 ± 0.839
3.119AlaMet: 3.119 ± 0.522
3.728AlaAsn: 3.728 ± 0.545
3.195AlaPro: 3.195 ± 0.747
3.195AlaGln: 3.195 ± 0.666
4.26AlaArg: 4.26 ± 0.768
4.336AlaSer: 4.336 ± 0.676
4.564AlaThr: 4.564 ± 0.567
4.564AlaVal: 4.564 ± 0.501
0.913AlaTrp: 0.913 ± 0.265
2.358AlaTyr: 2.358 ± 0.501
0.0AlaXaa: 0.0 ± 0.0
Cys
0.685CysAla: 0.685 ± 0.265
0.228CysCys: 0.228 ± 0.139
0.685CysAsp: 0.685 ± 0.288
0.837CysGlu: 0.837 ± 0.282
0.533CysPhe: 0.533 ± 0.189
0.456CysGly: 0.456 ± 0.186
0.152CysHis: 0.152 ± 0.114
0.304CysIle: 0.304 ± 0.159
0.456CysLys: 0.456 ± 0.22
0.533CysLeu: 0.533 ± 0.237
0.228CysMet: 0.228 ± 0.138
0.456CysAsn: 0.456 ± 0.177
0.761CysPro: 0.761 ± 0.285
0.989CysGln: 0.989 ± 0.305
0.533CysArg: 0.533 ± 0.175
0.304CysSer: 0.304 ± 0.17
0.533CysThr: 0.533 ± 0.228
0.913CysVal: 0.913 ± 0.286
0.0CysTrp: 0.0 ± 0.0
0.152CysTyr: 0.152 ± 0.104
0.0CysXaa: 0.0 ± 0.0
Asp
5.401AspAla: 5.401 ± 0.544
0.228AspCys: 0.228 ± 0.12
4.26AspAsp: 4.26 ± 0.682
5.858AspGlu: 5.858 ± 0.655
3.576AspPhe: 3.576 ± 0.498
4.488AspGly: 4.488 ± 0.617
1.065AspHis: 1.065 ± 0.265
4.336AspIle: 4.336 ± 0.561
2.891AspLys: 2.891 ± 0.402
4.869AspLeu: 4.869 ± 0.518
2.13AspMet: 2.13 ± 0.48
2.587AspAsn: 2.587 ± 0.441
2.51AspPro: 2.51 ± 0.403
1.598AspGln: 1.598 ± 0.316
3.043AspArg: 3.043 ± 0.446
3.728AspSer: 3.728 ± 0.844
2.815AspThr: 2.815 ± 0.407
3.499AspVal: 3.499 ± 0.519
1.674AspTrp: 1.674 ± 0.435
2.282AspTyr: 2.282 ± 0.502
0.0AspXaa: 0.0 ± 0.0
Glu
6.923GluAla: 6.923 ± 0.76
0.837GluCys: 0.837 ± 0.263
4.869GluAsp: 4.869 ± 0.677
5.858GluGlu: 5.858 ± 0.987
2.587GluPhe: 2.587 ± 0.398
4.793GluGly: 4.793 ± 0.534
1.065GluHis: 1.065 ± 0.283
3.576GluIle: 3.576 ± 0.59
5.477GluLys: 5.477 ± 0.668
6.01GluLeu: 6.01 ± 0.914
3.423GluMet: 3.423 ± 0.519
3.119GluAsn: 3.119 ± 0.527
2.663GluPro: 2.663 ± 0.764
3.195GluGln: 3.195 ± 0.559
3.728GluArg: 3.728 ± 0.524
4.184GluSer: 4.184 ± 0.543
4.488GluThr: 4.488 ± 0.507
5.249GluVal: 5.249 ± 0.662
1.598GluTrp: 1.598 ± 0.404
2.282GluTyr: 2.282 ± 0.426
0.0GluXaa: 0.0 ± 0.0
Phe
2.891PheAla: 2.891 ± 0.493
0.304PheCys: 0.304 ± 0.155
2.815PheAsp: 2.815 ± 0.44
2.51PheGlu: 2.51 ± 0.433
1.826PhePhe: 1.826 ± 0.404
2.587PheGly: 2.587 ± 0.418
0.609PheHis: 0.609 ± 0.238
2.51PheIle: 2.51 ± 0.506
2.663PheLys: 2.663 ± 0.511
2.815PheLeu: 2.815 ± 0.397
1.065PheMet: 1.065 ± 0.287
2.51PheAsn: 2.51 ± 0.532
0.989PhePro: 0.989 ± 0.191
1.445PheGln: 1.445 ± 0.326
2.434PheArg: 2.434 ± 0.385
1.902PheSer: 1.902 ± 0.366
2.51PheThr: 2.51 ± 0.46
2.13PheVal: 2.13 ± 0.466
0.533PheTrp: 0.533 ± 0.181
1.217PheTyr: 1.217 ± 0.355
0.0PheXaa: 0.0 ± 0.0
Gly
6.695GlyAla: 6.695 ± 0.839
0.837GlyCys: 0.837 ± 0.26
5.249GlyAsp: 5.249 ± 0.625
4.336GlyGlu: 4.336 ± 0.592
2.891GlyPhe: 2.891 ± 0.468
5.858GlyGly: 5.858 ± 0.797
0.837GlyHis: 0.837 ± 0.223
4.641GlyIle: 4.641 ± 0.639
3.499GlyLys: 3.499 ± 0.48
6.086GlyLeu: 6.086 ± 0.621
2.739GlyMet: 2.739 ± 0.566
3.804GlyAsn: 3.804 ± 0.49
0.913GlyPro: 0.913 ± 0.243
2.967GlyGln: 2.967 ± 0.44
3.043GlyArg: 3.043 ± 0.576
4.641GlySer: 4.641 ± 0.877
4.793GlyThr: 4.793 ± 0.764
5.097GlyVal: 5.097 ± 0.583
1.141GlyTrp: 1.141 ± 0.32
3.728GlyTyr: 3.728 ± 0.496
0.0GlyXaa: 0.0 ± 0.0
His
0.989HisAla: 0.989 ± 0.297
0.38HisCys: 0.38 ± 0.193
0.989HisAsp: 0.989 ± 0.334
1.141HisGlu: 1.141 ± 0.298
1.141HisPhe: 1.141 ± 0.333
0.837HisGly: 0.837 ± 0.191
0.38HisHis: 0.38 ± 0.134
0.913HisIle: 0.913 ± 0.234
1.141HisLys: 1.141 ± 0.302
1.826HisLeu: 1.826 ± 0.369
0.533HisMet: 0.533 ± 0.172
0.761HisAsn: 0.761 ± 0.258
0.761HisPro: 0.761 ± 0.303
0.304HisGln: 0.304 ± 0.134
0.38HisArg: 0.38 ± 0.151
0.989HisSer: 0.989 ± 0.296
0.685HisThr: 0.685 ± 0.242
1.369HisVal: 1.369 ± 0.344
0.304HisTrp: 0.304 ± 0.138
0.685HisTyr: 0.685 ± 0.249
0.0HisXaa: 0.0 ± 0.0
Ile
4.184IleAla: 4.184 ± 0.791
0.38IleCys: 0.38 ± 0.158
3.499IleAsp: 3.499 ± 0.488
3.043IleGlu: 3.043 ± 0.454
1.978IlePhe: 1.978 ± 0.355
2.51IleGly: 2.51 ± 0.557
1.217IleHis: 1.217 ± 0.255
2.891IleIle: 2.891 ± 0.449
3.652IleLys: 3.652 ± 0.684
4.336IleLeu: 4.336 ± 0.436
1.369IleMet: 1.369 ± 0.235
2.663IleAsn: 2.663 ± 0.414
2.815IlePro: 2.815 ± 0.431
1.978IleGln: 1.978 ± 0.442
2.054IleArg: 2.054 ± 0.457
3.347IleSer: 3.347 ± 0.427
3.195IleThr: 3.195 ± 0.478
3.195IleVal: 3.195 ± 0.63
0.913IleTrp: 0.913 ± 0.22
1.75IleTyr: 1.75 ± 0.356
0.0IleXaa: 0.0 ± 0.0
Lys
5.173LysAla: 5.173 ± 0.75
0.685LysCys: 0.685 ± 0.268
4.793LysAsp: 4.793 ± 0.521
4.641LysGlu: 4.641 ± 0.601
2.967LysPhe: 2.967 ± 0.45
3.195LysGly: 3.195 ± 0.507
1.141LysHis: 1.141 ± 0.283
2.815LysIle: 2.815 ± 0.595
5.249LysLys: 5.249 ± 0.837
5.477LysLeu: 5.477 ± 0.661
1.978LysMet: 1.978 ± 0.428
2.739LysAsn: 2.739 ± 0.382
3.119LysPro: 3.119 ± 0.529
2.663LysGln: 2.663 ± 0.577
3.499LysArg: 3.499 ± 0.455
3.347LysSer: 3.347 ± 0.449
4.564LysThr: 4.564 ± 0.603
4.717LysVal: 4.717 ± 0.494
1.065LysTrp: 1.065 ± 0.256
2.587LysTyr: 2.587 ± 0.614
0.0LysXaa: 0.0 ± 0.0
Leu
6.847LeuAla: 6.847 ± 0.769
0.609LeuCys: 0.609 ± 0.264
4.717LeuAsp: 4.717 ± 0.509
6.466LeuGlu: 6.466 ± 0.887
3.804LeuPhe: 3.804 ± 0.524
7.151LeuGly: 7.151 ± 0.806
1.445LeuHis: 1.445 ± 0.404
3.423LeuIle: 3.423 ± 0.566
6.01LeuLys: 6.01 ± 0.77
7.151LeuLeu: 7.151 ± 0.854
2.51LeuMet: 2.51 ± 0.409
3.88LeuAsn: 3.88 ± 0.545
3.499LeuPro: 3.499 ± 0.528
3.271LeuGln: 3.271 ± 0.663
3.423LeuArg: 3.423 ± 0.539
5.401LeuSer: 5.401 ± 0.611
4.032LeuThr: 4.032 ± 0.652
4.032LeuVal: 4.032 ± 0.467
0.228LeuTrp: 0.228 ± 0.143
1.674LeuTyr: 1.674 ± 0.34
0.0LeuXaa: 0.0 ± 0.0
Met
3.195MetAla: 3.195 ± 0.59
0.228MetCys: 0.228 ± 0.147
2.282MetAsp: 2.282 ± 0.436
2.967MetGlu: 2.967 ± 0.502
0.685MetPhe: 0.685 ± 0.261
2.13MetGly: 2.13 ± 0.414
0.685MetHis: 0.685 ± 0.212
0.837MetIle: 0.837 ± 0.226
2.891MetLys: 2.891 ± 0.405
3.195MetLeu: 3.195 ± 0.591
0.533MetMet: 0.533 ± 0.22
1.369MetAsn: 1.369 ± 0.339
1.75MetPro: 1.75 ± 0.301
1.293MetGln: 1.293 ± 0.322
2.358MetArg: 2.358 ± 0.327
2.51MetSer: 2.51 ± 0.445
1.445MetThr: 1.445 ± 0.368
1.674MetVal: 1.674 ± 0.463
0.456MetTrp: 0.456 ± 0.196
0.837MetTyr: 0.837 ± 0.227
0.0MetXaa: 0.0 ± 0.0
Asn
2.967AsnAla: 2.967 ± 0.456
0.533AsnCys: 0.533 ± 0.195
1.902AsnAsp: 1.902 ± 0.438
3.195AsnGlu: 3.195 ± 0.457
2.054AsnPhe: 2.054 ± 0.516
3.652AsnGly: 3.652 ± 0.51
0.38AsnHis: 0.38 ± 0.169
2.434AsnIle: 2.434 ± 0.455
3.804AsnLys: 3.804 ± 0.54
3.576AsnLeu: 3.576 ± 0.528
1.065AsnMet: 1.065 ± 0.33
2.054AsnAsn: 2.054 ± 0.303
2.739AsnPro: 2.739 ± 0.469
2.054AsnGln: 2.054 ± 0.441
1.521AsnArg: 1.521 ± 0.455
2.206AsnSer: 2.206 ± 0.443
3.043AsnThr: 3.043 ± 0.402
2.815AsnVal: 2.815 ± 0.535
0.989AsnTrp: 0.989 ± 0.286
2.13AsnTyr: 2.13 ± 0.433
0.0AsnXaa: 0.0 ± 0.0
Pro
4.108ProAla: 4.108 ± 0.734
0.304ProCys: 0.304 ± 0.146
2.815ProAsp: 2.815 ± 0.547
5.477ProGlu: 5.477 ± 0.948
1.293ProPhe: 1.293 ± 0.289
3.043ProGly: 3.043 ± 0.421
0.533ProHis: 0.533 ± 0.189
1.521ProIle: 1.521 ± 0.312
2.282ProLys: 2.282 ± 0.465
2.282ProLeu: 2.282 ± 0.424
0.761ProMet: 0.761 ± 0.226
1.978ProAsn: 1.978 ± 0.296
1.902ProPro: 1.902 ± 0.61
1.75ProGln: 1.75 ± 0.345
1.902ProArg: 1.902 ± 0.361
1.978ProSer: 1.978 ± 0.358
2.967ProThr: 2.967 ± 0.501
2.967ProVal: 2.967 ± 0.734
0.685ProTrp: 0.685 ± 0.234
1.065ProTyr: 1.065 ± 0.344
0.0ProXaa: 0.0 ± 0.0
Gln
4.184GlnAla: 4.184 ± 0.62
0.38GlnCys: 0.38 ± 0.171
2.663GlnAsp: 2.663 ± 0.57
2.739GlnGlu: 2.739 ± 0.459
1.674GlnPhe: 1.674 ± 0.359
3.195GlnGly: 3.195 ± 0.68
0.152GlnHis: 0.152 ± 0.105
1.445GlnIle: 1.445 ± 0.306
2.206GlnLys: 2.206 ± 0.336
3.652GlnLeu: 3.652 ± 0.54
1.445GlnMet: 1.445 ± 0.327
1.369GlnAsn: 1.369 ± 0.321
1.978GlnPro: 1.978 ± 0.395
2.206GlnGln: 2.206 ± 0.475
1.902GlnArg: 1.902 ± 0.423
2.663GlnSer: 2.663 ± 0.415
2.13GlnThr: 2.13 ± 0.432
2.587GlnVal: 2.587 ± 0.421
0.533GlnTrp: 0.533 ± 0.219
1.521GlnTyr: 1.521 ± 0.491
0.0GlnXaa: 0.0 ± 0.0
Arg
3.499ArgAla: 3.499 ± 0.481
0.304ArgCys: 0.304 ± 0.153
2.739ArgAsp: 2.739 ± 0.486
3.347ArgGlu: 3.347 ± 0.535
1.598ArgPhe: 1.598 ± 0.303
3.119ArgGly: 3.119 ± 0.458
0.913ArgHis: 0.913 ± 0.266
2.663ArgIle: 2.663 ± 0.415
3.804ArgLys: 3.804 ± 0.675
3.652ArgLeu: 3.652 ± 0.49
1.826ArgMet: 1.826 ± 0.403
2.434ArgAsn: 2.434 ± 0.408
1.674ArgPro: 1.674 ± 0.43
1.674ArgGln: 1.674 ± 0.324
2.13ArgArg: 2.13 ± 0.517
2.891ArgSer: 2.891 ± 0.537
2.51ArgThr: 2.51 ± 0.459
3.728ArgVal: 3.728 ± 0.703
0.685ArgTrp: 0.685 ± 0.192
1.445ArgTyr: 1.445 ± 0.286
0.0ArgXaa: 0.0 ± 0.0
Ser
4.793SerAla: 4.793 ± 0.764
0.685SerCys: 0.685 ± 0.265
2.891SerAsp: 2.891 ± 0.475
4.032SerGlu: 4.032 ± 0.584
1.902SerPhe: 1.902 ± 0.339
5.401SerGly: 5.401 ± 0.666
1.293SerHis: 1.293 ± 0.304
2.663SerIle: 2.663 ± 0.472
3.88SerLys: 3.88 ± 0.515
4.488SerLeu: 4.488 ± 0.862
2.358SerMet: 2.358 ± 0.456
1.902SerAsn: 1.902 ± 0.532
3.043SerPro: 3.043 ± 0.361
2.587SerGln: 2.587 ± 0.453
3.119SerArg: 3.119 ± 0.373
3.576SerSer: 3.576 ± 0.73
3.347SerThr: 3.347 ± 0.439
3.804SerVal: 3.804 ± 0.66
1.065SerTrp: 1.065 ± 0.277
2.358SerTyr: 2.358 ± 0.403
0.0SerXaa: 0.0 ± 0.0
Thr
5.401ThrAla: 5.401 ± 0.754
0.38ThrCys: 0.38 ± 0.185
3.347ThrAsp: 3.347 ± 0.515
3.728ThrGlu: 3.728 ± 0.434
1.826ThrPhe: 1.826 ± 0.324
4.336ThrGly: 4.336 ± 0.717
1.674ThrHis: 1.674 ± 0.472
2.815ThrIle: 2.815 ± 0.417
3.652ThrLys: 3.652 ± 0.49
4.793ThrLeu: 4.793 ± 0.564
2.13ThrMet: 2.13 ± 0.312
1.902ThrAsn: 1.902 ± 0.378
3.347ThrPro: 3.347 ± 0.562
2.358ThrGln: 2.358 ± 0.386
2.739ThrArg: 2.739 ± 0.428
3.956ThrSer: 3.956 ± 0.575
5.325ThrThr: 5.325 ± 0.687
4.412ThrVal: 4.412 ± 0.43
0.761ThrTrp: 0.761 ± 0.229
1.369ThrTyr: 1.369 ± 0.331
0.0ThrXaa: 0.0 ± 0.0
Val
5.249ValAla: 5.249 ± 0.748
0.533ValCys: 0.533 ± 0.211
3.271ValAsp: 3.271 ± 0.383
5.173ValGlu: 5.173 ± 0.798
2.13ValPhe: 2.13 ± 0.469
4.717ValGly: 4.717 ± 0.538
0.609ValHis: 0.609 ± 0.269
3.728ValIle: 3.728 ± 0.767
4.869ValLys: 4.869 ± 0.651
4.412ValLeu: 4.412 ± 0.655
2.13ValMet: 2.13 ± 0.406
3.195ValAsn: 3.195 ± 0.605
2.51ValPro: 2.51 ± 0.391
2.587ValGln: 2.587 ± 0.497
2.358ValArg: 2.358 ± 0.453
4.108ValSer: 4.108 ± 0.554
4.488ValThr: 4.488 ± 0.662
4.564ValVal: 4.564 ± 0.672
1.141ValTrp: 1.141 ± 0.307
2.51ValTyr: 2.51 ± 0.456
0.0ValXaa: 0.0 ± 0.0
Trp
1.293TrpAla: 1.293 ± 0.332
0.456TrpCys: 0.456 ± 0.181
1.521TrpAsp: 1.521 ± 0.405
0.989TrpGlu: 0.989 ± 0.348
0.304TrpPhe: 0.304 ± 0.12
1.293TrpGly: 1.293 ± 0.286
0.076TrpHis: 0.076 ± 0.077
0.837TrpIle: 0.837 ± 0.269
0.837TrpLys: 0.837 ± 0.26
0.989TrpLeu: 0.989 ± 0.256
0.304TrpMet: 0.304 ± 0.174
0.609TrpAsn: 0.609 ± 0.168
0.152TrpPro: 0.152 ± 0.112
1.445TrpGln: 1.445 ± 0.309
0.685TrpArg: 0.685 ± 0.194
1.141TrpSer: 1.141 ± 0.359
0.989TrpThr: 0.989 ± 0.247
1.217TrpVal: 1.217 ± 0.276
0.228TrpTrp: 0.228 ± 0.15
0.38TrpTyr: 0.38 ± 0.166
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.206TyrAla: 2.206 ± 0.484
0.456TyrCys: 0.456 ± 0.209
1.902TyrAsp: 1.902 ± 0.514
1.978TyrGlu: 1.978 ± 0.394
1.065TyrPhe: 1.065 ± 0.323
3.499TyrGly: 3.499 ± 0.461
0.989TyrHis: 0.989 ± 0.272
1.826TyrIle: 1.826 ± 0.397
1.978TyrLys: 1.978 ± 0.377
2.434TyrLeu: 2.434 ± 0.542
1.598TyrMet: 1.598 ± 0.327
2.054TyrAsn: 2.054 ± 0.661
1.293TyrPro: 1.293 ± 0.35
1.065TyrGln: 1.065 ± 0.266
1.598TyrArg: 1.598 ± 0.31
1.978TyrSer: 1.978 ± 0.374
1.826TyrThr: 1.826 ± 0.33
1.75TyrVal: 1.75 ± 0.356
0.837TyrTrp: 0.837 ± 0.212
1.065TyrTyr: 1.065 ± 0.299
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (13146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski