Amino acid dipepetide frequency for Rhodovulum bhavnagarense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.338AlaAla: 18.338 ± 0.241	1.129AlaCys: 1.129 ± 0.043	7.152AlaAsp: 7.152 ± 0.088	9.011AlaGlu: 9.011 ± 0.116	4.254AlaPhe: 4.254 ± 0.073	11.435AlaGly: 11.435 ± 0.132	2.603AlaHis: 2.603 ± 0.049	5.984AlaIle: 5.984 ± 0.085	3.142AlaLys: 3.142 ± 0.072	15.186AlaLeu: 15.186 ± 0.178	3.996AlaMet: 3.996 ± 0.066	2.515AlaAsn: 2.515 ± 0.052	6.632AlaPro: 6.632 ± 0.115	4.583AlaGln: 4.583 ± 0.073	11.114AlaArg: 11.114 ± 0.147	5.021AlaSer: 5.021 ± 0.079	5.823AlaThr: 5.823 ± 0.081	8.757AlaVal: 8.757 ± 0.115	1.545AlaTrp: 1.545 ± 0.035	2.557AlaTyr: 2.557 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.142CysAla: 1.142 ± 0.039	0.1CysCys: 0.1 ± 0.011	0.586CysAsp: 0.586 ± 0.024	0.482CysGlu: 0.482 ± 0.023	0.3CysPhe: 0.3 ± 0.017	0.875CysGly: 0.875 ± 0.035	0.249CysHis: 0.249 ± 0.02	0.401CysIle: 0.401 ± 0.023	0.179CysLys: 0.179 ± 0.016	0.886CysLeu: 0.886 ± 0.03	0.175CysMet: 0.175 ± 0.013	0.201CysAsn: 0.201 ± 0.013	0.592CysPro: 0.592 ± 0.026	0.237CysGln: 0.237 ± 0.015	0.631CysArg: 0.631 ± 0.025	0.389CysSer: 0.389 ± 0.02	0.399CysThr: 0.399 ± 0.021	0.602CysVal: 0.602 ± 0.029	0.112CysTrp: 0.112 ± 0.012	0.176CysTyr: 0.176 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.278AspAla: 7.278 ± 0.095	0.514AspCys: 0.514 ± 0.024	3.456AspAsp: 3.456 ± 0.089	3.664AspGlu: 3.664 ± 0.073	2.229AspPhe: 2.229 ± 0.047	5.273AspGly: 5.273 ± 0.088	1.409AspHis: 1.409 ± 0.041	3.21AspIle: 3.21 ± 0.053	1.625AspLys: 1.625 ± 0.048	6.602AspLeu: 6.602 ± 0.085	1.775AspMet: 1.775 ± 0.045	1.228AspAsn: 1.228 ± 0.037	3.954AspPro: 3.954 ± 0.07	1.711AspGln: 1.711 ± 0.049	4.844AspArg: 4.844 ± 0.078	2.165AspSer: 2.165 ± 0.044	2.887AspThr: 2.887 ± 0.073	3.802AspVal: 3.802 ± 0.067	1.223AspTrp: 1.223 ± 0.034	1.497AspTyr: 1.497 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.45GluAla: 8.45 ± 0.116	0.38GluCys: 0.38 ± 0.022	3.34GluAsp: 3.34 ± 0.066	3.44GluGlu: 3.44 ± 0.097	1.766GluPhe: 1.766 ± 0.04	5.2GluGly: 5.2 ± 0.074	1.098GluHis: 1.098 ± 0.037	3.745GluIle: 3.745 ± 0.064	2.155GluLys: 2.155 ± 0.066	5.247GluLeu: 5.247 ± 0.09	1.814GluMet: 1.814 ± 0.042	1.625GluAsn: 1.625 ± 0.038	2.546GluPro: 2.546 ± 0.056	1.876GluGln: 1.876 ± 0.046	4.81GluArg: 4.81 ± 0.078	2.116GluSer: 2.116 ± 0.046	4.005GluThr: 4.005 ± 0.067	4.399GluVal: 4.399 ± 0.073	0.68GluTrp: 0.68 ± 0.026	0.993GluTyr: 0.993 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.331PheAla: 4.331 ± 0.069	0.413PheCys: 0.413 ± 0.02	2.747PheAsp: 2.747 ± 0.051	2.136PheGlu: 2.136 ± 0.052	1.389PhePhe: 1.389 ± 0.049	3.455PheGly: 3.455 ± 0.061	0.77PheHis: 0.77 ± 0.029	1.492PheIle: 1.492 ± 0.037	0.818PheLys: 0.818 ± 0.031	3.432PheLeu: 3.432 ± 0.068	0.792PheMet: 0.792 ± 0.029	0.946PheAsn: 0.946 ± 0.034	1.513PhePro: 1.513 ± 0.038	0.956PheGln: 0.956 ± 0.031	2.301PheArg: 2.301 ± 0.053	1.926PheSer: 1.926 ± 0.052	1.939PheThr: 1.939 ± 0.05	2.721PheVal: 2.721 ± 0.057	0.498PheTrp: 0.498 ± 0.026	0.835PheTyr: 0.835 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.867GlyAla: 10.867 ± 0.114	0.87GlyCys: 0.87 ± 0.032	4.68GlyAsp: 4.68 ± 0.087	4.815GlyGlu: 4.815 ± 0.067	3.502GlyPhe: 3.502 ± 0.067	7.61GlyGly: 7.61 ± 0.122	2.003GlyHis: 2.003 ± 0.047	4.387GlyIle: 4.387 ± 0.065	2.85GlyLys: 2.85 ± 0.058	9.961GlyLeu: 9.961 ± 0.132	2.658GlyMet: 2.658 ± 0.053	1.904GlyAsn: 1.904 ± 0.047	3.997GlyPro: 3.997 ± 0.075	3.213GlyGln: 3.213 ± 0.057	6.756GlyArg: 6.756 ± 0.089	3.693GlySer: 3.693 ± 0.062	4.714GlyThr: 4.714 ± 0.083	6.474GlyVal: 6.474 ± 0.091	1.514GlyTrp: 1.514 ± 0.044	2.191GlyTyr: 2.191 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.543HisAla: 2.543 ± 0.053	0.226HisCys: 0.226 ± 0.015	1.411HisAsp: 1.411 ± 0.039	1.091HisGlu: 1.091 ± 0.033	0.769HisPhe: 0.769 ± 0.029	2.02HisGly: 2.02 ± 0.05	0.485HisHis: 0.485 ± 0.025	0.842HisIle: 0.842 ± 0.032	0.498HisLys: 0.498 ± 0.022	2.041HisLeu: 2.041 ± 0.054	0.537HisMet: 0.537 ± 0.024	0.42HisAsn: 0.42 ± 0.021	1.487HisPro: 1.487 ± 0.043	0.518HisGln: 0.518 ± 0.025	1.503HisArg: 1.503 ± 0.044	0.855HisSer: 0.855 ± 0.034	0.748HisThr: 0.748 ± 0.035	1.665HisVal: 1.665 ± 0.04	0.341HisTrp: 0.341 ± 0.02	0.53HisTyr: 0.53 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	7.245IleAla: 7.245 ± 0.085	0.547IleCys: 0.547 ± 0.027	3.389IleAsp: 3.389 ± 0.061	3.65IleGlu: 3.65 ± 0.066	1.545IlePhe: 1.545 ± 0.038	4.664IleGly: 4.664 ± 0.072	0.916IleHis: 0.916 ± 0.029	1.745IleIle: 1.745 ± 0.051	1.284IleLys: 1.284 ± 0.04	4.755IleLeu: 4.755 ± 0.084	0.962IleMet: 0.962 ± 0.038	1.168IleAsn: 1.168 ± 0.038	2.267IlePro: 2.267 ± 0.053	1.07IleGln: 1.07 ± 0.036	3.416IleArg: 3.416 ± 0.061	2.472IleSer: 2.472 ± 0.056	2.641IleThr: 2.641 ± 0.047	3.83IleVal: 3.83 ± 0.063	0.645IleTrp: 0.645 ± 0.027	1.066IleTyr: 1.066 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.508LysAla: 3.508 ± 0.071	0.192LysCys: 0.192 ± 0.015	1.469LysAsp: 1.469 ± 0.043	1.366LysGlu: 1.366 ± 0.046	0.758LysPhe: 0.758 ± 0.031	2.519LysGly: 2.519 ± 0.056	0.526LysHis: 0.526 ± 0.023	1.438LysIle: 1.438 ± 0.047	1.085LysLys: 1.085 ± 0.042	2.655LysLeu: 2.655 ± 0.063	0.695LysMet: 0.695 ± 0.027	0.661LysAsn: 0.661 ± 0.027	1.676LysPro: 1.676 ± 0.051	0.807LysGln: 0.807 ± 0.031	2.142LysArg: 2.142 ± 0.051	1.523LysSer: 1.523 ± 0.045	1.848LysThr: 1.848 ± 0.049	2.113LysVal: 2.113 ± 0.056	0.342LysTrp: 0.342 ± 0.023	0.593LysTyr: 0.593 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	14.541LeuAla: 14.541 ± 0.163	0.978LeuCys: 0.978 ± 0.039	6.536LeuAsp: 6.536 ± 0.084	5.515LeuGlu: 5.515 ± 0.092	3.607LeuPhe: 3.607 ± 0.073	9.072LeuGly: 9.072 ± 0.13	1.955LeuHis: 1.955 ± 0.043	4.983LeuIle: 4.983 ± 0.072	2.938LeuLys: 2.938 ± 0.058	8.672LeuLeu: 8.672 ± 0.125	2.65LeuMet: 2.65 ± 0.055	2.426LeuAsn: 2.426 ± 0.042	5.855LeuPro: 5.855 ± 0.098	2.43LeuGln: 2.43 ± 0.055	7.848LeuArg: 7.848 ± 0.102	6.565LeuSer: 6.565 ± 0.094	5.713LeuThr: 5.713 ± 0.068	7.519LeuVal: 7.519 ± 0.104	1.247LeuTrp: 1.247 ± 0.041	2.019LeuTyr: 2.019 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.647MetAla: 3.647 ± 0.072	0.186MetCys: 0.186 ± 0.014	1.386MetAsp: 1.386 ± 0.04	1.321MetGlu: 1.321 ± 0.038	0.711MetPhe: 0.711 ± 0.033	2.376MetGly: 2.376 ± 0.057	0.452MetHis: 0.452 ± 0.026	1.486MetIle: 1.486 ± 0.04	0.877MetLys: 0.877 ± 0.03	2.638MetLeu: 2.638 ± 0.05	0.733MetMet: 0.733 ± 0.027	0.832MetAsn: 0.832 ± 0.032	1.579MetPro: 1.579 ± 0.037	0.955MetGln: 0.955 ± 0.031	2.094MetArg: 2.094 ± 0.05	1.535MetSer: 1.535 ± 0.038	2.016MetThr: 2.016 ± 0.044	1.846MetVal: 1.846 ± 0.043	0.209MetTrp: 0.209 ± 0.016	0.299MetTyr: 0.299 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.921AsnAla: 2.921 ± 0.061	0.236AsnCys: 0.236 ± 0.017	1.332AsnAsp: 1.332 ± 0.043	1.087AsnGlu: 1.087 ± 0.035	0.85AsnPhe: 0.85 ± 0.033	2.129AsnGly: 2.129 ± 0.049	0.435AsnHis: 0.435 ± 0.022	1.183AsnIle: 1.183 ± 0.04	0.569AsnLys: 0.569 ± 0.029	2.307AsnLeu: 2.307 ± 0.051	0.598AsnMet: 0.598 ± 0.027	0.56AsnAsn: 0.56 ± 0.025	1.824AsnPro: 1.824 ± 0.045	0.586AsnGln: 0.586 ± 0.025	1.752AsnArg: 1.752 ± 0.045	0.946AsnSer: 0.946 ± 0.038	1.193AsnThr: 1.193 ± 0.035	1.647AsnVal: 1.647 ± 0.04	0.361AsnTrp: 0.361 ± 0.021	0.487AsnTyr: 0.487 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.661ProAla: 6.661 ± 0.106	0.39ProCys: 0.39 ± 0.021	4.24ProAsp: 4.24 ± 0.083	4.287ProGlu: 4.287 ± 0.07	1.918ProPhe: 1.918 ± 0.046	5.251ProGly: 5.251 ± 0.083	1.102ProHis: 1.102 ± 0.036	2.106ProIle: 2.106 ± 0.045	1.366ProLys: 1.366 ± 0.046	4.963ProLeu: 4.963 ± 0.086	1.315ProMet: 1.315 ± 0.042	1.103ProAsn: 1.103 ± 0.037	2.75ProPro: 2.75 ± 0.066	1.655ProGln: 1.655 ± 0.041	3.527ProArg: 3.527 ± 0.067	2.358ProSer: 2.358 ± 0.05	2.268ProThr: 2.268 ± 0.05	4.419ProVal: 4.419 ± 0.074	0.684ProTrp: 0.684 ± 0.028	1.129ProTyr: 1.129 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.221GlnAla: 4.221 ± 0.072	0.187GlnCys: 0.187 ± 0.014	1.632GlnAsp: 1.632 ± 0.044	1.611GlnGlu: 1.611 ± 0.045	0.978GlnPhe: 0.978 ± 0.034	2.709GlnGly: 2.709 ± 0.058	0.534GlnHis: 0.534 ± 0.025	1.789GlnIle: 1.789 ± 0.047	0.959GlnLys: 0.959 ± 0.034	2.518GlnLeu: 2.518 ± 0.056	1.004GlnMet: 1.004 ± 0.033	0.744GlnAsn: 0.744 ± 0.024	1.52GlnPro: 1.52 ± 0.039	0.993GlnGln: 0.993 ± 0.039	2.212GlnArg: 2.212 ± 0.051	1.524GlnSer: 1.524 ± 0.041	1.621GlnThr: 1.621 ± 0.043	2.473GlnVal: 2.473 ± 0.055	0.356GlnTrp: 0.356 ± 0.018	0.495GlnTyr: 0.495 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	10.038ArgAla: 10.038 ± 0.118	0.517ArgCys: 0.517 ± 0.025	4.791ArgAsp: 4.791 ± 0.072	4.31ArgGlu: 4.31 ± 0.073	2.886ArgPhe: 2.886 ± 0.063	5.414ArgGly: 5.414 ± 0.076	1.805ArgHis: 1.805 ± 0.041	4.171ArgIle: 4.171 ± 0.062	2.392ArgLys: 2.392 ± 0.062	8.993ArgLeu: 8.993 ± 0.122	2.194ArgMet: 2.194 ± 0.051	1.717ArgAsn: 1.717 ± 0.041	4.0ArgPro: 4.0 ± 0.08	2.432ArgGln: 2.432 ± 0.055	6.171ArgArg: 6.171 ± 0.098	3.131ArgSer: 3.131 ± 0.058	3.258ArgThr: 3.258 ± 0.059	5.344ArgVal: 5.344 ± 0.077	0.996ArgTrp: 0.996 ± 0.039	1.595ArgTyr: 1.595 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.62SerAla: 5.62 ± 0.077	0.388SerCys: 0.388 ± 0.021	2.832SerAsp: 2.832 ± 0.051	2.535SerGlu: 2.535 ± 0.061	1.971SerPhe: 1.971 ± 0.052	4.999SerGly: 4.999 ± 0.072	1.0SerHis: 1.0 ± 0.034	2.101SerIle: 2.101 ± 0.048	1.104SerLys: 1.104 ± 0.041	4.607SerLeu: 4.607 ± 0.075	1.166SerMet: 1.166 ± 0.043	1.118SerAsn: 1.118 ± 0.034	2.502SerPro: 2.502 ± 0.051	1.315SerGln: 1.315 ± 0.043	3.345SerArg: 3.345 ± 0.063	2.196SerSer: 2.196 ± 0.05	2.2SerThr: 2.2 ± 0.049	3.493SerVal: 3.493 ± 0.062	0.623SerTrp: 0.623 ± 0.027	1.104SerTyr: 1.104 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.168ThrAla: 6.168 ± 0.092	0.5ThrCys: 0.5 ± 0.026	2.986ThrAsp: 2.986 ± 0.056	2.916ThrGlu: 2.916 ± 0.059	1.759ThrPhe: 1.759 ± 0.047	5.512ThrGly: 5.512 ± 0.082	1.046ThrHis: 1.046 ± 0.035	2.516ThrIle: 2.516 ± 0.051	1.15ThrLys: 1.15 ± 0.037	5.924ThrLeu: 5.924 ± 0.072	1.196ThrMet: 1.196 ± 0.036	1.079ThrAsn: 1.079 ± 0.037	3.412ThrPro: 3.412 ± 0.068	1.401ThrGln: 1.401 ± 0.04	4.059ThrArg: 4.059 ± 0.068	2.224ThrSer: 2.224 ± 0.049	2.603ThrThr: 2.603 ± 0.067	3.945ThrVal: 3.945 ± 0.073	0.678ThrTrp: 0.678 ± 0.03	1.11ThrTyr: 1.11 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.263ValAla: 9.263 ± 0.118	0.609ValCys: 0.609 ± 0.024	4.107ValAsp: 4.107 ± 0.071	4.633ValGlu: 4.633 ± 0.074	2.844ValPhe: 2.844 ± 0.059	5.195ValGly: 5.195 ± 0.077	1.301ValHis: 1.301 ± 0.041	4.199ValIle: 4.199 ± 0.078	1.958ValLys: 1.958 ± 0.052	7.899ValLeu: 7.899 ± 0.102	2.101ValMet: 2.101 ± 0.054	1.878ValAsn: 1.878 ± 0.049	3.684ValPro: 3.684 ± 0.073	2.143ValGln: 2.143 ± 0.048	4.734ValArg: 4.734 ± 0.068	3.859ValSer: 3.859 ± 0.06	4.578ValThr: 4.578 ± 0.065	5.579ValVal: 5.579 ± 0.101	0.855ValTrp: 0.855 ± 0.032	1.515ValTyr: 1.515 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.446TrpAla: 1.446 ± 0.044	0.117TrpCys: 0.117 ± 0.011	0.726TrpAsp: 0.726 ± 0.028	0.607TrpGlu: 0.607 ± 0.023	0.521TrpPhe: 0.521 ± 0.021	0.986TrpGly: 0.986 ± 0.036	0.338TrpHis: 0.338 ± 0.019	0.663TrpIle: 0.663 ± 0.025	0.422TrpLys: 0.422 ± 0.022	1.61TrpLeu: 1.61 ± 0.045	0.379TrpMet: 0.379 ± 0.02	0.362TrpAsn: 0.362 ± 0.018	0.676TrpPro: 0.676 ± 0.029	0.583TrpGln: 0.583 ± 0.025	1.246TrpArg: 1.246 ± 0.038	0.694TrpSer: 0.694 ± 0.025	0.703TrpThr: 0.703 ± 0.029	0.917TrpVal: 0.917 ± 0.033	0.194TrpTrp: 0.194 ± 0.015	0.242TrpTyr: 0.242 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.549TyrAla: 2.549 ± 0.055	0.237TyrCys: 0.237 ± 0.015	1.548TyrAsp: 1.548 ± 0.041	1.207TyrGlu: 1.207 ± 0.035	0.852TyrPhe: 0.852 ± 0.028	1.965TyrGly: 1.965 ± 0.044	0.505TyrHis: 0.505 ± 0.022	0.836TyrIle: 0.836 ± 0.03	0.547TyrLys: 0.547 ± 0.023	2.172TyrLeu: 2.172 ± 0.046	0.434TyrMet: 0.434 ± 0.019	0.517TyrAsn: 0.517 ± 0.023	1.025TyrPro: 1.025 ± 0.032	0.615TyrGln: 0.615 ± 0.027	1.649TyrArg: 1.649 ± 0.04	1.023TyrSer: 1.023 ± 0.035	1.029TyrThr: 1.029 ± 0.032	1.391TyrVal: 1.391 ± 0.035	0.331TyrTrp: 0.331 ± 0.018	0.503TyrTyr: 0.503 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3085 proteins (951992 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---