Amino acid dipepetide frequency for Ornithobacterium rhinotracheale (strain ATCC 51463 / DSM 15997 / CCUG 23171 / CIP 104009 / LMG 9086)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.116AlaAla: 4.116 ± 0.12
0.619AlaCys: 0.619 ± 0.037
3.283AlaAsp: 3.283 ± 0.075
4.968AlaGlu: 4.968 ± 0.09
3.275AlaPhe: 3.275 ± 0.084
4.318AlaGly: 4.318 ± 0.098
1.186AlaHis: 1.186 ± 0.043
4.873AlaIle: 4.873 ± 0.094
5.649AlaLys: 5.649 ± 0.103
6.535AlaLeu: 6.535 ± 0.121
1.729AlaMet: 1.729 ± 0.064
3.408AlaAsn: 3.408 ± 0.077
2.166AlaPro: 2.166 ± 0.07
3.284AlaGln: 3.284 ± 0.077
2.268AlaArg: 2.268 ± 0.066
3.707AlaSer: 3.707 ± 0.074
3.444AlaThr: 3.444 ± 0.068
3.969AlaVal: 3.969 ± 0.095
0.717AlaTrp: 0.717 ± 0.034
2.763AlaTyr: 2.763 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.521CysAla: 0.521 ± 0.029
0.091CysCys: 0.091 ± 0.012
0.398CysAsp: 0.398 ± 0.025
0.478CysGlu: 0.478 ± 0.029
0.414CysPhe: 0.414 ± 0.028
0.619CysGly: 0.619 ± 0.028
0.171CysHis: 0.171 ± 0.021
0.523CysIle: 0.523 ± 0.032
0.511CysLys: 0.511 ± 0.03
0.73CysLeu: 0.73 ± 0.033
0.173CysMet: 0.173 ± 0.014
0.398CysAsn: 0.398 ± 0.025
0.33CysPro: 0.33 ± 0.026
0.292CysGln: 0.292 ± 0.02
0.276CysArg: 0.276 ± 0.022
0.488CysSer: 0.488 ± 0.028
0.389CysThr: 0.389 ± 0.025
0.515CysVal: 0.515 ± 0.027
0.057CysTrp: 0.057 ± 0.008
0.315CysTyr: 0.315 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.461AspAla: 3.461 ± 0.075
0.449AspCys: 0.449 ± 0.029
2.523AspAsp: 2.523 ± 0.059
4.009AspGlu: 4.009 ± 0.077
3.948AspPhe: 3.948 ± 0.085
3.235AspGly: 3.235 ± 0.071
0.755AspHis: 0.755 ± 0.03
3.856AspIle: 3.856 ± 0.069
4.325AspLys: 4.325 ± 0.096
5.642AspLeu: 5.642 ± 0.1
1.124AspMet: 1.124 ± 0.04
2.618AspAsn: 2.618 ± 0.069
1.616AspPro: 1.616 ± 0.052
1.509AspGln: 1.509 ± 0.05
1.993AspArg: 1.993 ± 0.048
2.738AspSer: 2.738 ± 0.071
2.445AspThr: 2.445 ± 0.063
3.268AspVal: 3.268 ± 0.078
0.775AspTrp: 0.775 ± 0.034
2.82AspTyr: 2.82 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
4.405GluAla: 4.405 ± 0.103
0.389GluCys: 0.389 ± 0.023
3.54GluAsp: 3.54 ± 0.082
5.416GluGlu: 5.416 ± 0.107
3.013GluPhe: 3.013 ± 0.075
3.766GluGly: 3.766 ± 0.083
1.164GluHis: 1.164 ± 0.041
6.258GluIle: 6.258 ± 0.101
7.227GluLys: 7.227 ± 0.124
6.316GluLeu: 6.316 ± 0.096
1.678GluMet: 1.678 ± 0.042
5.167GluAsn: 5.167 ± 0.103
1.796GluPro: 1.796 ± 0.055
2.767GluGln: 2.767 ± 0.069
2.889GluArg: 2.889 ± 0.083
3.155GluSer: 3.155 ± 0.055
3.229GluThr: 3.229 ± 0.072
4.454GluVal: 4.454 ± 0.083
0.74GluTrp: 0.74 ± 0.03
2.474GluTyr: 2.474 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.143PheAla: 3.143 ± 0.069
0.485PheCys: 0.485 ± 0.027
2.892PheAsp: 2.892 ± 0.056
3.12PheGlu: 3.12 ± 0.075
2.747PhePhe: 2.747 ± 0.074
3.511PheGly: 3.511 ± 0.084
0.828PheHis: 0.828 ± 0.035
3.667PheIle: 3.667 ± 0.091
3.861PheLys: 3.861 ± 0.068
4.817PheLeu: 4.817 ± 0.103
1.257PheMet: 1.257 ± 0.045
3.336PheAsn: 3.336 ± 0.081
1.816PhePro: 1.816 ± 0.051
1.506PheGln: 1.506 ± 0.048
1.742PheArg: 1.742 ± 0.05
4.057PheSer: 4.057 ± 0.089
2.824PheThr: 2.824 ± 0.071
3.217PheVal: 3.217 ± 0.067
0.597PheTrp: 0.597 ± 0.033
2.422PheTyr: 2.422 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.37GlyAla: 4.37 ± 0.085
0.482GlyCys: 0.482 ± 0.03
3.397GlyAsp: 3.397 ± 0.074
4.215GlyGlu: 4.215 ± 0.08
3.522GlyPhe: 3.522 ± 0.072
4.661GlyGly: 4.661 ± 0.114
1.035GlyHis: 1.035 ± 0.044
5.029GlyIle: 5.029 ± 0.081
5.728GlyLys: 5.728 ± 0.09
5.622GlyLeu: 5.622 ± 0.108
1.539GlyMet: 1.539 ± 0.052
3.554GlyAsn: 3.554 ± 0.073
1.018GlyPro: 1.018 ± 0.037
1.87GlyGln: 1.87 ± 0.054
2.29GlyArg: 2.29 ± 0.062
3.489GlySer: 3.489 ± 0.084
3.534GlyThr: 3.534 ± 0.093
4.787GlyVal: 4.787 ± 0.094
0.765GlyTrp: 0.765 ± 0.033
2.94GlyTyr: 2.94 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.093HisAla: 1.093 ± 0.043
0.177HisCys: 0.177 ± 0.017
0.889HisAsp: 0.889 ± 0.036
1.034HisGlu: 1.034 ± 0.044
1.108HisPhe: 1.108 ± 0.04
1.067HisGly: 1.067 ± 0.044
0.421HisHis: 0.421 ± 0.027
1.254HisIle: 1.254 ± 0.043
1.17HisLys: 1.17 ± 0.044
1.734HisLeu: 1.734 ± 0.051
0.363HisMet: 0.363 ± 0.021
0.829HisAsn: 0.829 ± 0.035
0.813HisPro: 0.813 ± 0.03
0.713HisGln: 0.713 ± 0.035
0.752HisArg: 0.752 ± 0.033
0.999HisSer: 0.999 ± 0.04
0.936HisThr: 0.936 ± 0.045
0.848HisVal: 0.848 ± 0.037
0.257HisTrp: 0.257 ± 0.02
0.835HisTyr: 0.835 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.176IleAla: 5.176 ± 0.084
0.594IleCys: 0.594 ± 0.032
4.408IleAsp: 4.408 ± 0.084
5.382IleGlu: 5.382 ± 0.09
3.832IlePhe: 3.832 ± 0.091
4.607IleGly: 4.607 ± 0.099
1.193IleHis: 1.193 ± 0.04
5.221IleIle: 5.221 ± 0.12
6.044IleLys: 6.044 ± 0.11
6.933IleLeu: 6.933 ± 0.128
1.423IleMet: 1.423 ± 0.056
4.292IleAsn: 4.292 ± 0.086
3.214IlePro: 3.214 ± 0.06
2.907IleGln: 2.907 ± 0.061
2.417IleArg: 2.417 ± 0.057
5.109IleSer: 5.109 ± 0.098
3.846IleThr: 3.846 ± 0.072
4.396IleVal: 4.396 ± 0.087
0.666IleTrp: 0.666 ± 0.033
2.869IleTyr: 2.869 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
5.577LysAla: 5.577 ± 0.099
0.437LysCys: 0.437 ± 0.027
5.061LysAsp: 5.061 ± 0.08
6.488LysGlu: 6.488 ± 0.122
3.455LysPhe: 3.455 ± 0.078
4.761LysGly: 4.761 ± 0.094
1.297LysHis: 1.297 ± 0.043
7.105LysIle: 7.105 ± 0.131
7.853LysLys: 7.853 ± 0.137
6.635LysLeu: 6.635 ± 0.101
2.279LysMet: 2.279 ± 0.06
6.166LysAsn: 6.166 ± 0.098
2.699LysPro: 2.699 ± 0.07
2.939LysGln: 2.939 ± 0.074
3.108LysArg: 3.108 ± 0.076
4.591LysSer: 4.591 ± 0.084
4.571LysThr: 4.571 ± 0.085
5.01LysVal: 5.01 ± 0.085
0.784LysTrp: 0.784 ± 0.034
3.567LysTyr: 3.567 ± 0.078
0.0LysXaa: 0.0 ± 0.0
Leu
6.25LeuAla: 6.25 ± 0.103
0.788LeuCys: 0.788 ± 0.036
4.92LeuAsp: 4.92 ± 0.084
5.838LeuGlu: 5.838 ± 0.123
4.634LeuPhe: 4.634 ± 0.09
6.258LeuGly: 6.258 ± 0.117
1.603LeuHis: 1.603 ± 0.056
6.474LeuIle: 6.474 ± 0.105
8.245LeuLys: 8.245 ± 0.124
8.28LeuLeu: 8.28 ± 0.107
2.147LeuMet: 2.147 ± 0.058
5.89LeuAsn: 5.89 ± 0.111
3.74LeuPro: 3.74 ± 0.08
3.377LeuGln: 3.377 ± 0.074
3.4LeuArg: 3.4 ± 0.082
7.023LeuSer: 7.023 ± 0.097
4.235LeuThr: 4.235 ± 0.074
5.254LeuVal: 5.254 ± 0.089
0.865LeuTrp: 0.865 ± 0.036
3.431LeuTyr: 3.431 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
1.702MetAla: 1.702 ± 0.056
0.151MetCys: 0.151 ± 0.015
1.019MetAsp: 1.019 ± 0.034
1.352MetGlu: 1.352 ± 0.047
0.891MetPhe: 0.891 ± 0.038
1.613MetGly: 1.613 ± 0.048
0.414MetHis: 0.414 ± 0.025
1.6MetIle: 1.6 ± 0.053
2.278MetLys: 2.278 ± 0.058
2.043MetLeu: 2.043 ± 0.05
0.568MetMet: 0.568 ± 0.035
1.331MetAsn: 1.331 ± 0.04
1.071MetPro: 1.071 ± 0.039
1.064MetGln: 1.064 ± 0.043
1.025MetArg: 1.025 ± 0.043
1.394MetSer: 1.394 ± 0.044
0.923MetThr: 0.923 ± 0.04
1.279MetVal: 1.279 ± 0.043
0.203MetTrp: 0.203 ± 0.017
0.765MetTyr: 0.765 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
4.01AsnAla: 4.01 ± 0.085
0.409AsnCys: 0.409 ± 0.025
2.944AsnAsp: 2.944 ± 0.068
3.786AsnGlu: 3.786 ± 0.071
3.257AsnPhe: 3.257 ± 0.076
4.019AsnGly: 4.019 ± 0.096
1.151AsnHis: 1.151 ± 0.04
4.601AsnIle: 4.601 ± 0.082
4.64AsnLys: 4.64 ± 0.104
5.835AsnLeu: 5.835 ± 0.11
1.185AsnMet: 1.185 ± 0.041
3.352AsnAsn: 3.352 ± 0.091
2.988AsnPro: 2.988 ± 0.07
2.718AsnGln: 2.718 ± 0.06
2.166AsnArg: 2.166 ± 0.051
3.194AsnSer: 3.194 ± 0.07
3.107AsnThr: 3.107 ± 0.076
3.409AsnVal: 3.409 ± 0.075
0.682AsnTrp: 0.682 ± 0.029
2.882AsnTyr: 2.882 ± 0.075
0.0AsnXaa: 0.0 ± 0.0
Pro
2.187ProAla: 2.187 ± 0.064
0.242ProCys: 0.242 ± 0.019
1.893ProAsp: 1.893 ± 0.054
3.219ProGlu: 3.219 ± 0.066
1.797ProPhe: 1.797 ± 0.048
1.818ProGly: 1.818 ± 0.055
0.695ProHis: 0.695 ± 0.034
2.689ProIle: 2.689 ± 0.075
3.052ProLys: 3.052 ± 0.066
2.956ProLeu: 2.956 ± 0.062
0.813ProMet: 0.813 ± 0.036
2.519ProAsn: 2.519 ± 0.064
0.891ProPro: 0.891 ± 0.041
1.532ProGln: 1.532 ± 0.05
1.087ProArg: 1.087 ± 0.039
2.207ProSer: 2.207 ± 0.058
1.959ProThr: 1.959 ± 0.061
2.32ProVal: 2.32 ± 0.065
0.364ProTrp: 0.364 ± 0.026
1.619ProTyr: 1.619 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
2.609GlnAla: 2.609 ± 0.071
0.221GlnCys: 0.221 ± 0.019
1.837GlnAsp: 1.837 ± 0.058
2.95GlnGlu: 2.95 ± 0.066
1.674GlnPhe: 1.674 ± 0.056
2.162GlnGly: 2.162 ± 0.059
0.61GlnHis: 0.61 ± 0.038
2.882GlnIle: 2.882 ± 0.062
3.945GlnLys: 3.945 ± 0.092
3.419GlnLeu: 3.419 ± 0.078
0.98GlnMet: 0.98 ± 0.033
2.734GlnAsn: 2.734 ± 0.068
1.202GlnPro: 1.202 ± 0.038
1.646GlnGln: 1.646 ± 0.056
1.532GlnArg: 1.532 ± 0.055
2.229GlnSer: 2.229 ± 0.06
1.877GlnThr: 1.877 ± 0.056
2.218GlnVal: 2.218 ± 0.054
0.427GlnTrp: 0.427 ± 0.022
1.397GlnTyr: 1.397 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.509ArgAla: 2.509 ± 0.059
0.212ArgCys: 0.212 ± 0.017
1.896ArgAsp: 1.896 ± 0.056
2.731ArgGlu: 2.731 ± 0.075
1.956ArgPhe: 1.956 ± 0.057
2.139ArgGly: 2.139 ± 0.06
0.643ArgHis: 0.643 ± 0.032
2.799ArgIle: 2.799 ± 0.061
3.204ArgLys: 3.204 ± 0.073
3.339ArgLeu: 3.339 ± 0.074
0.939ArgMet: 0.939 ± 0.036
2.282ArgAsn: 2.282 ± 0.066
1.189ArgPro: 1.189 ± 0.042
1.27ArgGln: 1.27 ± 0.043
1.568ArgArg: 1.568 ± 0.056
1.738ArgSer: 1.738 ± 0.052
1.655ArgThr: 1.655 ± 0.052
2.4ArgVal: 2.4 ± 0.06
0.393ArgTrp: 0.393 ± 0.025
1.706ArgTyr: 1.706 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
3.734SerAla: 3.734 ± 0.076
0.594SerCys: 0.594 ± 0.03
3.059SerAsp: 3.059 ± 0.072
3.922SerGlu: 3.922 ± 0.082
3.541SerPhe: 3.541 ± 0.073
4.023SerGly: 4.023 ± 0.102
1.074SerHis: 1.074 ± 0.04
4.504SerIle: 4.504 ± 0.083
4.293SerLys: 4.293 ± 0.086
6.034SerLeu: 6.034 ± 0.104
1.246SerMet: 1.246 ± 0.043
3.207SerAsn: 3.207 ± 0.074
2.442SerPro: 2.442 ± 0.061
2.269SerGln: 2.269 ± 0.059
2.004SerArg: 2.004 ± 0.056
3.63SerSer: 3.63 ± 0.084
3.085SerThr: 3.085 ± 0.075
4.019SerVal: 4.019 ± 0.077
0.658SerTrp: 0.658 ± 0.034
2.608SerTyr: 2.608 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
3.512ThrAla: 3.512 ± 0.089
0.338ThrCys: 0.338 ± 0.025
2.793ThrAsp: 2.793 ± 0.064
3.454ThrGlu: 3.454 ± 0.085
2.544ThrPhe: 2.544 ± 0.058
3.5ThrGly: 3.5 ± 0.08
1.063ThrHis: 1.063 ± 0.041
3.482ThrIle: 3.482 ± 0.076
3.476ThrLys: 3.476 ± 0.074
4.967ThrLeu: 4.967 ± 0.09
0.931ThrMet: 0.931 ± 0.031
2.637ThrAsn: 2.637 ± 0.076
2.804ThrPro: 2.804 ± 0.063
2.349ThrGln: 2.349 ± 0.063
1.681ThrArg: 1.681 ± 0.048
2.949ThrSer: 2.949 ± 0.069
2.747ThrThr: 2.747 ± 0.07
2.487ThrVal: 2.487 ± 0.062
0.473ThrTrp: 0.473 ± 0.031
2.121ThrTyr: 2.121 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.338ValAla: 4.338 ± 0.081
0.534ValCys: 0.534 ± 0.033
3.313ValAsp: 3.313 ± 0.079
4.269ValGlu: 4.269 ± 0.09
3.119ValPhe: 3.119 ± 0.07
4.241ValGly: 4.241 ± 0.078
0.941ValHis: 0.941 ± 0.037
4.234ValIle: 4.234 ± 0.094
4.791ValLys: 4.791 ± 0.082
5.778ValLeu: 5.778 ± 0.092
1.315ValMet: 1.315 ± 0.047
3.299ValAsn: 3.299 ± 0.074
2.348ValPro: 2.348 ± 0.065
2.181ValGln: 2.181 ± 0.055
2.245ValArg: 2.245 ± 0.061
4.149ValSer: 4.149 ± 0.089
2.759ValThr: 2.759 ± 0.074
4.39ValVal: 4.39 ± 0.095
0.556ValTrp: 0.556 ± 0.03
2.4ValTyr: 2.4 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.764TrpAla: 0.764 ± 0.035
0.11TrpCys: 0.11 ± 0.014
0.604TrpAsp: 0.604 ± 0.029
0.693TrpGlu: 0.693 ± 0.032
0.539TrpPhe: 0.539 ± 0.024
0.806TrpGly: 0.806 ± 0.04
0.218TrpHis: 0.218 ± 0.017
0.751TrpIle: 0.751 ± 0.032
0.819TrpLys: 0.819 ± 0.037
0.936TrpLeu: 0.936 ± 0.041
0.222TrpMet: 0.222 ± 0.019
0.694TrpAsn: 0.694 ± 0.035
0.151TrpPro: 0.151 ± 0.016
0.511TrpGln: 0.511 ± 0.028
0.42TrpArg: 0.42 ± 0.025
0.582TrpSer: 0.582 ± 0.033
0.437TrpThr: 0.437 ± 0.028
0.722TrpVal: 0.722 ± 0.037
0.157TrpTrp: 0.157 ± 0.017
0.499TrpTyr: 0.499 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.799TyrAla: 2.799 ± 0.064
0.364TyrCys: 0.364 ± 0.025
2.438TyrAsp: 2.438 ± 0.064
2.522TyrGlu: 2.522 ± 0.06
2.58TyrPhe: 2.58 ± 0.065
2.725TyrGly: 2.725 ± 0.067
0.829TyrHis: 0.829 ± 0.031
2.728TyrIle: 2.728 ± 0.073
3.273TyrLys: 3.273 ± 0.069
4.103TyrLeu: 4.103 ± 0.093
0.774TyrMet: 0.774 ± 0.029
2.624TyrAsn: 2.624 ± 0.063
1.565TyrPro: 1.565 ± 0.047
1.847TyrGln: 1.847 ± 0.063
1.706TyrArg: 1.706 ± 0.052
2.52TyrSer: 2.52 ± 0.063
2.306TyrThr: 2.306 ± 0.055
2.234TyrVal: 2.234 ± 0.064
0.495TyrTrp: 0.495 ± 0.029
2.009TyrTyr: 2.009 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2138 proteins (688764 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski