Amino acid dipepetide frequency for Capnocytophaga canis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.971AlaAla: 2.971 ± 0.085
0.558AlaCys: 0.558 ± 0.031
3.242AlaAsp: 3.242 ± 0.069
4.213AlaGlu: 4.213 ± 0.097
3.184AlaPhe: 3.184 ± 0.079
3.656AlaGly: 3.656 ± 0.083
1.059AlaHis: 1.059 ± 0.042
4.919AlaIle: 4.919 ± 0.089
4.713AlaLys: 4.713 ± 0.094
5.675AlaLeu: 5.675 ± 0.101
1.581AlaMet: 1.581 ± 0.057
3.22AlaAsn: 3.22 ± 0.071
1.804AlaPro: 1.804 ± 0.051
2.433AlaGln: 2.433 ± 0.062
2.031AlaArg: 2.031 ± 0.059
3.828AlaSer: 3.828 ± 0.073
3.685AlaThr: 3.685 ± 0.087
3.899AlaVal: 3.899 ± 0.081
0.553AlaTrp: 0.553 ± 0.029
2.591AlaTyr: 2.591 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.382CysAla: 0.382 ± 0.02
0.095CysCys: 0.095 ± 0.013
0.396CysAsp: 0.396 ± 0.023
0.464CysGlu: 0.464 ± 0.029
0.447CysPhe: 0.447 ± 0.029
0.563CysGly: 0.563 ± 0.031
0.194CysHis: 0.194 ± 0.023
0.551CysIle: 0.551 ± 0.028
0.548CysLys: 0.548 ± 0.027
0.665CysLeu: 0.665 ± 0.033
0.18CysMet: 0.18 ± 0.017
0.398CysAsn: 0.398 ± 0.027
0.289CysPro: 0.289 ± 0.027
0.258CysGln: 0.258 ± 0.023
0.239CysArg: 0.239 ± 0.02
0.543CysSer: 0.543 ± 0.027
0.403CysThr: 0.403 ± 0.025
0.494CysVal: 0.494 ± 0.03
0.091CysTrp: 0.091 ± 0.01
0.357CysTyr: 0.357 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.149AspAla: 3.149 ± 0.075
0.395AspCys: 0.395 ± 0.026
2.427AspAsp: 2.427 ± 0.072
3.576AspGlu: 3.576 ± 0.077
3.814AspPhe: 3.814 ± 0.088
2.979AspGly: 2.979 ± 0.075
0.685AspHis: 0.685 ± 0.03
4.3AspIle: 4.3 ± 0.078
4.226AspLys: 4.226 ± 0.083
4.768AspLeu: 4.768 ± 0.087
1.161AspMet: 1.161 ± 0.047
2.802AspAsn: 2.802 ± 0.065
1.444AspPro: 1.444 ± 0.055
1.203AspGln: 1.203 ± 0.039
1.936AspArg: 1.936 ± 0.052
2.889AspSer: 2.889 ± 0.068
2.54AspThr: 2.54 ± 0.062
3.469AspVal: 3.469 ± 0.084
0.684AspTrp: 0.684 ± 0.034
2.671AspTyr: 2.671 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
4.253GluAla: 4.253 ± 0.091
0.355GluCys: 0.355 ± 0.025
2.999GluAsp: 2.999 ± 0.07
5.164GluGlu: 5.164 ± 0.108
2.9GluPhe: 2.9 ± 0.074
3.756GluGly: 3.756 ± 0.088
1.161GluHis: 1.161 ± 0.041
5.773GluIle: 5.773 ± 0.097
7.177GluLys: 7.177 ± 0.105
6.236GluLeu: 6.236 ± 0.109
1.64GluMet: 1.64 ± 0.054
5.358GluAsn: 5.358 ± 0.093
1.571GluPro: 1.571 ± 0.05
2.654GluGln: 2.654 ± 0.062
3.005GluArg: 3.005 ± 0.075
3.429GluSer: 3.429 ± 0.069
3.542GluThr: 3.542 ± 0.076
4.544GluVal: 4.544 ± 0.086
0.648GluTrp: 0.648 ± 0.032
2.603GluTyr: 2.603 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.033PheAla: 3.033 ± 0.068
0.468PheCys: 0.468 ± 0.026
3.242PheAsp: 3.242 ± 0.067
3.598PheGlu: 3.598 ± 0.079
3.33PhePhe: 3.33 ± 0.079
3.629PheGly: 3.629 ± 0.072
0.931PheHis: 0.931 ± 0.04
3.814PheIle: 3.814 ± 0.084
3.307PheLys: 3.307 ± 0.081
5.154PheLeu: 5.154 ± 0.108
1.303PheMet: 1.303 ± 0.039
2.806PheAsn: 2.806 ± 0.076
1.861PhePro: 1.861 ± 0.051
1.806PheGln: 1.806 ± 0.053
1.942PheArg: 1.942 ± 0.051
4.353PheSer: 4.353 ± 0.093
3.024PheThr: 3.024 ± 0.073
3.725PheVal: 3.725 ± 0.074
0.66PheTrp: 0.66 ± 0.033
2.331PheTyr: 2.331 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
3.876GlyAla: 3.876 ± 0.086
0.6GlyCys: 0.6 ± 0.042
3.005GlyAsp: 3.005 ± 0.074
3.643GlyGlu: 3.643 ± 0.081
3.525GlyPhe: 3.525 ± 0.073
4.342GlyGly: 4.342 ± 0.09
1.025GlyHis: 1.025 ± 0.047
5.15GlyIle: 5.15 ± 0.09
5.568GlyLys: 5.568 ± 0.094
5.205GlyLeu: 5.205 ± 0.085
1.66GlyMet: 1.66 ± 0.057
3.571GlyAsn: 3.571 ± 0.086
0.805GlyPro: 0.805 ± 0.039
1.812GlyGln: 1.812 ± 0.058
2.161GlyArg: 2.161 ± 0.07
3.558GlySer: 3.558 ± 0.081
3.504GlyThr: 3.504 ± 0.083
4.768GlyVal: 4.768 ± 0.091
0.727GlyTrp: 0.727 ± 0.032
2.939GlyTyr: 2.939 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
0.846HisAla: 0.846 ± 0.034
0.195HisCys: 0.195 ± 0.016
0.8HisAsp: 0.8 ± 0.03
0.913HisGlu: 0.913 ± 0.034
1.207HisPhe: 1.207 ± 0.046
0.999HisGly: 0.999 ± 0.039
0.466HisHis: 0.466 ± 0.027
1.693HisIle: 1.693 ± 0.051
1.381HisLys: 1.381 ± 0.046
1.962HisLeu: 1.962 ± 0.058
0.267HisMet: 0.267 ± 0.021
1.006HisAsn: 1.006 ± 0.038
0.885HisPro: 0.885 ± 0.036
0.773HisGln: 0.773 ± 0.033
0.86HisArg: 0.86 ± 0.036
1.241HisSer: 1.241 ± 0.044
1.095HisThr: 1.095 ± 0.044
0.856HisVal: 0.856 ± 0.041
0.258HisTrp: 0.258 ± 0.02
0.921HisTyr: 0.921 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.379IleAla: 5.379 ± 0.088
0.633IleCys: 0.633 ± 0.031
4.588IleAsp: 4.588 ± 0.076
5.725IleGlu: 5.725 ± 0.096
4.203IlePhe: 4.203 ± 0.095
4.944IleGly: 4.944 ± 0.101
1.554IleHis: 1.554 ± 0.046
5.781IleIle: 5.781 ± 0.116
5.507IleLys: 5.507 ± 0.102
7.139IleLeu: 7.139 ± 0.11
1.278IleMet: 1.278 ± 0.046
4.06IleAsn: 4.06 ± 0.083
3.333IlePro: 3.333 ± 0.077
2.772IleGln: 2.772 ± 0.059
3.067IleArg: 3.067 ± 0.062
5.8IleSer: 5.8 ± 0.089
4.718IleThr: 4.718 ± 0.094
4.864IleVal: 4.864 ± 0.095
0.678IleTrp: 0.678 ± 0.032
3.077IleTyr: 3.077 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
4.812LysAla: 4.812 ± 0.092
0.338LysCys: 0.338 ± 0.024
4.195LysAsp: 4.195 ± 0.089
6.493LysGlu: 6.493 ± 0.108
2.84LysPhe: 2.84 ± 0.06
4.972LysGly: 4.972 ± 0.089
1.567LysHis: 1.567 ± 0.043
6.827LysIle: 6.827 ± 0.113
7.171LysLys: 7.171 ± 0.116
5.954LysLeu: 5.954 ± 0.096
2.257LysMet: 2.257 ± 0.061
5.719LysAsn: 5.719 ± 0.106
2.3LysPro: 2.3 ± 0.065
3.169LysGln: 3.169 ± 0.068
3.252LysArg: 3.252 ± 0.065
4.7LysSer: 4.7 ± 0.088
4.795LysThr: 4.795 ± 0.086
4.809LysVal: 4.809 ± 0.086
0.822LysTrp: 0.822 ± 0.034
3.361LysTyr: 3.361 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
5.619LeuAla: 5.619 ± 0.102
0.743LeuCys: 0.743 ± 0.031
4.36LeuAsp: 4.36 ± 0.089
5.872LeuGlu: 5.872 ± 0.094
5.244LeuPhe: 5.244 ± 0.103
5.801LeuGly: 5.801 ± 0.105
1.817LeuHis: 1.817 ± 0.053
6.615LeuIle: 6.615 ± 0.121
7.44LeuLys: 7.44 ± 0.109
8.726LeuLeu: 8.726 ± 0.156
2.051LeuMet: 2.051 ± 0.06
5.078LeuAsn: 5.078 ± 0.097
3.653LeuPro: 3.653 ± 0.077
3.769LeuGln: 3.769 ± 0.082
3.626LeuArg: 3.626 ± 0.075
6.778LeuSer: 6.778 ± 0.107
4.873LeuThr: 4.873 ± 0.087
5.219LeuVal: 5.219 ± 0.094
0.906LeuTrp: 0.906 ± 0.039
3.255LeuTyr: 3.255 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
1.503MetAla: 1.503 ± 0.042
0.139MetCys: 0.139 ± 0.016
1.052MetAsp: 1.052 ± 0.045
1.511MetGlu: 1.511 ± 0.054
1.025MetPhe: 1.025 ± 0.038
1.497MetGly: 1.497 ± 0.046
0.388MetHis: 0.388 ± 0.024
1.63MetIle: 1.63 ± 0.049
2.318MetLys: 2.318 ± 0.059
2.16MetLeu: 2.16 ± 0.06
0.645MetMet: 0.645 ± 0.027
1.377MetAsn: 1.377 ± 0.042
0.872MetPro: 0.872 ± 0.031
0.9MetGln: 0.9 ± 0.036
0.958MetArg: 0.958 ± 0.037
1.429MetSer: 1.429 ± 0.054
1.175MetThr: 1.175 ± 0.04
1.427MetVal: 1.427 ± 0.044
0.205MetTrp: 0.205 ± 0.018
0.819MetTyr: 0.819 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.426AsnAla: 3.426 ± 0.07
0.385AsnCys: 0.385 ± 0.024
2.822AsnAsp: 2.822 ± 0.058
3.835AsnGlu: 3.835 ± 0.088
3.031AsnPhe: 3.031 ± 0.072
3.523AsnGly: 3.523 ± 0.073
1.148AsnHis: 1.148 ± 0.04
5.035AsnIle: 5.035 ± 0.09
4.232AsnLys: 4.232 ± 0.081
5.13AsnLeu: 5.13 ± 0.098
1.234AsnMet: 1.234 ± 0.036
3.35AsnAsn: 3.35 ± 0.089
2.72AsnPro: 2.72 ± 0.056
2.569AsnGln: 2.569 ± 0.058
2.484AsnArg: 2.484 ± 0.069
3.378AsnSer: 3.378 ± 0.081
3.353AsnThr: 3.353 ± 0.075
3.643AsnVal: 3.643 ± 0.075
0.628AsnTrp: 0.628 ± 0.034
2.722AsnTyr: 2.722 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
1.79ProAla: 1.79 ± 0.059
0.221ProCys: 0.221 ± 0.016
1.731ProAsp: 1.731 ± 0.047
2.651ProGlu: 2.651 ± 0.068
1.945ProPhe: 1.945 ± 0.052
1.36ProGly: 1.36 ± 0.052
0.682ProHis: 0.682 ± 0.03
2.767ProIle: 2.767 ± 0.07
2.761ProLys: 2.761 ± 0.077
3.05ProLeu: 3.05 ± 0.07
0.829ProMet: 0.829 ± 0.036
2.148ProAsn: 2.148 ± 0.061
0.853ProPro: 0.853 ± 0.05
1.39ProGln: 1.39 ± 0.049
0.958ProArg: 0.958 ± 0.036
2.045ProSer: 2.045 ± 0.053
2.041ProThr: 2.041 ± 0.064
2.192ProVal: 2.192 ± 0.059
0.32ProTrp: 0.32 ± 0.021
1.543ProTyr: 1.543 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.034GlnAla: 2.034 ± 0.049
0.195GlnCys: 0.195 ± 0.014
1.448GlnAsp: 1.448 ± 0.049
2.651GlnGlu: 2.651 ± 0.066
1.714GlnPhe: 1.714 ± 0.051
2.106GlnGly: 2.106 ± 0.054
0.764GlnHis: 0.764 ± 0.036
2.937GlnIle: 2.937 ± 0.072
3.617GlnLys: 3.617 ± 0.081
3.692GlnLeu: 3.692 ± 0.081
0.947GlnMet: 0.947 ± 0.035
2.461GlnAsn: 2.461 ± 0.062
1.115GlnPro: 1.115 ± 0.045
2.007GlnGln: 2.007 ± 0.059
1.623GlnArg: 1.623 ± 0.047
2.096GlnSer: 2.096 ± 0.062
2.189GlnThr: 2.189 ± 0.058
2.303GlnVal: 2.303 ± 0.059
0.5GlnTrp: 0.5 ± 0.032
1.411GlnTyr: 1.411 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.08ArgAla: 2.08 ± 0.055
0.243ArgCys: 0.243 ± 0.019
1.772ArgAsp: 1.772 ± 0.054
2.669ArgGlu: 2.669 ± 0.076
2.155ArgPhe: 2.155 ± 0.059
2.095ArgGly: 2.095 ± 0.061
0.72ArgHis: 0.72 ± 0.037
3.264ArgIle: 3.264 ± 0.069
3.415ArgLys: 3.415 ± 0.065
3.582ArgLeu: 3.582 ± 0.075
1.128ArgMet: 1.128 ± 0.04
2.4ArgAsn: 2.4 ± 0.063
1.238ArgPro: 1.238 ± 0.045
1.377ArgGln: 1.377 ± 0.045
1.506ArgArg: 1.506 ± 0.049
1.966ArgSer: 1.966 ± 0.056
2.028ArgThr: 2.028 ± 0.056
2.39ArgVal: 2.39 ± 0.062
0.47ArgTrp: 0.47 ± 0.024
1.787ArgTyr: 1.787 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
3.452SerAla: 3.452 ± 0.076
0.635SerCys: 0.635 ± 0.033
3.51SerAsp: 3.51 ± 0.074
4.42SerGlu: 4.42 ± 0.086
3.827SerPhe: 3.827 ± 0.078
4.094SerGly: 4.094 ± 0.1
1.163SerHis: 1.163 ± 0.042
4.864SerIle: 4.864 ± 0.103
4.775SerLys: 4.775 ± 0.085
6.154SerLeu: 6.154 ± 0.112
1.277SerMet: 1.277 ± 0.046
3.391SerAsn: 3.391 ± 0.074
1.984SerPro: 1.984 ± 0.049
2.33SerGln: 2.33 ± 0.052
2.195SerArg: 2.195 ± 0.059
3.94SerSer: 3.94 ± 0.084
3.082SerThr: 3.082 ± 0.066
4.564SerVal: 4.564 ± 0.09
0.628SerTrp: 0.628 ± 0.03
2.775SerTyr: 2.775 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
3.532ThrAla: 3.532 ± 0.085
0.345ThrCys: 0.345 ± 0.028
3.126ThrAsp: 3.126 ± 0.065
3.801ThrGlu: 3.801 ± 0.073
3.06ThrPhe: 3.06 ± 0.071
3.489ThrGly: 3.489 ± 0.087
1.163ThrHis: 1.163 ± 0.041
4.508ThrIle: 4.508 ± 0.1
3.673ThrLys: 3.673 ± 0.084
5.395ThrLeu: 5.395 ± 0.096
1.073ThrMet: 1.073 ± 0.042
2.964ThrAsn: 2.964 ± 0.071
2.59ThrPro: 2.59 ± 0.071
2.264ThrGln: 2.264 ± 0.065
1.697ThrArg: 1.697 ± 0.052
3.445ThrSer: 3.445 ± 0.071
3.357ThrThr: 3.357 ± 0.101
3.357ThrVal: 3.357 ± 0.087
0.525ThrTrp: 0.525 ± 0.028
2.506ThrTyr: 2.506 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
4.396ValAla: 4.396 ± 0.091
0.583ValCys: 0.583 ± 0.029
3.312ValAsp: 3.312 ± 0.069
4.165ValGlu: 4.165 ± 0.076
3.623ValPhe: 3.623 ± 0.079
4.172ValGly: 4.172 ± 0.084
1.027ValHis: 1.027 ± 0.039
4.837ValIle: 4.837 ± 0.081
4.663ValLys: 4.663 ± 0.079
5.964ValLeu: 5.964 ± 0.094
1.446ValMet: 1.446 ± 0.049
3.442ValAsn: 3.442 ± 0.081
2.23ValPro: 2.23 ± 0.053
2.034ValGln: 2.034 ± 0.053
2.508ValArg: 2.508 ± 0.063
4.564ValSer: 4.564 ± 0.099
3.61ValThr: 3.61 ± 0.105
4.634ValVal: 4.634 ± 0.096
0.604ValTrp: 0.604 ± 0.029
2.587ValTyr: 2.587 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.594TrpAla: 0.594 ± 0.032
0.11TrpCys: 0.11 ± 0.013
0.582TrpAsp: 0.582 ± 0.032
0.733TrpGlu: 0.733 ± 0.036
0.579TrpPhe: 0.579 ± 0.028
0.73TrpGly: 0.73 ± 0.038
0.235TrpHis: 0.235 ± 0.018
0.798TrpIle: 0.798 ± 0.036
0.86TrpLys: 0.86 ± 0.041
1.052TrpLeu: 1.052 ± 0.039
0.272TrpMet: 0.272 ± 0.02
0.708TrpAsn: 0.708 ± 0.028
0.117TrpPro: 0.117 ± 0.015
0.498TrpGln: 0.498 ± 0.027
0.418TrpArg: 0.418 ± 0.025
0.566TrpSer: 0.566 ± 0.027
0.5TrpThr: 0.5 ± 0.027
0.634TrpVal: 0.634 ± 0.033
0.159TrpTrp: 0.159 ± 0.017
0.415TrpTyr: 0.415 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.688TyrAla: 2.688 ± 0.061
0.318TyrCys: 0.318 ± 0.022
2.509TyrAsp: 2.509 ± 0.064
2.669TyrGlu: 2.669 ± 0.066
2.665TyrPhe: 2.665 ± 0.07
2.739TyrGly: 2.739 ± 0.074
0.876TyrHis: 0.876 ± 0.034
3.037TyrIle: 3.037 ± 0.07
3.002TyrLys: 3.002 ± 0.059
3.782TyrLeu: 3.782 ± 0.08
0.8TyrMet: 0.8 ± 0.039
2.389TyrAsn: 2.389 ± 0.058
1.612TyrPro: 1.612 ± 0.051
1.795TyrGln: 1.795 ± 0.048
1.821TyrArg: 1.821 ± 0.053
2.512TyrSer: 2.512 ± 0.066
2.354TyrThr: 2.354 ± 0.066
2.611TyrVal: 2.611 ± 0.065
0.494TyrTrp: 0.494 ± 0.026
1.838TyrTyr: 1.838 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2202 proteins (706585 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski