Amino acid dipepetide frequency for Gordonia phage Catfish

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.877AlaAla: 17.877 ± 1.94
1.092AlaCys: 1.092 ± 0.298
8.529AlaAsp: 8.529 ± 0.666
7.71AlaGlu: 7.71 ± 0.684
3.616AlaPhe: 3.616 ± 0.452
10.439AlaGly: 10.439 ± 1.014
1.842AlaHis: 1.842 ± 0.278
4.367AlaIle: 4.367 ± 0.631
5.186AlaLys: 5.186 ± 0.752
10.098AlaLeu: 10.098 ± 1.098
2.866AlaMet: 2.866 ± 0.456
3.48AlaAsn: 3.48 ± 0.463
4.435AlaPro: 4.435 ± 0.65
3.753AlaGln: 3.753 ± 0.5
8.802AlaArg: 8.802 ± 0.716
5.868AlaSer: 5.868 ± 0.716
7.71AlaThr: 7.71 ± 0.917
8.87AlaVal: 8.87 ± 0.721
2.388AlaTrp: 2.388 ± 0.341
2.525AlaTyr: 2.525 ± 0.441
0.0AlaXaa: 0.0 ± 0.0
Cys
0.614CysAla: 0.614 ± 0.22
0.068CysCys: 0.068 ± 0.067
0.751CysAsp: 0.751 ± 0.213
1.092CysGlu: 1.092 ± 0.324
0.136CysPhe: 0.136 ± 0.101
0.819CysGly: 0.819 ± 0.26
0.341CysHis: 0.341 ± 0.151
0.205CysIle: 0.205 ± 0.114
0.136CysLys: 0.136 ± 0.103
0.341CysLeu: 0.341 ± 0.164
0.068CysMet: 0.068 ± 0.073
0.273CysAsn: 0.273 ± 0.139
0.409CysPro: 0.409 ± 0.185
0.341CysGln: 0.341 ± 0.145
0.409CysArg: 0.409 ± 0.158
0.614CysSer: 0.614 ± 0.189
0.273CysThr: 0.273 ± 0.12
0.887CysVal: 0.887 ± 0.275
0.273CysTrp: 0.273 ± 0.143
0.273CysTyr: 0.273 ± 0.112
0.0CysXaa: 0.0 ± 0.0
Asp
7.574AspAla: 7.574 ± 0.738
1.023AspCys: 1.023 ± 0.255
4.776AspAsp: 4.776 ± 0.815
5.322AspGlu: 5.322 ± 0.726
1.979AspPhe: 1.979 ± 0.308
6.755AspGly: 6.755 ± 0.552
1.569AspHis: 1.569 ± 0.329
1.569AspIle: 1.569 ± 0.385
1.842AspLys: 1.842 ± 0.272
6.141AspLeu: 6.141 ± 0.628
1.228AspMet: 1.228 ± 0.255
1.092AspAsn: 1.092 ± 0.311
3.753AspPro: 3.753 ± 0.564
2.252AspGln: 2.252 ± 0.449
4.913AspArg: 4.913 ± 0.53
2.797AspSer: 2.797 ± 0.438
3.548AspThr: 3.548 ± 0.465
5.254AspVal: 5.254 ± 0.673
1.706AspTrp: 1.706 ± 0.307
2.252AspTyr: 2.252 ± 0.436
0.0AspXaa: 0.0 ± 0.0
Glu
7.505GluAla: 7.505 ± 0.654
1.023GluCys: 1.023 ± 0.315
4.299GluAsp: 4.299 ± 0.561
2.388GluGlu: 2.388 ± 0.413
2.729GluPhe: 2.729 ± 0.423
5.39GluGly: 5.39 ± 0.808
1.365GluHis: 1.365 ± 0.269
2.593GluIle: 2.593 ± 0.481
2.115GluLys: 2.115 ± 0.397
6.277GluLeu: 6.277 ± 0.848
1.16GluMet: 1.16 ± 0.258
2.047GluAsn: 2.047 ± 0.355
2.866GluPro: 2.866 ± 0.48
2.525GluGln: 2.525 ± 0.488
4.64GluArg: 4.64 ± 0.603
3.753GluSer: 3.753 ± 0.465
2.866GluThr: 2.866 ± 0.396
5.322GluVal: 5.322 ± 0.53
1.433GluTrp: 1.433 ± 0.366
1.91GluTyr: 1.91 ± 0.394
0.0GluXaa: 0.0 ± 0.0
Phe
4.026PheAla: 4.026 ± 0.453
0.136PheCys: 0.136 ± 0.089
1.842PheAsp: 1.842 ± 0.36
2.593PheGlu: 2.593 ± 0.333
1.023PhePhe: 1.023 ± 0.239
2.934PheGly: 2.934 ± 0.404
0.546PheHis: 0.546 ± 0.146
0.955PheIle: 0.955 ± 0.238
0.614PheLys: 0.614 ± 0.204
1.842PheLeu: 1.842 ± 0.402
0.682PheMet: 0.682 ± 0.184
0.682PheAsn: 0.682 ± 0.199
1.023PhePro: 1.023 ± 0.246
0.751PheGln: 0.751 ± 0.219
3.07PheArg: 3.07 ± 0.446
1.706PheSer: 1.706 ± 0.369
2.525PheThr: 2.525 ± 0.396
2.115PheVal: 2.115 ± 0.349
0.068PheTrp: 0.068 ± 0.053
0.614PheTyr: 0.614 ± 0.224
0.0PheXaa: 0.0 ± 0.0
Gly
8.392GlyAla: 8.392 ± 0.938
0.819GlyCys: 0.819 ± 0.315
6.004GlyAsp: 6.004 ± 0.824
6.891GlyGlu: 6.891 ± 0.697
3.412GlyPhe: 3.412 ± 0.506
11.395GlyGly: 11.395 ± 1.265
1.774GlyHis: 1.774 ± 0.43
3.07GlyIle: 3.07 ± 0.477
3.412GlyLys: 3.412 ± 0.542
5.868GlyLeu: 5.868 ± 0.783
2.593GlyMet: 2.593 ± 0.453
3.548GlyAsn: 3.548 ± 0.664
4.503GlyPro: 4.503 ± 0.713
3.753GlyGln: 3.753 ± 0.409
7.847GlyArg: 7.847 ± 0.682
5.39GlySer: 5.39 ± 0.746
5.663GlyThr: 5.663 ± 0.745
7.983GlyVal: 7.983 ± 0.818
1.774GlyTrp: 1.774 ± 0.346
2.252GlyTyr: 2.252 ± 0.417
0.0GlyXaa: 0.0 ± 0.0
His
1.706HisAla: 1.706 ± 0.351
0.136HisCys: 0.136 ± 0.092
1.296HisAsp: 1.296 ± 0.286
1.023HisGlu: 1.023 ± 0.271
0.409HisPhe: 0.409 ± 0.147
2.252HisGly: 2.252 ± 0.322
0.273HisHis: 0.273 ± 0.143
0.341HisIle: 0.341 ± 0.157
0.614HisLys: 0.614 ± 0.247
1.092HisLeu: 1.092 ± 0.244
0.546HisMet: 0.546 ± 0.182
0.341HisAsn: 0.341 ± 0.164
1.365HisPro: 1.365 ± 0.414
0.478HisGln: 0.478 ± 0.158
1.228HisArg: 1.228 ± 0.316
0.887HisSer: 0.887 ± 0.23
1.365HisThr: 1.365 ± 0.269
1.91HisVal: 1.91 ± 0.321
0.546HisTrp: 0.546 ± 0.162
0.341HisTyr: 0.341 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
5.459IleAla: 5.459 ± 0.836
0.136IleCys: 0.136 ± 0.105
2.32IleAsp: 2.32 ± 0.355
3.684IleGlu: 3.684 ± 0.566
0.409IlePhe: 0.409 ± 0.157
3.684IleGly: 3.684 ± 0.535
0.682IleHis: 0.682 ± 0.206
1.023IleIle: 1.023 ± 0.339
0.682IleLys: 0.682 ± 0.211
2.252IleLeu: 2.252 ± 0.348
0.546IleMet: 0.546 ± 0.201
0.819IleAsn: 0.819 ± 0.22
2.456IlePro: 2.456 ± 0.354
0.887IleGln: 0.887 ± 0.239
2.456IleArg: 2.456 ± 0.461
2.183IleSer: 2.183 ± 0.401
2.32IleThr: 2.32 ± 0.378
2.934IleVal: 2.934 ± 0.457
0.341IleTrp: 0.341 ± 0.14
0.546IleTyr: 0.546 ± 0.24
0.0IleXaa: 0.0 ± 0.0
Lys
4.708LysAla: 4.708 ± 0.638
0.205LysCys: 0.205 ± 0.114
2.729LysAsp: 2.729 ± 0.534
1.16LysGlu: 1.16 ± 0.246
1.16LysPhe: 1.16 ± 0.257
2.661LysGly: 2.661 ± 0.416
0.546LysHis: 0.546 ± 0.186
0.955LysIle: 0.955 ± 0.235
0.819LysLys: 0.819 ± 0.243
3.207LysLeu: 3.207 ± 0.572
0.478LysMet: 0.478 ± 0.161
0.819LysAsn: 0.819 ± 0.237
2.183LysPro: 2.183 ± 0.364
0.887LysGln: 0.887 ± 0.216
3.275LysArg: 3.275 ± 0.505
2.525LysSer: 2.525 ± 0.595
1.91LysThr: 1.91 ± 0.463
2.934LysVal: 2.934 ± 0.413
0.546LysTrp: 0.546 ± 0.209
1.228LysTyr: 1.228 ± 0.352
0.0LysXaa: 0.0 ± 0.0
Leu
10.576LeuAla: 10.576 ± 0.858
0.682LeuCys: 0.682 ± 0.197
4.503LeuAsp: 4.503 ± 0.513
6.346LeuGlu: 6.346 ± 0.718
2.047LeuPhe: 2.047 ± 0.388
7.437LeuGly: 7.437 ± 0.984
1.16LeuHis: 1.16 ± 0.272
3.207LeuIle: 3.207 ± 0.474
3.684LeuLys: 3.684 ± 0.507
4.913LeuLeu: 4.913 ± 0.577
1.638LeuMet: 1.638 ± 0.337
2.388LeuAsn: 2.388 ± 0.419
4.094LeuPro: 4.094 ± 0.552
1.365LeuGln: 1.365 ± 0.275
5.527LeuArg: 5.527 ± 0.541
3.889LeuSer: 3.889 ± 0.501
5.936LeuThr: 5.936 ± 0.955
5.527LeuVal: 5.527 ± 0.535
1.296LeuTrp: 1.296 ± 0.292
1.979LeuTyr: 1.979 ± 0.449
0.0LeuXaa: 0.0 ± 0.0
Met
2.593MetAla: 2.593 ± 0.489
0.136MetCys: 0.136 ± 0.09
1.228MetAsp: 1.228 ± 0.304
0.546MetGlu: 0.546 ± 0.243
0.478MetPhe: 0.478 ± 0.168
1.638MetGly: 1.638 ± 0.374
0.273MetHis: 0.273 ± 0.14
0.819MetIle: 0.819 ± 0.282
0.546MetLys: 0.546 ± 0.187
1.501MetLeu: 1.501 ± 0.347
0.409MetMet: 0.409 ± 0.151
0.682MetAsn: 0.682 ± 0.285
0.887MetPro: 0.887 ± 0.226
0.546MetGln: 0.546 ± 0.248
1.774MetArg: 1.774 ± 0.311
2.047MetSer: 2.047 ± 0.325
2.183MetThr: 2.183 ± 0.452
1.16MetVal: 1.16 ± 0.278
0.341MetTrp: 0.341 ± 0.161
0.478MetTyr: 0.478 ± 0.17
0.0MetXaa: 0.0 ± 0.0
Asn
3.821AsnAla: 3.821 ± 0.574
0.0AsnCys: 0.0 ± 0.0
1.979AsnAsp: 1.979 ± 0.351
1.433AsnGlu: 1.433 ± 0.271
1.501AsnPhe: 1.501 ± 0.354
3.07AsnGly: 3.07 ± 0.447
0.273AsnHis: 0.273 ± 0.124
1.569AsnIle: 1.569 ± 0.351
0.751AsnLys: 0.751 ± 0.25
1.706AsnLeu: 1.706 ± 0.269
0.546AsnMet: 0.546 ± 0.208
0.341AsnAsn: 0.341 ± 0.156
2.593AsnPro: 2.593 ± 0.407
0.478AsnGln: 0.478 ± 0.203
3.139AsnArg: 3.139 ± 0.507
1.365AsnSer: 1.365 ± 0.328
1.16AsnThr: 1.16 ± 0.342
1.979AsnVal: 1.979 ± 0.349
0.341AsnTrp: 0.341 ± 0.147
0.682AsnTyr: 0.682 ± 0.327
0.0AsnXaa: 0.0 ± 0.0
Pro
4.708ProAla: 4.708 ± 0.514
0.614ProCys: 0.614 ± 0.2
3.821ProAsp: 3.821 ± 0.563
3.616ProGlu: 3.616 ± 0.478
1.433ProPhe: 1.433 ± 0.326
4.708ProGly: 4.708 ± 0.572
0.751ProHis: 0.751 ± 0.24
1.706ProIle: 1.706 ± 0.34
1.638ProLys: 1.638 ± 0.346
3.275ProLeu: 3.275 ± 0.489
0.682ProMet: 0.682 ± 0.242
1.979ProAsn: 1.979 ± 0.337
1.842ProPro: 1.842 ± 0.369
0.819ProGln: 0.819 ± 0.27
3.616ProArg: 3.616 ± 0.552
1.91ProSer: 1.91 ± 0.421
3.207ProThr: 3.207 ± 0.417
4.913ProVal: 4.913 ± 0.57
1.501ProTrp: 1.501 ± 0.367
1.228ProTyr: 1.228 ± 0.256
0.0ProXaa: 0.0 ± 0.0
Gln
4.435GlnAla: 4.435 ± 0.503
0.068GlnCys: 0.068 ± 0.066
1.228GlnAsp: 1.228 ± 0.302
0.955GlnGlu: 0.955 ± 0.205
0.273GlnPhe: 0.273 ± 0.15
3.002GlnGly: 3.002 ± 0.358
0.273GlnHis: 0.273 ± 0.14
1.023GlnIle: 1.023 ± 0.285
0.409GlnLys: 0.409 ± 0.145
3.343GlnLeu: 3.343 ± 0.452
1.092GlnMet: 1.092 ± 0.259
0.887GlnAsn: 0.887 ± 0.27
1.16GlnPro: 1.16 ± 0.207
1.023GlnGln: 1.023 ± 0.297
3.207GlnArg: 3.207 ± 0.54
1.774GlnSer: 1.774 ± 0.481
1.433GlnThr: 1.433 ± 0.315
1.842GlnVal: 1.842 ± 0.342
0.751GlnTrp: 0.751 ± 0.197
0.819GlnTyr: 0.819 ± 0.266
0.0GlnXaa: 0.0 ± 0.0
Arg
10.712ArgAla: 10.712 ± 1.046
0.614ArgCys: 0.614 ± 0.215
5.663ArgAsp: 5.663 ± 0.848
4.23ArgGlu: 4.23 ± 0.544
2.183ArgPhe: 2.183 ± 0.357
6.618ArgGly: 6.618 ± 0.702
1.91ArgHis: 1.91 ± 0.41
2.593ArgIle: 2.593 ± 0.418
3.957ArgLys: 3.957 ± 0.581
5.527ArgLeu: 5.527 ± 0.548
1.569ArgMet: 1.569 ± 0.304
2.456ArgAsn: 2.456 ± 0.453
2.797ArgPro: 2.797 ± 0.519
2.32ArgGln: 2.32 ± 0.346
6.687ArgArg: 6.687 ± 0.872
3.684ArgSer: 3.684 ± 0.419
4.23ArgThr: 4.23 ± 0.503
6.55ArgVal: 6.55 ± 0.653
1.365ArgTrp: 1.365 ± 0.305
2.252ArgTyr: 2.252 ± 0.388
0.0ArgXaa: 0.0 ± 0.0
Ser
6.346SerAla: 6.346 ± 0.785
0.205SerCys: 0.205 ± 0.134
3.684SerAsp: 3.684 ± 0.586
2.388SerGlu: 2.388 ± 0.441
1.979SerPhe: 1.979 ± 0.401
6.141SerGly: 6.141 ± 0.596
0.751SerHis: 0.751 ± 0.239
2.525SerIle: 2.525 ± 0.314
1.365SerLys: 1.365 ± 0.268
5.39SerLeu: 5.39 ± 0.609
0.682SerMet: 0.682 ± 0.193
1.638SerAsn: 1.638 ± 0.234
2.115SerPro: 2.115 ± 0.363
1.569SerGln: 1.569 ± 0.318
3.684SerArg: 3.684 ± 0.527
3.753SerSer: 3.753 ± 0.936
3.821SerThr: 3.821 ± 0.574
4.776SerVal: 4.776 ± 0.555
0.819SerTrp: 0.819 ± 0.213
1.365SerTyr: 1.365 ± 0.366
0.0SerXaa: 0.0 ± 0.0
Thr
7.233ThrAla: 7.233 ± 0.873
0.478ThrCys: 0.478 ± 0.215
4.299ThrAsp: 4.299 ± 0.522
4.162ThrGlu: 4.162 ± 0.538
1.842ThrPhe: 1.842 ± 0.405
5.8ThrGly: 5.8 ± 0.648
0.955ThrHis: 0.955 ± 0.313
2.32ThrIle: 2.32 ± 0.303
1.91ThrLys: 1.91 ± 0.334
5.254ThrLeu: 5.254 ± 0.618
1.092ThrMet: 1.092 ± 0.26
1.433ThrAsn: 1.433 ± 0.309
3.684ThrPro: 3.684 ± 0.422
1.296ThrGln: 1.296 ± 0.393
3.616ThrArg: 3.616 ± 0.505
3.07ThrSer: 3.07 ± 0.692
2.729ThrThr: 2.729 ± 0.459
6.346ThrVal: 6.346 ± 0.965
1.296ThrTrp: 1.296 ± 0.256
2.047ThrTyr: 2.047 ± 0.531
0.0ThrXaa: 0.0 ± 0.0
Val
8.597ValAla: 8.597 ± 0.947
0.751ValCys: 0.751 ± 0.267
5.049ValAsp: 5.049 ± 0.579
5.8ValGlu: 5.8 ± 0.668
1.842ValPhe: 1.842 ± 0.328
7.505ValGly: 7.505 ± 0.82
1.638ValHis: 1.638 ± 0.303
3.548ValIle: 3.548 ± 0.54
4.026ValLys: 4.026 ± 0.725
6.414ValLeu: 6.414 ± 0.79
1.433ValMet: 1.433 ± 0.313
2.115ValAsn: 2.115 ± 0.357
4.094ValPro: 4.094 ± 0.564
2.593ValGln: 2.593 ± 0.342
5.254ValArg: 5.254 ± 0.626
5.049ValSer: 5.049 ± 0.56
5.868ValThr: 5.868 ± 0.708
6.141ValVal: 6.141 ± 0.713
1.228ValTrp: 1.228 ± 0.334
1.91ValTyr: 1.91 ± 0.422
0.0ValXaa: 0.0 ± 0.0
Trp
1.91TrpAla: 1.91 ± 0.323
0.0TrpCys: 0.0 ± 0.0
1.638TrpAsp: 1.638 ± 0.298
1.365TrpGlu: 1.365 ± 0.298
0.478TrpPhe: 0.478 ± 0.178
1.365TrpGly: 1.365 ± 0.249
0.819TrpHis: 0.819 ± 0.196
0.682TrpIle: 0.682 ± 0.186
0.819TrpLys: 0.819 ± 0.244
1.638TrpLeu: 1.638 ± 0.391
0.341TrpMet: 0.341 ± 0.153
0.887TrpAsn: 0.887 ± 0.327
0.546TrpPro: 0.546 ± 0.195
0.478TrpGln: 0.478 ± 0.164
1.706TrpArg: 1.706 ± 0.363
1.501TrpSer: 1.501 ± 0.299
0.682TrpThr: 0.682 ± 0.283
1.433TrpVal: 1.433 ± 0.421
0.478TrpTrp: 0.478 ± 0.187
0.273TrpTyr: 0.273 ± 0.102
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.661TyrAla: 2.661 ± 0.451
0.136TyrCys: 0.136 ± 0.095
1.706TyrAsp: 1.706 ± 0.364
1.501TyrGlu: 1.501 ± 0.299
0.819TyrPhe: 0.819 ± 0.308
2.729TyrGly: 2.729 ± 0.483
0.409TyrHis: 0.409 ± 0.163
0.751TyrIle: 0.751 ± 0.219
0.409TyrLys: 0.409 ± 0.181
2.183TyrLeu: 2.183 ± 0.436
0.546TyrMet: 0.546 ± 0.201
0.819TyrAsn: 0.819 ± 0.198
1.16TyrPro: 1.16 ± 0.244
0.887TyrGln: 0.887 ± 0.249
3.07TyrArg: 3.07 ± 0.544
1.228TyrSer: 1.228 ± 0.281
1.433TyrThr: 1.433 ± 0.407
1.979TyrVal: 1.979 ± 0.457
0.546TyrTrp: 0.546 ± 0.174
0.887TyrTyr: 0.887 ± 0.229
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (14657 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski