Amino acid dipepetide frequency for Thermoplasmatales archaeon E-plasma

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.731AlaAla: 3.731 ± 0.109
0.393AlaCys: 0.393 ± 0.031
2.497AlaAsp: 2.497 ± 0.073
3.315AlaGlu: 3.315 ± 0.096
3.026AlaPhe: 3.026 ± 0.1
4.353AlaGly: 4.353 ± 0.115
0.801AlaHis: 0.801 ± 0.042
5.947AlaIle: 5.947 ± 0.111
3.277AlaLys: 3.277 ± 0.087
5.691AlaLeu: 5.691 ± 0.138
2.021AlaMet: 2.021 ± 0.063
2.293AlaAsn: 2.293 ± 0.066
1.557AlaPro: 1.557 ± 0.067
1.348AlaGln: 1.348 ± 0.058
2.634AlaArg: 2.634 ± 0.085
4.461AlaSer: 4.461 ± 0.091
2.818AlaThr: 2.818 ± 0.09
4.045AlaVal: 4.045 ± 0.112
0.425AlaTrp: 0.425 ± 0.033
2.093AlaTyr: 2.093 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.372CysAla: 0.372 ± 0.031
0.052CysCys: 0.052 ± 0.011
0.366CysAsp: 0.366 ± 0.028
0.368CysGlu: 0.368 ± 0.028
0.258CysPhe: 0.258 ± 0.022
0.764CysGly: 0.764 ± 0.038
0.146CysHis: 0.146 ± 0.019
0.581CysIle: 0.581 ± 0.036
0.454CysLys: 0.454 ± 0.033
0.512CysLeu: 0.512 ± 0.033
0.208CysMet: 0.208 ± 0.021
0.437CysAsn: 0.437 ± 0.032
0.462CysPro: 0.462 ± 0.037
0.154CysGln: 0.154 ± 0.014
0.362CysArg: 0.362 ± 0.026
0.595CysSer: 0.595 ± 0.037
0.314CysThr: 0.314 ± 0.029
0.36CysVal: 0.36 ± 0.027
0.033CysTrp: 0.033 ± 0.007
0.229CysTyr: 0.229 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
2.428AspAla: 2.428 ± 0.069
0.354AspCys: 0.354 ± 0.027
2.347AspAsp: 2.347 ± 0.085
3.533AspGlu: 3.533 ± 0.102
2.78AspPhe: 2.78 ± 0.079
3.101AspGly: 3.101 ± 0.101
0.822AspHis: 0.822 ± 0.04
4.942AspIle: 4.942 ± 0.109
2.957AspLys: 2.957 ± 0.09
5.036AspLeu: 5.036 ± 0.099
1.388AspMet: 1.388 ± 0.053
2.089AspAsn: 2.089 ± 0.069
2.216AspPro: 2.216 ± 0.068
1.386AspGln: 1.386 ± 0.056
2.172AspArg: 2.172 ± 0.078
3.719AspSer: 3.719 ± 0.084
1.996AspThr: 1.996 ± 0.065
2.972AspVal: 2.972 ± 0.085
0.393AspTrp: 0.393 ± 0.031
2.177AspTyr: 2.177 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
3.596GluAla: 3.596 ± 0.103
0.41GluCys: 0.41 ± 0.029
3.207GluAsp: 3.207 ± 0.083
5.167GluGlu: 5.167 ± 0.116
3.186GluPhe: 3.186 ± 0.098
3.692GluGly: 3.692 ± 0.102
0.995GluHis: 0.995 ± 0.053
7.21GluIle: 7.21 ± 0.131
6.17GluLys: 6.17 ± 0.14
5.552GluLeu: 5.552 ± 0.137
1.993GluMet: 1.993 ± 0.064
4.052GluAsn: 4.052 ± 0.102
1.873GluPro: 1.873 ± 0.072
1.544GluGln: 1.544 ± 0.056
3.367GluArg: 3.367 ± 0.103
4.711GluSer: 4.711 ± 0.111
3.332GluThr: 3.332 ± 0.079
3.729GluVal: 3.729 ± 0.086
0.576GluTrp: 0.576 ± 0.035
2.362GluTyr: 2.362 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
2.668PheAla: 2.668 ± 0.086
0.379PheCys: 0.379 ± 0.03
2.281PheAsp: 2.281 ± 0.069
2.53PheGlu: 2.53 ± 0.068
2.535PhePhe: 2.535 ± 0.093
3.379PheGly: 3.379 ± 0.107
0.924PheHis: 0.924 ± 0.044
4.618PheIle: 4.618 ± 0.114
2.657PheLys: 2.657 ± 0.077
4.994PheLeu: 4.994 ± 0.132
1.315PheMet: 1.315 ± 0.05
2.799PheAsn: 2.799 ± 0.09
1.975PhePro: 1.975 ± 0.071
1.305PheGln: 1.305 ± 0.051
2.172PheArg: 2.172 ± 0.067
4.747PheSer: 4.747 ± 0.104
2.972PheThr: 2.972 ± 0.088
2.87PheVal: 2.87 ± 0.073
0.414PheTrp: 0.414 ± 0.032
2.054PheTyr: 2.054 ± 0.068
0.0PheXaa: 0.0 ± 0.0
Gly
4.133GlyAla: 4.133 ± 0.126
0.468GlyCys: 0.468 ± 0.031
3.103GlyAsp: 3.103 ± 0.089
3.999GlyGlu: 3.999 ± 0.101
3.698GlyPhe: 3.698 ± 0.097
4.801GlyGly: 4.801 ± 0.122
1.07GlyHis: 1.07 ± 0.047
7.462GlyIle: 7.462 ± 0.128
6.095GlyLys: 6.095 ± 0.118
5.596GlyLeu: 5.596 ± 0.115
2.141GlyMet: 2.141 ± 0.067
3.831GlyAsn: 3.831 ± 0.111
1.9GlyPro: 1.9 ± 0.069
1.727GlyGln: 1.727 ± 0.069
3.051GlyArg: 3.051 ± 0.093
5.781GlySer: 5.781 ± 0.129
4.357GlyThr: 4.357 ± 0.116
4.245GlyVal: 4.245 ± 0.1
0.572GlyTrp: 0.572 ± 0.034
3.036GlyTyr: 3.036 ± 0.095
0.0GlyXaa: 0.0 ± 0.0
His
0.716HisAla: 0.716 ± 0.041
0.135HisCys: 0.135 ± 0.018
0.837HisAsp: 0.837 ± 0.039
0.945HisGlu: 0.945 ± 0.047
0.716HisPhe: 0.716 ± 0.04
1.24HisGly: 1.24 ± 0.058
0.285HisHis: 0.285 ± 0.024
1.259HisIle: 1.259 ± 0.048
0.886HisLys: 0.886 ± 0.045
1.421HisLeu: 1.421 ± 0.061
0.439HisMet: 0.439 ± 0.033
0.809HisAsn: 0.809 ± 0.045
0.747HisPro: 0.747 ± 0.04
0.343HisGln: 0.343 ± 0.026
0.72HisArg: 0.72 ± 0.034
1.257HisSer: 1.257 ± 0.052
0.772HisThr: 0.772 ± 0.043
0.932HisVal: 0.932 ± 0.045
0.129HisTrp: 0.129 ± 0.016
0.72HisTyr: 0.72 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
5.833IleAla: 5.833 ± 0.127
0.726IleCys: 0.726 ± 0.039
4.69IleAsp: 4.69 ± 0.111
5.891IleGlu: 5.891 ± 0.132
4.826IlePhe: 4.826 ± 0.138
6.134IleGly: 6.134 ± 0.127
1.43IleHis: 1.43 ± 0.057
8.319IleIle: 8.319 ± 0.171
5.76IleLys: 5.76 ± 0.124
8.659IleLeu: 8.659 ± 0.144
2.728IleMet: 2.728 ± 0.079
4.655IleAsn: 4.655 ± 0.112
4.195IlePro: 4.195 ± 0.096
2.077IleGln: 2.077 ± 0.073
4.205IleArg: 4.205 ± 0.114
8.921IleSer: 8.921 ± 0.162
5.138IleThr: 5.138 ± 0.108
5.593IleVal: 5.593 ± 0.123
0.674IleTrp: 0.674 ± 0.036
3.433IleTyr: 3.433 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
3.862LysAla: 3.862 ± 0.092
0.537LysCys: 0.537 ± 0.034
3.621LysAsp: 3.621 ± 0.112
5.498LysGlu: 5.498 ± 0.133
2.965LysPhe: 2.965 ± 0.068
4.484LysGly: 4.484 ± 0.102
0.98LysHis: 0.98 ± 0.045
6.7LysIle: 6.7 ± 0.146
5.928LysLys: 5.928 ± 0.145
5.712LysLeu: 5.712 ± 0.108
2.168LysMet: 2.168 ± 0.074
4.141LysAsn: 4.141 ± 0.109
2.17LysPro: 2.17 ± 0.067
1.527LysGln: 1.527 ± 0.054
3.304LysArg: 3.304 ± 0.091
4.568LysSer: 4.568 ± 0.1
3.456LysThr: 3.456 ± 0.085
4.131LysVal: 4.131 ± 0.11
0.635LysTrp: 0.635 ± 0.036
2.83LysTyr: 2.83 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
4.973LeuAla: 4.973 ± 0.123
0.608LeuCys: 0.608 ± 0.032
4.099LeuAsp: 4.099 ± 0.102
5.421LeuGlu: 5.421 ± 0.126
4.291LeuPhe: 4.291 ± 0.126
6.093LeuGly: 6.093 ± 0.126
1.276LeuHis: 1.276 ± 0.055
8.003LeuIle: 8.003 ± 0.162
6.846LeuLys: 6.846 ± 0.122
7.828LeuLeu: 7.828 ± 0.189
2.505LeuMet: 2.505 ± 0.068
4.963LeuAsn: 4.963 ± 0.123
3.379LeuPro: 3.379 ± 0.094
2.15LeuGln: 2.15 ± 0.062
4.22LeuArg: 4.22 ± 0.097
8.284LeuSer: 8.284 ± 0.132
4.794LeuThr: 4.794 ± 0.116
4.819LeuVal: 4.819 ± 0.134
0.762LeuTrp: 0.762 ± 0.047
3.277LeuTyr: 3.277 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
2.048MetAla: 2.048 ± 0.068
0.158MetCys: 0.158 ± 0.018
1.792MetAsp: 1.792 ± 0.067
2.503MetGlu: 2.503 ± 0.071
1.053MetPhe: 1.053 ± 0.046
2.187MetGly: 2.187 ± 0.068
0.414MetHis: 0.414 ± 0.03
2.52MetIle: 2.52 ± 0.073
2.634MetLys: 2.634 ± 0.083
2.085MetLeu: 2.085 ± 0.072
0.716MetMet: 0.716 ± 0.043
1.792MetAsn: 1.792 ± 0.059
1.072MetPro: 1.072 ± 0.047
0.739MetGln: 0.739 ± 0.045
1.274MetArg: 1.274 ± 0.056
2.033MetSer: 2.033 ± 0.067
1.452MetThr: 1.452 ± 0.056
1.929MetVal: 1.929 ± 0.062
0.171MetTrp: 0.171 ± 0.018
0.732MetTyr: 0.732 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
2.934AsnAla: 2.934 ± 0.088
0.402AsnCys: 0.402 ± 0.033
2.274AsnAsp: 2.274 ± 0.075
3.456AsnGlu: 3.456 ± 0.081
2.572AsnPhe: 2.572 ± 0.091
4.108AsnGly: 4.108 ± 0.156
0.803AsnHis: 0.803 ± 0.041
5.119AsnIle: 5.119 ± 0.1
2.763AsnLys: 2.763 ± 0.077
5.117AsnLeu: 5.117 ± 0.11
1.492AsnMet: 1.492 ± 0.06
2.641AsnAsn: 2.641 ± 0.103
2.516AsnPro: 2.516 ± 0.069
1.477AsnGln: 1.477 ± 0.064
2.281AsnArg: 2.281 ± 0.074
4.516AsnSer: 4.516 ± 0.141
2.505AsnThr: 2.505 ± 0.095
3.486AsnVal: 3.486 ± 0.108
0.437AsnTrp: 0.437 ± 0.03
2.353AsnTyr: 2.353 ± 0.089
0.0AsnXaa: 0.0 ± 0.0
Pro
1.971ProAla: 1.971 ± 0.067
0.214ProCys: 0.214 ± 0.023
2.335ProAsp: 2.335 ± 0.082
3.086ProGlu: 3.086 ± 0.077
1.85ProPhe: 1.85 ± 0.054
2.811ProGly: 2.811 ± 0.089
0.626ProHis: 0.626 ± 0.035
2.568ProIle: 2.568 ± 0.064
1.981ProLys: 1.981 ± 0.068
3.352ProLeu: 3.352 ± 0.09
0.907ProMet: 0.907 ± 0.044
1.552ProAsn: 1.552 ± 0.062
1.261ProPro: 1.261 ± 0.055
0.982ProGln: 0.982 ± 0.042
1.29ProArg: 1.29 ± 0.052
2.895ProSer: 2.895 ± 0.086
1.619ProThr: 1.619 ± 0.064
3.063ProVal: 3.063 ± 0.089
0.416ProTrp: 0.416 ± 0.029
1.7ProTyr: 1.7 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
1.357GlnAla: 1.357 ± 0.056
0.171GlnCys: 0.171 ± 0.019
1.032GlnAsp: 1.032 ± 0.047
1.696GlnGlu: 1.696 ± 0.069
1.157GlnPhe: 1.157 ± 0.051
1.611GlnGly: 1.611 ± 0.072
0.306GlnHis: 0.306 ± 0.025
2.381GlnIle: 2.381 ± 0.076
1.894GlnLys: 1.894 ± 0.066
1.858GlnLeu: 1.858 ± 0.062
0.751GlnMet: 0.751 ± 0.038
1.577GlnAsn: 1.577 ± 0.055
0.726GlnPro: 0.726 ± 0.042
0.591GlnGln: 0.591 ± 0.039
1.311GlnArg: 1.311 ± 0.059
1.8GlnSer: 1.8 ± 0.067
1.301GlnThr: 1.301 ± 0.053
1.338GlnVal: 1.338 ± 0.058
0.302GlnTrp: 0.302 ± 0.028
1.09GlnTyr: 1.09 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
2.301ArgAla: 2.301 ± 0.077
0.304ArgCys: 0.304 ± 0.03
2.543ArgAsp: 2.543 ± 0.073
4.083ArgGlu: 4.083 ± 0.108
1.914ArgPhe: 1.914 ± 0.066
2.847ArgGly: 2.847 ± 0.081
0.697ArgHis: 0.697 ± 0.036
4.511ArgIle: 4.511 ± 0.105
4.289ArgLys: 4.289 ± 0.107
3.323ArgLeu: 3.323 ± 0.089
1.448ArgMet: 1.448 ± 0.061
2.874ArgAsn: 2.874 ± 0.078
1.232ArgPro: 1.232 ± 0.054
1.018ArgGln: 1.018 ± 0.042
2.535ArgArg: 2.535 ± 0.074
2.897ArgSer: 2.897 ± 0.099
2.147ArgThr: 2.147 ± 0.075
2.547ArgVal: 2.547 ± 0.084
0.385ArgTrp: 0.385 ± 0.029
1.692ArgTyr: 1.692 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
4.497SerAla: 4.497 ± 0.115
0.47SerCys: 0.47 ± 0.039
3.773SerAsp: 3.773 ± 0.097
5.159SerGlu: 5.159 ± 0.115
4.216SerPhe: 4.216 ± 0.123
7.339SerGly: 7.339 ± 0.149
1.157SerHis: 1.157 ± 0.056
7.728SerIle: 7.728 ± 0.155
4.925SerLys: 4.925 ± 0.108
7.383SerLeu: 7.383 ± 0.122
2.674SerMet: 2.674 ± 0.087
4.016SerAsn: 4.016 ± 0.117
2.822SerPro: 2.822 ± 0.087
2.075SerGln: 2.075 ± 0.073
3.764SerArg: 3.764 ± 0.091
7.06SerSer: 7.06 ± 0.174
4.008SerThr: 4.008 ± 0.121
5.036SerVal: 5.036 ± 0.119
0.78SerTrp: 0.78 ± 0.045
3.502SerTyr: 3.502 ± 0.105
0.0SerXaa: 0.0 ± 0.0
Thr
3.198ThrAla: 3.198 ± 0.08
0.343ThrCys: 0.343 ± 0.028
2.63ThrAsp: 2.63 ± 0.077
3.013ThrGlu: 3.013 ± 0.084
2.822ThrPhe: 2.822 ± 0.104
4.88ThrGly: 4.88 ± 0.105
0.805ThrHis: 0.805 ± 0.041
4.441ThrIle: 4.441 ± 0.108
2.647ThrLys: 2.647 ± 0.073
4.582ThrLeu: 4.582 ± 0.101
1.467ThrMet: 1.467 ± 0.043
2.372ThrAsn: 2.372 ± 0.087
2.087ThrPro: 2.087 ± 0.064
1.194ThrGln: 1.194 ± 0.056
2.156ThrArg: 2.156 ± 0.077
3.995ThrSer: 3.995 ± 0.134
2.857ThrThr: 2.857 ± 0.092
3.719ThrVal: 3.719 ± 0.108
0.42ThrTrp: 0.42 ± 0.034
2.11ThrTyr: 2.11 ± 0.089
0.0ThrXaa: 0.0 ± 0.0
Val
3.475ValAla: 3.475 ± 0.095
0.501ValCys: 0.501 ± 0.035
2.938ValAsp: 2.938 ± 0.092
3.908ValGlu: 3.908 ± 0.11
3.049ValPhe: 3.049 ± 0.075
3.633ValGly: 3.633 ± 0.088
0.932ValHis: 0.932 ± 0.046
5.633ValIle: 5.633 ± 0.119
4.491ValLys: 4.491 ± 0.096
5.365ValLeu: 5.365 ± 0.119
1.802ValMet: 1.802 ± 0.065
3.508ValAsn: 3.508 ± 0.111
2.487ValPro: 2.487 ± 0.075
1.457ValGln: 1.457 ± 0.058
2.634ValArg: 2.634 ± 0.074
5.539ValSer: 5.539 ± 0.133
3.587ValThr: 3.587 ± 0.101
3.841ValVal: 3.841 ± 0.104
0.441ValTrp: 0.441 ± 0.029
2.326ValTyr: 2.326 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.468TrpAla: 0.468 ± 0.032
0.067TrpCys: 0.067 ± 0.012
0.412TrpAsp: 0.412 ± 0.031
0.522TrpGlu: 0.522 ± 0.037
0.414TrpPhe: 0.414 ± 0.032
0.529TrpGly: 0.529 ± 0.034
0.148TrpHis: 0.148 ± 0.016
0.826TrpIle: 0.826 ± 0.038
0.718TrpLys: 0.718 ± 0.041
0.685TrpLeu: 0.685 ± 0.036
0.237TrpMet: 0.237 ± 0.023
0.587TrpAsn: 0.587 ± 0.033
0.256TrpPro: 0.256 ± 0.026
0.252TrpGln: 0.252 ± 0.024
0.35TrpArg: 0.35 ± 0.029
0.549TrpSer: 0.549 ± 0.032
0.343TrpThr: 0.343 ± 0.025
0.57TrpVal: 0.57 ± 0.038
0.1TrpTrp: 0.1 ± 0.014
0.37TrpTyr: 0.37 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.164TyrAla: 2.164 ± 0.073
0.335TyrCys: 0.335 ± 0.027
2.033TyrAsp: 2.033 ± 0.065
2.628TyrGlu: 2.628 ± 0.071
2.26TyrPhe: 2.26 ± 0.068
3.08TyrGly: 3.08 ± 0.093
0.693TyrHis: 0.693 ± 0.043
3.119TyrIle: 3.119 ± 0.088
1.846TyrLys: 1.846 ± 0.07
3.841TyrLeu: 3.841 ± 0.091
0.901TyrMet: 0.901 ± 0.041
2.264TyrAsn: 2.264 ± 0.104
1.548TyrPro: 1.548 ± 0.059
0.903TyrGln: 0.903 ± 0.045
1.783TyrArg: 1.783 ± 0.061
4.058TyrSer: 4.058 ± 0.107
1.971TyrThr: 1.971 ± 0.086
2.324TyrVal: 2.324 ± 0.079
0.337TyrTrp: 0.337 ± 0.03
2.023TyrTyr: 2.023 ± 0.084
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1661 proteins (480563 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski