Amino acid dipepetide frequency for Bifidobacterium magnum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.992AlaAla: 11.992 ± 0.222
1.167AlaCys: 1.167 ± 0.051
6.619AlaAsp: 6.619 ± 0.118
5.512AlaGlu: 5.512 ± 0.135
3.26AlaPhe: 3.26 ± 0.086
7.791AlaGly: 7.791 ± 0.137
2.601AlaHis: 2.601 ± 0.073
5.64AlaIle: 5.64 ± 0.11
4.56AlaLys: 4.56 ± 0.124
9.801AlaLeu: 9.801 ± 0.156
3.497AlaMet: 3.497 ± 0.082
3.672AlaAsn: 3.672 ± 0.102
4.039AlaPro: 4.039 ± 0.1
5.407AlaGln: 5.407 ± 0.116
5.907AlaArg: 5.907 ± 0.113
5.889AlaSer: 5.889 ± 0.118
5.926AlaThr: 5.926 ± 0.121
7.778AlaVal: 7.778 ± 0.132
1.451AlaTrp: 1.451 ± 0.053
2.778AlaTyr: 2.778 ± 0.081
0.002AlaXaa: 0.002 ± 0.002
Cys
1.25CysAla: 1.25 ± 0.055
0.147CysCys: 0.147 ± 0.017
0.578CysAsp: 0.578 ± 0.031
0.589CysGlu: 0.589 ± 0.033
0.324CysPhe: 0.324 ± 0.023
1.048CysGly: 1.048 ± 0.048
0.235CysHis: 0.235 ± 0.021
0.501CysIle: 0.501 ± 0.034
0.28CysLys: 0.28 ± 0.025
0.74CysLeu: 0.74 ± 0.041
0.263CysMet: 0.263 ± 0.021
0.326CysAsn: 0.326 ± 0.026
0.472CysPro: 0.472 ± 0.033
0.282CysGln: 0.282 ± 0.022
0.501CysArg: 0.501 ± 0.029
0.57CysSer: 0.57 ± 0.038
0.595CysThr: 0.595 ± 0.032
0.888CysVal: 0.888 ± 0.039
0.145CysTrp: 0.145 ± 0.016
0.305CysTyr: 0.305 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
6.882AspAla: 6.882 ± 0.135
0.546AspCys: 0.546 ± 0.036
4.001AspAsp: 4.001 ± 0.114
4.94AspGlu: 4.94 ± 0.119
2.245AspPhe: 2.245 ± 0.079
5.236AspGly: 5.236 ± 0.126
1.558AspHis: 1.558 ± 0.052
3.316AspIle: 3.316 ± 0.085
2.499AspLys: 2.499 ± 0.078
5.397AspLeu: 5.397 ± 0.106
1.953AspMet: 1.953 ± 0.058
1.965AspAsn: 1.965 ± 0.065
3.64AspPro: 3.64 ± 0.086
2.053AspGln: 2.053 ± 0.068
3.239AspArg: 3.239 ± 0.093
3.241AspSer: 3.241 ± 0.082
3.286AspThr: 3.286 ± 0.092
5.064AspVal: 5.064 ± 0.125
0.924AspTrp: 0.924 ± 0.048
1.914AspTyr: 1.914 ± 0.068
0.002AspXaa: 0.002 ± 0.002
Glu
5.992GluAla: 5.992 ± 0.123
0.476GluCys: 0.476 ± 0.032
3.841GluAsp: 3.841 ± 0.104
4.178GluGlu: 4.178 ± 0.105
2.023GluPhe: 2.023 ± 0.069
3.92GluGly: 3.92 ± 0.091
1.982GluHis: 1.982 ± 0.058
2.987GluIle: 2.987 ± 0.08
2.128GluLys: 2.128 ± 0.091
5.589GluLeu: 5.589 ± 0.118
1.558GluMet: 1.558 ± 0.055
1.999GluAsn: 1.999 ± 0.065
2.936GluPro: 2.936 ± 0.084
3.252GluGln: 3.252 ± 0.09
4.408GluArg: 4.408 ± 0.104
3.463GluSer: 3.463 ± 0.088
3.378GluThr: 3.378 ± 0.082
3.627GluVal: 3.627 ± 0.094
0.683GluTrp: 0.683 ± 0.034
1.886GluTyr: 1.886 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
3.835PheAla: 3.835 ± 0.094
0.365PheCys: 0.365 ± 0.026
2.548PheAsp: 2.548 ± 0.087
1.921PheGlu: 1.921 ± 0.057
1.276PhePhe: 1.276 ± 0.059
3.056PheGly: 3.056 ± 0.087
0.837PheHis: 0.837 ± 0.038
1.969PheIle: 1.969 ± 0.082
1.137PheLys: 1.137 ± 0.049
2.746PheLeu: 2.746 ± 0.085
0.894PheMet: 0.894 ± 0.042
1.415PheAsn: 1.415 ± 0.056
1.312PhePro: 1.312 ± 0.053
0.98PheGln: 0.98 ± 0.046
1.626PheArg: 1.626 ± 0.053
2.253PheSer: 2.253 ± 0.063
2.32PheThr: 2.32 ± 0.065
2.655PheVal: 2.655 ± 0.083
0.444PheTrp: 0.444 ± 0.027
0.932PheTyr: 0.932 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
7.123GlyAla: 7.123 ± 0.14
0.854GlyCys: 0.854 ± 0.04
4.298GlyAsp: 4.298 ± 0.099
4.479GlyGlu: 4.479 ± 0.098
2.97GlyPhe: 2.97 ± 0.075
5.224GlyGly: 5.224 ± 0.125
1.709GlyHis: 1.709 ± 0.058
4.607GlyIle: 4.607 ± 0.105
3.796GlyLys: 3.796 ± 0.086
6.391GlyLeu: 6.391 ± 0.119
2.345GlyMet: 2.345 ± 0.088
2.718GlyAsn: 2.718 ± 0.091
2.514GlyPro: 2.514 ± 0.071
2.531GlyGln: 2.531 ± 0.076
3.995GlyArg: 3.995 ± 0.101
4.837GlySer: 4.837 ± 0.101
4.835GlyThr: 4.835 ± 0.113
6.058GlyVal: 6.058 ± 0.121
1.095GlyTrp: 1.095 ± 0.05
2.524GlyTyr: 2.524 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
2.435HisAla: 2.435 ± 0.08
0.277HisCys: 0.277 ± 0.025
1.65HisAsp: 1.65 ± 0.053
1.62HisGlu: 1.62 ± 0.058
0.717HisPhe: 0.717 ± 0.042
2.038HisGly: 2.038 ± 0.068
0.713HisHis: 0.713 ± 0.04
1.404HisIle: 1.404 ± 0.057
0.864HisLys: 0.864 ± 0.039
1.622HisLeu: 1.622 ± 0.052
0.903HisMet: 0.903 ± 0.042
0.93HisAsn: 0.93 ± 0.042
1.293HisPro: 1.293 ± 0.05
0.706HisGln: 0.706 ± 0.035
1.434HisArg: 1.434 ± 0.058
1.167HisSer: 1.167 ± 0.051
1.496HisThr: 1.496 ± 0.053
2.221HisVal: 2.221 ± 0.071
0.324HisTrp: 0.324 ± 0.023
0.638HisTyr: 0.638 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.353IleAla: 6.353 ± 0.087
0.715IleCys: 0.715 ± 0.042
4.069IleAsp: 4.069 ± 0.096
3.35IleGlu: 3.35 ± 0.091
1.837IlePhe: 1.837 ± 0.065
4.464IleGly: 4.464 ± 0.121
1.171IleHis: 1.171 ± 0.052
3.1IleIle: 3.1 ± 0.106
1.735IleLys: 1.735 ± 0.061
4.024IleLeu: 4.024 ± 0.105
1.496IleMet: 1.496 ± 0.054
1.931IleAsn: 1.931 ± 0.064
2.791IlePro: 2.791 ± 0.078
1.406IleGln: 1.406 ± 0.048
2.941IleArg: 2.941 ± 0.066
3.143IleSer: 3.143 ± 0.075
3.427IleThr: 3.427 ± 0.093
5.136IleVal: 5.136 ± 0.114
0.649IleTrp: 0.649 ± 0.032
1.229IleTyr: 1.229 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.249LysAla: 4.249 ± 0.113
0.166LysCys: 0.166 ± 0.017
2.477LysAsp: 2.477 ± 0.08
2.477LysGlu: 2.477 ± 0.079
1.231LysPhe: 1.231 ± 0.052
2.42LysGly: 2.42 ± 0.076
0.933LysHis: 0.933 ± 0.044
2.132LysIle: 2.132 ± 0.063
2.023LysLys: 2.023 ± 0.073
3.303LysLeu: 3.303 ± 0.083
1.12LysMet: 1.12 ± 0.051
1.592LysAsn: 1.592 ± 0.054
2.07LysPro: 2.07 ± 0.072
1.564LysGln: 1.564 ± 0.061
2.578LysArg: 2.578 ± 0.074
2.349LysSer: 2.349 ± 0.074
2.405LysThr: 2.405 ± 0.071
2.509LysVal: 2.509 ± 0.069
0.359LysTrp: 0.359 ± 0.025
1.148LysTyr: 1.148 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
9.656LeuAla: 9.656 ± 0.146
1.101LeuCys: 1.101 ± 0.049
5.84LeuAsp: 5.84 ± 0.115
5.057LeuGlu: 5.057 ± 0.115
3.135LeuPhe: 3.135 ± 0.095
6.788LeuGly: 6.788 ± 0.134
2.053LeuHis: 2.053 ± 0.069
4.62LeuIle: 4.62 ± 0.123
3.09LeuLys: 3.09 ± 0.089
7.422LeuLeu: 7.422 ± 0.166
2.422LeuMet: 2.422 ± 0.07
3.06LeuAsn: 3.06 ± 0.073
4.323LeuPro: 4.323 ± 0.09
2.812LeuGln: 2.812 ± 0.076
5.285LeuArg: 5.285 ± 0.115
5.187LeuSer: 5.187 ± 0.116
5.226LeuThr: 5.226 ± 0.104
6.653LeuVal: 6.653 ± 0.111
0.947LeuTrp: 0.947 ± 0.045
2.215LeuTyr: 2.215 ± 0.07
0.002LeuXaa: 0.002 ± 0.002
Met
3.203MetAla: 3.203 ± 0.085
0.262MetCys: 0.262 ± 0.025
1.675MetAsp: 1.675 ± 0.054
1.524MetGlu: 1.524 ± 0.053
0.975MetPhe: 0.975 ± 0.042
2.051MetGly: 2.051 ± 0.067
0.725MetHis: 0.725 ± 0.043
1.46MetIle: 1.46 ± 0.057
1.099MetLys: 1.099 ± 0.049
2.808MetLeu: 2.808 ± 0.083
0.875MetMet: 0.875 ± 0.045
1.178MetAsn: 1.178 ± 0.043
1.617MetPro: 1.617 ± 0.049
0.949MetGln: 0.949 ± 0.042
1.987MetArg: 1.987 ± 0.059
1.88MetSer: 1.88 ± 0.059
1.955MetThr: 1.955 ± 0.057
2.172MetVal: 2.172 ± 0.069
0.326MetTrp: 0.326 ± 0.026
0.642MetTyr: 0.642 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.858AsnAla: 3.858 ± 0.087
0.25AsnCys: 0.25 ± 0.02
2.211AsnAsp: 2.211 ± 0.064
2.142AsnGlu: 2.142 ± 0.07
1.037AsnPhe: 1.037 ± 0.041
3.318AsnGly: 3.318 ± 0.095
0.785AsnHis: 0.785 ± 0.041
1.967AsnIle: 1.967 ± 0.072
1.368AsnLys: 1.368 ± 0.058
2.71AsnLeu: 2.71 ± 0.076
1.024AsnMet: 1.024 ± 0.047
1.379AsnAsn: 1.379 ± 0.063
2.14AsnPro: 2.14 ± 0.062
0.969AsnGln: 0.969 ± 0.041
2.061AsnArg: 2.061 ± 0.065
1.846AsnSer: 1.846 ± 0.068
2.305AsnThr: 2.305 ± 0.069
2.768AsnVal: 2.768 ± 0.071
0.506AsnTrp: 0.506 ± 0.033
0.928AsnTyr: 0.928 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
4.566ProAla: 4.566 ± 0.104
0.388ProCys: 0.388 ± 0.028
3.372ProAsp: 3.372 ± 0.086
3.514ProGlu: 3.514 ± 0.086
1.554ProPhe: 1.554 ± 0.048
3.201ProGly: 3.201 ± 0.073
1.105ProHis: 1.105 ± 0.047
2.253ProIle: 2.253 ± 0.057
1.812ProLys: 1.812 ± 0.059
3.916ProLeu: 3.916 ± 0.096
1.225ProMet: 1.225 ± 0.052
1.634ProAsn: 1.634 ± 0.051
1.165ProPro: 1.165 ± 0.056
2.119ProGln: 2.119 ± 0.074
2.304ProArg: 2.304 ± 0.056
2.998ProSer: 2.998 ± 0.082
2.744ProThr: 2.744 ± 0.076
4.157ProVal: 4.157 ± 0.087
0.696ProTrp: 0.696 ± 0.032
1.413ProTyr: 1.413 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
4.142GlnAla: 4.142 ± 0.091
0.301GlnCys: 0.301 ± 0.023
2.059GlnAsp: 2.059 ± 0.062
2.149GlnGlu: 2.149 ± 0.064
1.267GlnPhe: 1.267 ± 0.052
2.561GlnGly: 2.561 ± 0.07
1.02GlnHis: 1.02 ± 0.041
2.26GlnIle: 2.26 ± 0.064
1.246GlnLys: 1.246 ± 0.053
3.628GlnLeu: 3.628 ± 0.085
1.097GlnMet: 1.097 ± 0.045
1.184GlnAsn: 1.184 ± 0.047
1.944GlnPro: 1.944 ± 0.086
2.038GlnGln: 2.038 ± 0.081
2.537GlnArg: 2.537 ± 0.079
2.174GlnSer: 2.174 ± 0.067
2.115GlnThr: 2.115 ± 0.064
2.59GlnVal: 2.59 ± 0.075
0.683GlnTrp: 0.683 ± 0.04
1.272GlnTyr: 1.272 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
5.388ArgAla: 5.388 ± 0.112
0.495ArgCys: 0.495 ± 0.028
3.61ArgAsp: 3.61 ± 0.088
3.85ArgGlu: 3.85 ± 0.083
2.049ArgPhe: 2.049 ± 0.066
3.515ArgGly: 3.515 ± 0.092
1.675ArgHis: 1.675 ± 0.052
3.427ArgIle: 3.427 ± 0.075
2.734ArgLys: 2.734 ± 0.082
5.04ArgLeu: 5.04 ± 0.109
1.97ArgMet: 1.97 ± 0.068
2.26ArgAsn: 2.26 ± 0.079
2.531ArgPro: 2.531 ± 0.089
2.285ArgGln: 2.285 ± 0.072
3.866ArgArg: 3.866 ± 0.123
3.13ArgSer: 3.13 ± 0.075
3.335ArgThr: 3.335 ± 0.078
4.372ArgVal: 4.372 ± 0.097
0.837ArgTrp: 0.837 ± 0.039
1.763ArgTyr: 1.763 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
5.932SerAla: 5.932 ± 0.114
0.536SerCys: 0.536 ± 0.033
3.448SerAsp: 3.448 ± 0.091
3.197SerGlu: 3.197 ± 0.082
2.176SerPhe: 2.176 ± 0.072
4.808SerGly: 4.808 ± 0.101
1.359SerHis: 1.359 ± 0.063
3.299SerIle: 3.299 ± 0.074
2.083SerLys: 2.083 ± 0.069
5.454SerLeu: 5.454 ± 0.109
1.884SerMet: 1.884 ± 0.061
1.997SerAsn: 1.997 ± 0.071
2.443SerPro: 2.443 ± 0.073
2.339SerGln: 2.339 ± 0.067
3.365SerArg: 3.365 ± 0.087
3.85SerSer: 3.85 ± 0.101
3.378SerThr: 3.378 ± 0.081
4.53SerVal: 4.53 ± 0.103
0.862SerTrp: 0.862 ± 0.039
1.677SerTyr: 1.677 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
5.971ThrAla: 5.971 ± 0.135
0.508ThrCys: 0.508 ± 0.026
3.702ThrAsp: 3.702 ± 0.09
2.825ThrGlu: 2.825 ± 0.083
2.142ThrPhe: 2.142 ± 0.06
4.942ThrGly: 4.942 ± 0.097
1.342ThrHis: 1.342 ± 0.048
3.472ThrIle: 3.472 ± 0.087
2.192ThrLys: 2.192 ± 0.063
5.674ThrLeu: 5.674 ± 0.108
1.607ThrMet: 1.607 ± 0.05
1.963ThrAsn: 1.963 ± 0.059
3.199ThrPro: 3.199 ± 0.078
2.428ThrGln: 2.428 ± 0.08
2.962ThrArg: 2.962 ± 0.086
3.354ThrSer: 3.354 ± 0.087
3.651ThrThr: 3.651 ± 0.095
5.444ThrVal: 5.444 ± 0.122
0.698ThrTrp: 0.698 ± 0.041
1.714ThrTyr: 1.714 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
8.273ValAla: 8.273 ± 0.128
0.99ValCys: 0.99 ± 0.048
5.241ValAsp: 5.241 ± 0.107
4.536ValGlu: 4.536 ± 0.092
2.744ValPhe: 2.744 ± 0.081
5.113ValGly: 5.113 ± 0.118
1.726ValHis: 1.726 ± 0.06
4.421ValIle: 4.421 ± 0.101
2.87ValLys: 2.87 ± 0.082
7.095ValLeu: 7.095 ± 0.143
2.091ValMet: 2.091 ± 0.06
2.797ValAsn: 2.797 ± 0.077
3.92ValPro: 3.92 ± 0.082
2.704ValGln: 2.704 ± 0.075
4.536ValArg: 4.536 ± 0.09
4.887ValSer: 4.887 ± 0.104
4.965ValThr: 4.965 ± 0.099
6.681ValVal: 6.681 ± 0.154
0.969ValTrp: 0.969 ± 0.04
1.818ValTyr: 1.818 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
1.108TrpAla: 1.108 ± 0.047
0.171TrpCys: 0.171 ± 0.018
0.768TrpAsp: 0.768 ± 0.039
0.617TrpGlu: 0.617 ± 0.039
0.548TrpPhe: 0.548 ± 0.034
0.866TrpGly: 0.866 ± 0.041
0.367TrpHis: 0.367 ± 0.027
0.839TrpIle: 0.839 ± 0.04
0.6TrpLys: 0.6 ± 0.034
1.331TrpLeu: 1.331 ± 0.062
0.423TrpMet: 0.423 ± 0.029
0.64TrpAsn: 0.64 ± 0.036
0.538TrpPro: 0.538 ± 0.034
0.533TrpGln: 0.533 ± 0.033
0.854TrpArg: 0.854 ± 0.046
0.807TrpSer: 0.807 ± 0.042
0.813TrpThr: 0.813 ± 0.043
0.768TrpVal: 0.768 ± 0.038
0.273TrpTrp: 0.273 ± 0.022
0.438TrpTyr: 0.438 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.073TyrAla: 3.073 ± 0.08
0.324TyrCys: 0.324 ± 0.027
1.895TyrAsp: 1.895 ± 0.064
1.827TyrGlu: 1.827 ± 0.06
1.014TyrPhe: 1.014 ± 0.047
2.541TyrGly: 2.541 ± 0.072
0.557TyrHis: 0.557 ± 0.032
1.293TyrIle: 1.293 ± 0.051
0.986TyrLys: 0.986 ± 0.048
2.202TyrLeu: 2.202 ± 0.081
0.709TyrMet: 0.709 ± 0.034
0.935TyrAsn: 0.935 ± 0.05
1.25TyrPro: 1.25 ± 0.047
0.913TyrGln: 0.913 ± 0.046
1.748TyrArg: 1.748 ± 0.065
1.594TyrSer: 1.594 ± 0.057
1.635TyrThr: 1.635 ± 0.061
2.305TyrVal: 2.305 ± 0.062
0.431TyrTrp: 0.431 ± 0.032
0.822TyrTyr: 0.822 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.004XaaAla: 0.004 ± 0.004
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.002XaaMet: 0.002 ± 0.002
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1507 proteins (531363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski