Amino acid dipepetide frequency for Pseudoxanthomonas dokdonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.536AlaAla: 16.536 ± 0.205	1.135AlaCys: 1.135 ± 0.036	7.663AlaAsp: 7.663 ± 0.085	6.381AlaGlu: 6.381 ± 0.083	3.752AlaPhe: 3.752 ± 0.063	11.145AlaGly: 11.145 ± 0.132	2.379AlaHis: 2.379 ± 0.058	5.489AlaIle: 5.489 ± 0.088	3.048AlaLys: 3.048 ± 0.078	14.588AlaLeu: 14.588 ± 0.184	3.198AlaMet: 3.198 ± 0.059	3.331AlaAsn: 3.331 ± 0.078	5.509AlaPro: 5.509 ± 0.088	5.538AlaGln: 5.538 ± 0.08	8.77AlaArg: 8.77 ± 0.112	7.711AlaSer: 7.711 ± 0.147	5.921AlaThr: 5.921 ± 0.123	8.294AlaVal: 8.294 ± 0.119	1.87AlaTrp: 1.87 ± 0.051	2.534AlaTyr: 2.534 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.907CysAla: 0.907 ± 0.033	0.086CysCys: 0.086 ± 0.011	0.451CysAsp: 0.451 ± 0.024	0.412CysGlu: 0.412 ± 0.022	0.262CysPhe: 0.262 ± 0.017	0.827CysGly: 0.827 ± 0.033	0.239CysHis: 0.239 ± 0.018	0.355CysIle: 0.355 ± 0.018	0.196CysLys: 0.196 ± 0.014	0.801CysLeu: 0.801 ± 0.03	0.161CysMet: 0.161 ± 0.011	0.195CysAsn: 0.195 ± 0.014	0.409CysPro: 0.409 ± 0.024	0.313CysGln: 0.313 ± 0.017	0.513CysArg: 0.513 ± 0.024	0.484CysSer: 0.484 ± 0.024	0.413CysThr: 0.413 ± 0.039	0.661CysVal: 0.661 ± 0.027	0.121CysTrp: 0.121 ± 0.011	0.211CysTyr: 0.211 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.033AspAla: 8.033 ± 0.1	0.486AspCys: 0.486 ± 0.026	3.746AspAsp: 3.746 ± 0.074	3.374AspGlu: 3.374 ± 0.065	2.149AspPhe: 2.149 ± 0.044	5.912AspGly: 5.912 ± 0.09	1.2AspHis: 1.2 ± 0.036	2.761AspIle: 2.761 ± 0.062	1.706AspLys: 1.706 ± 0.052	5.627AspLeu: 5.627 ± 0.091	1.241AspMet: 1.241 ± 0.037	1.832AspAsn: 1.832 ± 0.049	3.373AspPro: 3.373 ± 0.067	2.191AspGln: 2.191 ± 0.051	3.698AspArg: 3.698 ± 0.057	3.208AspSer: 3.208 ± 0.059	2.718AspThr: 2.718 ± 0.063	4.215AspVal: 4.215 ± 0.068	1.138AspTrp: 1.138 ± 0.036	1.894AspTyr: 1.894 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	6.086GluAla: 6.086 ± 0.094	0.304GluCys: 0.304 ± 0.019	2.468GluAsp: 2.468 ± 0.05	2.332GluGlu: 2.332 ± 0.064	1.729GluPhe: 1.729 ± 0.043	3.545GluGly: 3.545 ± 0.072	1.345GluHis: 1.345 ± 0.04	2.412GluIle: 2.412 ± 0.051	1.584GluLys: 1.584 ± 0.039	5.841GluLeu: 5.841 ± 0.084	1.193GluMet: 1.193 ± 0.033	1.277GluAsn: 1.277 ± 0.043	2.36GluPro: 2.36 ± 0.053	3.071GluGln: 3.071 ± 0.065	4.304GluArg: 4.304 ± 0.078	2.616GluSer: 2.616 ± 0.048	2.427GluThr: 2.427 ± 0.054	3.752GluVal: 3.752 ± 0.061	0.705GluTrp: 0.705 ± 0.027	1.233GluTyr: 1.233 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.075PheAla: 4.075 ± 0.078	0.309PheCys: 0.309 ± 0.021	2.654PheAsp: 2.654 ± 0.06	1.941PheGlu: 1.941 ± 0.048	1.176PhePhe: 1.176 ± 0.039	3.113PheGly: 3.113 ± 0.071	0.79PheHis: 0.79 ± 0.028	1.419PheIle: 1.419 ± 0.037	1.007PheLys: 1.007 ± 0.033	2.85PheLeu: 2.85 ± 0.064	0.715PheMet: 0.715 ± 0.031	1.316PheAsn: 1.316 ± 0.04	1.352PhePro: 1.352 ± 0.036	1.014PheGln: 1.014 ± 0.033	1.964PheArg: 1.964 ± 0.049	2.18PheSer: 2.18 ± 0.048	1.581PheThr: 1.581 ± 0.046	2.472PheVal: 2.472 ± 0.053	0.521PheTrp: 0.521 ± 0.024	0.895PheTyr: 0.895 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.196GlyAla: 8.196 ± 0.163	0.793GlyCys: 0.793 ± 0.03	4.977GlyAsp: 4.977 ± 0.087	4.546GlyGlu: 4.546 ± 0.076	3.376GlyPhe: 3.376 ± 0.064	6.809GlyGly: 6.809 ± 0.1	2.156GlyHis: 2.156 ± 0.045	4.124GlyIle: 4.124 ± 0.079	3.368GlyLys: 3.368 ± 0.064	8.415GlyLeu: 8.415 ± 0.11	2.295GlyMet: 2.295 ± 0.051	2.869GlyAsn: 2.869 ± 0.068	3.03GlyPro: 3.03 ± 0.061	3.912GlyGln: 3.912 ± 0.068	5.493GlyArg: 5.493 ± 0.083	5.254GlySer: 5.254 ± 0.12	3.929GlyThr: 3.929 ± 0.074	6.245GlyVal: 6.245 ± 0.096	1.65GlyTrp: 1.65 ± 0.047	2.573GlyTyr: 2.573 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	3.01HisAla: 3.01 ± 0.06	0.247HisCys: 0.247 ± 0.015	1.396HisAsp: 1.396 ± 0.04	1.076HisGlu: 1.076 ± 0.032	0.819HisPhe: 0.819 ± 0.033	2.351HisGly: 2.351 ± 0.051	0.64HisHis: 0.64 ± 0.027	0.829HisIle: 0.829 ± 0.034	0.487HisLys: 0.487 ± 0.023	2.146HisLeu: 2.146 ± 0.053	0.438HisMet: 0.438 ± 0.02	0.539HisAsn: 0.539 ± 0.022	1.476HisPro: 1.476 ± 0.037	0.816HisGln: 0.816 ± 0.03	1.593HisArg: 1.593 ± 0.048	1.093HisSer: 1.093 ± 0.033	0.907HisThr: 0.907 ± 0.032	1.564HisVal: 1.564 ± 0.035	0.463HisTrp: 0.463 ± 0.023	0.659HisTyr: 0.659 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.244IleAla: 6.244 ± 0.097	0.376IleCys: 0.376 ± 0.02	3.38IleAsp: 3.38 ± 0.056	2.988IleGlu: 2.988 ± 0.056	1.189IlePhe: 1.189 ± 0.037	4.474IleGly: 4.474 ± 0.081	0.909IleHis: 0.909 ± 0.028	1.775IleIle: 1.775 ± 0.051	1.348IleLys: 1.348 ± 0.038	3.164IleLeu: 3.164 ± 0.068	0.598IleMet: 0.598 ± 0.024	1.548IleAsn: 1.548 ± 0.041	2.055IlePro: 2.055 ± 0.054	1.354IleGln: 1.354 ± 0.039	2.685IleArg: 2.685 ± 0.058	2.625IleSer: 2.625 ± 0.054	2.279IleThr: 2.279 ± 0.067	3.065IleVal: 3.065 ± 0.065	0.503IleTrp: 0.503 ± 0.026	0.933IleTyr: 0.933 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.35LysAla: 3.35 ± 0.084	0.145LysCys: 0.145 ± 0.012	1.511LysAsp: 1.511 ± 0.045	1.138LysGlu: 1.138 ± 0.038	0.765LysPhe: 0.765 ± 0.033	2.006LysGly: 2.006 ± 0.05	0.597LysHis: 0.597 ± 0.023	1.17LysIle: 1.17 ± 0.04	1.017LysLys: 1.017 ± 0.061	3.153LysLeu: 3.153 ± 0.061	0.613LysMet: 0.613 ± 0.023	0.667LysAsn: 0.667 ± 0.027	1.948LysPro: 1.948 ± 0.059	1.44LysGln: 1.44 ± 0.039	2.19LysArg: 2.19 ± 0.046	1.544LysSer: 1.544 ± 0.04	1.46LysThr: 1.46 ± 0.046	2.147LysVal: 2.147 ± 0.057	0.3LysTrp: 0.3 ± 0.021	0.633LysTyr: 0.633 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	14.852LeuAla: 14.852 ± 0.139	0.87LeuCys: 0.87 ± 0.03	6.792LeuAsp: 6.792 ± 0.094	5.02LeuGlu: 5.02 ± 0.091	3.428LeuPhe: 3.428 ± 0.072	8.337LeuGly: 8.337 ± 0.118	2.3LeuHis: 2.3 ± 0.054	4.022LeuIle: 4.022 ± 0.08	3.148LeuLys: 3.148 ± 0.061	12.7LeuLeu: 12.7 ± 0.188	2.294LeuMet: 2.294 ± 0.049	2.498LeuAsn: 2.498 ± 0.058	6.672LeuPro: 6.672 ± 0.095	5.408LeuGln: 5.408 ± 0.086	8.166LeuArg: 8.166 ± 0.118	6.299LeuSer: 6.299 ± 0.083	4.602LeuThr: 4.602 ± 0.083	7.363LeuVal: 7.363 ± 0.113	1.365LeuTrp: 1.365 ± 0.04	2.235LeuTyr: 2.235 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.86MetAla: 2.86 ± 0.056	0.123MetCys: 0.123 ± 0.01	1.183MetAsp: 1.183 ± 0.035	0.951MetGlu: 0.951 ± 0.031	0.669MetPhe: 0.669 ± 0.026	1.619MetGly: 1.619 ± 0.045	0.454MetHis: 0.454 ± 0.021	0.874MetIle: 0.874 ± 0.032	0.827MetLys: 0.827 ± 0.03	2.561MetLeu: 2.561 ± 0.059	0.553MetMet: 0.553 ± 0.026	0.677MetAsn: 0.677 ± 0.023	1.417MetPro: 1.417 ± 0.032	1.155MetGln: 1.155 ± 0.042	1.662MetArg: 1.662 ± 0.041	1.563MetSer: 1.563 ± 0.034	1.377MetThr: 1.377 ± 0.035	1.492MetVal: 1.492 ± 0.043	0.245MetTrp: 0.245 ± 0.015	0.384MetTyr: 0.384 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.386AsnAla: 3.386 ± 0.07	0.208AsnCys: 0.208 ± 0.014	1.68AsnAsp: 1.68 ± 0.042	1.298AsnGlu: 1.298 ± 0.039	0.977AsnPhe: 0.977 ± 0.032	2.578AsnGly: 2.578 ± 0.058	0.623AsnHis: 0.623 ± 0.024	1.265AsnIle: 1.265 ± 0.039	0.711AsnLys: 0.711 ± 0.028	2.681AsnLeu: 2.681 ± 0.056	0.486AsnMet: 0.486 ± 0.024	0.891AsnAsn: 0.891 ± 0.041	1.944AsnPro: 1.944 ± 0.05	1.1AsnGln: 1.1 ± 0.034	1.819AsnArg: 1.819 ± 0.04	1.428AsnSer: 1.428 ± 0.053	1.482AsnThr: 1.482 ± 0.055	2.045AsnVal: 2.045 ± 0.053	0.387AsnTrp: 0.387 ± 0.022	0.778AsnTyr: 0.778 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	7.535ProAla: 7.535 ± 0.12	0.299ProCys: 0.299 ± 0.021	3.397ProAsp: 3.397 ± 0.061	2.835ProGlu: 2.835 ± 0.057	1.537ProPhe: 1.537 ± 0.037	4.587ProGly: 4.587 ± 0.074	1.071ProHis: 1.071 ± 0.032	1.973ProIle: 1.973 ± 0.051	1.135ProLys: 1.135 ± 0.039	5.527ProLeu: 5.527 ± 0.08	1.263ProMet: 1.263 ± 0.037	1.156ProAsn: 1.156 ± 0.036	2.656ProPro: 2.656 ± 0.065	2.366ProGln: 2.366 ± 0.055	3.359ProArg: 3.359 ± 0.071	2.851ProSer: 2.851 ± 0.052	2.319ProThr: 2.319 ± 0.051	4.098ProVal: 4.098 ± 0.075	0.887ProTrp: 0.887 ± 0.034	1.208ProTyr: 1.208 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	6.552GlnAla: 6.552 ± 0.106	0.296GlnCys: 0.296 ± 0.019	1.981GlnAsp: 1.981 ± 0.044	1.52GlnGlu: 1.52 ± 0.047	1.252GlnPhe: 1.252 ± 0.04	3.132GlnGly: 3.132 ± 0.059	1.162GlnHis: 1.162 ± 0.036	1.749GlnIle: 1.749 ± 0.044	0.992GlnLys: 0.992 ± 0.035	5.432GlnLeu: 5.432 ± 0.098	1.008GlnMet: 1.008 ± 0.03	0.78GlnAsn: 0.78 ± 0.029	2.873GlnPro: 2.873 ± 0.052	3.103GlnGln: 3.103 ± 0.069	4.484GlnArg: 4.484 ± 0.081	2.238GlnSer: 2.238 ± 0.052	1.986GlnThr: 1.986 ± 0.049	3.467GlnVal: 3.467 ± 0.07	0.846GlnTrp: 0.846 ± 0.03	0.944GlnTyr: 0.944 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.338ArgAla: 7.338 ± 0.108	0.516ArgCys: 0.516 ± 0.023	4.444ArgAsp: 4.444 ± 0.082	4.234ArgGlu: 4.234 ± 0.072	2.822ArgPhe: 2.822 ± 0.057	4.971ArgGly: 4.971 ± 0.084	1.911ArgHis: 1.911 ± 0.05	3.863ArgIle: 3.863 ± 0.06	2.051ArgLys: 2.051 ± 0.043	7.921ArgLeu: 7.921 ± 0.11	1.948ArgMet: 1.948 ± 0.045	2.013ArgAsn: 2.013 ± 0.044	3.097ArgPro: 3.097 ± 0.056	3.968ArgGln: 3.968 ± 0.074	5.145ArgArg: 5.145 ± 0.092	3.637ArgSer: 3.637 ± 0.066	2.935ArgThr: 2.935 ± 0.049	4.871ArgVal: 4.871 ± 0.066	1.406ArgTrp: 1.406 ± 0.044	2.212ArgTyr: 2.212 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.789SerAla: 6.789 ± 0.11	0.434SerCys: 0.434 ± 0.027	3.344SerAsp: 3.344 ± 0.069	2.891SerGlu: 2.891 ± 0.056	1.965SerPhe: 1.965 ± 0.045	5.554SerGly: 5.554 ± 0.091	1.354SerHis: 1.354 ± 0.037	2.411SerIle: 2.411 ± 0.061	1.485SerLys: 1.485 ± 0.047	5.981SerLeu: 5.981 ± 0.085	1.305SerMet: 1.305 ± 0.038	1.747SerAsn: 1.747 ± 0.041	2.987SerPro: 2.987 ± 0.062	2.467SerGln: 2.467 ± 0.047	4.009SerArg: 4.009 ± 0.076	3.357SerSer: 3.357 ± 0.084	2.897SerThr: 2.897 ± 0.07	4.08SerVal: 4.08 ± 0.089	0.887SerTrp: 0.887 ± 0.03	1.515SerTyr: 1.515 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.749ThrAla: 5.749 ± 0.119	0.414ThrCys: 0.414 ± 0.036	2.695ThrAsp: 2.695 ± 0.071	2.03ThrGlu: 2.03 ± 0.042	1.531ThrPhe: 1.531 ± 0.047	4.464ThrGly: 4.464 ± 0.079	0.995ThrHis: 0.995 ± 0.028	2.093ThrIle: 2.093 ± 0.064	0.8ThrLys: 0.8 ± 0.034	5.881ThrLeu: 5.881 ± 0.099	0.84ThrMet: 0.84 ± 0.028	1.059ThrAsn: 1.059 ± 0.05	3.224ThrPro: 3.224 ± 0.063	1.588ThrGln: 1.588 ± 0.04	3.255ThrArg: 3.255 ± 0.054	2.63ThrSer: 2.63 ± 0.059	2.548ThrThr: 2.548 ± 0.065	3.772ThrVal: 3.772 ± 0.101	0.656ThrTrp: 0.656 ± 0.028	1.097ThrTyr: 1.097 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.202ValAla: 9.202 ± 0.138	0.639ValCys: 0.639 ± 0.026	4.505ValAsp: 4.505 ± 0.067	3.977ValGlu: 3.977 ± 0.068	2.454ValPhe: 2.454 ± 0.056	5.397ValGly: 5.397 ± 0.1	1.528ValHis: 1.528 ± 0.042	3.419ValIle: 3.419 ± 0.066	1.858ValLys: 1.858 ± 0.054	8.016ValLeu: 8.016 ± 0.101	1.655ValMet: 1.655 ± 0.043	2.157ValAsn: 2.157 ± 0.051	3.631ValPro: 3.631 ± 0.067	2.713ValGln: 2.713 ± 0.059	4.755ValArg: 4.755 ± 0.076	4.433ValSer: 4.433 ± 0.063	3.588ValThr: 3.588 ± 0.098	5.802ValVal: 5.802 ± 0.086	0.869ValTrp: 0.869 ± 0.027	1.494ValTyr: 1.494 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.272TrpAla: 1.272 ± 0.034	0.144TrpCys: 0.144 ± 0.012	0.774TrpAsp: 0.774 ± 0.029	0.525TrpGlu: 0.525 ± 0.023	0.556TrpPhe: 0.556 ± 0.024	0.991TrpGly: 0.991 ± 0.035	0.368TrpHis: 0.368 ± 0.019	0.662TrpIle: 0.662 ± 0.027	0.486TrpLys: 0.486 ± 0.024	2.445TrpLeu: 2.445 ± 0.063	0.433TrpMet: 0.433 ± 0.021	0.493TrpAsn: 0.493 ± 0.023	0.787TrpPro: 0.787 ± 0.03	1.029TrpGln: 1.029 ± 0.035	1.317TrpArg: 1.317 ± 0.041	0.886TrpSer: 0.886 ± 0.032	0.701TrpThr: 0.701 ± 0.035	0.973TrpVal: 0.973 ± 0.035	0.355TrpTrp: 0.355 ± 0.021	0.392TrpTyr: 0.392 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.821TyrAla: 2.821 ± 0.063	0.193TyrCys: 0.193 ± 0.014	1.464TyrAsp: 1.464 ± 0.045	1.118TyrGlu: 1.118 ± 0.033	0.937TyrPhe: 0.937 ± 0.03	2.195TyrGly: 2.195 ± 0.056	0.527TyrHis: 0.527 ± 0.024	0.828TyrIle: 0.828 ± 0.027	0.539TyrLys: 0.539 ± 0.028	2.64TyrLeu: 2.64 ± 0.055	0.405TyrMet: 0.405 ± 0.019	0.723TyrAsn: 0.723 ± 0.035	1.259TyrPro: 1.259 ± 0.042	1.252TyrGln: 1.252 ± 0.039	2.119TyrArg: 2.119 ± 0.051	1.422TyrSer: 1.422 ± 0.047	1.251TyrThr: 1.251 ± 0.048	1.714TyrVal: 1.714 ± 0.04	0.414TyrTrp: 0.414 ± 0.022	0.687TyrTyr: 0.687 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3001 proteins (1002130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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