Amino acid dipepetide frequency for Desulfovibrio marinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.393AlaAla: 12.393 ± 0.144	1.393AlaCys: 1.393 ± 0.029	5.271AlaAsp: 5.271 ± 0.069	6.993AlaGlu: 6.993 ± 0.083	3.719AlaPhe: 3.719 ± 0.056	8.85AlaGly: 8.85 ± 0.09	2.036AlaHis: 2.036 ± 0.034	4.957AlaIle: 4.957 ± 0.059	4.054AlaLys: 4.054 ± 0.071	11.163AlaLeu: 11.163 ± 0.1	3.536AlaMet: 3.536 ± 0.052	2.594AlaAsn: 2.594 ± 0.045	4.483AlaPro: 4.483 ± 0.066	3.53AlaGln: 3.53 ± 0.054	6.525AlaArg: 6.525 ± 0.068	5.54AlaSer: 5.54 ± 0.063	4.839AlaThr: 4.839 ± 0.068	8.162AlaVal: 8.162 ± 0.09	1.264AlaTrp: 1.264 ± 0.032	2.461AlaTyr: 2.461 ± 0.043	0.001AlaXaa: 0.001 ± 0.001
Cys	1.167CysAla: 1.167 ± 0.028	0.247CysCys: 0.247 ± 0.016	0.623CysAsp: 0.623 ± 0.021	0.63CysGlu: 0.63 ± 0.019	0.49CysPhe: 0.49 ± 0.019	1.274CysGly: 1.274 ± 0.033	0.361CysHis: 0.361 ± 0.026	0.665CysIle: 0.665 ± 0.021	0.42CysLys: 0.42 ± 0.016	1.22CysLeu: 1.22 ± 0.027	0.347CysMet: 0.347 ± 0.017	0.352CysAsn: 0.352 ± 0.016	0.825CysPro: 0.825 ± 0.026	0.341CysGln: 0.341 ± 0.016	0.861CysArg: 0.861 ± 0.022	0.727CysSer: 0.727 ± 0.02	0.594CysThr: 0.594 ± 0.023	0.874CysVal: 0.874 ± 0.024	0.146CysTrp: 0.146 ± 0.009	0.299CysTyr: 0.299 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.953AspAla: 5.953 ± 0.076	0.6AspCys: 0.6 ± 0.022	3.217AspAsp: 3.217 ± 0.067	4.217AspGlu: 4.217 ± 0.054	2.28AspPhe: 2.28 ± 0.041	4.444AspGly: 4.444 ± 0.075	1.144AspHis: 1.144 ± 0.028	3.532AspIle: 3.532 ± 0.054	2.424AspLys: 2.424 ± 0.046	5.593AspLeu: 5.593 ± 0.056	1.668AspMet: 1.668 ± 0.035	1.584AspAsn: 1.584 ± 0.03	3.179AspPro: 3.179 ± 0.05	1.62AspGln: 1.62 ± 0.034	3.223AspArg: 3.223 ± 0.051	2.934AspSer: 2.934 ± 0.048	2.867AspThr: 2.867 ± 0.048	4.18AspVal: 4.18 ± 0.056	0.756AspTrp: 0.756 ± 0.022	1.607AspTyr: 1.607 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.218GluAla: 7.218 ± 0.085	0.66GluCys: 0.66 ± 0.023	3.699GluAsp: 3.699 ± 0.054	5.147GluGlu: 5.147 ± 0.083	2.195GluPhe: 2.195 ± 0.037	4.251GluGly: 4.251 ± 0.062	1.665GluHis: 1.665 ± 0.033	3.646GluIle: 3.646 ± 0.052	3.392GluLys: 3.392 ± 0.051	7.056GluLeu: 7.056 ± 0.073	1.851GluMet: 1.851 ± 0.038	2.267GluAsn: 2.267 ± 0.04	3.068GluPro: 3.068 ± 0.062	2.774GluGln: 2.774 ± 0.053	4.779GluArg: 4.779 ± 0.063	3.815GluSer: 3.815 ± 0.056	3.497GluThr: 3.497 ± 0.048	4.355GluVal: 4.355 ± 0.066	0.726GluTrp: 0.726 ± 0.021	1.792GluTyr: 1.792 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.612PheAla: 3.612 ± 0.051	0.537PheCys: 0.537 ± 0.018	2.337PheAsp: 2.337 ± 0.037	2.343PheGlu: 2.343 ± 0.041	1.854PhePhe: 1.854 ± 0.041	2.995PheGly: 2.995 ± 0.051	0.922PheHis: 0.922 ± 0.025	2.067PheIle: 2.067 ± 0.04	1.376PheLys: 1.376 ± 0.036	4.162PheLeu: 4.162 ± 0.06	1.1PheMet: 1.1 ± 0.029	1.129PheAsn: 1.129 ± 0.026	1.786PhePro: 1.786 ± 0.04	1.135PheGln: 1.135 ± 0.026	2.191PheArg: 2.191 ± 0.042	2.591PheSer: 2.591 ± 0.037	2.254PheThr: 2.254 ± 0.039	2.728PheVal: 2.728 ± 0.047	0.532PheTrp: 0.532 ± 0.021	1.185PheTyr: 1.185 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.278GlyAla: 7.278 ± 0.083	1.147GlyCys: 1.147 ± 0.033	4.041GlyAsp: 4.041 ± 0.074	5.14GlyGlu: 5.14 ± 0.067	3.298GlyPhe: 3.298 ± 0.05	6.344GlyGly: 6.344 ± 0.111	1.737GlyHis: 1.737 ± 0.037	4.154GlyIle: 4.154 ± 0.057	3.752GlyLys: 3.752 ± 0.06	8.388GlyLeu: 8.388 ± 0.102	2.613GlyMet: 2.613 ± 0.047	2.181GlyAsn: 2.181 ± 0.054	3.164GlyPro: 3.164 ± 0.044	2.481GlyGln: 2.481 ± 0.045	5.068GlyArg: 5.068 ± 0.063	4.563GlySer: 4.563 ± 0.062	3.726GlyThr: 3.726 ± 0.059	6.385GlyVal: 6.385 ± 0.076	1.076GlyTrp: 1.076 ± 0.027	2.489GlyTyr: 2.489 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.141HisAla: 2.141 ± 0.04	0.321HisCys: 0.321 ± 0.016	1.255HisAsp: 1.255 ± 0.031	1.416HisGlu: 1.416 ± 0.029	0.939HisPhe: 0.939 ± 0.024	2.006HisGly: 2.006 ± 0.044	0.578HisHis: 0.578 ± 0.022	1.122HisIle: 1.122 ± 0.025	0.78HisLys: 0.78 ± 0.024	2.008HisLeu: 2.008 ± 0.041	0.576HisMet: 0.576 ± 0.019	0.595HisAsn: 0.595 ± 0.022	1.338HisPro: 1.338 ± 0.032	0.614HisGln: 0.614 ± 0.02	1.246HisArg: 1.246 ± 0.032	1.135HisSer: 1.135 ± 0.026	1.168HisThr: 1.168 ± 0.029	1.513HisVal: 1.513 ± 0.035	0.282HisTrp: 0.282 ± 0.014	0.652HisTyr: 0.652 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.482IleAla: 5.482 ± 0.066	0.665IleCys: 0.665 ± 0.022	2.774IleAsp: 2.774 ± 0.042	3.249IleGlu: 3.249 ± 0.056	2.067IlePhe: 2.067 ± 0.042	3.873IleGly: 3.873 ± 0.054	1.216IleHis: 1.216 ± 0.028	2.944IleIle: 2.944 ± 0.056	1.946IleLys: 1.946 ± 0.04	5.386IleLeu: 5.386 ± 0.064	1.281IleMet: 1.281 ± 0.031	1.664IleAsn: 1.664 ± 0.044	2.701IlePro: 2.701 ± 0.048	1.512IleGln: 1.512 ± 0.037	3.223IleArg: 3.223 ± 0.044	3.038IleSer: 3.038 ± 0.05	2.836IleThr: 2.836 ± 0.051	4.013IleVal: 4.013 ± 0.057	0.526IleTrp: 0.526 ± 0.02	1.341IleTyr: 1.341 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.332LysAla: 4.332 ± 0.069	0.327LysCys: 0.327 ± 0.018	2.635LysAsp: 2.635 ± 0.044	3.042LysGlu: 3.042 ± 0.053	1.14LysPhe: 1.14 ± 0.034	2.995LysGly: 2.995 ± 0.057	0.842LysHis: 0.842 ± 0.025	2.043LysIle: 2.043 ± 0.042	2.31LysLys: 2.31 ± 0.055	3.661LysLeu: 3.661 ± 0.058	0.989LysMet: 0.989 ± 0.027	1.436LysAsn: 1.436 ± 0.036	2.185LysPro: 2.185 ± 0.042	1.457LysGln: 1.457 ± 0.034	2.794LysArg: 2.794 ± 0.046	2.238LysSer: 2.238 ± 0.038	2.201LysThr: 2.201 ± 0.036	2.641LysVal: 2.641 ± 0.057	0.358LysTrp: 0.358 ± 0.017	1.02LysTyr: 1.02 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.121LeuAla: 12.121 ± 0.105	1.338LeuCys: 1.338 ± 0.032	6.702LeuAsp: 6.702 ± 0.06	7.082LeuGlu: 7.082 ± 0.08	4.091LeuPhe: 4.091 ± 0.063	8.477LeuGly: 8.477 ± 0.095	2.128LeuHis: 2.128 ± 0.042	4.435LeuIle: 4.435 ± 0.062	3.971LeuLys: 3.971 ± 0.062	10.737LeuLeu: 10.737 ± 0.124	2.45LeuMet: 2.45 ± 0.044	2.802LeuAsn: 2.802 ± 0.047	5.293LeuPro: 5.293 ± 0.073	3.175LeuGln: 3.175 ± 0.052	6.274LeuArg: 6.274 ± 0.077	6.415LeuSer: 6.415 ± 0.072	5.374LeuThr: 5.374 ± 0.066	7.532LeuVal: 7.532 ± 0.087	1.052LeuTrp: 1.052 ± 0.029	2.525LeuTyr: 2.525 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.24MetAla: 3.24 ± 0.047	0.255MetCys: 0.255 ± 0.013	1.923MetAsp: 1.923 ± 0.035	1.943MetGlu: 1.943 ± 0.041	0.82MetPhe: 0.82 ± 0.03	2.177MetGly: 2.177 ± 0.044	0.576MetHis: 0.576 ± 0.021	1.158MetIle: 1.158 ± 0.028	1.071MetLys: 1.071 ± 0.026	2.862MetLeu: 2.862 ± 0.045	0.586MetMet: 0.586 ± 0.024	0.925MetAsn: 0.925 ± 0.025	1.549MetPro: 1.549 ± 0.036	1.052MetGln: 1.052 ± 0.024	1.926MetArg: 1.926 ± 0.038	1.634MetSer: 1.634 ± 0.03	1.577MetThr: 1.577 ± 0.034	1.894MetVal: 1.894 ± 0.041	0.197MetTrp: 0.197 ± 0.011	0.512MetTyr: 0.512 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.149AsnAla: 3.149 ± 0.056	0.352AsnCys: 0.352 ± 0.015	1.494AsnAsp: 1.494 ± 0.039	1.688AsnGlu: 1.688 ± 0.034	1.047AsnPhe: 1.047 ± 0.029	2.341AsnGly: 2.341 ± 0.044	0.606AsnHis: 0.606 ± 0.02	1.788AsnIle: 1.788 ± 0.037	1.105AsnLys: 1.105 ± 0.029	3.013AsnLeu: 3.013 ± 0.049	0.787AsnMet: 0.787 ± 0.024	0.83AsnAsn: 0.83 ± 0.024	1.947AsnPro: 1.947 ± 0.038	0.918AsnGln: 0.918 ± 0.027	1.775AsnArg: 1.775 ± 0.034	1.412AsnSer: 1.412 ± 0.034	1.491AsnThr: 1.491 ± 0.032	2.108AsnVal: 2.108 ± 0.038	0.353AsnTrp: 0.353 ± 0.015	0.831AsnTyr: 0.831 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.077ProAla: 5.077 ± 0.079	0.589ProCys: 0.589 ± 0.019	3.512ProAsp: 3.512 ± 0.056	4.481ProGlu: 4.481 ± 0.062	2.01ProPhe: 2.01 ± 0.041	4.33ProGly: 4.33 ± 0.062	1.054ProHis: 1.054 ± 0.028	2.048ProIle: 2.048 ± 0.04	1.863ProLys: 1.863 ± 0.039	4.653ProLeu: 4.653 ± 0.06	1.298ProMet: 1.298 ± 0.027	1.25ProAsn: 1.25 ± 0.034	2.43ProPro: 2.43 ± 0.041	1.688ProGln: 1.688 ± 0.035	2.622ProArg: 2.622 ± 0.047	2.611ProSer: 2.611 ± 0.044	2.204ProThr: 2.204 ± 0.035	3.796ProVal: 3.796 ± 0.051	0.639ProTrp: 0.639 ± 0.02	1.367ProTyr: 1.367 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.817GlnAla: 3.817 ± 0.054	0.383GlnCys: 0.383 ± 0.017	1.888GlnAsp: 1.888 ± 0.039	2.473GlnGlu: 2.473 ± 0.041	1.028GlnPhe: 1.028 ± 0.028	2.672GlnGly: 2.672 ± 0.044	0.693GlnHis: 0.693 ± 0.025	1.568GlnIle: 1.568 ± 0.036	1.457GlnLys: 1.457 ± 0.033	2.925GlnLeu: 2.925 ± 0.047	0.858GlnMet: 0.858 ± 0.025	1.094GlnAsn: 1.094 ± 0.03	1.594GlnPro: 1.594 ± 0.036	1.376GlnGln: 1.376 ± 0.036	2.229GlnArg: 2.229 ± 0.045	1.887GlnSer: 1.887 ± 0.043	1.674GlnThr: 1.674 ± 0.037	2.223GlnVal: 2.223 ± 0.038	0.396GlnTrp: 0.396 ± 0.016	0.844GlnTyr: 0.844 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.558ArgAla: 5.558 ± 0.067	0.769ArgCys: 0.769 ± 0.025	3.423ArgAsp: 3.423 ± 0.049	4.724ArgGlu: 4.724 ± 0.054	2.687ArgPhe: 2.687 ± 0.051	4.117ArgGly: 4.117 ± 0.068	1.452ArgHis: 1.452 ± 0.034	3.99ArgIle: 3.99 ± 0.053	2.866ArgLys: 2.866 ± 0.046	7.028ArgLeu: 7.028 ± 0.083	1.817ArgMet: 1.817 ± 0.04	2.009ArgAsn: 2.009 ± 0.036	2.754ArgPro: 2.754 ± 0.048	2.311ArgGln: 2.311 ± 0.043	4.726ArgArg: 4.726 ± 0.075	3.465ArgSer: 3.465 ± 0.056	3.353ArgThr: 3.353 ± 0.047	4.235ArgVal: 4.235 ± 0.061	0.74ArgTrp: 0.74 ± 0.025	1.888ArgTyr: 1.888 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.192SerAla: 5.192 ± 0.078	0.76SerCys: 0.76 ± 0.026	2.824SerAsp: 2.824 ± 0.047	3.355SerGlu: 3.355 ± 0.054	2.391SerPhe: 2.391 ± 0.042	5.159SerGly: 5.159 ± 0.079	1.231SerHis: 1.231 ± 0.029	3.159SerIle: 3.159 ± 0.046	2.121SerLys: 2.121 ± 0.044	6.222SerLeu: 6.222 ± 0.066	1.906SerMet: 1.906 ± 0.034	1.459SerAsn: 1.459 ± 0.029	2.791SerPro: 2.791 ± 0.045	1.89SerGln: 1.89 ± 0.038	3.854SerArg: 3.854 ± 0.06	3.429SerSer: 3.429 ± 0.062	2.814SerThr: 2.814 ± 0.043	3.901SerVal: 3.901 ± 0.057	0.742SerTrp: 0.742 ± 0.025	1.589SerTyr: 1.589 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.378ThrAla: 5.378 ± 0.065	0.569ThrCys: 0.569 ± 0.021	2.559ThrAsp: 2.559 ± 0.044	2.748ThrGlu: 2.748 ± 0.043	2.009ThrPhe: 2.009 ± 0.034	4.539ThrGly: 4.539 ± 0.067	1.067ThrHis: 1.067 ± 0.027	2.885ThrIle: 2.885 ± 0.048	1.771ThrLys: 1.771 ± 0.035	5.612ThrLeu: 5.612 ± 0.06	1.456ThrMet: 1.456 ± 0.034	1.382ThrAsn: 1.382 ± 0.032	3.242ThrPro: 3.242 ± 0.051	1.508ThrGln: 1.508 ± 0.034	3.107ThrArg: 3.107 ± 0.044	2.772ThrSer: 2.772 ± 0.043	2.653ThrThr: 2.653 ± 0.046	3.997ThrVal: 3.997 ± 0.059	0.6ThrTrp: 0.6 ± 0.021	1.321ThrTyr: 1.321 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.138ValAla: 7.138 ± 0.075	0.98ValCys: 0.98 ± 0.026	4.502ValAsp: 4.502 ± 0.056	4.818ValGlu: 4.818 ± 0.058	3.101ValPhe: 3.101 ± 0.053	5.087ValGly: 5.087 ± 0.059	1.577ValHis: 1.577 ± 0.034	3.756ValIle: 3.756 ± 0.055	2.472ValLys: 2.472 ± 0.053	8.14ValLeu: 8.14 ± 0.09	1.784ValMet: 1.784 ± 0.035	2.23ValAsn: 2.23 ± 0.038	3.277ValPro: 3.277 ± 0.056	2.424ValGln: 2.424 ± 0.045	4.87ValArg: 4.87 ± 0.061	4.418ValSer: 4.418 ± 0.053	3.956ValThr: 3.956 ± 0.06	5.916ValVal: 5.916 ± 0.077	0.786ValTrp: 0.786 ± 0.024	1.885ValTyr: 1.885 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.974TrpAla: 0.974 ± 0.027	0.162TrpCys: 0.162 ± 0.01	0.661TrpAsp: 0.661 ± 0.024	0.716TrpGlu: 0.716 ± 0.023	0.496TrpPhe: 0.496 ± 0.02	0.798TrpGly: 0.798 ± 0.027	0.232TrpHis: 0.232 ± 0.012	0.55TrpIle: 0.55 ± 0.02	0.514TrpLys: 0.514 ± 0.018	1.338TrpLeu: 1.338 ± 0.038	0.323TrpMet: 0.323 ± 0.016	0.423TrpAsn: 0.423 ± 0.016	0.589TrpPro: 0.589 ± 0.019	0.466TrpGln: 0.466 ± 0.018	0.891TrpArg: 0.891 ± 0.027	0.679TrpSer: 0.679 ± 0.02	0.633TrpThr: 0.633 ± 0.021	0.762TrpVal: 0.762 ± 0.027	0.197TrpTrp: 0.197 ± 0.011	0.304TrpTyr: 0.304 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.542TyrAla: 2.542 ± 0.045	0.41TyrCys: 0.41 ± 0.016	1.677TyrAsp: 1.677 ± 0.038	1.648TyrGlu: 1.648 ± 0.036	1.176TyrPhe: 1.176 ± 0.029	2.297TyrGly: 2.297 ± 0.042	0.569TyrHis: 0.569 ± 0.021	1.271TyrIle: 1.271 ± 0.031	0.982TyrLys: 0.982 ± 0.027	2.807TyrLeu: 2.807 ± 0.043	0.648TyrMet: 0.648 ± 0.022	0.83TyrAsn: 0.83 ± 0.025	1.328TyrPro: 1.328 ± 0.03	0.807TyrGln: 0.807 ± 0.024	1.729TyrArg: 1.729 ± 0.038	1.488TyrSer: 1.488 ± 0.033	1.464TyrThr: 1.464 ± 0.034	1.9TyrVal: 1.9 ± 0.038	0.34TyrTrp: 0.34 ± 0.016	0.865TyrTyr: 0.865 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4594 proteins (1459414 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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