Amino acid dipepetide frequency for Cryptosporangium arvum DSM 44712

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.009AlaAla: 23.009 ± 0.217	0.94AlaCys: 0.94 ± 0.032	9.026AlaAsp: 9.026 ± 0.109	8.511AlaGlu: 8.511 ± 0.111	3.688AlaPhe: 3.688 ± 0.057	13.836AlaGly: 13.836 ± 0.13	2.665AlaHis: 2.665 ± 0.048	4.567AlaIle: 4.567 ± 0.069	2.278AlaLys: 2.278 ± 0.066	15.767AlaLeu: 15.767 ± 0.127	2.396AlaMet: 2.396 ± 0.043	2.012AlaAsn: 2.012 ± 0.044	7.145AlaPro: 7.145 ± 0.102	3.431AlaGln: 3.431 ± 0.053	10.379AlaArg: 10.379 ± 0.124	6.56AlaSer: 6.56 ± 0.075	7.807AlaThr: 7.807 ± 0.075	13.253AlaVal: 13.253 ± 0.129	1.921AlaTrp: 1.921 ± 0.046	2.41AlaTyr: 2.41 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.93CysAla: 0.93 ± 0.027	0.083CysCys: 0.083 ± 0.009	0.391CysAsp: 0.391 ± 0.016	0.312CysGlu: 0.312 ± 0.014	0.176CysPhe: 0.176 ± 0.012	0.816CysGly: 0.816 ± 0.027	0.149CysHis: 0.149 ± 0.011	0.141CysIle: 0.141 ± 0.011	0.087CysLys: 0.087 ± 0.01	0.586CysLeu: 0.586 ± 0.022	0.084CysMet: 0.084 ± 0.008	0.117CysAsn: 0.117 ± 0.01	0.384CysPro: 0.384 ± 0.02	0.138CysGln: 0.138 ± 0.011	0.569CysArg: 0.569 ± 0.023	0.385CysSer: 0.385 ± 0.022	0.387CysThr: 0.387 ± 0.017	0.599CysVal: 0.599 ± 0.025	0.121CysTrp: 0.121 ± 0.01	0.135CysTyr: 0.135 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.89AspAla: 8.89 ± 0.122	0.309AspCys: 0.309 ± 0.016	4.199AspAsp: 4.199 ± 0.066	4.002AspGlu: 4.002 ± 0.062	1.455AspPhe: 1.455 ± 0.035	6.115AspGly: 6.115 ± 0.083	1.283AspHis: 1.283 ± 0.028	1.42AspIle: 1.42 ± 0.038	0.789AspLys: 0.789 ± 0.032	6.747AspLeu: 6.747 ± 0.082	0.617AspMet: 0.617 ± 0.02	0.831AspAsn: 0.831 ± 0.028	4.727AspPro: 4.727 ± 0.063	1.586AspGln: 1.586 ± 0.036	5.375AspArg: 5.375 ± 0.067	2.267AspSer: 2.267 ± 0.045	2.948AspThr: 2.948 ± 0.046	5.995AspVal: 5.995 ± 0.076	0.879AspTrp: 0.879 ± 0.031	1.153AspTyr: 1.153 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.691GluAla: 6.691 ± 0.089	0.345GluCys: 0.345 ± 0.018	2.359GluAsp: 2.359 ± 0.045	2.503GluGlu: 2.503 ± 0.055	1.573GluPhe: 1.573 ± 0.037	3.308GluGly: 3.308 ± 0.049	1.397GluHis: 1.397 ± 0.033	2.209GluIle: 2.209 ± 0.046	1.127GluLys: 1.127 ± 0.035	6.586GluLeu: 6.586 ± 0.083	0.786GluMet: 0.786 ± 0.027	1.036GluAsn: 1.036 ± 0.024	3.457GluPro: 3.457 ± 0.053	2.004GluGln: 2.004 ± 0.044	5.18GluArg: 5.18 ± 0.077	2.54GluSer: 2.54 ± 0.052	2.653GluThr: 2.653 ± 0.044	4.514GluVal: 4.514 ± 0.067	0.795GluTrp: 0.795 ± 0.026	1.003GluTyr: 1.003 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.086PheAla: 4.086 ± 0.061	0.219PheCys: 0.219 ± 0.011	2.057PheAsp: 2.057 ± 0.042	1.273PheGlu: 1.273 ± 0.032	0.847PhePhe: 0.847 ± 0.026	3.181PheGly: 3.181 ± 0.051	0.523PheHis: 0.523 ± 0.02	0.64PheIle: 0.64 ± 0.025	0.377PheLys: 0.377 ± 0.021	2.73PheLeu: 2.73 ± 0.056	0.305PheMet: 0.305 ± 0.014	0.472PheAsn: 0.472 ± 0.02	1.308PhePro: 1.308 ± 0.03	0.6PheGln: 0.6 ± 0.024	1.942PheArg: 1.942 ± 0.043	1.534PheSer: 1.534 ± 0.035	1.879PheThr: 1.879 ± 0.041	2.704PheVal: 2.704 ± 0.048	0.434PheTrp: 0.434 ± 0.02	0.562PheTyr: 0.562 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.394GlyAla: 11.394 ± 0.118	0.684GlyCys: 0.684 ± 0.025	5.094GlyAsp: 5.094 ± 0.062	4.562GlyGlu: 4.562 ± 0.063	2.959GlyPhe: 2.959 ± 0.047	8.12GlyGly: 8.12 ± 0.094	2.062GlyHis: 2.062 ± 0.054	3.382GlyIle: 3.382 ± 0.061	1.763GlyLys: 1.763 ± 0.052	9.916GlyLeu: 9.916 ± 0.111	1.694GlyMet: 1.694 ± 0.044	1.654GlyAsn: 1.654 ± 0.043	5.287GlyPro: 5.287 ± 0.073	2.405GlyGln: 2.405 ± 0.051	7.761GlyArg: 7.761 ± 0.103	5.223GlySer: 5.223 ± 0.079	5.79GlyThr: 5.79 ± 0.086	8.49GlyVal: 8.49 ± 0.116	1.764GlyTrp: 1.764 ± 0.039	2.214GlyTyr: 2.214 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.461HisAla: 2.461 ± 0.049	0.175HisCys: 0.175 ± 0.013	1.27HisAsp: 1.27 ± 0.03	1.133HisGlu: 1.133 ± 0.029	0.551HisPhe: 0.551 ± 0.024	2.064HisGly: 2.064 ± 0.047	0.629HisHis: 0.629 ± 0.027	0.463HisIle: 0.463 ± 0.018	0.25HisLys: 0.25 ± 0.014	2.333HisLeu: 2.333 ± 0.046	0.189HisMet: 0.189 ± 0.012	0.275HisAsn: 0.275 ± 0.012	1.64HisPro: 1.64 ± 0.043	0.541HisGln: 0.541 ± 0.021	2.113HisArg: 2.113 ± 0.045	0.915HisSer: 0.915 ± 0.032	1.052HisThr: 1.052 ± 0.031	1.763HisVal: 1.763 ± 0.041	0.332HisTrp: 0.332 ± 0.017	0.444HisTyr: 0.444 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.221IleAla: 5.221 ± 0.073	0.262IleCys: 0.262 ± 0.014	2.498IleAsp: 2.498 ± 0.047	2.033IleGlu: 2.033 ± 0.041	0.733IlePhe: 0.733 ± 0.027	3.741IleGly: 3.741 ± 0.065	0.569IleHis: 0.569 ± 0.024	0.798IleIle: 0.798 ± 0.028	0.571IleLys: 0.571 ± 0.024	2.522IleLeu: 2.522 ± 0.05	0.377IleMet: 0.377 ± 0.022	0.672IleAsn: 0.672 ± 0.023	1.766IlePro: 1.766 ± 0.039	0.701IleGln: 0.701 ± 0.021	2.473IleArg: 2.473 ± 0.044	1.814IleSer: 1.814 ± 0.042	2.144IleThr: 2.144 ± 0.049	3.297IleVal: 3.297 ± 0.058	0.385IleTrp: 0.385 ± 0.017	0.546IleTyr: 0.546 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.235LysAla: 2.235 ± 0.053	0.082LysCys: 0.082 ± 0.008	0.865LysAsp: 0.865 ± 0.032	0.71LysGlu: 0.71 ± 0.03	0.428LysPhe: 0.428 ± 0.021	1.095LysGly: 1.095 ± 0.034	0.335LysHis: 0.335 ± 0.016	0.648LysIle: 0.648 ± 0.028	0.516LysLys: 0.516 ± 0.027	1.656LysLeu: 1.656 ± 0.039	0.287LysMet: 0.287 ± 0.013	0.403LysAsn: 0.403 ± 0.02	1.103LysPro: 1.103 ± 0.035	0.532LysGln: 0.532 ± 0.025	1.218LysArg: 1.218 ± 0.038	1.037LysSer: 1.037 ± 0.035	1.04LysThr: 1.04 ± 0.039	1.369LysVal: 1.369 ± 0.04	0.21LysTrp: 0.21 ± 0.012	0.363LysTyr: 0.363 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	16.63LeuAla: 16.63 ± 0.12	0.653LeuCys: 0.653 ± 0.025	7.181LeuAsp: 7.181 ± 0.08	4.682LeuGlu: 4.682 ± 0.067	2.762LeuPhe: 2.762 ± 0.052	9.863LeuGly: 9.863 ± 0.09	2.2LeuHis: 2.2 ± 0.043	3.672LeuIle: 3.672 ± 0.063	1.368LeuLys: 1.368 ± 0.044	11.556LeuLeu: 11.556 ± 0.12	1.353LeuMet: 1.353 ± 0.037	1.691LeuAsn: 1.691 ± 0.039	6.327LeuPro: 6.327 ± 0.074	2.084LeuGln: 2.084 ± 0.039	9.093LeuArg: 9.093 ± 0.105	5.718LeuSer: 5.718 ± 0.073	7.239LeuThr: 7.239 ± 0.085	10.333LeuVal: 10.333 ± 0.103	1.278LeuTrp: 1.278 ± 0.037	1.671LeuTyr: 1.671 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	1.917MetAla: 1.917 ± 0.042	0.087MetCys: 0.087 ± 0.008	0.743MetAsp: 0.743 ± 0.026	0.508MetGlu: 0.508 ± 0.019	0.472MetPhe: 0.472 ± 0.022	1.018MetGly: 1.018 ± 0.031	0.266MetHis: 0.266 ± 0.015	0.64MetIle: 0.64 ± 0.021	0.312MetLys: 0.312 ± 0.016	1.611MetLeu: 1.611 ± 0.033	0.225MetMet: 0.225 ± 0.013	0.354MetAsn: 0.354 ± 0.016	0.925MetPro: 0.925 ± 0.029	0.356MetGln: 0.356 ± 0.017	1.312MetArg: 1.312 ± 0.03	1.202MetSer: 1.202 ± 0.03	1.492MetThr: 1.492 ± 0.036	1.259MetVal: 1.259 ± 0.034	0.143MetTrp: 0.143 ± 0.01	0.243MetTyr: 0.243 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.209AsnAla: 2.209 ± 0.045	0.139AsnCys: 0.139 ± 0.009	0.973AsnAsp: 0.973 ± 0.028	0.777AsnGlu: 0.777 ± 0.024	0.451AsnPhe: 0.451 ± 0.017	1.787AsnGly: 1.787 ± 0.045	0.348AsnHis: 0.348 ± 0.016	0.551AsnIle: 0.551 ± 0.024	0.315AsnLys: 0.315 ± 0.018	1.754AsnLeu: 1.754 ± 0.039	0.232AsnMet: 0.232 ± 0.014	0.367AsnAsn: 0.367 ± 0.017	1.363AsnPro: 1.363 ± 0.038	0.513AsnGln: 0.513 ± 0.019	1.334AsnArg: 1.334 ± 0.03	0.83AsnSer: 0.83 ± 0.028	1.076AsnThr: 1.076 ± 0.034	1.455AsnVal: 1.455 ± 0.04	0.296AsnTrp: 0.296 ± 0.014	0.381AsnTyr: 0.381 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	8.965ProAla: 8.965 ± 0.104	0.276ProCys: 0.276 ± 0.016	4.749ProAsp: 4.749 ± 0.071	3.778ProGlu: 3.778 ± 0.065	1.539ProPhe: 1.539 ± 0.035	6.46ProGly: 6.46 ± 0.095	1.184ProHis: 1.184 ± 0.032	1.834ProIle: 1.834 ± 0.038	0.941ProLys: 0.941 ± 0.03	5.328ProLeu: 5.328 ± 0.063	0.93ProMet: 0.93 ± 0.028	0.999ProAsn: 0.999 ± 0.03	3.776ProPro: 3.776 ± 0.076	1.324ProGln: 1.324 ± 0.035	3.889ProArg: 3.889 ± 0.054	3.344ProSer: 3.344 ± 0.063	3.688ProThr: 3.688 ± 0.06	5.776ProVal: 5.776 ± 0.079	0.914ProTrp: 0.914 ± 0.028	1.074ProTyr: 1.074 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.262GlnAla: 3.262 ± 0.057	0.155GlnCys: 0.155 ± 0.013	1.071GlnAsp: 1.071 ± 0.034	1.036GlnGlu: 1.036 ± 0.026	0.702GlnPhe: 0.702 ± 0.024	1.727GlnGly: 1.727 ± 0.044	0.583GlnHis: 0.583 ± 0.023	1.079GlnIle: 1.079 ± 0.029	0.502GlnLys: 0.502 ± 0.022	3.05GlnLeu: 3.05 ± 0.053	0.425GlnMet: 0.425 ± 0.02	0.533GlnAsn: 0.533 ± 0.02	1.573GlnPro: 1.573 ± 0.037	1.022GlnGln: 1.022 ± 0.032	2.491GlnArg: 2.491 ± 0.051	1.114GlnSer: 1.114 ± 0.026	1.208GlnThr: 1.208 ± 0.037	2.368GlnVal: 2.368 ± 0.04	0.442GlnTrp: 0.442 ± 0.018	0.53GlnTyr: 0.53 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.586ArgAla: 10.586 ± 0.128	0.552ArgCys: 0.552 ± 0.021	4.416ArgAsp: 4.416 ± 0.059	4.278ArgGlu: 4.278 ± 0.064	2.478ArgPhe: 2.478 ± 0.048	5.794ArgGly: 5.794 ± 0.072	1.889ArgHis: 1.889 ± 0.044	3.153ArgIle: 3.153 ± 0.052	1.242ArgLys: 1.242 ± 0.033	9.264ArgLeu: 9.264 ± 0.1	1.666ArgMet: 1.666 ± 0.037	1.388ArgAsn: 1.388 ± 0.033	5.272ArgPro: 5.272 ± 0.08	2.239ArgGln: 2.239 ± 0.039	8.528ArgArg: 8.528 ± 0.123	4.515ArgSer: 4.515 ± 0.061	5.251ArgThr: 5.251 ± 0.075	6.498ArgVal: 6.498 ± 0.081	1.581ArgTrp: 1.581 ± 0.038	1.929ArgTyr: 1.929 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	7.254SerAla: 7.254 ± 0.083	0.338SerCys: 0.338 ± 0.017	2.975SerAsp: 2.975 ± 0.053	2.4SerGlu: 2.4 ± 0.047	1.501SerPhe: 1.501 ± 0.034	5.956SerGly: 5.956 ± 0.079	0.893SerHis: 0.893 ± 0.025	1.803SerIle: 1.803 ± 0.04	0.796SerLys: 0.796 ± 0.026	4.935SerLeu: 4.935 ± 0.072	0.99SerMet: 0.99 ± 0.031	0.91SerAsn: 0.91 ± 0.031	3.291SerPro: 3.291 ± 0.06	1.135SerGln: 1.135 ± 0.033	3.876SerArg: 3.876 ± 0.062	3.022SerSer: 3.022 ± 0.064	3.291SerThr: 3.291 ± 0.053	4.649SerVal: 4.649 ± 0.064	0.894SerTrp: 0.894 ± 0.026	1.093SerTyr: 1.093 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.663ThrAla: 8.663 ± 0.085	0.355ThrCys: 0.355 ± 0.016	3.554ThrAsp: 3.554 ± 0.051	2.907ThrGlu: 2.907 ± 0.046	1.748ThrPhe: 1.748 ± 0.044	6.518ThrGly: 6.518 ± 0.084	1.101ThrHis: 1.101 ± 0.03	2.285ThrIle: 2.285 ± 0.051	0.974ThrLys: 0.974 ± 0.03	6.17ThrLeu: 6.17 ± 0.075	0.935ThrMet: 0.935 ± 0.032	1.095ThrAsn: 1.095 ± 0.029	4.033ThrPro: 4.033 ± 0.06	1.259ThrGln: 1.259 ± 0.032	4.127ThrArg: 4.127 ± 0.068	3.145ThrSer: 3.145 ± 0.053	3.925ThrThr: 3.925 ± 0.063	6.162ThrVal: 6.162 ± 0.073	0.852ThrTrp: 0.852 ± 0.023	1.2ThrTyr: 1.2 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	12.952ValAla: 12.952 ± 0.11	0.626ValCys: 0.626 ± 0.024	6.056ValAsp: 6.056 ± 0.083	5.076ValGlu: 5.076 ± 0.07	2.511ValPhe: 2.511 ± 0.055	7.796ValGly: 7.796 ± 0.083	1.787ValHis: 1.787 ± 0.033	2.917ValIle: 2.917 ± 0.05	1.409ValLys: 1.409 ± 0.041	10.811ValLeu: 10.811 ± 0.112	1.198ValMet: 1.198 ± 0.033	1.66ValAsn: 1.66 ± 0.039	5.374ValPro: 5.374 ± 0.074	1.891ValGln: 1.891 ± 0.035	7.567ValArg: 7.567 ± 0.08	4.876ValSer: 4.876 ± 0.079	6.214ValThr: 6.214 ± 0.07	10.107ValVal: 10.107 ± 0.12	1.135ValTrp: 1.135 ± 0.029	1.46ValTyr: 1.46 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.74TrpAla: 1.74 ± 0.041	0.147TrpCys: 0.147 ± 0.01	0.816TrpAsp: 0.816 ± 0.026	0.654TrpGlu: 0.654 ± 0.023	0.499TrpPhe: 0.499 ± 0.019	1.068TrpGly: 1.068 ± 0.034	0.366TrpHis: 0.366 ± 0.019	0.58TrpIle: 0.58 ± 0.022	0.266TrpLys: 0.266 ± 0.014	1.8TrpLeu: 1.8 ± 0.043	0.245TrpMet: 0.245 ± 0.016	0.375TrpAsn: 0.375 ± 0.018	0.87TrpPro: 0.87 ± 0.029	0.513TrpGln: 0.513 ± 0.02	1.388TrpArg: 1.388 ± 0.033	1.012TrpSer: 1.012 ± 0.031	0.892TrpThr: 0.892 ± 0.028	1.157TrpVal: 1.157 ± 0.026	0.374TrpTrp: 0.374 ± 0.017	0.321TrpTyr: 0.321 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.506TyrAla: 2.506 ± 0.047	0.16TyrCys: 0.16 ± 0.011	1.295TyrAsp: 1.295 ± 0.038	0.929TyrGlu: 0.929 ± 0.027	0.603TyrPhe: 0.603 ± 0.022	1.956TyrGly: 1.956 ± 0.042	0.364TyrHis: 0.364 ± 0.018	0.341TyrIle: 0.341 ± 0.017	0.25TyrLys: 0.25 ± 0.016	2.232TyrLeu: 2.232 ± 0.052	0.154TyrMet: 0.154 ± 0.01	0.307TyrAsn: 0.307 ± 0.017	1.145TyrPro: 1.145 ± 0.032	0.601TyrGln: 0.601 ± 0.024	1.903TyrArg: 1.903 ± 0.042	0.946TyrSer: 0.946 ± 0.028	1.031TyrThr: 1.031 ± 0.027	1.674TyrVal: 1.674 ± 0.04	0.335TyrTrp: 0.335 ± 0.018	0.42TyrTyr: 0.42 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4033 proteins (1372967 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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