JC polyomavirus (JCPyV) (JCV)

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Sepolyvirales; Polyomaviridae; Betapolyomavirus; Human polyomavirus 2

Average proteome isoelectric point is 6.99

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|O92720|O92720_POVJC Minor capsid protein OS=JC polyomavirus OX=10632 GN=VP3 PE=3 SV=1
MM1 pKa = 7.14GAALALLGDD10 pKa = 4.3LVATVSEE17 pKa = 4.25AAAATGFSVAEE28 pKa = 4.01IAAGEE33 pKa = 3.91AAATIEE39 pKa = 4.3VEE41 pKa = 4.28IASLATVEE49 pKa = 5.49GITSTSEE56 pKa = 3.82AIAAIGLTPEE66 pKa = 4.45TYY68 pKa = 10.83AVITGAPGAVAGFAALVQTVTGGSAIAQLGYY99 pKa = 10.77RR100 pKa = 11.84FFADD104 pKa = 3.05WDD106 pKa = 4.17HH107 pKa = 6.5KK108 pKa = 11.14VSTVGLFQQPAMALQLFNPEE128 pKa = 4.35DD129 pKa = 4.17YY130 pKa = 11.39YY131 pKa = 11.45DD132 pKa = 3.52ILFPGVNAFVNNIHH146 pKa = 6.25YY147 pKa = 10.37LDD149 pKa = 4.1PRR151 pKa = 11.84HH152 pKa = 6.33WGPSLFSTISQAFWNLVRR170 pKa = 11.84DD171 pKa = 4.39DD172 pKa = 5.17LPALTSQEE180 pKa = 3.86IQRR183 pKa = 11.84RR184 pKa = 11.84TQKK187 pKa = 11.02LFVEE191 pKa = 4.21NLARR195 pKa = 11.84FLEE198 pKa = 4.37EE199 pKa = 3.93TTWAIVNSPANLYY212 pKa = 10.82NYY214 pKa = 9.9ISDD217 pKa = 4.06YY218 pKa = 10.43YY219 pKa = 11.38SRR221 pKa = 11.84LSPVRR226 pKa = 11.84PSMVRR231 pKa = 11.84QVAQRR236 pKa = 11.84EE237 pKa = 4.28GTYY240 pKa = 10.19ISFGHH245 pKa = 6.57SYY247 pKa = 8.19TQSIDD252 pKa = 3.57DD253 pKa = 4.19ADD255 pKa = 4.52SIQEE259 pKa = 3.85VTQRR263 pKa = 11.84LDD265 pKa = 3.3LKK267 pKa = 9.91TPNVQSGEE275 pKa = 4.07FIEE278 pKa = 5.69RR279 pKa = 11.84SIAPGGANQRR289 pKa = 11.84SAPQWMLPLLLGLYY303 pKa = 8.21GTVTPALAAYY313 pKa = 9.61EE314 pKa = 4.43DD315 pKa = 4.33GPNKK319 pKa = 10.02KK320 pKa = 9.5KK321 pKa = 10.16RR322 pKa = 11.84RR323 pKa = 11.84KK324 pKa = 8.4EE325 pKa = 3.86GPRR328 pKa = 11.84ASSKK332 pKa = 9.28TSYY335 pKa = 10.17KK336 pKa = 9.95RR337 pKa = 11.84RR338 pKa = 11.84SRR340 pKa = 11.84SSRR343 pKa = 11.84SS344 pKa = 3.18

Molecular weight: 37.34 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|O55864|O55864_POVJC Minor capsid protein OS=JC polyomavirus OX=10632 GN=VP2 PE=3 SV=1
MM1 pKa = 7.53VLRR4 pKa = 11.84QLSRR8 pKa = 11.84KK9 pKa = 9.98ASVKK13 pKa = 10.15VSKK16 pKa = 8.76TWSGTKK22 pKa = 9.78KK23 pKa = 9.32RR24 pKa = 11.84AQRR27 pKa = 11.84ILIFLLEE34 pKa = 4.11FLLDD38 pKa = 4.07FCTGEE43 pKa = 4.54DD44 pKa = 3.53SVDD47 pKa = 3.0GKK49 pKa = 10.74KK50 pKa = 9.81RR51 pKa = 11.84QRR53 pKa = 11.84HH54 pKa = 5.41SGLTQQTYY62 pKa = 10.71SALPEE67 pKa = 4.2PKK69 pKa = 9.57ATT71 pKa = 3.91

Molecular weight: 8.08 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

1854

71

688

309.0

35.04

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.365 ± 1.593

2.05 ± 0.757

5.609 ± 0.428

6.365 ± 0.554

4.639 ± 0.425

6.203 ± 0.468

2.211 ± 0.437

3.883 ± 0.494

6.419 ± 1.201

9.277 ± 0.34

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.805 ± 0.508

4.369 ± 0.354

5.34 ± 0.473

4.585 ± 0.347

5.609 ± 0.641

7.012 ± 0.737

5.717 ± 0.635

6.365 ± 0.514

1.618 ± 0.259

3.56 ± 0.345
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski