Amino acid dipepetide frequency for JC polyomavirus (JCPyV) (JCV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.635AlaAla: 8.635 ± 3.867
0.0AlaCys: 0.0 ± 0.0
3.238AlaAsp: 3.238 ± 0.903
1.619AlaGlu: 1.619 ± 0.707
2.698AlaPhe: 2.698 ± 1.216
2.159AlaGly: 2.159 ± 0.727
1.619AlaHis: 1.619 ± 0.822
3.778AlaIle: 3.778 ± 1.512
0.54AlaLys: 0.54 ± 0.361
8.095AlaLeu: 8.095 ± 2.455
0.54AlaMet: 0.54 ± 0.427
2.698AlaAsn: 2.698 ± 1.216
3.238AlaPro: 3.238 ± 1.636
3.778AlaGln: 3.778 ± 0.867
2.159AlaArg: 2.159 ± 0.494
3.778AlaSer: 3.778 ± 1.064
4.857AlaThr: 4.857 ± 2.016
4.857AlaVal: 4.857 ± 1.436
1.619AlaTrp: 1.619 ± 0.822
3.778AlaTyr: 3.778 ± 0.567
0.0AlaXaa: 0.0 ± 0.0
Cys
0.54CysAla: 0.54 ± 0.651
0.0CysCys: 0.0 ± 0.0
1.079CysAsp: 1.079 ± 1.302
1.079CysGlu: 1.079 ± 0.722
2.159CysPhe: 2.159 ± 1.165
1.619CysGly: 1.619 ± 0.926
0.54CysHis: 0.54 ± 0.361
0.54CysIle: 0.54 ± 0.361
3.778CysLys: 3.778 ± 1.437
1.619CysLeu: 1.619 ± 0.822
0.54CysMet: 0.54 ± 0.651
0.0CysAsn: 0.0 ± 0.0
0.54CysPro: 0.54 ± 0.651
1.079CysGln: 1.079 ± 0.722
0.54CysArg: 0.54 ± 0.361
1.079CysSer: 1.079 ± 0.722
1.619CysThr: 1.619 ± 0.798
0.0CysVal: 0.0 ± 0.0
1.079CysTrp: 1.079 ± 0.724
1.079CysTyr: 1.079 ± 0.724
0.0CysXaa: 0.0 ± 0.0
Asp
1.619AspAla: 1.619 ± 0.782
1.619AspCys: 1.619 ± 1.247
2.698AspAsp: 2.698 ± 1.216
3.778AspGlu: 3.778 ± 1.231
5.936AspPhe: 5.936 ± 2.611
3.238AspGly: 3.238 ± 1.12
0.54AspHis: 0.54 ± 0.427
1.079AspIle: 1.079 ± 0.716
4.857AspLys: 4.857 ± 1.791
9.174AspLeu: 9.174 ± 1.363
1.079AspMet: 1.079 ± 1.009
1.079AspAsn: 1.079 ± 1.009
3.778AspPro: 3.778 ± 1.776
1.079AspGln: 1.079 ± 0.722
1.079AspArg: 1.079 ± 0.647
5.397AspSer: 5.397 ± 1.026
3.238AspThr: 3.238 ± 1.252
1.619AspVal: 1.619 ± 0.697
0.54AspTrp: 0.54 ± 0.427
2.698AspTyr: 2.698 ± 1.216
0.0AspXaa: 0.0 ± 0.0
Glu
4.317GluAla: 4.317 ± 1.037
1.079GluCys: 1.079 ± 1.009
7.555GluAsp: 7.555 ± 1.275
6.476GluGlu: 6.476 ± 1.517
2.159GluPhe: 2.159 ± 1.189
3.238GluGly: 3.238 ± 1.636
1.619GluHis: 1.619 ± 0.926
2.698GluIle: 2.698 ± 1.198
3.778GluLys: 3.778 ± 2.075
3.778GluLeu: 3.778 ± 1.26
1.619GluMet: 1.619 ± 0.697
3.778GluAsn: 3.778 ± 0.682
1.079GluPro: 1.079 ± 0.661
1.619GluGln: 1.619 ± 0.822
4.317GluArg: 4.317 ± 1.177
3.778GluSer: 3.778 ± 1.543
2.698GluThr: 2.698 ± 0.786
5.397GluVal: 5.397 ± 2.113
1.079GluTrp: 1.079 ± 0.647
1.619GluTyr: 1.619 ± 1.083
0.0GluXaa: 0.0 ± 0.0
Phe
3.238PheAla: 3.238 ± 1.414
1.079PheCys: 1.079 ± 0.661
0.54PheAsp: 0.54 ± 0.651
2.159PheGlu: 2.159 ± 0.979
1.619PhePhe: 1.619 ± 0.449
4.857PheGly: 4.857 ± 0.88
1.079PheHis: 1.079 ± 0.489
1.619PheIle: 1.619 ± 0.54
1.619PheLys: 1.619 ± 0.697
8.095PheLeu: 8.095 ± 1.443
0.54PheMet: 0.54 ± 0.361
3.778PheAsn: 3.778 ± 0.842
3.778PhePro: 3.778 ± 0.423
1.619PheGln: 1.619 ± 0.707
1.619PheArg: 1.619 ± 0.822
4.317PheSer: 4.317 ± 0.644
0.54PheThr: 0.54 ± 0.504
2.698PheVal: 2.698 ± 1.216
1.079PheTrp: 1.079 ± 0.716
0.54PheTyr: 0.54 ± 0.361
0.0PheXaa: 0.0 ± 0.0
Gly
4.857GlyAla: 4.857 ± 1.261
1.079GlyCys: 1.079 ± 1.302
3.778GlyAsp: 3.778 ± 1.476
3.778GlyGlu: 3.778 ± 1.78
2.698GlyPhe: 2.698 ± 0.755
5.936GlyGly: 5.936 ± 0.653
2.698GlyHis: 2.698 ± 0.794
2.159GlyIle: 2.159 ± 1.024
2.159GlyLys: 2.159 ± 0.733
4.857GlyLeu: 4.857 ± 1.133
2.698GlyMet: 2.698 ± 1.149
2.159GlyAsn: 2.159 ± 0.696
4.317GlyPro: 4.317 ± 1.825
1.619GlyGln: 1.619 ± 1.513
0.54GlyArg: 0.54 ± 0.361
2.698GlySer: 2.698 ± 0.866
7.016GlyThr: 7.016 ± 1.425
6.476GlyVal: 6.476 ± 1.732
0.0GlyTrp: 0.0 ± 0.0
0.54GlyTyr: 0.54 ± 0.427
0.0GlyXaa: 0.0 ± 0.0
His
0.54HisAla: 0.54 ± 0.361
1.619HisCys: 1.619 ± 1.247
1.079HisAsp: 1.079 ± 0.489
1.619HisGlu: 1.619 ± 1.083
1.079HisPhe: 1.079 ± 0.489
2.159HisGly: 2.159 ± 1.444
0.54HisHis: 0.54 ± 0.361
1.079HisIle: 1.079 ± 0.489
1.079HisLys: 1.079 ± 0.564
0.54HisLeu: 0.54 ± 0.504
0.54HisMet: 0.54 ± 0.361
0.54HisAsn: 0.54 ± 0.361
1.079HisPro: 1.079 ± 0.647
1.619HisGln: 1.619 ± 0.822
1.619HisArg: 1.619 ± 0.822
2.698HisSer: 2.698 ± 0.925
0.0HisThr: 0.0 ± 0.0
0.0HisVal: 0.0 ± 0.0
1.079HisTrp: 1.079 ± 0.716
1.619HisTyr: 1.619 ± 0.54
0.0HisXaa: 0.0 ± 0.0
Ile
3.238IleAla: 3.238 ± 2.159
1.619IleCys: 1.619 ± 1.083
3.238IleAsp: 3.238 ± 0.819
1.619IleGlu: 1.619 ± 1.002
2.159IlePhe: 2.159 ± 0.733
1.079IleGly: 1.079 ± 0.564
2.698IleHis: 2.698 ± 0.794
0.0IleIle: 0.0 ± 0.0
0.0IleLys: 0.0 ± 0.0
4.317IleLeu: 4.317 ± 0.865
0.0IleMet: 0.0 ± 0.0
1.079IleAsn: 1.079 ± 0.489
2.159IlePro: 2.159 ± 0.696
2.698IleGln: 2.698 ± 1.216
0.54IleArg: 0.54 ± 0.504
6.476IleSer: 6.476 ± 1.483
2.159IleThr: 2.159 ± 1.128
2.698IleVal: 2.698 ± 0.794
0.54IleTrp: 0.54 ± 0.361
0.54IleTyr: 0.54 ± 0.361
0.0IleXaa: 0.0 ± 0.0
Lys
4.857LysAla: 4.857 ± 1.302
2.698LysCys: 2.698 ± 1.403
2.159LysAsp: 2.159 ± 0.979
4.857LysGlu: 4.857 ± 1.549
0.54LysPhe: 0.54 ± 0.651
4.317LysGly: 4.317 ± 1.505
1.079LysHis: 1.079 ± 0.722
0.0LysIle: 0.0 ± 0.0
10.254LysLys: 10.254 ± 2.846
4.317LysLeu: 4.317 ± 0.955
3.778LysMet: 3.778 ± 1.412
2.159LysAsn: 2.159 ± 1.409
1.079LysPro: 1.079 ± 0.489
1.079LysGln: 1.079 ± 0.722
7.016LysArg: 7.016 ± 1.352
2.159LysSer: 2.159 ± 0.996
4.857LysThr: 4.857 ± 1.306
4.857LysVal: 4.857 ± 1.637
0.54LysTrp: 0.54 ± 0.361
1.619LysTyr: 1.619 ± 0.926
0.0LysXaa: 0.0 ± 0.0
Leu
3.778LeuAla: 3.778 ± 1.8
2.159LeuCys: 2.159 ± 0.996
8.635LeuAsp: 8.635 ± 1.216
5.936LeuGlu: 5.936 ± 1.286
7.555LeuPhe: 7.555 ± 2.146
4.317LeuGly: 4.317 ± 1.551
2.698LeuHis: 2.698 ± 1.154
3.238LeuIle: 3.238 ± 1.057
4.857LeuLys: 4.857 ± 1.579
11.333LeuLeu: 11.333 ± 1.548
4.317LeuMet: 4.317 ± 1.71
3.238LeuAsn: 3.238 ± 1.22
5.397LeuPro: 5.397 ± 1.52
3.238LeuGln: 3.238 ± 0.675
3.778LeuArg: 3.778 ± 1.206
3.778LeuSer: 3.778 ± 0.902
5.397LeuThr: 5.397 ± 1.783
3.778LeuVal: 3.778 ± 1.189
0.0LeuTrp: 0.0 ± 0.0
4.857LeuTyr: 4.857 ± 1.323
0.0LeuXaa: 0.0 ± 0.0
Met
2.159MetAla: 2.159 ± 0.494
0.54MetCys: 0.54 ± 0.651
3.778MetAsp: 3.778 ± 1.437
2.698MetGlu: 2.698 ± 1.435
1.079MetPhe: 1.079 ± 0.489
2.159MetGly: 2.159 ± 0.588
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.619MetLys: 1.619 ± 0.822
3.238MetLeu: 3.238 ± 0.841
0.54MetMet: 0.54 ± 0.504
2.698MetAsn: 2.698 ± 0.896
0.54MetPro: 0.54 ± 0.361
0.0MetGln: 0.0 ± 0.0
1.619MetArg: 1.619 ± 0.611
0.0MetSer: 0.0 ± 0.0
1.079MetThr: 1.079 ± 0.722
2.159MetVal: 2.159 ± 0.983
0.54MetTrp: 0.54 ± 0.504
1.619MetTyr: 1.619 ± 0.697
0.0MetXaa: 0.0 ± 0.0
Asn
2.698AsnAla: 2.698 ± 0.372
1.079AsnCys: 1.079 ± 0.647
0.0AsnAsp: 0.0 ± 0.0
2.159AsnGlu: 2.159 ± 0.979
2.159AsnPhe: 2.159 ± 1.092
1.079AsnGly: 1.079 ± 1.009
1.079AsnHis: 1.079 ± 0.722
3.778AsnIle: 3.778 ± 0.423
3.238AsnLys: 3.238 ± 0.675
5.397AsnLeu: 5.397 ± 1.589
0.54AsnMet: 0.54 ± 0.361
1.619AsnAsn: 1.619 ± 0.54
3.238AsnPro: 3.238 ± 0.399
1.619AsnGln: 1.619 ± 0.54
3.238AsnArg: 3.238 ± 1.223
2.698AsnSer: 2.698 ± 1.327
2.698AsnThr: 2.698 ± 1.393
3.238AsnVal: 3.238 ± 0.675
0.0AsnTrp: 0.0 ± 0.0
2.159AsnTyr: 2.159 ± 0.494
0.0AsnXaa: 0.0 ± 0.0
Pro
3.778ProAla: 3.778 ± 2.393
1.079ProCys: 1.079 ± 0.724
4.317ProAsp: 4.317 ± 1.83
3.778ProGlu: 3.778 ± 0.867
0.0ProPhe: 0.0 ± 0.0
3.778ProGly: 3.778 ± 1.362
0.54ProHis: 0.54 ± 0.361
1.619ProIle: 1.619 ± 0.697
4.857ProLys: 4.857 ± 1.787
3.238ProLeu: 3.238 ± 0.841
0.54ProMet: 0.54 ± 0.504
4.857ProAsn: 4.857 ± 1.573
3.238ProPro: 3.238 ± 1.22
2.159ProGln: 2.159 ± 0.575
3.778ProArg: 3.778 ± 0.904
3.238ProSer: 3.238 ± 1.345
1.619ProThr: 1.619 ± 0.926
5.397ProVal: 5.397 ± 1.325
0.0ProTrp: 0.0 ± 0.0
1.619ProTyr: 1.619 ± 0.611
0.0ProXaa: 0.0 ± 0.0
Gln
3.238GlnAla: 3.238 ± 0.541
1.619GlnCys: 1.619 ± 1.083
0.0GlnAsp: 0.0 ± 0.0
3.778GlnGlu: 3.778 ± 1.167
0.54GlnPhe: 0.54 ± 0.361
2.698GlnGly: 2.698 ± 0.896
0.54GlnHis: 0.54 ± 0.361
1.619GlnIle: 1.619 ± 1.083
2.159GlnLys: 2.159 ± 0.575
3.238GlnLeu: 3.238 ± 1.495
0.54GlnMet: 0.54 ± 0.361
0.54GlnAsn: 0.54 ± 0.361
3.238GlnPro: 3.238 ± 0.774
2.698GlnGln: 2.698 ± 0.649
5.936GlnArg: 5.936 ± 3.389
3.778GlnSer: 3.778 ± 0.904
1.619GlnThr: 1.619 ± 0.88
4.317GlnVal: 4.317 ± 1.07
2.698GlnTrp: 2.698 ± 0.633
1.079GlnTyr: 1.079 ± 0.722
0.0GlnXaa: 0.0 ± 0.0
Arg
1.619ArgAla: 1.619 ± 1.174
0.0ArgCys: 0.0 ± 0.0
2.698ArgAsp: 2.698 ± 0.711
3.238ArgGlu: 3.238 ± 0.819
2.698ArgPhe: 2.698 ± 0.786
1.619ArgGly: 1.619 ± 1.513
3.238ArgHis: 3.238 ± 0.988
2.159ArgIle: 2.159 ± 0.733
5.936ArgLys: 5.936 ± 1.105
3.238ArgLeu: 3.238 ± 1.08
1.079ArgMet: 1.079 ± 0.647
1.079ArgAsn: 1.079 ± 0.724
2.698ArgPro: 2.698 ± 0.794
3.778ArgGln: 3.778 ± 1.562
4.317ArgArg: 4.317 ± 2.167
7.555ArgSer: 7.555 ± 3.443
3.778ArgThr: 3.778 ± 0.682
3.238ArgVal: 3.238 ± 1.468
0.0ArgTrp: 0.0 ± 0.0
2.159ArgTyr: 2.159 ± 1.409
0.0ArgXaa: 0.0 ± 0.0
Ser
4.857SerAla: 4.857 ± 0.685
0.54SerCys: 0.54 ± 0.361
3.238SerAsp: 3.238 ± 0.841
3.778SerGlu: 3.778 ± 1.36
3.238SerPhe: 3.238 ± 0.675
5.397SerGly: 5.397 ± 1.441
0.0SerHis: 0.0 ± 0.0
6.476SerIle: 6.476 ± 1.483
2.698SerLys: 2.698 ± 0.925
3.238SerLeu: 3.238 ± 0.555
3.778SerMet: 3.778 ± 1.145
1.619SerAsn: 1.619 ± 0.697
3.238SerPro: 3.238 ± 1.518
5.936SerGln: 5.936 ± 0.856
5.397SerArg: 5.397 ± 1.919
4.857SerSer: 4.857 ± 1.444
3.778SerThr: 3.778 ± 1.169
4.857SerVal: 4.857 ± 1.122
1.079SerTrp: 1.079 ± 0.722
2.159SerTyr: 2.159 ± 1.432
0.0SerXaa: 0.0 ± 0.0
Thr
0.54ThrAla: 0.54 ± 0.504
0.54ThrCys: 0.54 ± 0.504
1.079ThrAsp: 1.079 ± 0.489
2.698ThrGlu: 2.698 ± 1.902
3.238ThrPhe: 3.238 ± 1.669
4.317ThrGly: 4.317 ± 1.155
0.54ThrHis: 0.54 ± 0.504
2.159ThrIle: 2.159 ± 0.992
3.778ThrLys: 3.778 ± 1.375
3.238ThrLeu: 3.238 ± 1.015
1.619ThrMet: 1.619 ± 0.762
1.619ThrAsn: 1.619 ± 1.064
5.936ThrPro: 5.936 ± 0.795
5.936ThrGln: 5.936 ± 1.929
1.619ThrArg: 1.619 ± 0.926
4.317ThrSer: 4.317 ± 1.984
2.698ThrThr: 2.698 ± 0.372
5.936ThrVal: 5.936 ± 1.565
2.698ThrTrp: 2.698 ± 1.123
2.698ThrTyr: 2.698 ± 1.174
0.0ThrXaa: 0.0 ± 0.0
Val
6.476ValAla: 6.476 ± 1.28
0.54ValCys: 0.54 ± 0.504
4.317ValAsp: 4.317 ± 1.781
5.936ValGlu: 5.936 ± 1.458
2.698ValPhe: 2.698 ± 1.326
3.238ValGly: 3.238 ± 0.728
1.079ValHis: 1.079 ± 0.724
1.619ValIle: 1.619 ± 0.449
3.238ValLys: 3.238 ± 0.882
5.397ValLeu: 5.397 ± 1.671
1.619ValMet: 1.619 ± 0.611
4.857ValAsn: 4.857 ± 1.619
2.698ValPro: 2.698 ± 1.393
4.317ValGln: 4.317 ± 1.753
4.857ValArg: 4.857 ± 1.588
3.238ValSer: 3.238 ± 1.122
5.397ValThr: 5.397 ± 0.946
1.079ValVal: 1.079 ± 0.722
0.54ValTrp: 0.54 ± 0.651
0.54ValTyr: 0.54 ± 0.361
0.0ValXaa: 0.0 ± 0.0
Trp
1.079TrpAla: 1.079 ± 0.716
0.0TrpCys: 0.0 ± 0.0
1.079TrpAsp: 1.079 ± 0.459
1.619TrpGlu: 1.619 ± 0.611
1.079TrpPhe: 1.079 ± 0.647
2.159TrpGly: 2.159 ± 0.776
0.0TrpHis: 0.0 ± 0.0
1.079TrpIle: 1.079 ± 0.647
1.079TrpLys: 1.079 ± 0.722
0.54TrpLeu: 0.54 ± 0.361
1.079TrpMet: 1.079 ± 0.716
2.698TrpAsn: 2.698 ± 0.711
0.54TrpPro: 0.54 ± 0.651
0.0TrpGln: 0.0 ± 0.0
0.54TrpArg: 0.54 ± 0.504
0.54TrpSer: 0.54 ± 0.705
0.0TrpThr: 0.0 ± 0.0
0.54TrpVal: 0.54 ± 0.504
0.54TrpTrp: 0.54 ± 0.361
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.619TyrAla: 1.619 ± 0.707
1.619TyrCys: 1.619 ± 1.247
1.619TyrAsp: 1.619 ± 0.54
1.079TyrGlu: 1.079 ± 0.716
1.079TyrPhe: 1.079 ± 1.009
2.698TyrGly: 2.698 ± 0.84
0.0TyrHis: 0.0 ± 0.0
2.159TyrIle: 2.159 ± 1.432
2.698TyrLys: 2.698 ± 0.711
5.936TyrLeu: 5.936 ± 1.176
0.54TyrMet: 0.54 ± 0.361
1.619TyrAsn: 1.619 ± 0.54
1.619TyrPro: 1.619 ± 1.513
0.0TyrGln: 0.0 ± 0.0
1.619TyrArg: 1.619 ± 0.757
3.778TyrSer: 3.778 ± 0.724
2.159TyrThr: 2.159 ± 0.575
0.54TyrVal: 0.54 ± 0.504
0.54TyrTrp: 0.54 ± 0.361
2.698TyrTyr: 2.698 ± 1.216
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1854 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski