Amino acid dipepetide frequency for Rhodopirellula solitaria

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.898AlaAla: 12.898 ± 0.134	1.214AlaCys: 1.214 ± 0.03	6.844AlaAsp: 6.844 ± 0.076	6.832AlaGlu: 6.832 ± 0.07	3.195AlaPhe: 3.195 ± 0.044	8.336AlaGly: 8.336 ± 0.082	1.676AlaHis: 1.676 ± 0.03	5.876AlaIle: 5.876 ± 0.058	3.575AlaLys: 3.575 ± 0.061	7.676AlaLeu: 7.676 ± 0.08	2.804AlaMet: 2.804 ± 0.041	2.98AlaAsn: 2.98 ± 0.045	4.227AlaPro: 4.227 ± 0.058	3.246AlaGln: 3.246 ± 0.049	5.64AlaArg: 5.64 ± 0.058	7.11AlaSer: 7.11 ± 0.082	6.125AlaThr: 6.125 ± 0.063	7.243AlaVal: 7.243 ± 0.059	1.422AlaTrp: 1.422 ± 0.034	1.975AlaTyr: 1.975 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.775CysAla: 0.775 ± 0.02	0.263CysCys: 0.263 ± 0.014	0.769CysAsp: 0.769 ± 0.025	0.753CysGlu: 0.753 ± 0.02	0.458CysPhe: 0.458 ± 0.015	1.087CysGly: 1.087 ± 0.033	0.452CysHis: 0.452 ± 0.018	0.447CysIle: 0.447 ± 0.016	0.279CysLys: 0.279 ± 0.014	1.159CysLeu: 1.159 ± 0.027	0.207CysMet: 0.207 ± 0.01	0.284CysAsn: 0.284 ± 0.013	0.592CysPro: 0.592 ± 0.018	0.508CysGln: 0.508 ± 0.018	0.88CysArg: 0.88 ± 0.025	0.754CysSer: 0.754 ± 0.021	0.506CysThr: 0.506 ± 0.016	0.929CysVal: 0.929 ± 0.026	0.169CysTrp: 0.169 ± 0.009	0.312CysTyr: 0.312 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.165AspAla: 7.165 ± 0.084	0.691AspCys: 0.691 ± 0.019	4.554AspAsp: 4.554 ± 0.071	4.781AspGlu: 4.781 ± 0.061	2.327AspPhe: 2.327 ± 0.038	5.509AspGly: 5.509 ± 0.087	1.544AspHis: 1.544 ± 0.029	2.465AspIle: 2.465 ± 0.039	1.485AspLys: 1.485 ± 0.03	5.885AspLeu: 5.885 ± 0.062	1.035AspMet: 1.035 ± 0.019	1.667AspAsn: 1.667 ± 0.042	3.925AspPro: 3.925 ± 0.053	2.841AspGln: 2.841 ± 0.045	4.773AspArg: 4.773 ± 0.061	4.223AspSer: 4.223 ± 0.061	2.94AspThr: 2.94 ± 0.052	4.496AspVal: 4.496 ± 0.057	1.115AspTrp: 1.115 ± 0.027	1.61AspTyr: 1.61 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.645GluAla: 5.645 ± 0.063	0.497GluCys: 0.497 ± 0.017	3.034GluAsp: 3.034 ± 0.049	3.213GluGlu: 3.213 ± 0.067	2.225GluPhe: 2.225 ± 0.034	3.69GluGly: 3.69 ± 0.052	1.505GluHis: 1.505 ± 0.03	3.591GluIle: 3.591 ± 0.046	2.353GluLys: 2.353 ± 0.04	6.618GluLeu: 6.618 ± 0.072	1.667GluMet: 1.667 ± 0.031	2.133GluAsn: 2.133 ± 0.036	3.032GluPro: 3.032 ± 0.046	3.118GluGln: 3.118 ± 0.045	4.122GluArg: 4.122 ± 0.049	4.715GluSer: 4.715 ± 0.057	3.833GluThr: 3.833 ± 0.05	4.077GluVal: 4.077 ± 0.057	0.633GluTrp: 0.633 ± 0.018	1.307GluTyr: 1.307 ± 0.03	0.001GluXaa: 0.001 ± 0.0
Phe	3.76PheAla: 3.76 ± 0.048	0.482PheCys: 0.482 ± 0.018	2.797PheAsp: 2.797 ± 0.045	2.148PheGlu: 2.148 ± 0.04	1.399PhePhe: 1.399 ± 0.03	2.971PheGly: 2.971 ± 0.04	0.838PheHis: 0.838 ± 0.021	1.353PheIle: 1.353 ± 0.029	0.765PheLys: 0.765 ± 0.023	3.249PheLeu: 3.249 ± 0.044	0.61PheMet: 0.61 ± 0.016	1.042PheAsn: 1.042 ± 0.029	1.564PhePro: 1.564 ± 0.029	1.357PheGln: 1.357 ± 0.028	2.338PheArg: 2.338 ± 0.037	2.44PheSer: 2.44 ± 0.04	1.985PheThr: 1.985 ± 0.04	2.624PheVal: 2.624 ± 0.041	0.542PheTrp: 0.542 ± 0.02	0.928PheTyr: 0.928 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	5.869GlyAla: 5.869 ± 0.068	1.081GlyCys: 1.081 ± 0.028	5.129GlyAsp: 5.129 ± 0.076	4.884GlyGlu: 4.884 ± 0.055	2.871GlyPhe: 2.871 ± 0.042	6.966GlyGly: 6.966 ± 0.132	1.647GlyHis: 1.647 ± 0.036	3.86GlyIle: 3.86 ± 0.049	3.169GlyLys: 3.169 ± 0.049	6.861GlyLeu: 6.861 ± 0.071	1.993GlyMet: 1.993 ± 0.038	2.682GlyAsn: 2.682 ± 0.06	3.163GlyPro: 3.163 ± 0.048	3.023GlyGln: 3.023 ± 0.043	5.199GlyArg: 5.199 ± 0.068	5.381GlySer: 5.381 ± 0.071	4.353GlyThr: 4.353 ± 0.077	5.588GlyVal: 5.588 ± 0.059	1.321GlyTrp: 1.321 ± 0.027	2.157GlyTyr: 2.157 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.23HisAla: 2.23 ± 0.032	0.349HisCys: 0.349 ± 0.013	1.429HisAsp: 1.429 ± 0.032	1.302HisGlu: 1.302 ± 0.026	0.956HisPhe: 0.956 ± 0.026	1.822HisGly: 1.822 ± 0.037	0.705HisHis: 0.705 ± 0.022	0.765HisIle: 0.765 ± 0.021	0.443HisLys: 0.443 ± 0.016	2.166HisLeu: 2.166 ± 0.037	0.338HisMet: 0.338 ± 0.013	0.578HisAsn: 0.578 ± 0.018	1.463HisPro: 1.463 ± 0.028	0.974HisGln: 0.974 ± 0.02	1.833HisArg: 1.833 ± 0.036	1.413HisSer: 1.413 ± 0.028	0.985HisThr: 0.985 ± 0.024	1.539HisVal: 1.539 ± 0.031	0.467HisTrp: 0.467 ± 0.016	0.618HisTyr: 0.618 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.227IleAla: 6.227 ± 0.053	0.59IleCys: 0.59 ± 0.019	4.313IleAsp: 4.313 ± 0.057	3.954IleGlu: 3.954 ± 0.052	1.348IlePhe: 1.348 ± 0.028	4.263IleGly: 4.263 ± 0.057	1.112IleHis: 1.112 ± 0.028	1.767IleIle: 1.767 ± 0.037	1.205IleLys: 1.205 ± 0.026	3.855IleLeu: 3.855 ± 0.056	0.719IleMet: 0.719 ± 0.022	1.465IleAsn: 1.465 ± 0.032	2.411IlePro: 2.411 ± 0.039	1.707IleGln: 1.707 ± 0.029	3.393IleArg: 3.393 ± 0.048	3.115IleSer: 3.115 ± 0.042	2.602IleThr: 2.602 ± 0.045	3.888IleVal: 3.888 ± 0.048	0.59IleTrp: 0.59 ± 0.017	1.078IleTyr: 1.078 ± 0.023	0.001IleXaa: 0.001 ± 0.001
Lys	2.592LysAla: 2.592 ± 0.048	0.288LysCys: 0.288 ± 0.011	1.457LysAsp: 1.457 ± 0.029	1.546LysGlu: 1.546 ± 0.034	1.053LysPhe: 1.053 ± 0.025	1.723LysGly: 1.723 ± 0.034	0.712LysHis: 0.712 ± 0.021	1.766LysIle: 1.766 ± 0.038	1.52LysLys: 1.52 ± 0.048	3.285LysLeu: 3.285 ± 0.058	0.788LysMet: 0.788 ± 0.022	1.002LysAsn: 1.002 ± 0.025	1.892LysPro: 1.892 ± 0.034	1.437LysGln: 1.437 ± 0.031	2.356LysArg: 2.356 ± 0.037	2.215LysSer: 2.215 ± 0.041	2.006LysThr: 2.006 ± 0.039	1.981LysVal: 1.981 ± 0.032	0.488LysTrp: 0.488 ± 0.016	0.752LysTyr: 0.752 ± 0.02	0.001LysXaa: 0.001 ± 0.0
Leu	10.656LeuAla: 10.656 ± 0.094	1.124LeuCys: 1.124 ± 0.028	6.06LeuAsp: 6.06 ± 0.061	5.113LeuGlu: 5.113 ± 0.06	3.145LeuPhe: 3.145 ± 0.048	6.821LeuGly: 6.821 ± 0.067	2.011LeuHis: 2.011 ± 0.038	4.713LeuIle: 4.713 ± 0.059	2.882LeuLys: 2.882 ± 0.045	9.28LeuLeu: 9.28 ± 0.098	2.005LeuMet: 2.005 ± 0.033	2.632LeuAsn: 2.632 ± 0.043	5.599LeuPro: 5.599 ± 0.066	3.771LeuGln: 3.771 ± 0.048	6.561LeuArg: 6.561 ± 0.076	6.685LeuSer: 6.685 ± 0.065	5.444LeuThr: 5.444 ± 0.058	6.851LeuVal: 6.851 ± 0.078	1.188LeuTrp: 1.188 ± 0.031	1.941LeuTyr: 1.941 ± 0.036	0.001LeuXaa: 0.001 ± 0.001
Met	2.149MetAla: 2.149 ± 0.037	0.195MetCys: 0.195 ± 0.011	1.092MetAsp: 1.092 ± 0.029	1.013MetGlu: 1.013 ± 0.024	0.708MetPhe: 0.708 ± 0.021	1.558MetGly: 1.558 ± 0.04	0.504MetHis: 0.504 ± 0.017	1.287MetIle: 1.287 ± 0.026	0.911MetLys: 0.911 ± 0.025	2.378MetLeu: 2.378 ± 0.042	0.597MetMet: 0.597 ± 0.022	0.854MetAsn: 0.854 ± 0.021	1.444MetPro: 1.444 ± 0.031	1.031MetGln: 1.031 ± 0.026	1.527MetArg: 1.527 ± 0.03	1.625MetSer: 1.625 ± 0.036	1.56MetThr: 1.56 ± 0.033	1.502MetVal: 1.502 ± 0.029	0.245MetTrp: 0.245 ± 0.013	0.332MetTyr: 0.332 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.908AsnAla: 2.908 ± 0.049	0.322AsnCys: 0.322 ± 0.013	1.923AsnAsp: 1.923 ± 0.047	1.855AsnGlu: 1.855 ± 0.031	1.056AsnPhe: 1.056 ± 0.026	2.438AsnGly: 2.438 ± 0.057	0.744AsnHis: 0.744 ± 0.022	1.226AsnIle: 1.226 ± 0.027	0.671AsnLys: 0.671 ± 0.019	2.773AsnLeu: 2.773 ± 0.036	0.539AsnMet: 0.539 ± 0.02	0.969AsnAsn: 0.969 ± 0.036	2.019AsnPro: 2.019 ± 0.042	1.36AsnGln: 1.36 ± 0.027	2.383AsnArg: 2.383 ± 0.04	1.909AsnSer: 1.909 ± 0.041	1.564AsnThr: 1.564 ± 0.037	2.129AsnVal: 2.129 ± 0.039	0.491AsnTrp: 0.491 ± 0.019	0.808AsnTyr: 0.808 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.833ProAla: 5.833 ± 0.069	0.44ProCys: 0.44 ± 0.016	3.63ProAsp: 3.63 ± 0.051	3.781ProGlu: 3.781 ± 0.051	1.733ProPhe: 1.733 ± 0.033	4.028ProGly: 4.028 ± 0.051	1.153ProHis: 1.153 ± 0.029	2.66ProIle: 2.66 ± 0.037	1.583ProLys: 1.583 ± 0.033	4.676ProLeu: 4.676 ± 0.051	1.224ProMet: 1.224 ± 0.028	1.768ProAsn: 1.768 ± 0.033	3.295ProPro: 3.295 ± 0.051	1.999ProGln: 1.999 ± 0.034	2.984ProArg: 2.984 ± 0.04	4.07ProSer: 4.07 ± 0.048	3.3ProThr: 3.3 ± 0.047	3.812ProVal: 3.812 ± 0.052	0.747ProTrp: 0.747 ± 0.022	1.096ProTyr: 1.096 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.929GlnAla: 3.929 ± 0.046	0.466GlnCys: 0.466 ± 0.015	1.873GlnAsp: 1.873 ± 0.031	1.823GlnGlu: 1.823 ± 0.036	1.546GlnPhe: 1.546 ± 0.026	2.43GlnGly: 2.43 ± 0.038	0.982GlnHis: 0.982 ± 0.023	2.172GlnIle: 2.172 ± 0.034	1.209GlnLys: 1.209 ± 0.028	4.131GlnLeu: 4.131 ± 0.056	0.933GlnMet: 0.933 ± 0.024	1.183GlnAsn: 1.183 ± 0.026	2.442GlnPro: 2.442 ± 0.038	2.093GlnGln: 2.093 ± 0.047	3.337GlnArg: 3.337 ± 0.044	3.335GlnSer: 3.335 ± 0.045	2.499GlnThr: 2.499 ± 0.042	2.625GlnVal: 2.625 ± 0.045	0.834GlnTrp: 0.834 ± 0.024	1.019GlnTyr: 1.019 ± 0.027	0.001GlnXaa: 0.001 ± 0.001
Arg	5.233ArgAla: 5.233 ± 0.055	0.915ArgCys: 0.915 ± 0.022	4.331ArgAsp: 4.331 ± 0.057	4.198ArgGlu: 4.198 ± 0.057	2.914ArgPhe: 2.914 ± 0.042	4.643ArgGly: 4.643 ± 0.051	1.536ArgHis: 1.536 ± 0.033	3.666ArgIle: 3.666 ± 0.044	2.15ArgLys: 2.15 ± 0.039	7.11ArgLeu: 7.11 ± 0.068	1.797ArgMet: 1.797 ± 0.033	2.021ArgAsn: 2.021 ± 0.035	3.415ArgPro: 3.415 ± 0.052	3.029ArgGln: 3.029 ± 0.045	5.733ArgArg: 5.733 ± 0.075	4.836ArgSer: 4.836 ± 0.067	3.322ArgThr: 3.322 ± 0.056	4.932ArgVal: 4.932 ± 0.054	1.312ArgTrp: 1.312 ± 0.027	1.95ArgTyr: 1.95 ± 0.04	0.001ArgXaa: 0.001 ± 0.001
Ser	6.262SerAla: 6.262 ± 0.069	0.689SerCys: 0.689 ± 0.023	4.768SerAsp: 4.768 ± 0.059	4.296SerGlu: 4.296 ± 0.052	2.257SerPhe: 2.257 ± 0.037	6.205SerGly: 6.205 ± 0.084	1.476SerHis: 1.476 ± 0.028	3.532SerIle: 3.532 ± 0.042	2.029SerLys: 2.029 ± 0.036	6.842SerLeu: 6.842 ± 0.074	1.667SerMet: 1.667 ± 0.031	2.024SerAsn: 2.024 ± 0.037	4.126SerPro: 4.126 ± 0.05	2.844SerGln: 2.844 ± 0.041	4.657SerArg: 4.657 ± 0.059	4.984SerSer: 4.984 ± 0.084	3.824SerThr: 3.824 ± 0.052	4.91SerVal: 4.91 ± 0.055	0.938SerTrp: 0.938 ± 0.023	1.456SerTyr: 1.456 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.823ThrAla: 5.823 ± 0.064	0.517ThrCys: 0.517 ± 0.016	3.633ThrAsp: 3.633 ± 0.05	3.054ThrGlu: 3.054 ± 0.042	1.94ThrPhe: 1.94 ± 0.039	4.602ThrGly: 4.602 ± 0.064	1.214ThrHis: 1.214 ± 0.029	3.077ThrIle: 3.077 ± 0.054	1.616ThrLys: 1.616 ± 0.032	5.728ThrLeu: 5.728 ± 0.056	1.165ThrMet: 1.165 ± 0.029	1.595ThrAsn: 1.595 ± 0.034	3.733ThrPro: 3.733 ± 0.04	2.082ThrGln: 2.082 ± 0.033	3.43ThrArg: 3.43 ± 0.046	3.792ThrSer: 3.792 ± 0.049	3.361ThrThr: 3.361 ± 0.054	3.956ThrVal: 3.956 ± 0.059	0.777ThrTrp: 0.777 ± 0.022	1.31ThrTyr: 1.31 ± 0.033	0.001ThrXaa: 0.001 ± 0.0
Val	7.697ValAla: 7.697 ± 0.078	0.913ValCys: 0.913 ± 0.026	5.002ValAsp: 5.002 ± 0.06	4.359ValGlu: 4.359 ± 0.048	2.444ValPhe: 2.444 ± 0.038	5.328ValGly: 5.328 ± 0.062	1.494ValHis: 1.494 ± 0.028	3.687ValIle: 3.687 ± 0.053	1.918ValLys: 1.918 ± 0.034	6.721ValLeu: 6.721 ± 0.068	1.588ValMet: 1.588 ± 0.033	1.998ValAsn: 1.998 ± 0.038	3.552ValPro: 3.552 ± 0.053	2.465ValGln: 2.465 ± 0.033	4.758ValArg: 4.758 ± 0.06	4.854ValSer: 4.854 ± 0.051	4.162ValThr: 4.162 ± 0.063	5.49ValVal: 5.49 ± 0.065	0.983ValTrp: 0.983 ± 0.027	1.586ValTyr: 1.586 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.129TrpAla: 1.129 ± 0.026	0.208TrpCys: 0.208 ± 0.011	0.814TrpAsp: 0.814 ± 0.02	0.625TrpGlu: 0.625 ± 0.019	0.6TrpPhe: 0.6 ± 0.02	0.901TrpGly: 0.901 ± 0.023	0.414TrpHis: 0.414 ± 0.016	0.899TrpIle: 0.899 ± 0.023	0.599TrpLys: 0.599 ± 0.017	1.68TrpLeu: 1.68 ± 0.036	0.465TrpMet: 0.465 ± 0.016	0.544TrpAsn: 0.544 ± 0.021	0.718TrpPro: 0.718 ± 0.021	0.846TrpGln: 0.846 ± 0.023	1.05TrpArg: 1.05 ± 0.025	1.011TrpSer: 1.011 ± 0.027	0.882TrpThr: 0.882 ± 0.025	0.937TrpVal: 0.937 ± 0.024	0.285TrpTrp: 0.285 ± 0.012	0.357TrpTyr: 0.357 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.114TyrAla: 2.114 ± 0.034	0.34TyrCys: 0.34 ± 0.014	1.58TyrAsp: 1.58 ± 0.04	1.475TyrGlu: 1.475 ± 0.031	1.015TyrPhe: 1.015 ± 0.026	1.879TyrGly: 1.879 ± 0.035	0.656TyrHis: 0.656 ± 0.019	0.79TyrIle: 0.79 ± 0.021	0.499TyrLys: 0.499 ± 0.017	2.411TyrLeu: 2.411 ± 0.035	0.369TyrMet: 0.369 ± 0.012	0.664TyrAsn: 0.664 ± 0.02	1.202TyrPro: 1.202 ± 0.028	1.129TyrGln: 1.129 ± 0.025	2.088TyrArg: 2.088 ± 0.038	1.32TyrSer: 1.32 ± 0.032	1.153TyrThr: 1.153 ± 0.032	1.49TyrVal: 1.49 ± 0.026	0.417TyrTrp: 0.417 ± 0.014	0.71TyrTyr: 0.71 ± 0.024	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5210 proteins (1953092 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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