Amino acid dipepetide frequency for Bernardetia litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4) (Flexibacter litoralis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.884AlaAla: 3.884 ± 0.081	0.508AlaCys: 0.508 ± 0.019	3.069AlaAsp: 3.069 ± 0.048	3.801AlaGlu: 3.801 ± 0.059	3.315AlaPhe: 3.315 ± 0.056	3.66AlaGly: 3.66 ± 0.065	1.035AlaHis: 1.035 ± 0.029	4.834AlaIle: 4.834 ± 0.065	4.575AlaLys: 4.575 ± 0.071	5.396AlaLeu: 5.396 ± 0.08	1.298AlaMet: 1.298 ± 0.034	3.097AlaAsn: 3.097 ± 0.051	1.684AlaPro: 1.684 ± 0.042	2.696AlaGln: 2.696 ± 0.045	1.922AlaArg: 1.922 ± 0.043	3.59AlaSer: 3.59 ± 0.06	3.692AlaThr: 3.692 ± 0.078	3.263AlaVal: 3.263 ± 0.056	0.53AlaTrp: 0.53 ± 0.021	2.337AlaTyr: 2.337 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.466CysAla: 0.466 ± 0.017	0.101CysCys: 0.101 ± 0.009	0.411CysAsp: 0.411 ± 0.02	0.487CysGlu: 0.487 ± 0.023	0.483CysPhe: 0.483 ± 0.018	0.558CysGly: 0.558 ± 0.025	0.155CysHis: 0.155 ± 0.013	0.62CysIle: 0.62 ± 0.024	0.549CysLys: 0.549 ± 0.019	0.687CysLeu: 0.687 ± 0.019	0.137CysMet: 0.137 ± 0.009	0.41CysAsn: 0.41 ± 0.018	0.287CysPro: 0.287 ± 0.015	0.331CysGln: 0.331 ± 0.017	0.24CysArg: 0.24 ± 0.013	0.575CysSer: 0.575 ± 0.025	0.444CysThr: 0.444 ± 0.023	0.474CysVal: 0.474 ± 0.019	0.052CysTrp: 0.052 ± 0.007	0.26CysTyr: 0.26 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.183AspAla: 3.183 ± 0.052	0.461AspCys: 0.461 ± 0.02	2.59AspAsp: 2.59 ± 0.053	3.845AspGlu: 3.845 ± 0.06	3.725AspPhe: 3.725 ± 0.06	3.097AspGly: 3.097 ± 0.068	0.521AspHis: 0.521 ± 0.021	4.304AspIle: 4.304 ± 0.058	4.719AspLys: 4.719 ± 0.059	4.761AspLeu: 4.761 ± 0.068	1.09AspMet: 1.09 ± 0.031	3.083AspAsn: 3.083 ± 0.057	1.202AspPro: 1.202 ± 0.034	1.059AspGln: 1.059 ± 0.03	1.745AspArg: 1.745 ± 0.044	3.813AspSer: 3.813 ± 0.082	3.01AspThr: 3.01 ± 0.064	2.825AspVal: 2.825 ± 0.049	0.682AspTrp: 0.682 ± 0.027	2.607AspTyr: 2.607 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.106GluAla: 4.106 ± 0.062	0.364GluCys: 0.364 ± 0.018	3.598GluAsp: 3.598 ± 0.056	6.461GluGlu: 6.461 ± 0.108	3.313GluPhe: 3.313 ± 0.053	3.923GluGly: 3.923 ± 0.053	1.033GluHis: 1.033 ± 0.032	6.485GluIle: 6.485 ± 0.074	7.477GluLys: 7.477 ± 0.097	6.65GluLeu: 6.65 ± 0.091	1.733GluMet: 1.733 ± 0.041	5.85GluAsn: 5.85 ± 0.081	1.553GluPro: 1.553 ± 0.037	2.94GluGln: 2.94 ± 0.056	2.812GluArg: 2.812 ± 0.052	3.684GluSer: 3.684 ± 0.059	3.923GluThr: 3.923 ± 0.053	4.125GluVal: 4.125 ± 0.06	0.855GluTrp: 0.855 ± 0.031	2.803GluTyr: 2.803 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.228PheAla: 3.228 ± 0.052	0.632PheCys: 0.632 ± 0.025	3.271PheAsp: 3.271 ± 0.046	4.162PheGlu: 4.162 ± 0.065	3.35PhePhe: 3.35 ± 0.061	3.309PheGly: 3.309 ± 0.061	0.834PheHis: 0.834 ± 0.024	4.216PheIle: 4.216 ± 0.059	3.252PheLys: 3.252 ± 0.052	5.749PheLeu: 5.749 ± 0.084	1.149PheMet: 1.149 ± 0.032	2.63PheAsn: 2.63 ± 0.058	1.732PhePro: 1.732 ± 0.039	1.723PheGln: 1.723 ± 0.036	1.784PheArg: 1.784 ± 0.038	4.411PheSer: 4.411 ± 0.068	3.019PheThr: 3.019 ± 0.051	3.397PheVal: 3.397 ± 0.053	0.74PheTrp: 0.74 ± 0.029	2.63PheTyr: 2.63 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	3.499GlyAla: 3.499 ± 0.071	0.509GlyCys: 0.509 ± 0.022	2.783GlyAsp: 2.783 ± 0.062	3.499GlyGlu: 3.499 ± 0.054	3.282GlyPhe: 3.282 ± 0.054	3.951GlyGly: 3.951 ± 0.077	0.928GlyHis: 0.928 ± 0.029	5.048GlyIle: 5.048 ± 0.066	4.844GlyLys: 4.844 ± 0.07	4.834GlyLeu: 4.834 ± 0.073	1.485GlyMet: 1.485 ± 0.036	3.568GlyAsn: 3.568 ± 0.081	0.408GlyPro: 0.408 ± 0.022	1.868GlyGln: 1.868 ± 0.043	1.944GlyArg: 1.944 ± 0.044	3.383GlySer: 3.383 ± 0.061	3.751GlyThr: 3.751 ± 0.083	3.637GlyVal: 3.637 ± 0.052	0.615GlyTrp: 0.615 ± 0.022	2.366GlyTyr: 2.366 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	0.8HisAla: 0.8 ± 0.029	0.165HisCys: 0.165 ± 0.011	0.632HisAsp: 0.632 ± 0.021	0.903HisGlu: 0.903 ± 0.029	1.135HisPhe: 1.135 ± 0.031	0.822HisGly: 0.822 ± 0.026	0.452HisHis: 0.452 ± 0.021	1.281HisIle: 1.281 ± 0.03	1.195HisLys: 1.195 ± 0.032	1.715HisLeu: 1.715 ± 0.04	0.233HisMet: 0.233 ± 0.013	0.883HisAsn: 0.883 ± 0.026	0.692HisPro: 0.692 ± 0.022	0.784HisGln: 0.784 ± 0.024	0.633HisArg: 0.633 ± 0.025	1.17HisSer: 1.17 ± 0.029	1.018HisThr: 1.018 ± 0.028	0.761HisVal: 0.761 ± 0.026	0.184HisTrp: 0.184 ± 0.011	0.824HisTyr: 0.824 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.976IleAla: 4.976 ± 0.066	0.725IleCys: 0.725 ± 0.023	4.967IleAsp: 4.967 ± 0.069	6.411IleGlu: 6.411 ± 0.085	4.473IlePhe: 4.473 ± 0.061	4.728IleGly: 4.728 ± 0.063	1.3IleHis: 1.3 ± 0.032	6.404IleIle: 6.404 ± 0.082	5.862IleLys: 5.862 ± 0.076	7.753IleLeu: 7.753 ± 0.098	1.367IleMet: 1.367 ± 0.035	4.77IleAsn: 4.77 ± 0.059	3.156IlePro: 3.156 ± 0.046	3.02IleGln: 3.02 ± 0.044	2.724IleArg: 2.724 ± 0.052	5.921IleSer: 5.921 ± 0.074	4.926IleThr: 4.926 ± 0.082	4.304IleVal: 4.304 ± 0.061	0.862IleTrp: 0.862 ± 0.03	3.312IleTyr: 3.312 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.366LysAla: 4.366 ± 0.062	0.355LysCys: 0.355 ± 0.016	4.312LysAsp: 4.312 ± 0.07	7.521LysGlu: 7.521 ± 0.098	2.891LysPhe: 2.891 ± 0.05	4.31LysGly: 4.31 ± 0.063	1.283LysHis: 1.283 ± 0.033	7.396LysIle: 7.396 ± 0.091	7.939LysLys: 7.939 ± 0.106	6.627LysLeu: 6.627 ± 0.082	2.256LysMet: 2.256 ± 0.042	6.343LysAsn: 6.343 ± 0.08	2.192LysPro: 2.192 ± 0.051	3.198LysGln: 3.198 ± 0.057	2.91LysArg: 2.91 ± 0.054	4.448LysSer: 4.448 ± 0.077	4.994LysThr: 4.994 ± 0.064	4.348LysVal: 4.348 ± 0.068	0.896LysTrp: 0.896 ± 0.025	3.324LysTyr: 3.324 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.637LeuAla: 5.637 ± 0.079	0.723LeuCys: 0.723 ± 0.024	4.938LeuAsp: 4.938 ± 0.067	7.262LeuGlu: 7.262 ± 0.099	5.376LeuPhe: 5.376 ± 0.078	5.224LeuGly: 5.224 ± 0.071	1.62LeuHis: 1.62 ± 0.038	7.019LeuIle: 7.019 ± 0.088	7.215LeuLys: 7.215 ± 0.094	8.836LeuLeu: 8.836 ± 0.105	1.854LeuMet: 1.854 ± 0.041	5.323LeuAsn: 5.323 ± 0.075	3.638LeuPro: 3.638 ± 0.054	3.681LeuGln: 3.681 ± 0.065	3.4LeuArg: 3.4 ± 0.052	6.988LeuSer: 6.988 ± 0.077	4.913LeuThr: 4.913 ± 0.062	5.125LeuVal: 5.125 ± 0.066	0.855LeuTrp: 0.855 ± 0.027	3.266LeuTyr: 3.266 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.465MetAla: 1.465 ± 0.033	0.139MetCys: 0.139 ± 0.009	0.968MetAsp: 0.968 ± 0.028	1.293MetGlu: 1.293 ± 0.037	0.818MetPhe: 0.818 ± 0.033	1.243MetGly: 1.243 ± 0.034	0.338MetHis: 0.338 ± 0.017	1.551MetIle: 1.551 ± 0.037	2.042MetLys: 2.042 ± 0.043	1.829MetLeu: 1.829 ± 0.045	0.546MetMet: 0.546 ± 0.023	1.42MetAsn: 1.42 ± 0.034	0.813MetPro: 0.813 ± 0.026	0.918MetGln: 0.918 ± 0.022	0.973MetArg: 0.973 ± 0.027	1.41MetSer: 1.41 ± 0.036	1.155MetThr: 1.155 ± 0.031	1.03MetVal: 1.03 ± 0.028	0.174MetTrp: 0.174 ± 0.01	0.705MetTyr: 0.705 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.192AsnAla: 3.192 ± 0.056	0.469AsnCys: 0.469 ± 0.021	3.1AsnAsp: 3.1 ± 0.048	4.337AsnGlu: 4.337 ± 0.064	3.457AsnPhe: 3.457 ± 0.052	3.586AsnGly: 3.586 ± 0.074	1.056AsnHis: 1.056 ± 0.031	4.734AsnIle: 4.734 ± 0.068	4.861AsnLys: 4.861 ± 0.07	5.944AsnLeu: 5.944 ± 0.07	1.149AsnMet: 1.149 ± 0.034	3.93AsnAsn: 3.93 ± 0.062	2.853AsnPro: 2.853 ± 0.049	3.194AsnGln: 3.194 ± 0.064	2.139AsnArg: 2.139 ± 0.04	4.277AsnSer: 4.277 ± 0.06	3.836AsnThr: 3.836 ± 0.079	3.006AsnVal: 3.006 ± 0.062	0.801AsnTrp: 0.801 ± 0.026	3.196AsnTyr: 3.196 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	1.754ProAla: 1.754 ± 0.046	0.199ProCys: 0.199 ± 0.011	1.464ProAsp: 1.464 ± 0.038	1.913ProGlu: 1.913 ± 0.047	1.911ProPhe: 1.911 ± 0.039	0.714ProGly: 0.714 ± 0.029	0.597ProHis: 0.597 ± 0.022	2.817ProIle: 2.817 ± 0.05	2.663ProLys: 2.663 ± 0.051	2.915ProLeu: 2.915 ± 0.045	0.55ProMet: 0.55 ± 0.019	2.393ProAsn: 2.393 ± 0.042	0.866ProPro: 0.866 ± 0.031	1.289ProGln: 1.289 ± 0.027	0.932ProArg: 0.932 ± 0.029	2.244ProSer: 2.244 ± 0.052	2.361ProThr: 2.361 ± 0.061	1.885ProVal: 1.885 ± 0.036	0.216ProTrp: 0.216 ± 0.014	1.329ProTyr: 1.329 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.201GlnAla: 2.201 ± 0.044	0.157GlnCys: 0.157 ± 0.012	1.967GlnAsp: 1.967 ± 0.035	3.0GlnGlu: 3.0 ± 0.06	1.676GlnPhe: 1.676 ± 0.039	1.679GlnGly: 1.679 ± 0.039	0.58GlnHis: 0.58 ± 0.023	3.499GlnIle: 3.499 ± 0.052	4.24GlnLys: 4.24 ± 0.079	3.327GlnLeu: 3.327 ± 0.058	0.814GlnMet: 0.814 ± 0.025	3.611GlnAsn: 3.611 ± 0.063	1.035GlnPro: 1.035 ± 0.03	1.579GlnGln: 1.579 ± 0.045	1.438GlnArg: 1.438 ± 0.038	2.187GlnSer: 2.187 ± 0.042	2.733GlnThr: 2.733 ± 0.049	2.009GlnVal: 2.009 ± 0.037	0.31GlnTrp: 0.31 ± 0.016	1.162GlnTyr: 1.162 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	1.881ArgAla: 1.881 ± 0.041	0.201ArgCys: 0.201 ± 0.013	1.582ArgAsp: 1.582 ± 0.04	2.411ArgGlu: 2.411 ± 0.048	2.058ArgPhe: 2.058 ± 0.038	1.843ArgGly: 1.843 ± 0.04	0.546ArgHis: 0.546 ± 0.022	3.05ArgIle: 3.05 ± 0.04	3.069ArgLys: 3.069 ± 0.054	3.326ArgLeu: 3.326 ± 0.054	0.867ArgMet: 0.867 ± 0.027	2.259ArgAsn: 2.259 ± 0.046	1.056ArgPro: 1.056 ± 0.025	1.414ArgGln: 1.414 ± 0.034	1.423ArgArg: 1.423 ± 0.043	1.928ArgSer: 1.928 ± 0.033	2.042ArgThr: 2.042 ± 0.038	2.04ArgVal: 2.04 ± 0.039	0.373ArgTrp: 0.373 ± 0.015	1.6ArgTyr: 1.6 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.551SerAla: 3.551 ± 0.059	0.705SerCys: 0.705 ± 0.026	3.543SerAsp: 3.543 ± 0.048	4.545SerGlu: 4.545 ± 0.067	4.148SerPhe: 4.148 ± 0.058	3.439SerGly: 3.439 ± 0.062	1.087SerHis: 1.087 ± 0.033	5.664SerIle: 5.664 ± 0.079	5.098SerLys: 5.098 ± 0.068	6.538SerLeu: 6.538 ± 0.075	1.232SerMet: 1.232 ± 0.033	3.942SerAsn: 3.942 ± 0.064	2.142SerPro: 2.142 ± 0.044	2.559SerGln: 2.559 ± 0.05	1.983SerArg: 1.983 ± 0.04	4.927SerSer: 4.927 ± 0.094	3.889SerThr: 3.889 ± 0.077	3.86SerVal: 3.86 ± 0.064	0.702SerTrp: 0.702 ± 0.025	2.97SerTyr: 2.97 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.589ThrAla: 3.589 ± 0.08	0.332ThrCys: 0.332 ± 0.018	3.47ThrAsp: 3.47 ± 0.072	4.252ThrGlu: 4.252 ± 0.056	3.2ThrPhe: 3.2 ± 0.051	3.776ThrGly: 3.776 ± 0.082	1.057ThrHis: 1.057 ± 0.029	4.843ThrIle: 4.843 ± 0.076	4.19ThrLys: 4.19 ± 0.057	5.628ThrLeu: 5.628 ± 0.085	0.926ThrMet: 0.926 ± 0.029	3.651ThrAsn: 3.651 ± 0.076	2.348ThrPro: 2.348 ± 0.049	2.613ThrGln: 2.613 ± 0.053	1.746ThrArg: 1.746 ± 0.037	3.87ThrSer: 3.87 ± 0.071	4.052ThrThr: 4.052 ± 0.1	3.484ThrVal: 3.484 ± 0.085	0.574ThrTrp: 0.574 ± 0.022	2.342ThrTyr: 2.342 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	3.63ValAla: 3.63 ± 0.061	0.543ValCys: 0.543 ± 0.022	2.775ValAsp: 2.775 ± 0.052	4.188ValGlu: 4.188 ± 0.056	3.263ValPhe: 3.263 ± 0.053	3.524ValGly: 3.524 ± 0.061	0.843ValHis: 0.843 ± 0.025	4.366ValIle: 4.366 ± 0.056	3.833ValLys: 3.833 ± 0.064	5.296ValLeu: 5.296 ± 0.076	1.256ValMet: 1.256 ± 0.036	2.768ValAsn: 2.768 ± 0.055	1.845ValPro: 1.845 ± 0.04	1.818ValGln: 1.818 ± 0.041	2.169ValArg: 2.169 ± 0.044	4.052ValSer: 4.052 ± 0.059	3.131ValThr: 3.131 ± 0.082	3.575ValVal: 3.575 ± 0.057	0.647ValTrp: 0.647 ± 0.023	2.179ValTyr: 2.179 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.565TrpAla: 0.565 ± 0.019	0.096TrpCys: 0.096 ± 0.01	0.497TrpAsp: 0.497 ± 0.02	0.724TrpGlu: 0.724 ± 0.024	0.591TrpPhe: 0.591 ± 0.022	0.576TrpGly: 0.576 ± 0.021	0.194TrpHis: 0.194 ± 0.011	0.991TrpIle: 0.991 ± 0.031	1.025TrpLys: 1.025 ± 0.03	1.05TrpLeu: 1.05 ± 0.027	0.189TrpMet: 0.189 ± 0.013	0.751TrpAsn: 0.751 ± 0.038	0.063TrpPro: 0.063 ± 0.008	0.56TrpGln: 0.56 ± 0.023	0.423TrpArg: 0.423 ± 0.016	0.593TrpSer: 0.593 ± 0.022	0.655TrpThr: 0.655 ± 0.026	0.64TrpVal: 0.64 ± 0.025	0.158TrpTrp: 0.158 ± 0.012	0.381TrpTyr: 0.381 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.211TyrAla: 2.211 ± 0.037	0.346TyrCys: 0.346 ± 0.017	2.384TyrAsp: 2.384 ± 0.051	2.674TyrGlu: 2.674 ± 0.057	2.752TyrPhe: 2.752 ± 0.058	2.241TyrGly: 2.241 ± 0.042	0.823TyrHis: 0.823 ± 0.026	2.843TyrIle: 2.843 ± 0.048	3.261TyrLys: 3.261 ± 0.053	4.03TyrLeu: 4.03 ± 0.059	0.699TyrMet: 0.699 ± 0.026	2.435TyrAsn: 2.435 ± 0.044	1.446TyrPro: 1.446 ± 0.032	1.959TyrGln: 1.959 ± 0.04	1.628TyrArg: 1.628 ± 0.041	3.054TyrSer: 3.054 ± 0.056	2.397TyrThr: 2.397 ± 0.053	1.913TyrVal: 1.913 ± 0.034	0.496TyrTrp: 0.496 ± 0.02	1.999TyrTyr: 1.999 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3832 proteins (1339793 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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