Amino acid dipepetide frequency for Spirosoma radiotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.887AlaAla: 6.887 ± 0.078	0.703AlaCys: 0.703 ± 0.021	5.202AlaAsp: 5.202 ± 0.063	4.53AlaGlu: 4.53 ± 0.059	3.682AlaPhe: 3.682 ± 0.045	6.586AlaGly: 6.586 ± 0.072	1.448AlaHis: 1.448 ± 0.029	5.179AlaIle: 5.179 ± 0.061	4.168AlaLys: 4.168 ± 0.056	8.383AlaLeu: 8.383 ± 0.079	1.939AlaMet: 1.939 ± 0.038	3.906AlaAsn: 3.906 ± 0.045	3.249AlaPro: 3.249 ± 0.052	3.965AlaGln: 3.965 ± 0.053	3.794AlaArg: 3.794 ± 0.045	5.245AlaSer: 5.245 ± 0.072	5.443AlaThr: 5.443 ± 0.086	5.768AlaVal: 5.768 ± 0.062	0.963AlaTrp: 0.963 ± 0.022	3.183AlaTyr: 3.183 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.506CysAla: 0.506 ± 0.02	0.102CysCys: 0.102 ± 0.007	0.359CysAsp: 0.359 ± 0.016	0.35CysGlu: 0.35 ± 0.021	0.358CysPhe: 0.358 ± 0.014	0.562CysGly: 0.562 ± 0.019	0.196CysHis: 0.196 ± 0.01	0.425CysIle: 0.425 ± 0.016	0.273CysLys: 0.273 ± 0.013	0.803CysLeu: 0.803 ± 0.021	0.145CysMet: 0.145 ± 0.009	0.264CysAsn: 0.264 ± 0.013	0.373CysPro: 0.373 ± 0.02	0.378CysGln: 0.378 ± 0.021	0.371CysArg: 0.371 ± 0.015	0.471CysSer: 0.471 ± 0.022	0.441CysThr: 0.441 ± 0.018	0.509CysVal: 0.509 ± 0.018	0.104CysTrp: 0.104 ± 0.007	0.261CysTyr: 0.261 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.48AspAla: 4.48 ± 0.05	0.345AspCys: 0.345 ± 0.014	2.68AspAsp: 2.68 ± 0.051	3.283AspGlu: 3.283 ± 0.046	2.629AspPhe: 2.629 ± 0.043	4.087AspGly: 4.087 ± 0.061	0.977AspHis: 0.977 ± 0.025	3.084AspIle: 3.084 ± 0.046	2.896AspLys: 2.896 ± 0.046	5.184AspLeu: 5.184 ± 0.061	1.125AspMet: 1.125 ± 0.025	2.274AspAsn: 2.274 ± 0.037	2.469AspPro: 2.469 ± 0.041	2.348AspGln: 2.348 ± 0.04	2.895AspArg: 2.895 ± 0.044	2.971AspSer: 2.971 ± 0.052	2.818AspThr: 2.818 ± 0.044	3.75AspVal: 3.75 ± 0.05	0.893AspTrp: 0.893 ± 0.026	2.367AspTyr: 2.367 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	4.521GluAla: 4.521 ± 0.06	0.257GluCys: 0.257 ± 0.011	2.106GluAsp: 2.106 ± 0.035	2.881GluGlu: 2.881 ± 0.049	2.042GluPhe: 2.042 ± 0.034	3.192GluGly: 3.192 ± 0.044	1.003GluHis: 1.003 ± 0.023	2.927GluIle: 2.927 ± 0.048	3.3GluLys: 3.3 ± 0.046	5.371GluLeu: 5.371 ± 0.064	1.217GluMet: 1.217 ± 0.027	2.281GluAsn: 2.281 ± 0.039	2.078GluPro: 2.078 ± 0.034	2.685GluGln: 2.685 ± 0.04	3.143GluArg: 3.143 ± 0.046	2.817GluSer: 2.817 ± 0.043	3.111GluThr: 3.111 ± 0.047	3.47GluVal: 3.47 ± 0.049	0.649GluTrp: 0.649 ± 0.021	1.697GluTyr: 1.697 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.472PheAla: 3.472 ± 0.05	0.409PheCys: 0.409 ± 0.015	2.823PheAsp: 2.823 ± 0.042	2.043PheGlu: 2.043 ± 0.037	2.164PhePhe: 2.164 ± 0.044	3.539PheGly: 3.539 ± 0.052	0.748PheHis: 0.748 ± 0.02	2.556PheIle: 2.556 ± 0.04	1.915PheLys: 1.915 ± 0.036	4.248PheLeu: 4.248 ± 0.055	1.038PheMet: 1.038 ± 0.021	2.066PheAsn: 2.066 ± 0.037	1.819PhePro: 1.819 ± 0.033	1.581PheGln: 1.581 ± 0.03	2.437PheArg: 2.437 ± 0.038	3.275PheSer: 3.275 ± 0.045	3.018PheThr: 3.018 ± 0.043	3.065PheVal: 3.065 ± 0.042	0.613PheTrp: 0.613 ± 0.018	1.758PheTyr: 1.758 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.249GlyAla: 5.249 ± 0.066	0.728GlyCys: 0.728 ± 0.036	3.405GlyAsp: 3.405 ± 0.055	3.237GlyGlu: 3.237 ± 0.04	3.459GlyPhe: 3.459 ± 0.044	5.401GlyGly: 5.401 ± 0.084	1.378GlyHis: 1.378 ± 0.031	4.643GlyIle: 4.643 ± 0.054	4.331GlyLys: 4.331 ± 0.052	7.379GlyLeu: 7.379 ± 0.074	1.695GlyMet: 1.695 ± 0.032	3.23GlyAsn: 3.23 ± 0.049	2.364GlyPro: 2.364 ± 0.041	3.452GlyGln: 3.452 ± 0.049	3.603GlyArg: 3.603 ± 0.044	4.729GlySer: 4.729 ± 0.067	4.607GlyThr: 4.607 ± 0.072	4.979GlyVal: 4.979 ± 0.059	1.146GlyTrp: 1.146 ± 0.029	3.057GlyTyr: 3.057 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.239HisAla: 1.239 ± 0.027	0.186HisCys: 0.186 ± 0.011	0.955HisAsp: 0.955 ± 0.025	1.005HisGlu: 1.005 ± 0.026	0.979HisPhe: 0.979 ± 0.027	1.157HisGly: 1.157 ± 0.023	0.483HisHis: 0.483 ± 0.016	1.172HisIle: 1.172 ± 0.025	0.802HisLys: 0.802 ± 0.021	1.888HisLeu: 1.888 ± 0.037	0.342HisMet: 0.342 ± 0.015	0.735HisAsn: 0.735 ± 0.02	1.16HisPro: 1.16 ± 0.027	0.93HisGln: 0.93 ± 0.026	1.008HisArg: 1.008 ± 0.024	1.009HisSer: 1.009 ± 0.026	1.129HisThr: 1.129 ± 0.021	1.103HisVal: 1.103 ± 0.025	0.319HisTrp: 0.319 ± 0.013	0.823HisTyr: 0.823 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.132IleAla: 5.132 ± 0.064	0.532IleCys: 0.532 ± 0.018	3.718IleAsp: 3.718 ± 0.047	3.139IleGlu: 3.139 ± 0.044	2.112IlePhe: 2.112 ± 0.038	4.641IleGly: 4.641 ± 0.053	1.119IleHis: 1.119 ± 0.025	3.218IleIle: 3.218 ± 0.045	2.871IleLys: 2.871 ± 0.04	4.991IleLeu: 4.991 ± 0.06	1.091IleMet: 1.091 ± 0.026	3.014IleAsn: 3.014 ± 0.046	2.902IlePro: 2.902 ± 0.044	2.446IleGln: 2.446 ± 0.041	3.581IleArg: 3.581 ± 0.049	3.848IleSer: 3.848 ± 0.059	3.852IleThr: 3.852 ± 0.044	3.888IleVal: 3.888 ± 0.051	0.661IleTrp: 0.661 ± 0.021	2.001IleTyr: 2.001 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.805LysAla: 4.805 ± 0.054	0.185LysCys: 0.185 ± 0.01	2.544LysAsp: 2.544 ± 0.037	2.932LysGlu: 2.932 ± 0.051	1.627LysPhe: 1.627 ± 0.033	3.538LysGly: 3.538 ± 0.049	0.903LysHis: 0.903 ± 0.019	2.8LysIle: 2.8 ± 0.046	3.024LysLys: 3.024 ± 0.046	4.971LysLeu: 4.971 ± 0.053	1.221LysMet: 1.221 ± 0.028	2.444LysAsn: 2.444 ± 0.036	2.926LysPro: 2.926 ± 0.045	2.431LysGln: 2.431 ± 0.041	2.724LysArg: 2.724 ± 0.035	2.843LysSer: 2.843 ± 0.042	3.51LysThr: 3.51 ± 0.05	3.272LysVal: 3.272 ± 0.043	0.579LysTrp: 0.579 ± 0.02	1.706LysTyr: 1.706 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	9.046LeuAla: 9.046 ± 0.091	0.72LeuCys: 0.72 ± 0.019	5.068LeuAsp: 5.068 ± 0.057	4.411LeuGlu: 4.411 ± 0.06	4.656LeuPhe: 4.656 ± 0.058	6.467LeuGly: 6.467 ± 0.073	1.81LeuHis: 1.81 ± 0.032	5.973LeuIle: 5.973 ± 0.076	5.18LeuLys: 5.18 ± 0.054	10.755LeuLeu: 10.755 ± 0.128	2.246LeuMet: 2.246 ± 0.035	4.794LeuAsn: 4.794 ± 0.058	5.145LeuPro: 5.145 ± 0.056	3.717LeuGln: 3.717 ± 0.054	4.998LeuArg: 4.998 ± 0.059	6.996LeuSer: 6.996 ± 0.08	7.532LeuThr: 7.532 ± 0.069	6.652LeuVal: 6.652 ± 0.065	1.073LeuTrp: 1.073 ± 0.026	3.33LeuTyr: 3.33 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.174MetAla: 2.174 ± 0.032	0.108MetCys: 0.108 ± 0.007	1.079MetAsp: 1.079 ± 0.023	1.028MetGlu: 1.028 ± 0.028	0.656MetPhe: 0.656 ± 0.018	1.539MetGly: 1.539 ± 0.031	0.444MetHis: 0.444 ± 0.016	1.16MetIle: 1.16 ± 0.024	1.47MetLys: 1.47 ± 0.028	2.154MetLeu: 2.154 ± 0.039	0.504MetMet: 0.504 ± 0.018	1.209MetAsn: 1.209 ± 0.026	1.172MetPro: 1.172 ± 0.025	0.914MetGln: 0.914 ± 0.023	1.099MetArg: 1.099 ± 0.028	1.308MetSer: 1.308 ± 0.027	1.411MetThr: 1.411 ± 0.026	1.315MetVal: 1.315 ± 0.029	0.18MetTrp: 0.18 ± 0.009	0.578MetTyr: 0.578 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.648AsnAla: 3.648 ± 0.049	0.315AsnCys: 0.315 ± 0.014	2.385AsnAsp: 2.385 ± 0.038	2.396AsnGlu: 2.396 ± 0.037	1.928AsnPhe: 1.928 ± 0.036	3.741AsnGly: 3.741 ± 0.055	0.855AsnHis: 0.855 ± 0.025	2.364AsnIle: 2.364 ± 0.04	2.133AsnLys: 2.133 ± 0.035	4.384AsnLeu: 4.384 ± 0.054	0.913AsnMet: 0.913 ± 0.023	2.179AsnAsn: 2.179 ± 0.041	2.841AsnPro: 2.841 ± 0.037	2.364AsnGln: 2.364 ± 0.038	2.729AsnArg: 2.729 ± 0.042	2.641AsnSer: 2.641 ± 0.047	2.859AsnThr: 2.859 ± 0.05	3.072AsnVal: 3.072 ± 0.052	0.707AsnTrp: 0.707 ± 0.021	1.927AsnTyr: 1.927 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.625ProAla: 4.625 ± 0.065	0.227ProCys: 0.227 ± 0.01	3.278ProAsp: 3.278 ± 0.042	2.897ProGlu: 2.897 ± 0.044	2.11ProPhe: 2.11 ± 0.033	3.362ProGly: 3.362 ± 0.047	0.802ProHis: 0.802 ± 0.021	2.886ProIle: 2.886 ± 0.038	2.194ProLys: 2.194 ± 0.041	4.061ProLeu: 4.061 ± 0.052	0.908ProMet: 0.908 ± 0.022	2.325ProAsn: 2.325 ± 0.037	1.51ProPro: 1.51 ± 0.034	1.614ProGln: 1.614 ± 0.03	1.599ProArg: 1.599 ± 0.03	2.685ProSer: 2.685 ± 0.04	3.398ProThr: 3.398 ± 0.059	3.829ProVal: 3.829 ± 0.052	0.469ProTrp: 0.469 ± 0.017	1.732ProTyr: 1.732 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.058GlnAla: 4.058 ± 0.056	0.225GlnCys: 0.225 ± 0.01	1.723GlnAsp: 1.723 ± 0.03	2.06GlnGlu: 2.06 ± 0.039	2.012GlnPhe: 2.012 ± 0.034	2.487GlnGly: 2.487 ± 0.037	0.878GlnHis: 0.878 ± 0.023	2.526GlnIle: 2.526 ± 0.045	2.397GlnLys: 2.397 ± 0.04	4.972GlnLeu: 4.972 ± 0.056	0.932GlnMet: 0.932 ± 0.021	1.925GlnAsn: 1.925 ± 0.032	2.489GlnPro: 2.489 ± 0.037	2.651GlnGln: 2.651 ± 0.05	2.394GlnArg: 2.394 ± 0.036	2.619GlnSer: 2.619 ± 0.035	3.144GlnThr: 3.144 ± 0.046	2.986GlnVal: 2.986 ± 0.043	0.55GlnTrp: 0.55 ± 0.019	1.688GlnTyr: 1.688 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.71ArgAla: 3.71 ± 0.044	0.289ArgCys: 0.289 ± 0.015	2.505ArgAsp: 2.505 ± 0.038	2.732ArgGlu: 2.732 ± 0.043	2.575ArgPhe: 2.575 ± 0.037	2.757ArgGly: 2.757 ± 0.048	0.967ArgHis: 0.967 ± 0.023	3.388ArgIle: 3.388 ± 0.041	2.747ArgLys: 2.747 ± 0.043	5.592ArgLeu: 5.592 ± 0.073	1.277ArgMet: 1.277 ± 0.024	2.412ArgAsn: 2.412 ± 0.034	2.353ArgPro: 2.353 ± 0.042	2.941ArgGln: 2.941 ± 0.042	2.706ArgArg: 2.706 ± 0.039	3.002ArgSer: 3.002 ± 0.047	3.074ArgThr: 3.074 ± 0.04	3.494ArgVal: 3.494 ± 0.039	0.788ArgTrp: 0.788 ± 0.021	2.222ArgTyr: 2.222 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.145SerAla: 5.145 ± 0.065	0.481SerCys: 0.481 ± 0.02	3.2SerAsp: 3.2 ± 0.046	2.837SerGlu: 2.837 ± 0.042	3.196SerPhe: 3.196 ± 0.039	5.028SerGly: 5.028 ± 0.079	1.065SerHis: 1.065 ± 0.028	3.792SerIle: 3.792 ± 0.052	2.642SerLys: 2.642 ± 0.039	6.841SerLeu: 6.841 ± 0.061	1.246SerMet: 1.246 ± 0.025	2.453SerAsn: 2.453 ± 0.044	2.973SerPro: 2.973 ± 0.043	2.597SerGln: 2.597 ± 0.038	3.056SerArg: 3.056 ± 0.042	4.073SerSer: 4.073 ± 0.066	4.03SerThr: 4.03 ± 0.061	4.738SerVal: 4.738 ± 0.075	0.782SerTrp: 0.782 ± 0.021	2.424SerTyr: 2.424 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.619ThrAla: 5.619 ± 0.085	0.399ThrCys: 0.399 ± 0.017	3.923ThrAsp: 3.923 ± 0.043	3.059ThrGlu: 3.059 ± 0.038	2.895ThrPhe: 2.895 ± 0.039	5.377ThrGly: 5.377 ± 0.073	1.159ThrHis: 1.159 ± 0.027	4.092ThrIle: 4.092 ± 0.048	2.862ThrLys: 2.862 ± 0.039	6.65ThrLeu: 6.65 ± 0.07	1.117ThrMet: 1.117 ± 0.027	3.163ThrAsn: 3.163 ± 0.047	3.452ThrPro: 3.452 ± 0.053	2.442ThrGln: 2.442 ± 0.037	2.641ThrArg: 2.641 ± 0.037	3.915ThrSer: 3.915 ± 0.061	4.427ThrThr: 4.427 ± 0.077	4.877ThrVal: 4.877 ± 0.085	0.737ThrTrp: 0.737 ± 0.024	2.694ThrTyr: 2.694 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	6.009ValAla: 6.009 ± 0.066	0.625ValCys: 0.625 ± 0.027	3.818ValAsp: 3.818 ± 0.043	3.438ValGlu: 3.438 ± 0.046	3.018ValPhe: 3.018 ± 0.04	4.977ValGly: 4.977 ± 0.063	1.163ValHis: 1.163 ± 0.027	4.004ValIle: 4.004 ± 0.051	3.335ValLys: 3.335 ± 0.038	6.789ValLeu: 6.789 ± 0.075	1.495ValMet: 1.495 ± 0.035	3.337ValAsn: 3.337 ± 0.05	3.039ValPro: 3.039 ± 0.045	2.565ValGln: 2.565 ± 0.036	3.717ValArg: 3.717 ± 0.045	4.978ValSer: 4.978 ± 0.071	4.424ValThr: 4.424 ± 0.079	5.224ValVal: 5.224 ± 0.062	0.849ValTrp: 0.849 ± 0.024	2.444ValTyr: 2.444 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.975TrpAla: 0.975 ± 0.031	0.102TrpCys: 0.102 ± 0.008	0.627TrpAsp: 0.627 ± 0.018	0.603TrpGlu: 0.603 ± 0.018	0.624TrpPhe: 0.624 ± 0.019	0.863TrpGly: 0.863 ± 0.025	0.309TrpHis: 0.309 ± 0.012	0.627TrpIle: 0.627 ± 0.018	0.638TrpLys: 0.638 ± 0.02	1.525TrpLeu: 1.525 ± 0.038	0.342TrpMet: 0.342 ± 0.013	0.573TrpAsn: 0.573 ± 0.018	0.468TrpPro: 0.468 ± 0.017	0.772TrpGln: 0.772 ± 0.02	0.719TrpArg: 0.719 ± 0.021	0.755TrpSer: 0.755 ± 0.022	0.755TrpThr: 0.755 ± 0.02	0.848TrpVal: 0.848 ± 0.027	0.24TrpTrp: 0.24 ± 0.013	0.484TrpTyr: 0.484 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.922TyrAla: 2.922 ± 0.04	0.315TyrCys: 0.315 ± 0.014	2.154TyrAsp: 2.154 ± 0.034	1.891TyrGlu: 1.891 ± 0.032	1.866TyrPhe: 1.866 ± 0.03	2.769TyrGly: 2.769 ± 0.042	0.718TyrHis: 0.718 ± 0.021	1.941TyrIle: 1.941 ± 0.035	1.807TyrLys: 1.807 ± 0.034	3.628TyrLeu: 3.628 ± 0.05	0.707TyrMet: 0.707 ± 0.02	1.797TyrAsn: 1.797 ± 0.03	1.728TyrPro: 1.728 ± 0.036	1.924TyrGln: 1.924 ± 0.031	2.317TyrArg: 2.317 ± 0.035	2.421TyrSer: 2.421 ± 0.042	2.517TyrThr: 2.517 ± 0.04	2.407TyrVal: 2.407 ± 0.038	0.547TyrTrp: 0.547 ± 0.018	1.616TyrTyr: 1.616 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5328 proteins (1911320 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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