Amino acid dipepetide frequency for Lactobacillus hayakitensis DSM 18933 = JCM 14209

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.451AlaAla: 5.451 ± 0.163
0.37AlaCys: 0.37 ± 0.029
3.917AlaAsp: 3.917 ± 0.1
3.985AlaGlu: 3.985 ± 0.112
2.919AlaPhe: 2.919 ± 0.088
4.605AlaGly: 4.605 ± 0.126
1.13AlaHis: 1.13 ± 0.039
5.398AlaIle: 5.398 ± 0.135
6.02AlaLys: 6.02 ± 0.152
6.825AlaLeu: 6.825 ± 0.154
1.976AlaMet: 1.976 ± 0.07
3.726AlaAsn: 3.726 ± 0.1
1.857AlaPro: 1.857 ± 0.067
3.471AlaGln: 3.471 ± 0.14
2.354AlaArg: 2.354 ± 0.078
4.3AlaSer: 4.3 ± 0.158
4.191AlaThr: 4.191 ± 0.113
4.565AlaVal: 4.565 ± 0.118
0.533AlaTrp: 0.533 ± 0.034
2.311AlaTyr: 2.311 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.308CysAla: 0.308 ± 0.024
0.032CysCys: 0.032 ± 0.008
0.289CysAsp: 0.289 ± 0.023
0.229CysGlu: 0.229 ± 0.022
0.244CysPhe: 0.244 ± 0.024
0.425CysGly: 0.425 ± 0.032
0.138CysHis: 0.138 ± 0.018
0.321CysIle: 0.321 ± 0.032
0.225CysLys: 0.225 ± 0.02
0.457CysLeu: 0.457 ± 0.03
0.098CysMet: 0.098 ± 0.015
0.166CysAsn: 0.166 ± 0.02
0.225CysPro: 0.225 ± 0.023
0.208CysGln: 0.208 ± 0.024
0.168CysArg: 0.168 ± 0.02
0.266CysSer: 0.266 ± 0.024
0.172CysThr: 0.172 ± 0.02
0.319CysVal: 0.319 ± 0.025
0.047CysTrp: 0.047 ± 0.01
0.178CysTyr: 0.178 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.873AspAla: 3.873 ± 0.104
0.242AspCys: 0.242 ± 0.023
3.569AspAsp: 3.569 ± 0.139
4.964AspGlu: 4.964 ± 0.107
2.974AspPhe: 2.974 ± 0.086
3.675AspGly: 3.675 ± 0.116
0.841AspHis: 0.841 ± 0.039
4.195AspIle: 4.195 ± 0.096
4.578AspLys: 4.578 ± 0.121
5.419AspLeu: 5.419 ± 0.135
1.447AspMet: 1.447 ± 0.058
3.223AspAsn: 3.223 ± 0.089
1.861AspPro: 1.861 ± 0.074
2.129AspGln: 2.129 ± 0.077
1.882AspArg: 1.882 ± 0.058
3.189AspSer: 3.189 ± 0.088
2.91AspThr: 2.91 ± 0.099
4.074AspVal: 4.074 ± 0.12
0.582AspTrp: 0.582 ± 0.04
2.498AspTyr: 2.498 ± 0.088
0.002AspXaa: 0.002 ± 0.002
Glu
4.824GluAla: 4.824 ± 0.119
0.24GluCys: 0.24 ± 0.023
3.635GluAsp: 3.635 ± 0.101
4.877GluGlu: 4.877 ± 0.114
2.855GluPhe: 2.855 ± 0.087
3.104GluGly: 3.104 ± 0.085
1.015GluHis: 1.015 ± 0.048
5.625GluIle: 5.625 ± 0.13
6.092GluLys: 6.092 ± 0.127
6.445GluLeu: 6.445 ± 0.147
2.099GluMet: 2.099 ± 0.071
4.448GluAsn: 4.448 ± 0.098
1.561GluPro: 1.561 ± 0.066
2.802GluGln: 2.802 ± 0.076
2.366GluArg: 2.366 ± 0.073
3.443GluSer: 3.443 ± 0.137
3.193GluThr: 3.193 ± 0.082
4.952GluVal: 4.952 ± 0.121
0.482GluTrp: 0.482 ± 0.036
2.417GluTyr: 2.417 ± 0.08
0.0GluXaa: 0.0 ± 0.0
Phe
2.883PheAla: 2.883 ± 0.083
0.276PheCys: 0.276 ± 0.025
2.997PheAsp: 2.997 ± 0.089
3.108PheGlu: 3.108 ± 0.084
2.086PhePhe: 2.086 ± 0.076
3.123PheGly: 3.123 ± 0.097
0.663PheHis: 0.663 ± 0.042
3.439PheIle: 3.439 ± 0.107
3.312PheLys: 3.312 ± 0.088
3.934PheLeu: 3.934 ± 0.129
1.128PheMet: 1.128 ± 0.052
2.541PheAsn: 2.541 ± 0.086
1.289PhePro: 1.289 ± 0.053
1.345PheGln: 1.345 ± 0.078
1.285PheArg: 1.285 ± 0.057
2.921PheSer: 2.921 ± 0.089
2.337PheThr: 2.337 ± 0.076
3.101PheVal: 3.101 ± 0.089
0.429PheTrp: 0.429 ± 0.033
1.636PheTyr: 1.636 ± 0.074
0.0PheXaa: 0.0 ± 0.0
Gly
4.378GlyAla: 4.378 ± 0.118
0.306GlyCys: 0.306 ± 0.022
3.135GlyAsp: 3.135 ± 0.086
3.324GlyGlu: 3.324 ± 0.083
3.07GlyPhe: 3.07 ± 0.088
3.93GlyGly: 3.93 ± 0.125
1.219GlyHis: 1.219 ± 0.062
5.563GlyIle: 5.563 ± 0.134
5.34GlyLys: 5.34 ± 0.126
5.84GlyLeu: 5.84 ± 0.142
1.942GlyMet: 1.942 ± 0.069
3.144GlyAsn: 3.144 ± 0.074
1.36GlyPro: 1.36 ± 0.057
2.615GlyGln: 2.615 ± 0.109
2.288GlyArg: 2.288 ± 0.067
3.762GlySer: 3.762 ± 0.105
3.675GlyThr: 3.675 ± 0.092
4.382GlyVal: 4.382 ± 0.117
0.625GlyTrp: 0.625 ± 0.036
2.757GlyTyr: 2.757 ± 0.086
0.002GlyXaa: 0.002 ± 0.002
His
1.045HisAla: 1.045 ± 0.053
0.089HisCys: 0.089 ± 0.015
0.954HisAsp: 0.954 ± 0.044
1.079HisGlu: 1.079 ± 0.055
0.816HisPhe: 0.816 ± 0.037
1.23HisGly: 1.23 ± 0.059
0.467HisHis: 0.467 ± 0.034
1.134HisIle: 1.134 ± 0.051
1.03HisLys: 1.03 ± 0.045
1.687HisLeu: 1.687 ± 0.067
0.421HisMet: 0.421 ± 0.029
0.841HisAsn: 0.841 ± 0.041
0.833HisPro: 0.833 ± 0.053
0.892HisGln: 0.892 ± 0.049
0.707HisArg: 0.707 ± 0.039
0.841HisSer: 0.841 ± 0.042
0.771HisThr: 0.771 ± 0.04
1.241HisVal: 1.241 ± 0.045
0.204HisTrp: 0.204 ± 0.031
0.758HisTyr: 0.758 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.644IleAla: 5.644 ± 0.115
0.452IleCys: 0.452 ± 0.027
4.782IleAsp: 4.782 ± 0.104
4.856IleGlu: 4.856 ± 0.115
3.601IlePhe: 3.601 ± 0.115
4.933IleGly: 4.933 ± 0.146
1.145IleHis: 1.145 ± 0.048
5.99IleIle: 5.99 ± 0.154
5.831IleLys: 5.831 ± 0.126
7.099IleLeu: 7.099 ± 0.183
1.689IleMet: 1.689 ± 0.071
4.276IleAsn: 4.276 ± 0.095
2.813IlePro: 2.813 ± 0.08
2.691IleGln: 2.691 ± 0.078
2.555IleArg: 2.555 ± 0.083
5.19IleSer: 5.19 ± 0.121
4.314IleThr: 4.314 ± 0.111
5.003IleVal: 5.003 ± 0.116
0.493IleTrp: 0.493 ± 0.04
2.649IleTyr: 2.649 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
5.183LysAla: 5.183 ± 0.131
0.229LysCys: 0.229 ± 0.022
4.771LysAsp: 4.771 ± 0.134
6.031LysGlu: 6.031 ± 0.118
2.976LysPhe: 2.976 ± 0.083
3.983LysGly: 3.983 ± 0.097
1.283LysHis: 1.283 ± 0.055
6.163LysIle: 6.163 ± 0.13
7.711LysLys: 7.711 ± 0.179
6.963LysLeu: 6.963 ± 0.13
2.706LysMet: 2.706 ± 0.077
5.355LysAsn: 5.355 ± 0.122
2.254LysPro: 2.254 ± 0.085
4.008LysGln: 4.008 ± 0.116
3.375LysArg: 3.375 ± 0.094
4.089LysSer: 4.089 ± 0.135
4.289LysThr: 4.289 ± 0.107
5.602LysVal: 5.602 ± 0.113
0.654LysTrp: 0.654 ± 0.042
3.339LysTyr: 3.339 ± 0.086
0.006LysXaa: 0.006 ± 0.004
Leu
7.121LeuAla: 7.121 ± 0.151
0.442LeuCys: 0.442 ± 0.035
5.451LeuAsp: 5.451 ± 0.105
6.303LeuGlu: 6.303 ± 0.129
3.962LeuPhe: 3.962 ± 0.124
6.252LeuGly: 6.252 ± 0.157
1.485LeuHis: 1.485 ± 0.05
6.74LeuIle: 6.74 ± 0.172
7.265LeuLys: 7.265 ± 0.148
8.259LeuLeu: 8.259 ± 0.197
2.36LeuMet: 2.36 ± 0.084
5.353LeuAsn: 5.353 ± 0.121
3.492LeuPro: 3.492 ± 0.109
3.401LeuGln: 3.401 ± 0.101
3.329LeuArg: 3.329 ± 0.1
6.262LeuSer: 6.262 ± 0.141
5.691LeuThr: 5.691 ± 0.102
6.322LeuVal: 6.322 ± 0.141
0.608LeuTrp: 0.608 ± 0.041
2.779LeuTyr: 2.779 ± 0.086
0.0LeuXaa: 0.0 ± 0.0
Met
1.848MetAla: 1.848 ± 0.06
0.121MetCys: 0.121 ± 0.017
1.442MetAsp: 1.442 ± 0.053
1.566MetGlu: 1.566 ± 0.056
1.018MetPhe: 1.018 ± 0.047
1.623MetGly: 1.623 ± 0.062
0.455MetHis: 0.455 ± 0.034
2.126MetIle: 2.126 ± 0.074
2.388MetLys: 2.388 ± 0.067
2.477MetLeu: 2.477 ± 0.085
0.882MetMet: 0.882 ± 0.042
1.578MetAsn: 1.578 ± 0.053
0.994MetPro: 0.994 ± 0.049
1.37MetGln: 1.37 ± 0.065
0.947MetArg: 0.947 ± 0.052
1.557MetSer: 1.557 ± 0.06
1.566MetThr: 1.566 ± 0.055
1.712MetVal: 1.712 ± 0.069
0.193MetTrp: 0.193 ± 0.02
0.839MetTyr: 0.839 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.531AsnAla: 3.531 ± 0.088
0.244AsnCys: 0.244 ± 0.022
3.38AsnAsp: 3.38 ± 0.092
4.074AsnGlu: 4.074 ± 0.097
2.492AsnPhe: 2.492 ± 0.074
3.741AsnGly: 3.741 ± 0.106
1.177AsnHis: 1.177 ± 0.056
3.915AsnIle: 3.915 ± 0.095
4.461AsnLys: 4.461 ± 0.115
5.232AsnLeu: 5.232 ± 0.119
1.432AsnMet: 1.432 ± 0.06
3.375AsnAsn: 3.375 ± 0.095
2.292AsnPro: 2.292 ± 0.09
3.114AsnGln: 3.114 ± 0.103
2.084AsnArg: 2.084 ± 0.074
3.097AsnSer: 3.097 ± 0.097
2.757AsnThr: 2.757 ± 0.079
3.698AsnVal: 3.698 ± 0.104
0.586AsnTrp: 0.586 ± 0.037
2.239AsnTyr: 2.239 ± 0.075
0.002AsnXaa: 0.002 ± 0.002
Pro
2.097ProAla: 2.097 ± 0.082
0.11ProCys: 0.11 ± 0.017
1.908ProAsp: 1.908 ± 0.071
2.568ProGlu: 2.568 ± 0.125
1.587ProPhe: 1.587 ± 0.059
1.944ProGly: 1.944 ± 0.075
0.603ProHis: 0.603 ± 0.037
2.247ProIle: 2.247 ± 0.079
2.757ProLys: 2.757 ± 0.08
2.704ProLeu: 2.704 ± 0.079
0.699ProMet: 0.699 ± 0.038
1.937ProAsn: 1.937 ± 0.094
0.474ProPro: 0.474 ± 0.035
1.481ProGln: 1.481 ± 0.058
0.941ProArg: 0.941 ± 0.045
1.959ProSer: 1.959 ± 0.068
2.12ProThr: 2.12 ± 0.092
2.522ProVal: 2.522 ± 0.084
0.27ProTrp: 0.27 ± 0.023
1.2ProTyr: 1.2 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.69GlnAla: 3.69 ± 0.117
0.096GlnCys: 0.096 ± 0.012
2.118GlnAsp: 2.118 ± 0.077
3.076GlnGlu: 3.076 ± 0.104
1.464GlnPhe: 1.464 ± 0.057
2.305GlnGly: 2.305 ± 0.072
0.656GlnHis: 0.656 ± 0.045
3.125GlnIle: 3.125 ± 0.098
3.926GlnLys: 3.926 ± 0.116
4.002GlnLeu: 4.002 ± 0.121
1.179GlnMet: 1.179 ± 0.063
2.611GlnAsn: 2.611 ± 0.091
1.156GlnPro: 1.156 ± 0.057
2.158GlnGln: 2.158 ± 0.094
1.772GlnArg: 1.772 ± 0.067
2.415GlnSer: 2.415 ± 0.131
2.609GlnThr: 2.609 ± 0.097
3.148GlnVal: 3.148 ± 0.099
0.389GlnTrp: 0.389 ± 0.027
1.604GlnTyr: 1.604 ± 0.099
0.0GlnXaa: 0.0 ± 0.0
Arg
2.18ArgAla: 2.18 ± 0.073
0.161ArgCys: 0.161 ± 0.018
1.939ArgAsp: 1.939 ± 0.067
2.188ArgGlu: 2.188 ± 0.074
1.651ArgPhe: 1.651 ± 0.066
2.105ArgGly: 2.105 ± 0.079
0.65ArgHis: 0.65 ± 0.036
2.842ArgIle: 2.842 ± 0.069
3.027ArgLys: 3.027 ± 0.083
3.418ArgLeu: 3.418 ± 0.097
0.952ArgMet: 0.952 ± 0.047
2.031ArgAsn: 2.031 ± 0.067
1.088ArgPro: 1.088 ± 0.054
1.869ArgGln: 1.869 ± 0.072
1.799ArgArg: 1.799 ± 0.075
1.829ArgSer: 1.829 ± 0.07
1.818ArgThr: 1.818 ± 0.062
2.492ArgVal: 2.492 ± 0.074
0.302ArgTrp: 0.302 ± 0.027
1.638ArgTyr: 1.638 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
3.866SerAla: 3.866 ± 0.145
0.189SerCys: 0.189 ± 0.021
3.477SerAsp: 3.477 ± 0.094
4.297SerGlu: 4.297 ± 0.188
2.636SerPhe: 2.636 ± 0.083
4.1SerGly: 4.1 ± 0.103
1.069SerHis: 1.069 ± 0.042
4.193SerIle: 4.193 ± 0.094
4.729SerLys: 4.729 ± 0.104
5.674SerLeu: 5.674 ± 0.151
1.54SerMet: 1.54 ± 0.056
3.14SerAsn: 3.14 ± 0.091
1.721SerPro: 1.721 ± 0.06
2.804SerGln: 2.804 ± 0.116
2.107SerArg: 2.107 ± 0.07
3.779SerSer: 3.779 ± 0.131
3.469SerThr: 3.469 ± 0.122
4.059SerVal: 4.059 ± 0.129
0.65SerTrp: 0.65 ± 0.042
2.262SerTyr: 2.262 ± 0.072
0.011SerXaa: 0.011 ± 0.006
Thr
3.853ThrAla: 3.853 ± 0.104
0.234ThrCys: 0.234 ± 0.023
3.244ThrAsp: 3.244 ± 0.101
3.082ThrGlu: 3.082 ± 0.099
2.409ThrPhe: 2.409 ± 0.084
3.994ThrGly: 3.994 ± 0.094
0.988ThrHis: 0.988 ± 0.05
4.113ThrIle: 4.113 ± 0.094
4.104ThrLys: 4.104 ± 0.094
5.275ThrLeu: 5.275 ± 0.104
1.319ThrMet: 1.319 ± 0.053
3.012ThrAsn: 3.012 ± 0.09
2.638ThrPro: 2.638 ± 0.103
2.209ThrGln: 2.209 ± 0.083
1.738ThrArg: 1.738 ± 0.071
3.683ThrSer: 3.683 ± 0.132
3.705ThrThr: 3.705 ± 0.123
4.17ThrVal: 4.17 ± 0.126
0.486ThrTrp: 0.486 ± 0.035
2.152ThrTyr: 2.152 ± 0.088
0.002ThrXaa: 0.002 ± 0.002
Val
5.207ValAla: 5.207 ± 0.139
0.406ValCys: 0.406 ± 0.032
4.37ValAsp: 4.37 ± 0.114
4.321ValGlu: 4.321 ± 0.113
2.6ValPhe: 2.6 ± 0.074
4.531ValGly: 4.531 ± 0.118
1.045ValHis: 1.045 ± 0.04
5.629ValIle: 5.629 ± 0.114
5.472ValLys: 5.472 ± 0.131
6.154ValLeu: 6.154 ± 0.129
1.699ValMet: 1.699 ± 0.071
3.709ValAsn: 3.709 ± 0.103
2.549ValPro: 2.549 ± 0.119
2.356ValGln: 2.356 ± 0.074
2.241ValArg: 2.241 ± 0.08
4.578ValSer: 4.578 ± 0.117
4.423ValThr: 4.423 ± 0.141
5.232ValVal: 5.232 ± 0.124
0.535ValTrp: 0.535 ± 0.038
2.392ValTyr: 2.392 ± 0.093
0.004ValXaa: 0.004 ± 0.004
Trp
0.503TrpAla: 0.503 ± 0.031
0.062TrpCys: 0.062 ± 0.011
0.467TrpAsp: 0.467 ± 0.033
0.41TrpGlu: 0.41 ± 0.035
0.442TrpPhe: 0.442 ± 0.029
0.588TrpGly: 0.588 ± 0.035
0.193TrpHis: 0.193 ± 0.023
0.684TrpIle: 0.684 ± 0.046
0.601TrpLys: 0.601 ± 0.037
0.884TrpLeu: 0.884 ± 0.049
0.321TrpMet: 0.321 ± 0.025
0.478TrpAsn: 0.478 ± 0.032
0.221TrpPro: 0.221 ± 0.024
0.469TrpGln: 0.469 ± 0.029
0.291TrpArg: 0.291 ± 0.029
0.489TrpSer: 0.489 ± 0.038
0.395TrpThr: 0.395 ± 0.028
0.535TrpVal: 0.535 ± 0.032
0.093TrpTrp: 0.093 ± 0.013
0.452TrpTyr: 0.452 ± 0.06
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.417TyrAla: 2.417 ± 0.068
0.212TyrCys: 0.212 ± 0.019
2.281TyrAsp: 2.281 ± 0.085
2.137TyrGlu: 2.137 ± 0.071
2.033TyrPhe: 2.033 ± 0.067
2.466TyrGly: 2.466 ± 0.096
0.816TyrHis: 0.816 ± 0.041
2.562TyrIle: 2.562 ± 0.079
2.099TyrLys: 2.099 ± 0.072
4.125TyrLeu: 4.125 ± 0.124
0.811TyrMet: 0.811 ± 0.045
1.978TyrAsn: 1.978 ± 0.079
1.451TyrPro: 1.451 ± 0.062
2.101TyrGln: 2.101 ± 0.074
1.748TyrArg: 1.748 ± 0.064
2.118TyrSer: 2.118 ± 0.072
2.003TyrThr: 2.003 ± 0.065
2.322TyrVal: 2.322 ± 0.085
0.418TyrTrp: 0.418 ± 0.031
1.77TyrTyr: 1.77 ± 0.093
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.002XaaHis: 0.002 ± 0.002
0.0XaaIle: 0.0 ± 0.0
0.004XaaLys: 0.004 ± 0.003
0.002XaaLeu: 0.002 ± 0.002
0.002XaaMet: 0.002 ± 0.002
0.002XaaAsn: 0.002 ± 0.002
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.002
0.0XaaArg: 0.0 ± 0.0
0.006XaaSer: 0.006 ± 0.004
0.002XaaThr: 0.002 ± 0.002
0.002XaaVal: 0.002 ± 0.002
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.251XaaXaa: 0.251 ± 0.113
Statistics based on 1536 proteins (470751 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski