Amino acid dipepetide frequency for Rhodobacteraceae bacterium THAF1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.322AlaAla: 16.322 ± 0.186	1.114AlaCys: 1.114 ± 0.04	7.835AlaAsp: 7.835 ± 0.108	8.025AlaGlu: 8.025 ± 0.115	4.446AlaPhe: 4.446 ± 0.074	10.381AlaGly: 10.381 ± 0.111	2.305AlaHis: 2.305 ± 0.055	6.285AlaIle: 6.285 ± 0.087	3.503AlaLys: 3.503 ± 0.077	13.853AlaLeu: 13.853 ± 0.16	3.905AlaMet: 3.905 ± 0.076	2.685AlaAsn: 2.685 ± 0.052	5.962AlaPro: 5.962 ± 0.099	4.68AlaGln: 4.68 ± 0.081	8.727AlaArg: 8.727 ± 0.128	5.569AlaSer: 5.569 ± 0.073	6.774AlaThr: 6.774 ± 0.114	8.604AlaVal: 8.604 ± 0.112	1.556AlaTrp: 1.556 ± 0.047	2.451AlaTyr: 2.451 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.122CysAla: 1.122 ± 0.036	0.112CysCys: 0.112 ± 0.01	0.633CysAsp: 0.633 ± 0.027	0.407CysGlu: 0.407 ± 0.02	0.314CysPhe: 0.314 ± 0.017	0.94CysGly: 0.94 ± 0.034	0.255CysHis: 0.255 ± 0.016	0.432CysIle: 0.432 ± 0.023	0.164CysLys: 0.164 ± 0.013	0.846CysLeu: 0.846 ± 0.034	0.18CysMet: 0.18 ± 0.012	0.21CysAsn: 0.21 ± 0.014	0.476CysPro: 0.476 ± 0.024	0.222CysGln: 0.222 ± 0.017	0.581CysArg: 0.581 ± 0.028	0.403CysSer: 0.403 ± 0.021	0.457CysThr: 0.457 ± 0.03	0.656CysVal: 0.656 ± 0.027	0.104CysTrp: 0.104 ± 0.011	0.18CysTyr: 0.18 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	9.105AspAla: 9.105 ± 0.103	0.518AspCys: 0.518 ± 0.023	4.433AspAsp: 4.433 ± 0.115	3.573AspGlu: 3.573 ± 0.075	2.271AspPhe: 2.271 ± 0.048	6.566AspGly: 6.566 ± 0.113	1.466AspHis: 1.466 ± 0.043	3.075AspIle: 3.075 ± 0.057	1.497AspLys: 1.497 ± 0.046	6.756AspLeu: 6.756 ± 0.083	1.832AspMet: 1.832 ± 0.037	1.271AspAsn: 1.271 ± 0.039	3.891AspPro: 3.891 ± 0.073	1.978AspGln: 1.978 ± 0.046	5.009AspArg: 5.009 ± 0.067	2.459AspSer: 2.459 ± 0.064	3.726AspThr: 3.726 ± 0.089	4.738AspVal: 4.738 ± 0.075	1.346AspTrp: 1.346 ± 0.038	1.572AspTyr: 1.572 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.536GluAla: 7.536 ± 0.114	0.361GluCys: 0.361 ± 0.019	3.569GluAsp: 3.569 ± 0.064	3.401GluGlu: 3.401 ± 0.075	1.459GluPhe: 1.459 ± 0.042	4.734GluGly: 4.734 ± 0.077	1.057GluHis: 1.057 ± 0.033	3.357GluIle: 3.357 ± 0.055	1.858GluLys: 1.858 ± 0.056	4.688GluLeu: 4.688 ± 0.076	1.856GluMet: 1.856 ± 0.048	1.574GluAsn: 1.574 ± 0.05	2.556GluPro: 2.556 ± 0.065	2.039GluGln: 2.039 ± 0.047	4.489GluArg: 4.489 ± 0.074	2.209GluSer: 2.209 ± 0.047	3.969GluThr: 3.969 ± 0.066	4.096GluVal: 4.096 ± 0.07	0.729GluTrp: 0.729 ± 0.026	0.962GluTyr: 0.962 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.59PheAla: 4.59 ± 0.073	0.43PheCys: 0.43 ± 0.019	2.948PheAsp: 2.948 ± 0.054	2.006PheGlu: 2.006 ± 0.05	1.4PhePhe: 1.4 ± 0.043	3.645PheGly: 3.645 ± 0.068	0.724PheHis: 0.724 ± 0.027	1.568PheIle: 1.568 ± 0.048	0.789PheLys: 0.789 ± 0.031	3.353PheLeu: 3.353 ± 0.072	0.822PheMet: 0.822 ± 0.027	0.917PheAsn: 0.917 ± 0.028	1.537PhePro: 1.537 ± 0.039	1.007PheGln: 1.007 ± 0.032	2.079PheArg: 2.079 ± 0.042	1.873PheSer: 1.873 ± 0.048	2.138PheThr: 2.138 ± 0.055	2.766PheVal: 2.766 ± 0.062	0.569PheTrp: 0.569 ± 0.028	0.872PheTyr: 0.872 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.181GlyAla: 10.181 ± 0.118	0.885GlyCys: 0.885 ± 0.035	5.474GlyAsp: 5.474 ± 0.135	4.607GlyGlu: 4.607 ± 0.081	3.589GlyPhe: 3.589 ± 0.059	7.764GlyGly: 7.764 ± 0.144	1.865GlyHis: 1.865 ± 0.043	4.597GlyIle: 4.597 ± 0.085	2.78GlyLys: 2.78 ± 0.06	9.093GlyLeu: 9.093 ± 0.092	2.535GlyMet: 2.535 ± 0.055	2.092GlyAsn: 2.092 ± 0.095	3.925GlyPro: 3.925 ± 0.063	3.261GlyGln: 3.261 ± 0.065	5.97GlyArg: 5.97 ± 0.092	4.278GlySer: 4.278 ± 0.07	5.173GlyThr: 5.173 ± 0.082	6.534GlyVal: 6.534 ± 0.091	1.508GlyTrp: 1.508 ± 0.042	2.294GlyTyr: 2.294 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.426HisAla: 2.426 ± 0.059	0.233HisCys: 0.233 ± 0.015	1.43HisAsp: 1.43 ± 0.04	0.984HisGlu: 0.984 ± 0.032	0.723HisPhe: 0.723 ± 0.026	1.828HisGly: 1.828 ± 0.048	0.497HisHis: 0.497 ± 0.023	0.945HisIle: 0.945 ± 0.033	0.442HisLys: 0.442 ± 0.021	2.046HisLeu: 2.046 ± 0.052	0.495HisMet: 0.495 ± 0.022	0.415HisAsn: 0.415 ± 0.023	1.371HisPro: 1.371 ± 0.043	0.524HisGln: 0.524 ± 0.022	1.4HisArg: 1.4 ± 0.037	0.815HisSer: 0.815 ± 0.032	0.869HisThr: 0.869 ± 0.03	1.567HisVal: 1.567 ± 0.041	0.348HisTrp: 0.348 ± 0.018	0.535HisTyr: 0.535 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.477IleAla: 7.477 ± 0.101	0.586IleCys: 0.586 ± 0.023	3.787IleAsp: 3.787 ± 0.068	3.56IleGlu: 3.56 ± 0.061	1.803IlePhe: 1.803 ± 0.048	4.947IleGly: 4.947 ± 0.085	0.946IleHis: 0.946 ± 0.034	2.058IleIle: 2.058 ± 0.055	1.144IleLys: 1.144 ± 0.034	4.777IleLeu: 4.777 ± 0.084	1.026IleMet: 1.026 ± 0.04	1.164IleAsn: 1.164 ± 0.037	2.357IlePro: 2.357 ± 0.051	1.148IleGln: 1.148 ± 0.033	3.122IleArg: 3.122 ± 0.066	2.59IleSer: 2.59 ± 0.053	2.851IleThr: 2.851 ± 0.071	4.23IleVal: 4.23 ± 0.068	0.701IleTrp: 0.701 ± 0.032	1.135IleTyr: 1.135 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.363LysAla: 3.363 ± 0.07	0.159LysCys: 0.159 ± 0.014	1.673LysAsp: 1.673 ± 0.053	1.387LysGlu: 1.387 ± 0.046	0.774LysPhe: 0.774 ± 0.031	2.488LysGly: 2.488 ± 0.059	0.551LysHis: 0.551 ± 0.026	1.48LysIle: 1.48 ± 0.04	1.046LysLys: 1.046 ± 0.047	2.588LysLeu: 2.588 ± 0.057	0.809LysMet: 0.809 ± 0.035	0.684LysAsn: 0.684 ± 0.029	1.568LysPro: 1.568 ± 0.052	0.789LysGln: 0.789 ± 0.034	2.281LysArg: 2.281 ± 0.053	1.526LysSer: 1.526 ± 0.042	1.715LysThr: 1.715 ± 0.042	2.004LysVal: 2.004 ± 0.051	0.357LysTrp: 0.357 ± 0.019	0.513LysTyr: 0.513 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.382LeuAla: 12.382 ± 0.145	0.945LeuCys: 0.945 ± 0.03	6.389LeuAsp: 6.389 ± 0.085	4.902LeuGlu: 4.902 ± 0.077	3.448LeuPhe: 3.448 ± 0.076	8.405LeuGly: 8.405 ± 0.119	1.868LeuHis: 1.868 ± 0.047	5.306LeuIle: 5.306 ± 0.084	2.762LeuLys: 2.762 ± 0.067	8.526LeuLeu: 8.526 ± 0.114	2.595LeuMet: 2.595 ± 0.049	2.67LeuAsn: 2.67 ± 0.056	5.589LeuPro: 5.589 ± 0.082	2.62LeuGln: 2.62 ± 0.054	6.963LeuArg: 6.963 ± 0.11	6.7LeuSer: 6.7 ± 0.082	6.336LeuThr: 6.336 ± 0.109	6.651LeuVal: 6.651 ± 0.09	1.284LeuTrp: 1.284 ± 0.041	1.925LeuTyr: 1.925 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.52MetAla: 3.52 ± 0.066	0.183MetCys: 0.183 ± 0.012	1.58MetAsp: 1.58 ± 0.038	1.332MetGlu: 1.332 ± 0.04	0.807MetPhe: 0.807 ± 0.032	2.518MetGly: 2.518 ± 0.056	0.466MetHis: 0.466 ± 0.025	1.472MetIle: 1.472 ± 0.037	0.978MetLys: 0.978 ± 0.031	2.571MetLeu: 2.571 ± 0.052	0.769MetMet: 0.769 ± 0.026	0.809MetAsn: 0.809 ± 0.029	1.493MetPro: 1.493 ± 0.04	0.941MetGln: 0.941 ± 0.03	1.924MetArg: 1.924 ± 0.046	1.762MetSer: 1.762 ± 0.043	2.177MetThr: 2.177 ± 0.048	1.826MetVal: 1.826 ± 0.048	0.279MetTrp: 0.279 ± 0.017	0.321MetTyr: 0.321 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.288AsnAla: 3.288 ± 0.065	0.22AsnCys: 0.22 ± 0.014	1.5AsnAsp: 1.5 ± 0.068	1.158AsnGlu: 1.158 ± 0.03	0.892AsnPhe: 0.892 ± 0.033	2.415AsnGly: 2.415 ± 0.064	0.492AsnHis: 0.492 ± 0.025	1.255AsnIle: 1.255 ± 0.036	0.533AsnLys: 0.533 ± 0.023	2.33AsnLeu: 2.33 ± 0.046	0.657AsnMet: 0.657 ± 0.031	0.577AsnAsn: 0.577 ± 0.028	1.665AsnPro: 1.665 ± 0.044	0.649AsnGln: 0.649 ± 0.029	1.696AsnArg: 1.696 ± 0.04	1.016AsnSer: 1.016 ± 0.036	1.335AsnThr: 1.335 ± 0.058	1.866AsnVal: 1.866 ± 0.065	0.382AsnTrp: 0.382 ± 0.019	0.593AsnTyr: 0.593 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.587ProAla: 5.587 ± 0.095	0.359ProCys: 0.359 ± 0.02	4.506ProAsp: 4.506 ± 0.075	3.873ProGlu: 3.873 ± 0.074	1.985ProPhe: 1.985 ± 0.041	4.531ProGly: 4.531 ± 0.074	1.013ProHis: 1.013 ± 0.03	2.424ProIle: 2.424 ± 0.048	1.608ProLys: 1.608 ± 0.048	4.606ProLeu: 4.606 ± 0.072	1.411ProMet: 1.411 ± 0.04	1.377ProAsn: 1.377 ± 0.035	2.291ProPro: 2.291 ± 0.053	1.645ProGln: 1.645 ± 0.042	2.776ProArg: 2.776 ± 0.064	2.647ProSer: 2.647 ± 0.047	2.625ProThr: 2.625 ± 0.064	4.242ProVal: 4.242 ± 0.066	0.674ProTrp: 0.674 ± 0.028	1.087ProTyr: 1.087 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.01GlnAla: 4.01 ± 0.068	0.191GlnCys: 0.191 ± 0.013	1.918GlnAsp: 1.918 ± 0.049	1.455GlnGlu: 1.455 ± 0.037	1.021GlnPhe: 1.021 ± 0.035	2.69GlnGly: 2.69 ± 0.052	0.545GlnHis: 0.545 ± 0.026	2.059GlnIle: 2.059 ± 0.049	0.948GlnLys: 0.948 ± 0.032	2.597GlnLeu: 2.597 ± 0.055	1.067GlnMet: 1.067 ± 0.031	0.884GlnAsn: 0.884 ± 0.029	1.668GlnPro: 1.668 ± 0.042	1.028GlnGln: 1.028 ± 0.038	2.177GlnArg: 2.177 ± 0.051	1.732GlnSer: 1.732 ± 0.047	2.046GlnThr: 2.046 ± 0.051	2.445GlnVal: 2.445 ± 0.057	0.396GlnTrp: 0.396 ± 0.02	0.575GlnTyr: 0.575 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.428ArgAla: 8.428 ± 0.122	0.488ArgCys: 0.488 ± 0.024	4.898ArgAsp: 4.898 ± 0.08	3.609ArgGlu: 3.609 ± 0.064	2.678ArgPhe: 2.678 ± 0.055	4.614ArgGly: 4.614 ± 0.068	1.519ArgHis: 1.519 ± 0.041	4.043ArgIle: 4.043 ± 0.076	2.061ArgLys: 2.061 ± 0.051	7.375ArgLeu: 7.375 ± 0.106	2.098ArgMet: 2.098 ± 0.049	1.725ArgAsn: 1.725 ± 0.048	3.376ArgPro: 3.376 ± 0.067	2.199ArgGln: 2.199 ± 0.051	5.127ArgArg: 5.127 ± 0.096	3.2ArgSer: 3.2 ± 0.056	3.395ArgThr: 3.395 ± 0.054	5.04ArgVal: 5.04 ± 0.077	0.92ArgTrp: 0.92 ± 0.033	1.534ArgTyr: 1.534 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.68SerAla: 5.68 ± 0.078	0.387SerCys: 0.387 ± 0.021	3.734SerAsp: 3.734 ± 0.059	2.9SerGlu: 2.9 ± 0.056	2.097SerPhe: 2.097 ± 0.048	5.362SerGly: 5.362 ± 0.078	0.973SerHis: 0.973 ± 0.027	2.451SerIle: 2.451 ± 0.061	1.323SerLys: 1.323 ± 0.035	4.785SerLeu: 4.785 ± 0.078	1.376SerMet: 1.376 ± 0.036	1.303SerAsn: 1.303 ± 0.038	2.395SerPro: 2.395 ± 0.056	1.53SerGln: 1.53 ± 0.045	3.247SerArg: 3.247 ± 0.063	2.434SerSer: 2.434 ± 0.055	2.462SerThr: 2.462 ± 0.053	3.846SerVal: 3.846 ± 0.067	0.611SerTrp: 0.611 ± 0.026	1.234SerTyr: 1.234 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.826ThrAla: 6.826 ± 0.122	0.528ThrCys: 0.528 ± 0.031	3.941ThrAsp: 3.941 ± 0.074	3.173ThrGlu: 3.173 ± 0.055	2.12ThrPhe: 2.12 ± 0.049	5.668ThrGly: 5.668 ± 0.101	1.211ThrHis: 1.211 ± 0.034	2.871ThrIle: 2.871 ± 0.061	1.419ThrLys: 1.419 ± 0.04	6.284ThrLeu: 6.284 ± 0.107	1.357ThrMet: 1.357 ± 0.042	1.392ThrAsn: 1.392 ± 0.061	3.579ThrPro: 3.579 ± 0.069	1.723ThrGln: 1.723 ± 0.069	3.707ThrArg: 3.707 ± 0.064	2.642ThrSer: 2.642 ± 0.058	3.08ThrThr: 3.08 ± 0.061	4.686ThrVal: 4.686 ± 0.106	0.713ThrTrp: 0.713 ± 0.027	1.299ThrTyr: 1.299 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	9.163ValAla: 9.163 ± 0.11	0.631ValCys: 0.631 ± 0.025	4.361ValAsp: 4.361 ± 0.077	4.384ValGlu: 4.384 ± 0.068	2.817ValPhe: 2.817 ± 0.065	5.772ValGly: 5.772 ± 0.082	1.311ValHis: 1.311 ± 0.039	4.08ValIle: 4.08 ± 0.066	1.998ValLys: 1.998 ± 0.058	7.412ValLeu: 7.412 ± 0.105	2.09ValMet: 2.09 ± 0.048	1.866ValAsn: 1.866 ± 0.044	3.803ValPro: 3.803 ± 0.066	2.216ValGln: 2.216 ± 0.051	4.368ValArg: 4.368 ± 0.076	4.321ValSer: 4.321 ± 0.076	5.093ValThr: 5.093 ± 0.143	5.742ValVal: 5.742 ± 0.09	1.003ValTrp: 1.003 ± 0.03	1.491ValTyr: 1.491 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.407TrpAla: 1.407 ± 0.043	0.136TrpCys: 0.136 ± 0.013	0.798TrpAsp: 0.798 ± 0.03	0.621TrpGlu: 0.621 ± 0.024	0.564TrpPhe: 0.564 ± 0.024	1.002TrpGly: 1.002 ± 0.035	0.322TrpHis: 0.322 ± 0.019	0.758TrpIle: 0.758 ± 0.029	0.435TrpLys: 0.435 ± 0.021	1.635TrpLeu: 1.635 ± 0.048	0.417TrpMet: 0.417 ± 0.021	0.368TrpAsn: 0.368 ± 0.02	0.715TrpPro: 0.715 ± 0.026	0.614TrpGln: 0.614 ± 0.027	1.179TrpArg: 1.179 ± 0.038	0.881TrpSer: 0.881 ± 0.032	0.814TrpThr: 0.814 ± 0.028	0.926TrpVal: 0.926 ± 0.032	0.257TrpTrp: 0.257 ± 0.017	0.24TrpTyr: 0.24 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.57TyrAla: 2.57 ± 0.046	0.23TyrCys: 0.23 ± 0.015	1.675TyrAsp: 1.675 ± 0.046	1.142TyrGlu: 1.142 ± 0.041	0.824TyrPhe: 0.824 ± 0.028	2.138TyrGly: 2.138 ± 0.048	0.506TyrHis: 0.506 ± 0.023	0.893TyrIle: 0.893 ± 0.032	0.468TyrLys: 0.468 ± 0.024	2.146TyrLeu: 2.146 ± 0.044	0.429TyrMet: 0.429 ± 0.024	0.539TyrAsn: 0.539 ± 0.026	1.048TyrPro: 1.048 ± 0.033	0.638TyrGln: 0.638 ± 0.024	1.507TyrArg: 1.507 ± 0.038	1.07TyrSer: 1.07 ± 0.035	1.184TyrThr: 1.184 ± 0.05	1.458TyrVal: 1.458 ± 0.037	0.349TyrTrp: 0.349 ± 0.018	0.514TyrTyr: 0.514 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3313 proteins (1009387 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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