Amino acid dipepetide frequency for Marinicauda algicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.653AlaAla: 19.653 ± 0.251	1.265AlaCys: 1.265 ± 0.037	7.47AlaAsp: 7.47 ± 0.105	9.444AlaGlu: 9.444 ± 0.121	5.057AlaPhe: 5.057 ± 0.076	13.607AlaGly: 13.607 ± 0.138	2.482AlaHis: 2.482 ± 0.055	6.089AlaIle: 6.089 ± 0.092	3.328AlaLys: 3.328 ± 0.071	15.584AlaLeu: 15.584 ± 0.177	3.365AlaMet: 3.365 ± 0.063	2.549AlaAsn: 2.549 ± 0.049	6.722AlaPro: 6.722 ± 0.09	4.149AlaGln: 4.149 ± 0.062	12.115AlaArg: 12.115 ± 0.143	6.433AlaSer: 6.433 ± 0.093	4.947AlaThr: 4.947 ± 0.084	9.067AlaVal: 9.067 ± 0.09	1.767AlaTrp: 1.767 ± 0.039	2.713AlaTyr: 2.713 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.133CysAla: 1.133 ± 0.036	0.078CysCys: 0.078 ± 0.009	0.502CysAsp: 0.502 ± 0.022	0.529CysGlu: 0.529 ± 0.023	0.242CysPhe: 0.242 ± 0.014	0.844CysGly: 0.844 ± 0.03	0.194CysHis: 0.194 ± 0.015	0.276CysIle: 0.276 ± 0.017	0.144CysLys: 0.144 ± 0.012	0.668CysLeu: 0.668 ± 0.023	0.118CysMet: 0.118 ± 0.009	0.171CysAsn: 0.171 ± 0.013	0.493CysPro: 0.493 ± 0.019	0.169CysGln: 0.169 ± 0.013	0.578CysArg: 0.578 ± 0.026	0.371CysSer: 0.371 ± 0.02	0.352CysThr: 0.352 ± 0.018	0.559CysVal: 0.559 ± 0.022	0.103CysTrp: 0.103 ± 0.009	0.142CysTyr: 0.142 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.887AspAla: 7.887 ± 0.107	0.446AspCys: 0.446 ± 0.024	2.898AspAsp: 2.898 ± 0.059	4.089AspGlu: 4.089 ± 0.071	2.321AspPhe: 2.321 ± 0.054	5.407AspGly: 5.407 ± 0.09	1.233AspHis: 1.233 ± 0.037	2.859AspIle: 2.859 ± 0.06	1.266AspLys: 1.266 ± 0.037	6.309AspLeu: 6.309 ± 0.085	1.236AspMet: 1.236 ± 0.039	1.026AspAsn: 1.026 ± 0.038	4.205AspPro: 4.205 ± 0.062	1.5AspGln: 1.5 ± 0.036	4.886AspArg: 4.886 ± 0.083	2.15AspSer: 2.15 ± 0.047	2.631AspThr: 2.631 ± 0.05	3.891AspVal: 3.891 ± 0.063	1.14AspTrp: 1.14 ± 0.032	1.553AspTyr: 1.553 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	11.126GluAla: 11.126 ± 0.145	0.321GluCys: 0.321 ± 0.019	4.115GluAsp: 4.115 ± 0.076	4.779GluGlu: 4.779 ± 0.083	2.054GluPhe: 2.054 ± 0.045	5.895GluGly: 5.895 ± 0.075	1.3GluHis: 1.3 ± 0.04	4.038GluIle: 4.038 ± 0.064	2.064GluLys: 2.064 ± 0.054	5.758GluLeu: 5.758 ± 0.078	1.613GluMet: 1.613 ± 0.039	1.524GluAsn: 1.524 ± 0.04	3.705GluPro: 3.705 ± 0.067	2.058GluGln: 2.058 ± 0.051	6.714GluArg: 6.714 ± 0.095	2.762GluSer: 2.762 ± 0.054	4.551GluThr: 4.551 ± 0.074	4.281GluVal: 4.281 ± 0.077	0.728GluTrp: 0.728 ± 0.026	1.17GluTyr: 1.17 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	5.305PheAla: 5.305 ± 0.084	0.341PheCys: 0.341 ± 0.017	2.854PheAsp: 2.854 ± 0.056	2.97PheGlu: 2.97 ± 0.05	1.439PhePhe: 1.439 ± 0.041	3.503PheGly: 3.503 ± 0.066	0.73PheHis: 0.73 ± 0.027	1.497PheIle: 1.497 ± 0.042	0.801PheLys: 0.801 ± 0.029	3.351PheLeu: 3.351 ± 0.063	0.764PheMet: 0.764 ± 0.031	0.906PheAsn: 0.906 ± 0.03	1.504PhePro: 1.504 ± 0.037	0.922PheGln: 0.922 ± 0.031	2.238PheArg: 2.238 ± 0.043	2.003PheSer: 2.003 ± 0.047	2.093PheThr: 2.093 ± 0.052	2.705PheVal: 2.705 ± 0.06	0.534PheTrp: 0.534 ± 0.026	0.887PheTyr: 0.887 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	11.134GlyAla: 11.134 ± 0.12	0.724GlyCys: 0.724 ± 0.027	4.929GlyAsp: 4.929 ± 0.079	7.461GlyGlu: 7.461 ± 0.104	3.934GlyPhe: 3.934 ± 0.065	7.789GlyGly: 7.789 ± 0.108	1.822GlyHis: 1.822 ± 0.042	3.591GlyIle: 3.591 ± 0.072	2.396GlyLys: 2.396 ± 0.052	9.33GlyLeu: 9.33 ± 0.106	2.002GlyMet: 2.002 ± 0.051	1.604GlyAsn: 1.604 ± 0.042	4.237GlyPro: 4.237 ± 0.07	2.74GlyGln: 2.74 ± 0.053	7.021GlyArg: 7.021 ± 0.089	4.236GlySer: 4.236 ± 0.082	4.099GlyThr: 4.099 ± 0.078	6.365GlyVal: 6.365 ± 0.08	1.53GlyTrp: 1.53 ± 0.042	2.249GlyTyr: 2.249 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.674HisAla: 2.674 ± 0.055	0.217HisCys: 0.217 ± 0.015	1.129HisAsp: 1.129 ± 0.041	1.271HisGlu: 1.271 ± 0.039	0.794HisPhe: 0.794 ± 0.03	1.899HisGly: 1.899 ± 0.057	0.543HisHis: 0.543 ± 0.029	0.787HisIle: 0.787 ± 0.026	0.381HisLys: 0.381 ± 0.021	1.836HisLeu: 1.836 ± 0.042	0.424HisMet: 0.424 ± 0.021	0.375HisAsn: 0.375 ± 0.02	1.287HisPro: 1.287 ± 0.038	0.52HisGln: 0.52 ± 0.023	1.435HisArg: 1.435 ± 0.04	0.773HisSer: 0.773 ± 0.029	0.819HisThr: 0.819 ± 0.03	1.449HisVal: 1.449 ± 0.037	0.285HisTrp: 0.285 ± 0.017	0.531HisTyr: 0.531 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.472IleAla: 7.472 ± 0.096	0.39IleCys: 0.39 ± 0.02	3.219IleAsp: 3.219 ± 0.055	4.14IleGlu: 4.14 ± 0.061	1.467IlePhe: 1.467 ± 0.037	4.265IleGly: 4.265 ± 0.071	0.858IleHis: 0.858 ± 0.029	1.547IleIle: 1.547 ± 0.046	0.966IleLys: 0.966 ± 0.034	4.079IleLeu: 4.079 ± 0.069	0.723IleMet: 0.723 ± 0.028	1.095IleAsn: 1.095 ± 0.035	1.911IlePro: 1.911 ± 0.042	0.995IleGln: 0.995 ± 0.025	3.006IleArg: 3.006 ± 0.056	2.318IleSer: 2.318 ± 0.046	2.277IleThr: 2.277 ± 0.051	3.784IleVal: 3.784 ± 0.068	0.518IleTrp: 0.518 ± 0.021	1.017IleTyr: 1.017 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.783LysAla: 3.783 ± 0.086	0.113LysCys: 0.113 ± 0.011	1.495LysAsp: 1.495 ± 0.042	1.384LysGlu: 1.384 ± 0.042	0.681LysPhe: 0.681 ± 0.029	2.182LysGly: 2.182 ± 0.052	0.491LysHis: 0.491 ± 0.023	1.242LysIle: 1.242 ± 0.039	1.195LysLys: 1.195 ± 0.046	2.397LysLeu: 2.397 ± 0.054	0.549LysMet: 0.549 ± 0.024	0.548LysAsn: 0.548 ± 0.022	1.71LysPro: 1.71 ± 0.047	0.731LysGln: 0.731 ± 0.025	2.204LysArg: 2.204 ± 0.052	1.469LysSer: 1.469 ± 0.038	1.638LysThr: 1.638 ± 0.04	1.739LysVal: 1.739 ± 0.043	0.266LysTrp: 0.266 ± 0.016	0.483LysTyr: 0.483 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.211LeuAla: 15.211 ± 0.18	0.745LeuCys: 0.745 ± 0.029	6.612LeuAsp: 6.612 ± 0.091	6.568LeuGlu: 6.568 ± 0.094	3.759LeuPhe: 3.759 ± 0.064	7.952LeuGly: 7.952 ± 0.097	1.828LeuHis: 1.828 ± 0.041	4.698LeuIle: 4.698 ± 0.072	3.419LeuLys: 3.419 ± 0.067	8.526LeuLeu: 8.526 ± 0.117	2.134LeuMet: 2.134 ± 0.049	2.192LeuAsn: 2.192 ± 0.048	5.015LeuPro: 5.015 ± 0.062	2.525LeuGln: 2.525 ± 0.051	6.569LeuArg: 6.569 ± 0.091	6.087LeuSer: 6.087 ± 0.084	5.074LeuThr: 5.074 ± 0.069	7.59LeuVal: 7.59 ± 0.094	1.141LeuTrp: 1.141 ± 0.038	2.043LeuTyr: 2.043 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.053MetAla: 3.053 ± 0.057	0.128MetCys: 0.128 ± 0.011	1.143MetAsp: 1.143 ± 0.029	1.273MetGlu: 1.273 ± 0.038	0.576MetPhe: 0.576 ± 0.023	1.608MetGly: 1.608 ± 0.038	0.375MetHis: 0.375 ± 0.018	1.188MetIle: 1.188 ± 0.033	0.863MetLys: 0.863 ± 0.027	1.935MetLeu: 1.935 ± 0.048	0.596MetMet: 0.596 ± 0.026	0.637MetAsn: 0.637 ± 0.023	1.13MetPro: 1.13 ± 0.038	0.589MetGln: 0.589 ± 0.025	1.807MetArg: 1.807 ± 0.049	1.523MetSer: 1.523 ± 0.039	1.635MetThr: 1.635 ± 0.04	1.323MetVal: 1.323 ± 0.035	0.203MetTrp: 0.203 ± 0.012	0.271MetTyr: 0.271 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.887AsnAla: 2.887 ± 0.053	0.159AsnCys: 0.159 ± 0.012	1.054AsnAsp: 1.054 ± 0.03	1.164AsnGlu: 1.164 ± 0.031	0.82AsnPhe: 0.82 ± 0.028	1.85AsnGly: 1.85 ± 0.044	0.422AsnHis: 0.422 ± 0.02	1.008AsnIle: 1.008 ± 0.031	0.454AsnLys: 0.454 ± 0.02	2.202AsnLeu: 2.202 ± 0.045	0.452AsnMet: 0.452 ± 0.019	0.474AsnAsn: 0.474 ± 0.027	1.59AsnPro: 1.59 ± 0.048	0.592AsnGln: 0.592 ± 0.024	1.623AsnArg: 1.623 ± 0.039	0.907AsnSer: 0.907 ± 0.038	1.026AsnThr: 1.026 ± 0.036	1.587AsnVal: 1.587 ± 0.048	0.374AsnTrp: 0.374 ± 0.02	0.547AsnTyr: 0.547 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.289ProAla: 7.289 ± 0.09	0.334ProCys: 0.334 ± 0.018	4.09ProAsp: 4.09 ± 0.069	4.518ProGlu: 4.518 ± 0.069	1.937ProPhe: 1.937 ± 0.048	5.579ProGly: 5.579 ± 0.08	1.006ProHis: 1.006 ± 0.033	1.883ProIle: 1.883 ± 0.046	1.254ProLys: 1.254 ± 0.043	4.421ProLeu: 4.421 ± 0.074	0.975ProMet: 0.975 ± 0.031	1.097ProAsn: 1.097 ± 0.033	2.601ProPro: 2.601 ± 0.068	1.6ProGln: 1.6 ± 0.039	3.326ProArg: 3.326 ± 0.062	2.42ProSer: 2.42 ± 0.046	1.81ProThr: 1.81 ± 0.044	4.559ProVal: 4.559 ± 0.062	0.698ProTrp: 0.698 ± 0.028	1.081ProTyr: 1.081 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.192GlnAla: 4.192 ± 0.07	0.165GlnCys: 0.165 ± 0.011	1.507GlnAsp: 1.507 ± 0.043	1.586GlnGlu: 1.586 ± 0.04	0.868GlnPhe: 0.868 ± 0.027	2.387GlnGly: 2.387 ± 0.044	0.465GlnHis: 0.465 ± 0.022	1.6GlnIle: 1.6 ± 0.037	0.753GlnLys: 0.753 ± 0.029	2.498GlnLeu: 2.498 ± 0.051	0.684GlnMet: 0.684 ± 0.024	0.621GlnAsn: 0.621 ± 0.028	1.444GlnPro: 1.444 ± 0.039	0.796GlnGln: 0.796 ± 0.032	2.303GlnArg: 2.303 ± 0.052	1.57GlnSer: 1.57 ± 0.041	1.626GlnThr: 1.626 ± 0.036	1.975GlnVal: 1.975 ± 0.041	0.337GlnTrp: 0.337 ± 0.018	0.53GlnTyr: 0.53 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	10.274ArgAla: 10.274 ± 0.127	0.521ArgCys: 0.521 ± 0.024	4.219ArgAsp: 4.219 ± 0.063	5.909ArgGlu: 5.909 ± 0.093	3.452ArgPhe: 3.452 ± 0.06	5.525ArgGly: 5.525 ± 0.078	1.677ArgHis: 1.677 ± 0.043	4.042ArgIle: 4.042 ± 0.059	2.061ArgLys: 2.061 ± 0.048	9.33ArgLeu: 9.33 ± 0.112	1.781ArgMet: 1.781 ± 0.042	1.582ArgAsn: 1.582 ± 0.038	4.018ArgPro: 4.018 ± 0.069	2.289ArgGln: 2.289 ± 0.051	6.65ArgArg: 6.65 ± 0.111	3.698ArgSer: 3.698 ± 0.064	3.753ArgThr: 3.753 ± 0.064	5.203ArgVal: 5.203 ± 0.076	1.14ArgTrp: 1.14 ± 0.034	1.917ArgTyr: 1.917 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.432SerAla: 6.432 ± 0.077	0.34SerCys: 0.34 ± 0.018	2.853SerAsp: 2.853 ± 0.053	3.157SerGlu: 3.157 ± 0.052	1.886SerPhe: 1.886 ± 0.042	5.46SerGly: 5.46 ± 0.086	0.938SerHis: 0.938 ± 0.035	2.147SerIle: 2.147 ± 0.05	1.192SerLys: 1.192 ± 0.039	4.897SerLeu: 4.897 ± 0.061	1.082SerMet: 1.082 ± 0.035	1.07SerAsn: 1.07 ± 0.034	2.749SerPro: 2.749 ± 0.05	1.437SerGln: 1.437 ± 0.035	3.792SerArg: 3.792 ± 0.059	2.306SerSer: 2.306 ± 0.055	2.125SerThr: 2.125 ± 0.053	3.515SerVal: 3.515 ± 0.055	0.784SerTrp: 0.784 ± 0.029	1.126SerTyr: 1.126 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.989ThrAla: 5.989 ± 0.086	0.377ThrCys: 0.377 ± 0.021	2.546ThrAsp: 2.546 ± 0.046	2.769ThrGlu: 2.769 ± 0.055	1.638ThrPhe: 1.638 ± 0.048	5.576ThrGly: 5.576 ± 0.083	0.892ThrHis: 0.892 ± 0.031	2.354ThrIle: 2.354 ± 0.052	0.952ThrLys: 0.952 ± 0.029	5.662ThrLeu: 5.662 ± 0.079	0.85ThrMet: 0.85 ± 0.029	1.057ThrAsn: 1.057 ± 0.03	3.235ThrPro: 3.235 ± 0.053	1.297ThrGln: 1.297 ± 0.039	3.636ThrArg: 3.636 ± 0.06	2.213ThrSer: 2.213 ± 0.047	2.177ThrThr: 2.177 ± 0.058	3.883ThrVal: 3.883 ± 0.075	0.587ThrTrp: 0.587 ± 0.022	1.083ThrTyr: 1.083 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.043ValAla: 8.043 ± 0.101	0.661ValCys: 0.661 ± 0.03	4.064ValAsp: 4.064 ± 0.057	5.358ValGlu: 5.358 ± 0.071	3.074ValPhe: 3.074 ± 0.062	4.846ValGly: 4.846 ± 0.067	1.462ValHis: 1.462 ± 0.04	3.707ValIle: 3.707 ± 0.065	1.978ValLys: 1.978 ± 0.051	7.189ValLeu: 7.189 ± 0.089	1.768ValMet: 1.768 ± 0.047	1.799ValAsn: 1.799 ± 0.047	3.256ValPro: 3.256 ± 0.06	1.816ValGln: 1.816 ± 0.048	5.753ValArg: 5.753 ± 0.063	4.135ValSer: 4.135 ± 0.066	4.241ValThr: 4.241 ± 0.085	5.052ValVal: 5.052 ± 0.072	1.098ValTrp: 1.098 ± 0.034	1.626ValTyr: 1.626 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.445TrpAla: 1.445 ± 0.042	0.118TrpCys: 0.118 ± 0.012	0.671TrpAsp: 0.671 ± 0.025	0.632TrpGlu: 0.632 ± 0.022	0.541TrpPhe: 0.541 ± 0.026	0.874TrpGly: 0.874 ± 0.032	0.28TrpHis: 0.28 ± 0.016	0.721TrpIle: 0.721 ± 0.026	0.383TrpLys: 0.383 ± 0.017	1.607TrpLeu: 1.607 ± 0.043	0.343TrpMet: 0.343 ± 0.017	0.402TrpAsn: 0.402 ± 0.02	0.69TrpPro: 0.69 ± 0.027	0.496TrpGln: 0.496 ± 0.022	1.515TrpArg: 1.515 ± 0.043	0.886TrpSer: 0.886 ± 0.03	0.877TrpThr: 0.877 ± 0.034	0.803TrpVal: 0.803 ± 0.027	0.23TrpTrp: 0.23 ± 0.016	0.277TrpTyr: 0.277 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.825TyrAla: 2.825 ± 0.051	0.225TyrCys: 0.225 ± 0.014	1.566TyrAsp: 1.566 ± 0.039	1.556TyrGlu: 1.556 ± 0.042	0.809TyrPhe: 0.809 ± 0.027	2.142TyrGly: 2.142 ± 0.054	0.429TyrHis: 0.429 ± 0.023	0.771TyrIle: 0.771 ± 0.028	0.45TyrLys: 0.45 ± 0.022	2.109TyrLeu: 2.109 ± 0.045	0.395TyrMet: 0.395 ± 0.02	0.462TyrAsn: 0.462 ± 0.025	0.976TyrPro: 0.976 ± 0.03	0.686TyrGln: 0.686 ± 0.029	1.869TyrArg: 1.869 ± 0.045	1.029TyrSer: 1.029 ± 0.028	1.023TyrThr: 1.023 ± 0.038	1.596TyrVal: 1.596 ± 0.045	0.328TyrTrp: 0.328 ± 0.018	0.549TyrTyr: 0.549 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3306 proteins (1029613 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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