Amino acid dipepetide frequency for Alkalitalea saponilacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.363AlaAla: 4.363 ± 0.076	0.549AlaCys: 0.549 ± 0.021	3.431AlaAsp: 3.431 ± 0.055	4.021AlaGlu: 4.021 ± 0.059	3.195AlaPhe: 3.195 ± 0.052	5.08AlaGly: 5.08 ± 0.089	1.165AlaHis: 1.165 ± 0.032	5.126AlaIle: 5.126 ± 0.064	3.052AlaLys: 3.052 ± 0.058	5.796AlaLeu: 5.796 ± 0.078	1.643AlaMet: 1.643 ± 0.037	3.123AlaAsn: 3.123 ± 0.058	2.118AlaPro: 2.118 ± 0.042	2.019AlaGln: 2.019 ± 0.044	2.926AlaArg: 2.926 ± 0.052	4.146AlaSer: 4.146 ± 0.063	3.253AlaThr: 3.253 ± 0.052	4.08AlaVal: 4.08 ± 0.069	0.744AlaTrp: 0.744 ± 0.024	2.248AlaTyr: 2.248 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.436CysAla: 0.436 ± 0.02	0.105CysCys: 0.105 ± 0.01	0.439CysAsp: 0.439 ± 0.02	0.492CysGlu: 0.492 ± 0.029	0.435CysPhe: 0.435 ± 0.017	0.673CysGly: 0.673 ± 0.024	0.222CysHis: 0.222 ± 0.014	0.535CysIle: 0.535 ± 0.021	0.473CysLys: 0.473 ± 0.018	0.644CysLeu: 0.644 ± 0.022	0.173CysMet: 0.173 ± 0.011	0.483CysAsn: 0.483 ± 0.018	0.324CysPro: 0.324 ± 0.019	0.248CysGln: 0.248 ± 0.015	0.37CysArg: 0.37 ± 0.019	0.582CysSer: 0.582 ± 0.025	0.392CysThr: 0.392 ± 0.023	0.442CysVal: 0.442 ± 0.023	0.084CysTrp: 0.084 ± 0.009	0.309CysTyr: 0.309 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.559AspAla: 3.559 ± 0.064	0.413AspCys: 0.413 ± 0.022	3.226AspAsp: 3.226 ± 0.062	4.177AspGlu: 4.177 ± 0.063	3.515AspPhe: 3.515 ± 0.046	4.09AspGly: 4.09 ± 0.082	1.063AspHis: 1.063 ± 0.025	4.197AspIle: 4.197 ± 0.063	3.027AspLys: 3.027 ± 0.053	5.132AspLeu: 5.132 ± 0.077	1.289AspMet: 1.289 ± 0.03	2.88AspAsn: 2.88 ± 0.055	2.017AspPro: 2.017 ± 0.048	1.696AspGln: 1.696 ± 0.042	2.45AspArg: 2.45 ± 0.05	3.046AspSer: 3.046 ± 0.05	2.258AspThr: 2.258 ± 0.042	3.753AspVal: 3.753 ± 0.048	0.793AspTrp: 0.793 ± 0.026	2.562AspTyr: 2.562 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.193GluAla: 4.193 ± 0.056	0.4GluCys: 0.4 ± 0.018	3.31GluAsp: 3.31 ± 0.05	4.911GluGlu: 4.911 ± 0.074	3.171GluPhe: 3.171 ± 0.049	3.906GluGly: 3.906 ± 0.066	1.243GluHis: 1.243 ± 0.034	5.621GluIle: 5.621 ± 0.076	5.098GluLys: 5.098 ± 0.088	6.562GluLeu: 6.562 ± 0.099	2.022GluMet: 2.022 ± 0.047	4.286GluAsn: 4.286 ± 0.066	2.18GluPro: 2.18 ± 0.042	2.369GluGln: 2.369 ± 0.051	3.204GluArg: 3.204 ± 0.053	3.893GluSer: 3.893 ± 0.056	3.531GluThr: 3.531 ± 0.055	4.514GluVal: 4.514 ± 0.07	0.83GluTrp: 0.83 ± 0.025	2.5GluTyr: 2.5 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.928PheAla: 2.928 ± 0.056	0.44PheCys: 0.44 ± 0.019	3.152PheAsp: 3.152 ± 0.049	3.306PheGlu: 3.306 ± 0.051	2.847PhePhe: 2.847 ± 0.05	3.611PheGly: 3.611 ± 0.056	1.033PheHis: 1.033 ± 0.027	3.762PheIle: 3.762 ± 0.061	2.717PheLys: 2.717 ± 0.051	4.737PheLeu: 4.737 ± 0.072	1.307PheMet: 1.307 ± 0.031	3.262PheAsn: 3.262 ± 0.052	1.901PhePro: 1.901 ± 0.04	1.538PheGln: 1.538 ± 0.04	2.596PheArg: 2.596 ± 0.047	4.288PheSer: 4.288 ± 0.065	2.878PheThr: 2.878 ± 0.047	3.063PheVal: 3.063 ± 0.05	0.646PheTrp: 0.646 ± 0.026	2.174PheTyr: 2.174 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.193GlyAla: 4.193 ± 0.073	0.725GlyCys: 0.725 ± 0.046	3.67GlyAsp: 3.67 ± 0.063	4.405GlyGlu: 4.405 ± 0.058	3.907GlyPhe: 3.907 ± 0.059	4.942GlyGly: 4.942 ± 0.104	1.373GlyHis: 1.373 ± 0.035	5.401GlyIle: 5.401 ± 0.071	4.042GlyLys: 4.042 ± 0.062	6.162GlyLeu: 6.162 ± 0.077	1.914GlyMet: 1.914 ± 0.039	3.932GlyAsn: 3.932 ± 0.088	1.516GlyPro: 1.516 ± 0.043	2.089GlyGln: 2.089 ± 0.04	3.093GlyArg: 3.093 ± 0.057	4.405GlySer: 4.405 ± 0.093	3.918GlyThr: 3.918 ± 0.089	4.909GlyVal: 4.909 ± 0.077	0.957GlyTrp: 0.957 ± 0.027	2.973GlyTyr: 2.973 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.165HisAla: 1.165 ± 0.029	0.2HisCys: 0.2 ± 0.011	1.007HisAsp: 1.007 ± 0.03	1.193HisGlu: 1.193 ± 0.03	1.32HisPhe: 1.32 ± 0.033	1.417HisGly: 1.417 ± 0.04	0.676HisHis: 0.676 ± 0.022	1.587HisIle: 1.587 ± 0.03	1.069HisLys: 1.069 ± 0.035	2.123HisLeu: 2.123 ± 0.043	0.383HisMet: 0.383 ± 0.016	1.142HisAsn: 1.142 ± 0.032	1.149HisPro: 1.149 ± 0.031	0.936HisGln: 0.936 ± 0.03	0.998HisArg: 0.998 ± 0.029	1.255HisSer: 1.255 ± 0.035	1.038HisThr: 1.038 ± 0.028	1.155HisVal: 1.155 ± 0.032	0.262HisTrp: 0.262 ± 0.017	0.903HisTyr: 0.903 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	4.774IleAla: 4.774 ± 0.063	0.647IleCys: 0.647 ± 0.025	4.641IleAsp: 4.641 ± 0.06	5.573IleGlu: 5.573 ± 0.071	3.44IlePhe: 3.44 ± 0.059	4.931IleGly: 4.931 ± 0.065	1.724IleHis: 1.724 ± 0.034	6.014IleIle: 6.014 ± 0.091	4.565IleLys: 4.565 ± 0.071	6.719IleLeu: 6.719 ± 0.077	1.54IleMet: 1.54 ± 0.033	4.681IleAsn: 4.681 ± 0.067	3.443IlePro: 3.443 ± 0.052	2.372IleGln: 2.372 ± 0.046	3.796IleArg: 3.796 ± 0.059	5.746IleSer: 5.746 ± 0.076	4.522IleThr: 4.522 ± 0.081	4.487IleVal: 4.487 ± 0.076	0.878IleTrp: 0.878 ± 0.034	2.84IleTyr: 2.84 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	3.768LysAla: 3.768 ± 0.062	0.401LysCys: 0.401 ± 0.017	2.987LysAsp: 2.987 ± 0.059	4.689LysGlu: 4.689 ± 0.091	2.189LysPhe: 2.189 ± 0.045	3.657LysGly: 3.657 ± 0.065	1.24LysHis: 1.24 ± 0.035	4.414LysIle: 4.414 ± 0.078	4.191LysLys: 4.191 ± 0.081	4.984LysLeu: 4.984 ± 0.084	1.709LysMet: 1.709 ± 0.04	3.456LysAsn: 3.456 ± 0.066	2.185LysPro: 2.185 ± 0.048	1.984LysGln: 1.984 ± 0.04	2.683LysArg: 2.683 ± 0.056	3.726LysSer: 3.726 ± 0.067	3.342LysThr: 3.342 ± 0.051	3.616LysVal: 3.616 ± 0.067	0.719LysTrp: 0.719 ± 0.026	2.299LysTyr: 2.299 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	5.777LeuAla: 5.777 ± 0.074	0.702LeuCys: 0.702 ± 0.027	4.602LeuAsp: 4.602 ± 0.058	5.699LeuGlu: 5.699 ± 0.082	5.107LeuPhe: 5.107 ± 0.077	5.214LeuGly: 5.214 ± 0.079	1.743LeuHis: 1.743 ± 0.034	7.111LeuIle: 7.111 ± 0.082	6.246LeuLys: 6.246 ± 0.094	8.599LeuLeu: 8.599 ± 0.121	2.406LeuMet: 2.406 ± 0.054	5.572LeuAsn: 5.572 ± 0.072	3.852LeuPro: 3.852 ± 0.053	2.99LeuGln: 2.99 ± 0.046	4.058LeuArg: 4.058 ± 0.058	6.813LeuSer: 6.813 ± 0.079	5.029LeuThr: 5.029 ± 0.059	5.544LeuVal: 5.544 ± 0.073	0.992LeuTrp: 0.992 ± 0.034	3.22LeuTyr: 3.22 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.025MetAla: 2.025 ± 0.044	0.129MetCys: 0.129 ± 0.009	1.454MetAsp: 1.454 ± 0.033	1.731MetGlu: 1.731 ± 0.038	1.064MetPhe: 1.064 ± 0.03	1.762MetGly: 1.762 ± 0.039	0.542MetHis: 0.542 ± 0.023	1.722MetIle: 1.722 ± 0.036	1.739MetLys: 1.739 ± 0.038	2.18MetLeu: 2.18 ± 0.049	0.669MetMet: 0.669 ± 0.025	1.42MetAsn: 1.42 ± 0.036	1.13MetPro: 1.13 ± 0.031	0.988MetGln: 0.988 ± 0.027	1.258MetArg: 1.258 ± 0.036	1.415MetSer: 1.415 ± 0.035	1.218MetThr: 1.218 ± 0.032	1.852MetVal: 1.852 ± 0.041	0.226MetTrp: 0.226 ± 0.014	0.671MetTyr: 0.671 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.358AsnAla: 3.358 ± 0.058	0.499AsnCys: 0.499 ± 0.021	3.009AsnAsp: 3.009 ± 0.053	3.639AsnGlu: 3.639 ± 0.062	2.542AsnPhe: 2.542 ± 0.048	4.136AsnGly: 4.136 ± 0.08	1.439AsnHis: 1.439 ± 0.037	4.558AsnIle: 4.558 ± 0.066	2.974AsnLys: 2.974 ± 0.058	5.15AsnLeu: 5.15 ± 0.069	1.416AsnMet: 1.416 ± 0.034	3.571AsnAsn: 3.571 ± 0.08	2.966AsnPro: 2.966 ± 0.04	2.357AsnGln: 2.357 ± 0.053	3.134AsnArg: 3.134 ± 0.047	3.812AsnSer: 3.812 ± 0.077	2.841AsnThr: 2.841 ± 0.056	3.238AsnVal: 3.238 ± 0.068	0.887AsnTrp: 0.887 ± 0.028	2.429AsnTyr: 2.429 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.569ProAla: 2.569 ± 0.046	0.245ProCys: 0.245 ± 0.015	2.866ProAsp: 2.866 ± 0.053	3.448ProGlu: 3.448 ± 0.052	2.075ProPhe: 2.075 ± 0.042	3.064ProGly: 3.064 ± 0.062	0.802ProHis: 0.802 ± 0.025	2.429ProIle: 2.429 ± 0.043	1.648ProLys: 1.648 ± 0.041	3.248ProLeu: 3.248 ± 0.056	0.889ProMet: 0.889 ± 0.026	1.926ProAsn: 1.926 ± 0.039	1.183ProPro: 1.183 ± 0.031	1.259ProGln: 1.259 ± 0.031	1.353ProArg: 1.353 ± 0.034	2.386ProSer: 2.386 ± 0.048	1.668ProThr: 1.668 ± 0.04	3.409ProVal: 3.409 ± 0.055	0.469ProTrp: 0.469 ± 0.019	1.493ProTyr: 1.493 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	1.918GlnAla: 1.918 ± 0.04	0.18GlnCys: 0.18 ± 0.01	1.442GlnAsp: 1.442 ± 0.034	2.084GlnGlu: 2.084 ± 0.043	1.637GlnPhe: 1.637 ± 0.036	1.852GlnGly: 1.852 ± 0.038	0.724GlnHis: 0.724 ± 0.026	2.742GlnIle: 2.742 ± 0.044	2.249GlnLys: 2.249 ± 0.053	3.359GlnLeu: 3.359 ± 0.056	1.006GlnMet: 1.006 ± 0.029	2.059GlnAsn: 2.059 ± 0.043	1.314GlnPro: 1.314 ± 0.035	1.435GlnGln: 1.435 ± 0.042	1.679GlnArg: 1.679 ± 0.029	2.18GlnSer: 2.18 ± 0.043	1.845GlnThr: 1.845 ± 0.043	2.077GlnVal: 2.077 ± 0.041	0.491GlnTrp: 0.491 ± 0.02	1.291GlnTyr: 1.291 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.561ArgAla: 2.561 ± 0.051	0.287ArgCys: 0.287 ± 0.015	2.575ArgAsp: 2.575 ± 0.04	3.362ArgGlu: 3.362 ± 0.056	2.793ArgPhe: 2.793 ± 0.051	2.675ArgGly: 2.675 ± 0.052	0.997ArgHis: 0.997 ± 0.029	3.875ArgIle: 3.875 ± 0.052	2.847ArgLys: 2.847 ± 0.061	4.392ArgLeu: 4.392 ± 0.06	1.39ArgMet: 1.39 ± 0.032	2.896ArgAsn: 2.896 ± 0.052	1.558ArgPro: 1.558 ± 0.033	1.758ArgGln: 1.758 ± 0.045	2.356ArgArg: 2.356 ± 0.053	2.67ArgSer: 2.67 ± 0.05	2.324ArgThr: 2.324 ± 0.041	3.035ArgVal: 3.035 ± 0.047	0.658ArgTrp: 0.658 ± 0.03	2.085ArgTyr: 2.085 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.029SerAla: 4.029 ± 0.064	0.607SerCys: 0.607 ± 0.022	3.823SerAsp: 3.823 ± 0.057	4.328SerGlu: 4.328 ± 0.058	3.743SerPhe: 3.743 ± 0.057	5.597SerGly: 5.597 ± 0.097	1.466SerHis: 1.466 ± 0.034	5.115SerIle: 5.115 ± 0.063	3.325SerLys: 3.325 ± 0.062	6.034SerLeu: 6.034 ± 0.071	1.482SerMet: 1.482 ± 0.038	3.561SerAsn: 3.561 ± 0.064	2.552SerPro: 2.552 ± 0.052	2.167SerGln: 2.167 ± 0.04	3.091SerArg: 3.091 ± 0.059	4.529SerSer: 4.529 ± 0.077	3.303SerThr: 3.303 ± 0.059	4.595SerVal: 4.595 ± 0.062	0.861SerTrp: 0.861 ± 0.033	2.589SerTyr: 2.589 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	3.33ThrAla: 3.33 ± 0.058	0.332ThrCys: 0.332 ± 0.02	3.04ThrAsp: 3.04 ± 0.051	3.207ThrGlu: 3.207 ± 0.051	2.636ThrPhe: 2.636 ± 0.048	4.678ThrGly: 4.678 ± 0.07	1.069ThrHis: 1.069 ± 0.03	4.605ThrIle: 4.605 ± 0.079	2.407ThrLys: 2.407 ± 0.049	4.633ThrLeu: 4.633 ± 0.064	1.074ThrMet: 1.074 ± 0.026	2.823ThrAsn: 2.823 ± 0.053	2.542ThrPro: 2.542 ± 0.054	1.56ThrGln: 1.56 ± 0.042	2.318ThrArg: 2.318 ± 0.043	3.484ThrSer: 3.484 ± 0.057	2.925ThrThr: 2.925 ± 0.053	3.35ThrVal: 3.35 ± 0.075	0.604ThrTrp: 0.604 ± 0.022	2.009ThrTyr: 2.009 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.189ValAla: 4.189 ± 0.069	0.555ValCys: 0.555 ± 0.024	3.544ValAsp: 3.544 ± 0.055	4.371ValGlu: 4.371 ± 0.062	3.607ValPhe: 3.607 ± 0.054	3.727ValGly: 3.727 ± 0.068	1.181ValHis: 1.181 ± 0.033	4.999ValIle: 4.999 ± 0.061	3.829ValLys: 3.829 ± 0.063	5.96ValLeu: 5.96 ± 0.081	1.584ValMet: 1.584 ± 0.041	3.665ValAsn: 3.665 ± 0.065	2.516ValPro: 2.516 ± 0.045	1.755ValGln: 1.755 ± 0.036	2.902ValArg: 2.902 ± 0.058	4.812ValSer: 4.812 ± 0.071	3.648ValThr: 3.648 ± 0.077	4.827ValVal: 4.827 ± 0.078	0.771ValTrp: 0.771 ± 0.023	2.503ValTyr: 2.503 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.681TrpAla: 0.681 ± 0.024	0.099TrpCys: 0.099 ± 0.009	0.749TrpAsp: 0.749 ± 0.028	0.826TrpGlu: 0.826 ± 0.03	0.686TrpPhe: 0.686 ± 0.025	0.867TrpGly: 0.867 ± 0.03	0.299TrpHis: 0.299 ± 0.018	0.866TrpIle: 0.866 ± 0.029	0.627TrpLys: 0.627 ± 0.025	1.204TrpLeu: 1.204 ± 0.034	0.405TrpMet: 0.405 ± 0.018	0.786TrpAsn: 0.786 ± 0.027	0.372TrpPro: 0.372 ± 0.017	0.537TrpGln: 0.537 ± 0.021	0.624TrpArg: 0.624 ± 0.025	0.804TrpSer: 0.804 ± 0.03	0.62TrpThr: 0.62 ± 0.026	0.82TrpVal: 0.82 ± 0.028	0.202TrpTrp: 0.202 ± 0.013	0.522TrpTyr: 0.522 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.264TyrAla: 2.264 ± 0.049	0.347TyrCys: 0.347 ± 0.018	2.177TyrAsp: 2.177 ± 0.045	2.286TyrGlu: 2.286 ± 0.05	2.276TyrPhe: 2.276 ± 0.05	2.648TyrGly: 2.648 ± 0.048	0.975TyrHis: 0.975 ± 0.029	2.655TyrIle: 2.655 ± 0.043	2.117TyrLys: 2.117 ± 0.047	3.656TyrLeu: 3.656 ± 0.064	0.895TyrMet: 0.895 ± 0.026	2.435TyrAsn: 2.435 ± 0.053	1.61TyrPro: 1.61 ± 0.037	1.504TyrGln: 1.504 ± 0.037	2.204TyrArg: 2.204 ± 0.043	2.804TyrSer: 2.804 ± 0.05	2.072TyrThr: 2.072 ± 0.053	2.177TyrVal: 2.177 ± 0.04	0.52TyrTrp: 0.52 ± 0.019	1.817TyrTyr: 1.817 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3564 proteins (1322236 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---