Amino acid dipepetide frequency for Listeria kieliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.346AlaAla: 6.346 ± 0.104
0.553AlaCys: 0.553 ± 0.029
3.946AlaAsp: 3.946 ± 0.074
5.879AlaGlu: 5.879 ± 0.109
3.853AlaPhe: 3.853 ± 0.076
5.944AlaGly: 5.944 ± 0.107
1.339AlaHis: 1.339 ± 0.04
6.135AlaIle: 6.135 ± 0.104
5.689AlaLys: 5.689 ± 0.094
7.892AlaLeu: 7.892 ± 0.113
2.004AlaMet: 2.004 ± 0.052
3.012AlaAsn: 3.012 ± 0.069
2.189AlaPro: 2.189 ± 0.059
2.352AlaGln: 2.352 ± 0.052
3.273AlaArg: 3.273 ± 0.08
4.725AlaSer: 4.725 ± 0.088
3.917AlaThr: 3.917 ± 0.074
5.697AlaVal: 5.697 ± 0.09
0.576AlaTrp: 0.576 ± 0.03
2.499AlaTyr: 2.499 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.411CysAla: 0.411 ± 0.027
0.06CysCys: 0.06 ± 0.009
0.319CysAsp: 0.319 ± 0.022
0.363CysGlu: 0.363 ± 0.024
0.344CysPhe: 0.344 ± 0.022
0.624CysGly: 0.624 ± 0.032
0.124CysHis: 0.124 ± 0.014
0.418CysIle: 0.418 ± 0.026
0.217CysLys: 0.217 ± 0.016
0.663CysLeu: 0.663 ± 0.028
0.121CysMet: 0.121 ± 0.011
0.201CysAsn: 0.201 ± 0.017
0.285CysPro: 0.285 ± 0.02
0.172CysGln: 0.172 ± 0.016
0.244CysArg: 0.244 ± 0.016
0.422CysSer: 0.422 ± 0.025
0.325CysThr: 0.325 ± 0.023
0.37CysVal: 0.37 ± 0.026
0.053CysTrp: 0.053 ± 0.008
0.265CysTyr: 0.265 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.001AspAla: 4.001 ± 0.086
0.285AspCys: 0.285 ± 0.021
2.431AspAsp: 2.431 ± 0.064
4.577AspGlu: 4.577 ± 0.08
2.866AspPhe: 2.866 ± 0.06
3.633AspGly: 3.633 ± 0.086
0.95AspHis: 0.95 ± 0.036
3.378AspIle: 3.378 ± 0.067
3.389AspLys: 3.389 ± 0.079
5.068AspLeu: 5.068 ± 0.095
1.26AspMet: 1.26 ± 0.041
1.668AspAsn: 1.668 ± 0.056
2.072AspPro: 2.072 ± 0.059
1.968AspGln: 1.968 ± 0.05
2.147AspArg: 2.147 ± 0.056
2.731AspSer: 2.731 ± 0.065
2.488AspThr: 2.488 ± 0.064
3.741AspVal: 3.741 ± 0.078
0.566AspTrp: 0.566 ± 0.028
2.274AspTyr: 2.274 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
6.591GluAla: 6.591 ± 0.103
0.269GluCys: 0.269 ± 0.021
3.4GluAsp: 3.4 ± 0.075
6.609GluGlu: 6.609 ± 0.125
2.739GluPhe: 2.739 ± 0.061
3.953GluGly: 3.953 ± 0.079
1.361GluHis: 1.361 ± 0.046
5.659GluIle: 5.659 ± 0.103
7.27GluLys: 7.27 ± 0.124
7.713GluLeu: 7.713 ± 0.116
2.428GluMet: 2.428 ± 0.053
3.846GluAsn: 3.846 ± 0.08
1.991GluPro: 1.991 ± 0.055
3.253GluGln: 3.253 ± 0.079
3.773GluArg: 3.773 ± 0.08
3.444GluSer: 3.444 ± 0.066
4.571GluThr: 4.571 ± 0.079
5.183GluVal: 5.183 ± 0.093
0.688GluTrp: 0.688 ± 0.033
1.93GluTyr: 1.93 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.452PheAla: 3.452 ± 0.084
0.347PheCys: 0.347 ± 0.023
2.686PheAsp: 2.686 ± 0.067
3.238PheGlu: 3.238 ± 0.065
2.709PhePhe: 2.709 ± 0.094
3.537PheGly: 3.537 ± 0.083
0.946PheHis: 0.946 ± 0.04
3.786PheIle: 3.786 ± 0.098
2.561PheLys: 2.561 ± 0.057
5.318PheLeu: 5.318 ± 0.117
1.218PheMet: 1.218 ± 0.043
1.731PheAsn: 1.731 ± 0.058
1.684PhePro: 1.684 ± 0.049
1.593PheGln: 1.593 ± 0.054
1.783PheArg: 1.783 ± 0.056
3.527PheSer: 3.527 ± 0.079
2.61PheThr: 2.61 ± 0.066
3.564PheVal: 3.564 ± 0.077
0.531PheTrp: 0.531 ± 0.029
1.91PheTyr: 1.91 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
5.229GlyAla: 5.229 ± 0.093
0.468GlyCys: 0.468 ± 0.029
3.139GlyAsp: 3.139 ± 0.064
4.776GlyGlu: 4.776 ± 0.08
3.569GlyPhe: 3.569 ± 0.073
4.77GlyGly: 4.77 ± 0.112
1.239GlyHis: 1.239 ± 0.045
5.811GlyIle: 5.811 ± 0.099
5.48GlyLys: 5.48 ± 0.099
6.602GlyLeu: 6.602 ± 0.112
1.963GlyMet: 1.963 ± 0.056
2.66GlyAsn: 2.66 ± 0.072
1.5GlyPro: 1.5 ± 0.045
2.028GlyGln: 2.028 ± 0.056
2.57GlyArg: 2.57 ± 0.064
4.001GlySer: 4.001 ± 0.081
4.173GlyThr: 4.173 ± 0.089
5.012GlyVal: 5.012 ± 0.102
0.659GlyTrp: 0.659 ± 0.04
2.608GlyTyr: 2.608 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.295HisAla: 1.295 ± 0.039
0.154HisCys: 0.154 ± 0.015
1.016HisAsp: 1.016 ± 0.033
1.276HisGlu: 1.276 ± 0.045
1.162HisPhe: 1.162 ± 0.039
1.284HisGly: 1.284 ± 0.042
0.471HisHis: 0.471 ± 0.026
1.17HisIle: 1.17 ± 0.037
0.913HisLys: 0.913 ± 0.035
2.034HisLeu: 2.034 ± 0.055
0.401HisMet: 0.401 ± 0.019
0.599HisAsn: 0.599 ± 0.032
0.961HisPro: 0.961 ± 0.042
0.714HisGln: 0.714 ± 0.028
0.753HisArg: 0.753 ± 0.033
1.05HisSer: 1.05 ± 0.041
0.894HisThr: 0.894 ± 0.031
1.294HisVal: 1.294 ± 0.042
0.169HisTrp: 0.169 ± 0.015
0.846HisTyr: 0.846 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.167IleAla: 6.167 ± 0.112
0.663IleCys: 0.663 ± 0.034
3.87IleAsp: 3.87 ± 0.084
5.142IleGlu: 5.142 ± 0.084
3.475IlePhe: 3.475 ± 0.091
5.679IleGly: 5.679 ± 0.108
1.473IleHis: 1.473 ± 0.043
5.078IleIle: 5.078 ± 0.112
4.052IleLys: 4.052 ± 0.079
7.603IleLeu: 7.603 ± 0.13
1.592IleMet: 1.592 ± 0.049
2.626IleAsn: 2.626 ± 0.058
3.235IlePro: 3.235 ± 0.067
2.808IleGln: 2.808 ± 0.065
3.243IleArg: 3.243 ± 0.07
4.772IleSer: 4.772 ± 0.073
3.893IleThr: 3.893 ± 0.079
5.118IleVal: 5.118 ± 0.088
0.666IleTrp: 0.666 ± 0.033
2.364IleTyr: 2.364 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
5.387LysAla: 5.387 ± 0.117
0.277LysCys: 0.277 ± 0.017
3.449LysAsp: 3.449 ± 0.089
6.668LysGlu: 6.668 ± 0.103
2.08LysPhe: 2.08 ± 0.058
4.042LysGly: 4.042 ± 0.079
1.138LysHis: 1.138 ± 0.04
4.8LysIle: 4.8 ± 0.084
6.546LysLys: 6.546 ± 0.123
6.419LysLeu: 6.419 ± 0.093
2.417LysMet: 2.417 ± 0.058
3.461LysAsn: 3.461 ± 0.072
2.389LysPro: 2.389 ± 0.054
3.47LysGln: 3.47 ± 0.061
3.803LysArg: 3.803 ± 0.076
3.517LysSer: 3.517 ± 0.08
4.054LysThr: 4.054 ± 0.082
4.6LysVal: 4.6 ± 0.09
0.752LysTrp: 0.752 ± 0.033
2.071LysTyr: 2.071 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
8.381LeuAla: 8.381 ± 0.122
0.606LeuCys: 0.606 ± 0.032
5.376LeuAsp: 5.376 ± 0.098
7.323LeuGlu: 7.323 ± 0.13
5.289LeuPhe: 5.289 ± 0.13
6.583LeuGly: 6.583 ± 0.094
1.754LeuHis: 1.754 ± 0.054
7.036LeuIle: 7.036 ± 0.119
6.919LeuLys: 6.919 ± 0.097
10.563LeuLeu: 10.563 ± 0.168
2.506LeuMet: 2.506 ± 0.061
4.01LeuAsn: 4.01 ± 0.078
3.943LeuPro: 3.943 ± 0.079
3.317LeuGln: 3.317 ± 0.07
3.852LeuArg: 3.852 ± 0.069
6.804LeuSer: 6.804 ± 0.118
5.88LeuThr: 5.88 ± 0.079
6.946LeuVal: 6.946 ± 0.103
0.659LeuTrp: 0.659 ± 0.035
3.051LeuTyr: 3.051 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.12MetAla: 2.12 ± 0.052
0.127MetCys: 0.127 ± 0.013
1.42MetAsp: 1.42 ± 0.046
1.905MetGlu: 1.905 ± 0.053
0.946MetPhe: 0.946 ± 0.035
1.683MetGly: 1.683 ± 0.05
0.386MetHis: 0.386 ± 0.021
1.957MetIle: 1.957 ± 0.053
2.386MetLys: 2.386 ± 0.06
2.468MetLeu: 2.468 ± 0.06
0.773MetMet: 0.773 ± 0.03
1.312MetAsn: 1.312 ± 0.042
1.055MetPro: 1.055 ± 0.045
0.998MetGln: 0.998 ± 0.039
1.164MetArg: 1.164 ± 0.042
1.435MetSer: 1.435 ± 0.047
1.63MetThr: 1.63 ± 0.048
1.592MetVal: 1.592 ± 0.047
0.161MetTrp: 0.161 ± 0.016
0.643MetTyr: 0.643 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.887AsnAla: 2.887 ± 0.066
0.239AsnCys: 0.239 ± 0.017
2.072AsnAsp: 2.072 ± 0.057
3.108AsnGlu: 3.108 ± 0.074
1.871AsnPhe: 1.871 ± 0.05
3.16AsnGly: 3.16 ± 0.079
0.869AsnHis: 0.869 ± 0.034
2.794AsnIle: 2.794 ± 0.063
2.633AsnLys: 2.633 ± 0.067
3.911AsnLeu: 3.911 ± 0.085
1.084AsnMet: 1.084 ± 0.033
1.544AsnAsn: 1.544 ± 0.051
1.944AsnPro: 1.944 ± 0.05
1.972AsnGln: 1.972 ± 0.053
1.942AsnArg: 1.942 ± 0.049
2.139AsnSer: 2.139 ± 0.071
1.874AsnThr: 1.874 ± 0.048
2.787AsnVal: 2.787 ± 0.064
0.558AsnTrp: 0.558 ± 0.03
1.572AsnTyr: 1.572 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
2.494ProAla: 2.494 ± 0.062
0.197ProCys: 0.197 ± 0.015
2.136ProAsp: 2.136 ± 0.055
3.27ProGlu: 3.27 ± 0.06
2.062ProPhe: 2.062 ± 0.061
2.147ProGly: 2.147 ± 0.054
0.71ProHis: 0.71 ± 0.032
2.589ProIle: 2.589 ± 0.058
2.23ProLys: 2.23 ± 0.05
3.358ProLeu: 3.358 ± 0.082
0.644ProMet: 0.644 ± 0.029
1.665ProAsn: 1.665 ± 0.048
0.785ProPro: 0.785 ± 0.038
0.984ProGln: 0.984 ± 0.036
1.16ProArg: 1.16 ± 0.044
2.024ProSer: 2.024 ± 0.048
1.858ProThr: 1.858 ± 0.053
2.907ProVal: 2.907 ± 0.07
0.247ProTrp: 0.247 ± 0.017
1.29ProTyr: 1.29 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
3.172GlnAla: 3.172 ± 0.07
0.128GlnCys: 0.128 ± 0.013
1.837GlnAsp: 1.837 ± 0.052
3.128GlnGlu: 3.128 ± 0.072
1.743GlnPhe: 1.743 ± 0.049
1.937GlnGly: 1.937 ± 0.052
0.519GlnHis: 0.519 ± 0.028
3.093GlnIle: 3.093 ± 0.069
3.075GlnLys: 3.075 ± 0.072
3.527GlnLeu: 3.527 ± 0.071
1.062GlnMet: 1.062 ± 0.042
1.933GlnAsn: 1.933 ± 0.05
0.98GlnPro: 0.98 ± 0.038
1.226GlnGln: 1.226 ± 0.045
1.108GlnArg: 1.108 ± 0.041
1.743GlnSer: 1.743 ± 0.044
2.042GlnThr: 2.042 ± 0.059
2.769GlnVal: 2.769 ± 0.06
0.228GlnTrp: 0.228 ± 0.018
1.05GlnTyr: 1.05 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
3.029ArgAla: 3.029 ± 0.073
0.177ArgCys: 0.177 ± 0.017
2.21ArgAsp: 2.21 ± 0.059
3.678ArgGlu: 3.678 ± 0.083
2.204ArgPhe: 2.204 ± 0.057
2.525ArgGly: 2.525 ± 0.061
0.827ArgHis: 0.827 ± 0.032
3.158ArgIle: 3.158 ± 0.072
3.328ArgLys: 3.328 ± 0.07
4.153ArgLeu: 4.153 ± 0.078
1.242ArgMet: 1.242 ± 0.045
1.718ArgAsn: 1.718 ± 0.052
1.265ArgPro: 1.265 ± 0.045
1.402ArgGln: 1.402 ± 0.048
1.895ArgArg: 1.895 ± 0.051
2.252ArgSer: 2.252 ± 0.055
2.03ArgThr: 2.03 ± 0.052
2.831ArgVal: 2.831 ± 0.061
0.263ArgTrp: 0.263 ± 0.018
1.686ArgTyr: 1.686 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
4.136SerAla: 4.136 ± 0.085
0.37SerCys: 0.37 ± 0.026
3.115SerAsp: 3.115 ± 0.071
4.465SerGlu: 4.465 ± 0.082
3.415SerPhe: 3.415 ± 0.069
4.896SerGly: 4.896 ± 0.084
1.091SerHis: 1.091 ± 0.038
4.306SerIle: 4.306 ± 0.09
3.957SerLys: 3.957 ± 0.081
5.909SerLeu: 5.909 ± 0.097
1.385SerMet: 1.385 ± 0.044
2.307SerAsn: 2.307 ± 0.066
1.929SerPro: 1.929 ± 0.051
1.84SerGln: 1.84 ± 0.046
2.35SerArg: 2.35 ± 0.059
3.939SerSer: 3.939 ± 0.084
2.816SerThr: 2.816 ± 0.059
4.133SerVal: 4.133 ± 0.075
0.553SerTrp: 0.553 ± 0.026
2.251SerTyr: 2.251 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.271ThrAla: 4.271 ± 0.081
0.288ThrCys: 0.288 ± 0.022
2.955ThrAsp: 2.955 ± 0.063
3.805ThrGlu: 3.805 ± 0.077
2.698ThrPhe: 2.698 ± 0.07
4.446ThrGly: 4.446 ± 0.09
0.984ThrHis: 0.984 ± 0.037
4.174ThrIle: 4.174 ± 0.081
3.666ThrLys: 3.666 ± 0.08
5.387ThrLeu: 5.387 ± 0.085
1.237ThrMet: 1.237 ± 0.042
2.299ThrAsn: 2.299 ± 0.054
2.195ThrPro: 2.195 ± 0.053
1.607ThrGln: 1.607 ± 0.047
1.979ThrArg: 1.979 ± 0.054
3.298ThrSer: 3.298 ± 0.058
2.928ThrThr: 2.928 ± 0.07
4.066ThrVal: 4.066 ± 0.083
0.478ThrTrp: 0.478 ± 0.028
1.799ThrTyr: 1.799 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
5.684ValAla: 5.684 ± 0.099
0.547ValCys: 0.547 ± 0.029
3.743ValAsp: 3.743 ± 0.079
4.684ValGlu: 4.684 ± 0.098
3.281ValPhe: 3.281 ± 0.07
4.523ValGly: 4.523 ± 0.085
1.257ValHis: 1.257 ± 0.042
5.338ValIle: 5.338 ± 0.088
4.491ValLys: 4.491 ± 0.08
7.346ValLeu: 7.346 ± 0.118
1.731ValMet: 1.731 ± 0.048
2.686ValAsn: 2.686 ± 0.073
2.787ValPro: 2.787 ± 0.064
2.415ValGln: 2.415 ± 0.054
2.802ValArg: 2.802 ± 0.068
4.825ValSer: 4.825 ± 0.08
4.295ValThr: 4.295 ± 0.087
5.24ValVal: 5.24 ± 0.1
0.531ValTrp: 0.531 ± 0.026
2.208ValTyr: 2.208 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.478TrpAla: 0.478 ± 0.026
0.044TrpCys: 0.044 ± 0.008
0.474TrpAsp: 0.474 ± 0.027
0.465TrpGlu: 0.465 ± 0.027
0.444TrpPhe: 0.444 ± 0.025
0.557TrpGly: 0.557 ± 0.025
0.206TrpHis: 0.206 ± 0.017
0.781TrpIle: 0.781 ± 0.034
0.647TrpLys: 0.647 ± 0.029
1.065TrpLeu: 1.065 ± 0.038
0.291TrpMet: 0.291 ± 0.021
0.48TrpAsn: 0.48 ± 0.028
0.218TrpPro: 0.218 ± 0.017
0.423TrpGln: 0.423 ± 0.026
0.366TrpArg: 0.366 ± 0.024
0.48TrpSer: 0.48 ± 0.026
0.478TrpThr: 0.478 ± 0.029
0.516TrpVal: 0.516 ± 0.025
0.097TrpTrp: 0.097 ± 0.013
0.277TrpTyr: 0.277 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.293TyrAla: 2.293 ± 0.056
0.202TyrCys: 0.202 ± 0.018
1.901TyrAsp: 1.901 ± 0.066
2.312TyrGlu: 2.312 ± 0.054
1.975TyrPhe: 1.975 ± 0.058
2.335TyrGly: 2.335 ± 0.064
0.812TyrHis: 0.812 ± 0.037
2.056TyrIle: 2.056 ± 0.059
1.892TyrLys: 1.892 ± 0.059
3.8TyrLeu: 3.8 ± 0.08
0.8TyrMet: 0.8 ± 0.031
1.201TyrAsn: 1.201 ± 0.037
1.35TyrPro: 1.35 ± 0.042
1.761TyrGln: 1.761 ± 0.059
1.667TyrArg: 1.667 ± 0.048
2.034TyrSer: 2.034 ± 0.052
1.804TyrThr: 1.804 ± 0.054
2.049TyrVal: 2.049 ± 0.054
0.349TyrTrp: 0.349 ± 0.02
1.343TyrTyr: 1.343 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2426 proteins (732639 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski