Amino acid dipepetide frequency for Sphingomonas sp. XS-10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.09AlaAla: 20.09 ± 0.199	0.964AlaCys: 0.964 ± 0.03	7.633AlaAsp: 7.633 ± 0.073	7.857AlaGlu: 7.857 ± 0.104	4.502AlaPhe: 4.502 ± 0.062	11.335AlaGly: 11.335 ± 0.106	2.29AlaHis: 2.29 ± 0.044	7.105AlaIle: 7.105 ± 0.088	3.972AlaLys: 3.972 ± 0.074	14.399AlaLeu: 14.399 ± 0.124	4.009AlaMet: 4.009 ± 0.072	3.152AlaAsn: 3.152 ± 0.053	7.007AlaPro: 7.007 ± 0.091	4.792AlaGln: 4.792 ± 0.068	10.457AlaArg: 10.457 ± 0.116	6.679AlaSer: 6.679 ± 0.074	7.076AlaThr: 7.076 ± 0.088	8.914AlaVal: 8.914 ± 0.087	1.738AlaTrp: 1.738 ± 0.035	2.639AlaTyr: 2.639 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.974CysAla: 0.974 ± 0.03	0.078CysCys: 0.078 ± 0.009	0.522CysAsp: 0.522 ± 0.023	0.359CysGlu: 0.359 ± 0.018	0.292CysPhe: 0.292 ± 0.014	0.753CysGly: 0.753 ± 0.026	0.194CysHis: 0.194 ± 0.014	0.329CysIle: 0.329 ± 0.016	0.151CysLys: 0.151 ± 0.011	0.622CysLeu: 0.622 ± 0.021	0.117CysMet: 0.117 ± 0.01	0.183CysAsn: 0.183 ± 0.013	0.394CysPro: 0.394 ± 0.017	0.175CysGln: 0.175 ± 0.012	0.538CysArg: 0.538 ± 0.019	0.375CysSer: 0.375 ± 0.019	0.36CysThr: 0.36 ± 0.018	0.503CysVal: 0.503 ± 0.021	0.111CysTrp: 0.111 ± 0.009	0.146CysTyr: 0.146 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.645AspAla: 8.645 ± 0.083	0.445AspCys: 0.445 ± 0.02	3.368AspAsp: 3.368 ± 0.064	3.187AspGlu: 3.187 ± 0.055	2.085AspPhe: 2.085 ± 0.044	5.822AspGly: 5.822 ± 0.103	1.235AspHis: 1.235 ± 0.037	2.788AspIle: 2.788 ± 0.052	1.645AspLys: 1.645 ± 0.043	5.728AspLeu: 5.728 ± 0.068	1.349AspMet: 1.349 ± 0.035	1.261AspAsn: 1.261 ± 0.038	4.214AspPro: 4.214 ± 0.061	1.741AspGln: 1.741 ± 0.033	5.123AspArg: 5.123 ± 0.067	2.54AspSer: 2.54 ± 0.048	2.776AspThr: 2.776 ± 0.05	3.939AspVal: 3.939 ± 0.059	1.18AspTrp: 1.18 ± 0.029	1.733AspTyr: 1.733 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.743GluAla: 7.743 ± 0.095	0.271GluCys: 0.271 ± 0.017	2.664GluAsp: 2.664 ± 0.055	2.742GluGlu: 2.742 ± 0.055	1.595GluPhe: 1.595 ± 0.036	4.572GluGly: 4.572 ± 0.071	1.029GluHis: 1.029 ± 0.033	2.869GluIle: 2.869 ± 0.046	1.782GluLys: 1.782 ± 0.043	5.06GluLeu: 5.06 ± 0.061	1.368GluMet: 1.368 ± 0.032	1.265GluAsn: 1.265 ± 0.034	2.664GluPro: 2.664 ± 0.055	1.969GluGln: 1.969 ± 0.042	5.116GluArg: 5.116 ± 0.08	2.349GluSer: 2.349 ± 0.047	3.268GluThr: 3.268 ± 0.047	3.519GluVal: 3.519 ± 0.062	0.731GluTrp: 0.731 ± 0.023	0.903GluTyr: 0.903 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	5.04PheAla: 5.04 ± 0.067	0.271PheCys: 0.271 ± 0.014	2.878PheAsp: 2.878 ± 0.061	2.05PheGlu: 2.05 ± 0.041	1.208PhePhe: 1.208 ± 0.033	3.736PheGly: 3.736 ± 0.06	0.692PheHis: 0.692 ± 0.024	1.35PheIle: 1.35 ± 0.035	0.864PheLys: 0.864 ± 0.027	3.089PheLeu: 3.089 ± 0.054	0.685PheMet: 0.685 ± 0.025	0.968PheAsn: 0.968 ± 0.034	1.492PhePro: 1.492 ± 0.036	0.882PheGln: 0.882 ± 0.026	2.288PheArg: 2.288 ± 0.042	1.815PheSer: 1.815 ± 0.04	2.063PheThr: 2.063 ± 0.045	2.719PheVal: 2.719 ± 0.052	0.519PheTrp: 0.519 ± 0.024	0.894PheTyr: 0.894 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.443GlyAla: 10.443 ± 0.106	0.792GlyCys: 0.792 ± 0.024	5.066GlyAsp: 5.066 ± 0.073	5.077GlyGlu: 5.077 ± 0.061	3.626GlyPhe: 3.626 ± 0.054	8.37GlyGly: 8.37 ± 0.109	1.716GlyHis: 1.716 ± 0.038	4.444GlyIle: 4.444 ± 0.063	3.238GlyLys: 3.238 ± 0.058	8.373GlyLeu: 8.373 ± 0.099	2.306GlyMet: 2.306 ± 0.045	2.282GlyAsn: 2.282 ± 0.058	3.779GlyPro: 3.779 ± 0.057	2.926GlyGln: 2.926 ± 0.049	6.465GlyArg: 6.465 ± 0.073	4.836GlySer: 4.836 ± 0.086	5.084GlyThr: 5.084 ± 0.081	6.522GlyVal: 6.522 ± 0.081	1.767GlyTrp: 1.767 ± 0.043	2.385GlyTyr: 2.385 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.304HisAla: 2.304 ± 0.053	0.197HisCys: 0.197 ± 0.014	1.132HisAsp: 1.132 ± 0.036	0.9HisGlu: 0.9 ± 0.029	0.769HisPhe: 0.769 ± 0.026	1.868HisGly: 1.868 ± 0.045	0.516HisHis: 0.516 ± 0.023	0.847HisIle: 0.847 ± 0.029	0.411HisLys: 0.411 ± 0.018	1.836HisLeu: 1.836 ± 0.036	0.385HisMet: 0.385 ± 0.018	0.423HisAsn: 0.423 ± 0.018	1.273HisPro: 1.273 ± 0.033	0.503HisGln: 0.503 ± 0.021	1.509HisArg: 1.509 ± 0.039	0.928HisSer: 0.928 ± 0.027	0.66HisThr: 0.66 ± 0.022	1.418HisVal: 1.418 ± 0.035	0.351HisTrp: 0.351 ± 0.017	0.549HisTyr: 0.549 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	8.243IleAla: 8.243 ± 0.1	0.395IleCys: 0.395 ± 0.019	4.171IleAsp: 4.171 ± 0.057	3.486IleGlu: 3.486 ± 0.053	1.502IlePhe: 1.502 ± 0.042	5.123IleGly: 5.123 ± 0.075	0.842IleHis: 0.842 ± 0.027	1.703IleIle: 1.703 ± 0.046	1.127IleLys: 1.127 ± 0.032	4.127IleLeu: 4.127 ± 0.062	0.738IleMet: 0.738 ± 0.026	1.173IleAsn: 1.173 ± 0.035	2.23IlePro: 2.23 ± 0.04	1.142IleGln: 1.142 ± 0.029	3.206IleArg: 3.206 ± 0.054	2.316IleSer: 2.316 ± 0.05	2.419IleThr: 2.419 ± 0.049	4.137IleVal: 4.137 ± 0.062	0.635IleTrp: 0.635 ± 0.024	0.964IleTyr: 0.964 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.72LysAla: 3.72 ± 0.069	0.143LysCys: 0.143 ± 0.011	1.53LysAsp: 1.53 ± 0.049	1.182LysGlu: 1.182 ± 0.04	0.82LysPhe: 0.82 ± 0.023	2.515LysGly: 2.515 ± 0.051	0.504LysHis: 0.504 ± 0.02	1.347LysIle: 1.347 ± 0.039	1.004LysLys: 1.004 ± 0.037	3.076LysLeu: 3.076 ± 0.051	0.738LysMet: 0.738 ± 0.025	0.607LysAsn: 0.607 ± 0.024	2.0LysPro: 2.0 ± 0.041	0.853LysGln: 0.853 ± 0.03	2.245LysArg: 2.245 ± 0.047	1.482LysSer: 1.482 ± 0.038	1.596LysThr: 1.596 ± 0.036	1.993LysVal: 1.993 ± 0.049	0.411LysTrp: 0.411 ± 0.022	0.55LysTyr: 0.55 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.33LeuAla: 14.33 ± 0.142	0.737LeuCys: 0.737 ± 0.028	6.321LeuAsp: 6.321 ± 0.085	4.441LeuGlu: 4.441 ± 0.076	3.667LeuPhe: 3.667 ± 0.06	8.148LeuGly: 8.148 ± 0.095	1.688LeuHis: 1.688 ± 0.039	5.077LeuIle: 5.077 ± 0.07	2.932LeuLys: 2.932 ± 0.047	9.245LeuLeu: 9.245 ± 0.133	2.039LeuMet: 2.039 ± 0.045	2.454LeuAsn: 2.454 ± 0.046	5.524LeuPro: 5.524 ± 0.071	2.279LeuGln: 2.279 ± 0.038	7.021LeuArg: 7.021 ± 0.086	5.606LeuSer: 5.606 ± 0.076	5.754LeuThr: 5.754 ± 0.085	6.973LeuVal: 6.973 ± 0.091	1.278LeuTrp: 1.278 ± 0.041	2.03LeuTyr: 2.03 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.175MetAla: 3.175 ± 0.052	0.126MetCys: 0.126 ± 0.011	1.059MetAsp: 1.059 ± 0.029	0.968MetGlu: 0.968 ± 0.03	0.695MetPhe: 0.695 ± 0.026	1.865MetGly: 1.865 ± 0.044	0.403MetHis: 0.403 ± 0.022	1.318MetIle: 1.318 ± 0.038	0.87MetLys: 0.87 ± 0.026	2.584MetLeu: 2.584 ± 0.051	0.598MetMet: 0.598 ± 0.022	0.641MetAsn: 0.641 ± 0.022	1.427MetPro: 1.427 ± 0.039	0.718MetGln: 0.718 ± 0.024	1.979MetArg: 1.979 ± 0.039	1.31MetSer: 1.31 ± 0.034	1.708MetThr: 1.708 ± 0.033	1.604MetVal: 1.604 ± 0.034	0.251MetTrp: 0.251 ± 0.015	0.268MetTyr: 0.268 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.171AsnAla: 3.171 ± 0.051	0.216AsnCys: 0.216 ± 0.015	1.286AsnAsp: 1.286 ± 0.042	1.073AsnGlu: 1.073 ± 0.032	0.951AsnPhe: 0.951 ± 0.034	2.391AsnGly: 2.391 ± 0.053	0.474AsnHis: 0.474 ± 0.02	1.241AsnIle: 1.241 ± 0.032	0.531AsnLys: 0.531 ± 0.022	2.488AsnLeu: 2.488 ± 0.048	0.514AsnMet: 0.514 ± 0.022	0.642AsnAsn: 0.642 ± 0.028	1.816AsnPro: 1.816 ± 0.05	0.718AsnGln: 0.718 ± 0.026	1.829AsnArg: 1.829 ± 0.043	1.125AsnSer: 1.125 ± 0.036	1.048AsnThr: 1.048 ± 0.037	1.844AsnVal: 1.844 ± 0.045	0.456AsnTrp: 0.456 ± 0.019	0.764AsnTyr: 0.764 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	7.259ProAla: 7.259 ± 0.102	0.322ProCys: 0.322 ± 0.017	4.067ProAsp: 4.067 ± 0.064	3.585ProGlu: 3.585 ± 0.054	1.981ProPhe: 1.981 ± 0.041	5.271ProGly: 5.271 ± 0.075	1.029ProHis: 1.029 ± 0.035	2.378ProIle: 2.378 ± 0.052	1.421ProLys: 1.421 ± 0.036	4.947ProLeu: 4.947 ± 0.069	1.219ProMet: 1.219 ± 0.035	1.306ProAsn: 1.306 ± 0.035	3.032ProPro: 3.032 ± 0.081	1.761ProGln: 1.761 ± 0.04	3.373ProArg: 3.373 ± 0.067	2.706ProSer: 2.706 ± 0.042	2.714ProThr: 2.714 ± 0.05	4.633ProVal: 4.633 ± 0.064	0.743ProTrp: 0.743 ± 0.025	1.126ProTyr: 1.126 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.98GlnAla: 3.98 ± 0.063	0.21GlnCys: 0.21 ± 0.014	1.45GlnAsp: 1.45 ± 0.038	1.243GlnGlu: 1.243 ± 0.033	1.058GlnPhe: 1.058 ± 0.032	2.502GlnGly: 2.502 ± 0.044	0.554GlnHis: 0.554 ± 0.02	1.709GlnIle: 1.709 ± 0.041	0.815GlnLys: 0.815 ± 0.028	3.049GlnLeu: 3.049 ± 0.05	0.8GlnMet: 0.8 ± 0.022	0.744GlnAsn: 0.744 ± 0.028	1.784GlnPro: 1.784 ± 0.049	1.12GlnGln: 1.12 ± 0.032	2.604GlnArg: 2.604 ± 0.051	1.59GlnSer: 1.59 ± 0.039	1.655GlnThr: 1.655 ± 0.036	2.252GlnVal: 2.252 ± 0.048	0.42GlnTrp: 0.42 ± 0.02	0.586GlnTyr: 0.586 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.825ArgAla: 9.825 ± 0.103	0.494ArgCys: 0.494 ± 0.02	4.877ArgAsp: 4.877 ± 0.066	4.178ArgGlu: 4.178 ± 0.065	3.223ArgPhe: 3.223 ± 0.053	5.503ArgGly: 5.503 ± 0.071	1.626ArgHis: 1.626 ± 0.031	4.407ArgIle: 4.407 ± 0.063	2.014ArgLys: 2.014 ± 0.044	7.817ArgLeu: 7.817 ± 0.104	2.055ArgMet: 2.055 ± 0.039	1.841ArgAsn: 1.841 ± 0.046	3.82ArgPro: 3.82 ± 0.069	2.278ArgGln: 2.278 ± 0.041	6.083ArgArg: 6.083 ± 0.084	3.712ArgSer: 3.712 ± 0.061	3.787ArgThr: 3.787 ± 0.051	5.276ArgVal: 5.276 ± 0.074	1.325ArgTrp: 1.325 ± 0.035	1.932ArgTyr: 1.932 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.415SerAla: 6.415 ± 0.082	0.374SerCys: 0.374 ± 0.018	3.191SerAsp: 3.191 ± 0.053	2.426SerGlu: 2.426 ± 0.045	2.076SerPhe: 2.076 ± 0.046	5.482SerGly: 5.482 ± 0.076	0.892SerHis: 0.892 ± 0.029	2.614SerIle: 2.614 ± 0.045	1.343SerLys: 1.343 ± 0.039	4.68SerLeu: 4.68 ± 0.075	1.113SerMet: 1.113 ± 0.034	1.349SerAsn: 1.349 ± 0.037	2.87SerPro: 2.87 ± 0.053	1.387SerGln: 1.387 ± 0.041	3.471SerArg: 3.471 ± 0.056	2.54SerSer: 2.54 ± 0.058	2.607SerThr: 2.607 ± 0.047	3.629SerVal: 3.629 ± 0.055	0.818SerTrp: 0.818 ± 0.03	1.357SerTyr: 1.357 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.771ThrAla: 6.771 ± 0.088	0.355ThrCys: 0.355 ± 0.017	3.003ThrAsp: 3.003 ± 0.052	2.341ThrGlu: 2.341 ± 0.046	1.786ThrPhe: 1.786 ± 0.048	5.534ThrGly: 5.534 ± 0.088	0.979ThrHis: 0.979 ± 0.029	2.949ThrIle: 2.949 ± 0.052	1.2ThrLys: 1.2 ± 0.035	6.097ThrLeu: 6.097 ± 0.079	1.165ThrMet: 1.165 ± 0.031	1.349ThrAsn: 1.349 ± 0.039	3.738ThrPro: 3.738 ± 0.059	1.526ThrGln: 1.526 ± 0.037	3.831ThrArg: 3.831 ± 0.058	2.599ThrSer: 2.599 ± 0.057	2.661ThrThr: 2.661 ± 0.052	4.192ThrVal: 4.192 ± 0.066	0.612ThrTrp: 0.612 ± 0.023	1.16ThrTyr: 1.16 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	10.263ValAla: 10.263 ± 0.103	0.458ValCys: 0.458 ± 0.019	4.239ValAsp: 4.239 ± 0.06	4.677ValGlu: 4.677 ± 0.076	2.186ValPhe: 2.186 ± 0.044	5.503ValGly: 5.503 ± 0.069	1.282ValHis: 1.282 ± 0.034	3.64ValIle: 3.64 ± 0.05	1.989ValLys: 1.989 ± 0.044	6.418ValLeu: 6.418 ± 0.092	1.62ValMet: 1.62 ± 0.036	1.908ValAsn: 1.908 ± 0.048	3.98ValPro: 3.98 ± 0.059	2.086ValGln: 2.086 ± 0.041	5.39ValArg: 5.39 ± 0.069	3.959ValSer: 3.959 ± 0.057	4.735ValThr: 4.735 ± 0.071	5.273ValVal: 5.273 ± 0.092	0.851ValTrp: 0.851 ± 0.029	1.32ValTyr: 1.32 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.467TrpAla: 1.467 ± 0.041	0.13TrpCys: 0.13 ± 0.011	0.78TrpAsp: 0.78 ± 0.027	0.602TrpGlu: 0.602 ± 0.026	0.583TrpPhe: 0.583 ± 0.021	1.062TrpGly: 1.062 ± 0.03	0.356TrpHis: 0.356 ± 0.018	0.722TrpIle: 0.722 ± 0.024	0.474TrpLys: 0.474 ± 0.02	1.779TrpLeu: 1.779 ± 0.044	0.373TrpMet: 0.373 ± 0.02	0.439TrpAsn: 0.439 ± 0.018	0.72TrpPro: 0.72 ± 0.025	0.598TrpGln: 0.598 ± 0.024	1.467TrpArg: 1.467 ± 0.036	0.925TrpSer: 0.925 ± 0.032	0.847TrpThr: 0.847 ± 0.026	0.926TrpVal: 0.926 ± 0.027	0.275TrpTrp: 0.275 ± 0.016	0.337TrpTyr: 0.337 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.752TyrAla: 2.752 ± 0.057	0.197TyrCys: 0.197 ± 0.013	1.567TyrAsp: 1.567 ± 0.047	1.104TyrGlu: 1.104 ± 0.033	0.898TyrPhe: 0.898 ± 0.027	2.142TyrGly: 2.142 ± 0.048	0.478TyrHis: 0.478 ± 0.016	0.841TyrIle: 0.841 ± 0.026	0.534TyrLys: 0.534 ± 0.02	2.13TyrLeu: 2.13 ± 0.046	0.376TyrMet: 0.376 ± 0.019	0.591TyrAsn: 0.591 ± 0.027	1.111TyrPro: 1.111 ± 0.03	0.668TyrGln: 0.668 ± 0.029	2.079TyrArg: 2.079 ± 0.045	1.241TyrSer: 1.241 ± 0.038	1.032TyrThr: 1.032 ± 0.036	1.511TyrVal: 1.511 ± 0.038	0.391TyrTrp: 0.391 ± 0.021	0.641TyrTyr: 0.641 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3831 proteins (1241582 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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