Amino acid dipepetide frequency for Erwinia phage vB_EamM_TropicalSun

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.38AlaAla: 9.38 ± 0.79
0.65AlaCys: 0.65 ± 0.211
5.665AlaAsp: 5.665 ± 0.435
5.758AlaGlu: 5.758 ± 0.865
3.111AlaPhe: 3.111 ± 0.394
5.618AlaGly: 5.618 ± 0.452
1.811AlaHis: 1.811 ± 0.304
5.34AlaIle: 5.34 ± 0.449
6.501AlaLys: 6.501 ± 0.706
6.594AlaLeu: 6.594 ± 0.608
2.693AlaMet: 2.693 ± 0.37
4.179AlaAsn: 4.179 ± 0.514
3.854AlaPro: 3.854 ± 0.443
2.74AlaGln: 2.74 ± 0.495
4.411AlaArg: 4.411 ± 0.483
5.711AlaSer: 5.711 ± 0.543
5.061AlaThr: 5.061 ± 0.555
6.269AlaVal: 6.269 ± 0.669
1.022AlaTrp: 1.022 ± 0.223
2.972AlaTyr: 2.972 ± 0.335
0.0AlaXaa: 0.0 ± 0.0
Cys
0.836CysAla: 0.836 ± 0.185
0.139CysCys: 0.139 ± 0.065
0.789CysAsp: 0.789 ± 0.216
0.418CysGlu: 0.418 ± 0.121
0.511CysPhe: 0.511 ± 0.205
0.789CysGly: 0.789 ± 0.204
0.139CysHis: 0.139 ± 0.079
0.557CysIle: 0.557 ± 0.16
0.557CysLys: 0.557 ± 0.169
0.882CysLeu: 0.882 ± 0.22
0.371CysMet: 0.371 ± 0.119
0.604CysAsn: 0.604 ± 0.182
0.464CysPro: 0.464 ± 0.167
0.279CysGln: 0.279 ± 0.104
0.697CysArg: 0.697 ± 0.181
0.464CysSer: 0.464 ± 0.153
1.022CysThr: 1.022 ± 0.205
0.65CysVal: 0.65 ± 0.17
0.371CysTrp: 0.371 ± 0.139
0.743CysTyr: 0.743 ± 0.213
0.0CysXaa: 0.0 ± 0.0
Asp
5.293AspAla: 5.293 ± 0.48
0.557AspCys: 0.557 ± 0.145
3.947AspAsp: 3.947 ± 0.453
4.69AspGlu: 4.69 ± 0.492
2.322AspPhe: 2.322 ± 0.362
5.526AspGly: 5.526 ± 0.501
0.975AspHis: 0.975 ± 0.196
3.993AspIle: 3.993 ± 0.386
2.879AspLys: 2.879 ± 0.375
4.458AspLeu: 4.458 ± 0.462
2.09AspMet: 2.09 ± 0.334
2.136AspAsn: 2.136 ± 0.252
2.832AspPro: 2.832 ± 0.356
2.229AspGln: 2.229 ± 0.316
2.461AspArg: 2.461 ± 0.337
3.622AspSer: 3.622 ± 0.455
3.436AspThr: 3.436 ± 0.333
4.597AspVal: 4.597 ± 0.463
1.114AspTrp: 1.114 ± 0.191
2.275AspTyr: 2.275 ± 0.294
0.0AspXaa: 0.0 ± 0.0
Glu
5.804GluAla: 5.804 ± 0.872
0.371GluCys: 0.371 ± 0.126
3.111GluAsp: 3.111 ± 0.399
4.597GluGlu: 4.597 ± 0.636
2.879GluPhe: 2.879 ± 0.396
3.575GluGly: 3.575 ± 0.386
1.114GluHis: 1.114 ± 0.217
3.25GluIle: 3.25 ± 0.354
2.832GluLys: 2.832 ± 0.395
5.479GluLeu: 5.479 ± 0.497
1.672GluMet: 1.672 ± 0.237
2.647GluAsn: 2.647 ± 0.303
2.275GluPro: 2.275 ± 0.428
2.554GluGln: 2.554 ± 0.402
3.761GluArg: 3.761 ± 0.666
4.551GluSer: 4.551 ± 0.399
2.507GluThr: 2.507 ± 0.318
4.179GluVal: 4.179 ± 0.434
0.836GluTrp: 0.836 ± 0.176
2.693GluTyr: 2.693 ± 0.352
0.0GluXaa: 0.0 ± 0.0
Phe
3.39PheAla: 3.39 ± 0.298
0.325PheCys: 0.325 ± 0.111
3.39PheAsp: 3.39 ± 0.391
2.972PheGlu: 2.972 ± 0.337
1.347PhePhe: 1.347 ± 0.317
3.854PheGly: 3.854 ± 0.405
0.511PheHis: 0.511 ± 0.165
2.415PheIle: 2.415 ± 0.295
2.879PheLys: 2.879 ± 0.401
2.554PheLeu: 2.554 ± 0.386
1.068PheMet: 1.068 ± 0.225
2.647PheAsn: 2.647 ± 0.287
1.068PhePro: 1.068 ± 0.191
1.579PheGln: 1.579 ± 0.324
1.857PheArg: 1.857 ± 0.294
2.647PheSer: 2.647 ± 0.388
2.322PheThr: 2.322 ± 0.31
2.786PheVal: 2.786 ± 0.355
0.65PheTrp: 0.65 ± 0.206
1.579PheTyr: 1.579 ± 0.206
0.0PheXaa: 0.0 ± 0.0
Gly
6.408GlyAla: 6.408 ± 0.689
1.068GlyCys: 1.068 ± 0.207
4.922GlyAsp: 4.922 ± 0.497
4.365GlyGlu: 4.365 ± 0.448
3.622GlyPhe: 3.622 ± 0.396
5.479GlyGly: 5.479 ± 0.774
1.114GlyHis: 1.114 ± 0.263
5.479GlyIle: 5.479 ± 0.46
5.34GlyLys: 5.34 ± 0.581
4.922GlyLeu: 4.922 ± 0.487
1.904GlyMet: 1.904 ± 0.298
3.39GlyAsn: 3.39 ± 0.438
1.347GlyPro: 1.347 ± 0.279
2.693GlyGln: 2.693 ± 0.394
3.575GlyArg: 3.575 ± 0.482
4.551GlySer: 4.551 ± 0.651
3.575GlyThr: 3.575 ± 0.561
5.897GlyVal: 5.897 ± 0.473
1.3GlyTrp: 1.3 ± 0.224
2.693GlyTyr: 2.693 ± 0.378
0.0GlyXaa: 0.0 ± 0.0
His
0.975HisAla: 0.975 ± 0.229
0.371HisCys: 0.371 ± 0.121
0.975HisAsp: 0.975 ± 0.212
1.114HisGlu: 1.114 ± 0.235
0.789HisPhe: 0.789 ± 0.179
1.393HisGly: 1.393 ± 0.284
0.371HisHis: 0.371 ± 0.151
1.068HisIle: 1.068 ± 0.212
1.3HisLys: 1.3 ± 0.266
1.532HisLeu: 1.532 ± 0.288
0.371HisMet: 0.371 ± 0.116
0.697HisAsn: 0.697 ± 0.215
0.882HisPro: 0.882 ± 0.231
0.464HisGln: 0.464 ± 0.123
0.789HisArg: 0.789 ± 0.166
1.161HisSer: 1.161 ± 0.223
0.882HisThr: 0.882 ± 0.188
0.697HisVal: 0.697 ± 0.187
0.418HisTrp: 0.418 ± 0.118
0.697HisTyr: 0.697 ± 0.204
0.0HisXaa: 0.0 ± 0.0
Ile
4.736IleAla: 4.736 ± 0.506
0.65IleCys: 0.65 ± 0.163
4.736IleAsp: 4.736 ± 0.646
3.715IleGlu: 3.715 ± 0.323
1.997IlePhe: 1.997 ± 0.245
4.597IleGly: 4.597 ± 0.437
1.207IleHis: 1.207 ± 0.236
4.272IleIle: 4.272 ± 0.436
5.34IleLys: 5.34 ± 0.603
4.133IleLeu: 4.133 ± 0.419
2.275IleMet: 2.275 ± 0.285
3.158IleAsn: 3.158 ± 0.46
2.368IlePro: 2.368 ± 0.317
2.879IleGln: 2.879 ± 0.407
2.322IleArg: 2.322 ± 0.3
3.808IleSer: 3.808 ± 0.575
4.597IleThr: 4.597 ± 0.489
4.922IleVal: 4.922 ± 0.476
0.789IleTrp: 0.789 ± 0.219
1.857IleTyr: 1.857 ± 0.412
0.0IleXaa: 0.0 ± 0.0
Lys
6.408LysAla: 6.408 ± 0.705
0.789LysCys: 0.789 ± 0.23
3.761LysAsp: 3.761 ± 0.42
3.993LysGlu: 3.993 ± 0.725
2.693LysPhe: 2.693 ± 0.264
4.179LysGly: 4.179 ± 0.526
1.114LysHis: 1.114 ± 0.236
3.529LysIle: 3.529 ± 0.45
3.854LysLys: 3.854 ± 0.566
3.993LysLeu: 3.993 ± 0.382
2.182LysMet: 2.182 ± 0.355
2.74LysAsn: 2.74 ± 0.36
2.786LysPro: 2.786 ± 0.372
2.461LysGln: 2.461 ± 0.341
4.318LysArg: 4.318 ± 0.427
4.225LysSer: 4.225 ± 0.452
3.483LysThr: 3.483 ± 0.359
4.318LysVal: 4.318 ± 0.399
0.557LysTrp: 0.557 ± 0.14
1.811LysTyr: 1.811 ± 0.354
0.0LysXaa: 0.0 ± 0.0
Leu
6.779LeuAla: 6.779 ± 0.755
1.254LeuCys: 1.254 ± 0.244
3.9LeuAsp: 3.9 ± 0.517
4.133LeuGlu: 4.133 ± 0.41
2.972LeuPhe: 2.972 ± 0.393
4.829LeuGly: 4.829 ± 0.453
0.882LeuHis: 0.882 ± 0.178
4.458LeuIle: 4.458 ± 0.51
5.711LeuLys: 5.711 ± 0.551
5.015LeuLeu: 5.015 ± 0.446
2.554LeuMet: 2.554 ± 0.382
4.551LeuAsn: 4.551 ± 0.47
2.972LeuPro: 2.972 ± 0.289
2.554LeuGln: 2.554 ± 0.363
3.668LeuArg: 3.668 ± 0.397
5.293LeuSer: 5.293 ± 0.442
4.504LeuThr: 4.504 ± 0.446
4.318LeuVal: 4.318 ± 0.537
0.697LeuTrp: 0.697 ± 0.198
2.322LeuTyr: 2.322 ± 0.275
0.0LeuXaa: 0.0 ± 0.0
Met
2.461MetAla: 2.461 ± 0.304
0.186MetCys: 0.186 ± 0.097
1.579MetAsp: 1.579 ± 0.293
1.718MetGlu: 1.718 ± 0.227
0.836MetPhe: 0.836 ± 0.214
1.579MetGly: 1.579 ± 0.274
0.511MetHis: 0.511 ± 0.13
1.393MetIle: 1.393 ± 0.266
1.904MetLys: 1.904 ± 0.276
2.554MetLeu: 2.554 ± 0.282
0.557MetMet: 0.557 ± 0.156
1.579MetAsn: 1.579 ± 0.233
1.857MetPro: 1.857 ± 0.255
1.022MetGln: 1.022 ± 0.21
1.347MetArg: 1.347 ± 0.201
2.322MetSer: 2.322 ± 0.328
2.322MetThr: 2.322 ± 0.314
2.09MetVal: 2.09 ± 0.348
0.325MetTrp: 0.325 ± 0.124
1.207MetTyr: 1.207 ± 0.233
0.0MetXaa: 0.0 ± 0.0
Asn
4.179AsnAla: 4.179 ± 0.434
0.789AsnCys: 0.789 ± 0.209
1.997AsnAsp: 1.997 ± 0.298
2.322AsnGlu: 2.322 ± 0.311
2.09AsnPhe: 2.09 ± 0.318
5.061AsnGly: 5.061 ± 0.507
1.114AsnHis: 1.114 ± 0.218
3.575AsnIle: 3.575 ± 0.494
2.6AsnLys: 2.6 ± 0.382
3.529AsnLeu: 3.529 ± 0.385
1.3AsnMet: 1.3 ± 0.229
1.904AsnAsn: 1.904 ± 0.338
2.786AsnPro: 2.786 ± 0.392
1.579AsnGln: 1.579 ± 0.27
2.275AsnArg: 2.275 ± 0.317
3.018AsnSer: 3.018 ± 0.351
2.832AsnThr: 2.832 ± 0.429
2.832AsnVal: 2.832 ± 0.424
0.743AsnTrp: 0.743 ± 0.152
1.857AsnTyr: 1.857 ± 0.337
0.0AsnXaa: 0.0 ± 0.0
Pro
3.111ProAla: 3.111 ± 0.364
0.371ProCys: 0.371 ± 0.128
3.436ProAsp: 3.436 ± 0.389
2.74ProGlu: 2.74 ± 0.357
2.182ProPhe: 2.182 ± 0.283
2.972ProGly: 2.972 ± 0.448
0.418ProHis: 0.418 ± 0.127
2.786ProIle: 2.786 ± 0.387
2.275ProLys: 2.275 ± 0.34
2.368ProLeu: 2.368 ± 0.302
1.579ProMet: 1.579 ± 0.285
1.997ProAsn: 1.997 ± 0.337
1.207ProPro: 1.207 ± 0.24
1.207ProGln: 1.207 ± 0.243
1.254ProArg: 1.254 ± 0.225
2.972ProSer: 2.972 ± 0.375
2.09ProThr: 2.09 ± 0.317
3.065ProVal: 3.065 ± 0.349
0.557ProTrp: 0.557 ± 0.17
1.393ProTyr: 1.393 ± 0.263
0.0ProXaa: 0.0 ± 0.0
Gln
4.086GlnAla: 4.086 ± 0.457
0.186GlnCys: 0.186 ± 0.12
1.161GlnAsp: 1.161 ± 0.18
2.368GlnGlu: 2.368 ± 0.424
2.647GlnPhe: 2.647 ± 0.398
2.368GlnGly: 2.368 ± 0.294
0.371GlnHis: 0.371 ± 0.108
1.95GlnIle: 1.95 ± 0.289
1.95GlnLys: 1.95 ± 0.315
3.761GlnLeu: 3.761 ± 0.474
1.347GlnMet: 1.347 ± 0.227
1.625GlnAsn: 1.625 ± 0.344
1.857GlnPro: 1.857 ± 0.298
2.09GlnGln: 2.09 ± 0.363
2.275GlnArg: 2.275 ± 0.339
2.832GlnSer: 2.832 ± 0.392
1.95GlnThr: 1.95 ± 0.292
2.182GlnVal: 2.182 ± 0.31
0.232GlnTrp: 0.232 ± 0.089
1.393GlnTyr: 1.393 ± 0.226
0.0GlnXaa: 0.0 ± 0.0
Arg
5.154ArgAla: 5.154 ± 0.587
0.65ArgCys: 0.65 ± 0.184
2.832ArgAsp: 2.832 ± 0.369
3.111ArgGlu: 3.111 ± 0.427
2.322ArgPhe: 2.322 ± 0.367
2.507ArgGly: 2.507 ± 0.311
1.114ArgHis: 1.114 ± 0.178
3.39ArgIle: 3.39 ± 0.384
2.925ArgLys: 2.925 ± 0.356
4.225ArgLeu: 4.225 ± 0.447
1.347ArgMet: 1.347 ± 0.269
1.857ArgAsn: 1.857 ± 0.325
1.857ArgPro: 1.857 ± 0.245
2.6ArgGln: 2.6 ± 0.505
2.647ArgArg: 2.647 ± 0.412
2.136ArgSer: 2.136 ± 0.287
2.229ArgThr: 2.229 ± 0.346
3.529ArgVal: 3.529 ± 0.39
0.929ArgTrp: 0.929 ± 0.214
1.718ArgTyr: 1.718 ± 0.316
0.0ArgXaa: 0.0 ± 0.0
Ser
5.618SerAla: 5.618 ± 0.659
0.975SerCys: 0.975 ± 0.206
4.272SerAsp: 4.272 ± 0.361
3.715SerGlu: 3.715 ± 0.386
2.647SerPhe: 2.647 ± 0.481
5.711SerGly: 5.711 ± 0.499
1.347SerHis: 1.347 ± 0.272
4.736SerIle: 4.736 ± 0.635
3.715SerLys: 3.715 ± 0.407
4.597SerLeu: 4.597 ± 0.419
1.672SerMet: 1.672 ± 0.249
3.39SerAsn: 3.39 ± 0.36
2.647SerPro: 2.647 ± 0.422
2.229SerGln: 2.229 ± 0.289
2.554SerArg: 2.554 ± 0.331
3.993SerSer: 3.993 ± 0.409
3.204SerThr: 3.204 ± 0.465
5.015SerVal: 5.015 ± 0.469
1.161SerTrp: 1.161 ± 0.233
1.764SerTyr: 1.764 ± 0.244
0.0SerXaa: 0.0 ± 0.0
Thr
4.318ThrAla: 4.318 ± 0.451
0.557ThrCys: 0.557 ± 0.162
2.786ThrAsp: 2.786 ± 0.344
2.507ThrGlu: 2.507 ± 0.401
1.811ThrPhe: 1.811 ± 0.262
5.386ThrGly: 5.386 ± 0.458
1.114ThrHis: 1.114 ± 0.187
3.993ThrIle: 3.993 ± 0.377
2.972ThrLys: 2.972 ± 0.377
4.411ThrLeu: 4.411 ± 0.41
1.486ThrMet: 1.486 ± 0.299
2.647ThrAsn: 2.647 ± 0.358
2.879ThrPro: 2.879 ± 0.309
2.461ThrGln: 2.461 ± 0.394
2.832ThrArg: 2.832 ± 0.356
4.086ThrSer: 4.086 ± 0.373
3.39ThrThr: 3.39 ± 0.594
3.715ThrVal: 3.715 ± 0.462
0.975ThrTrp: 0.975 ± 0.23
1.486ThrTyr: 1.486 ± 0.279
0.0ThrXaa: 0.0 ± 0.0
Val
6.779ValAla: 6.779 ± 0.626
0.882ValCys: 0.882 ± 0.176
5.201ValAsp: 5.201 ± 0.422
4.133ValGlu: 4.133 ± 0.42
2.6ValPhe: 2.6 ± 0.333
4.411ValGly: 4.411 ± 0.452
0.929ValHis: 0.929 ± 0.181
4.876ValIle: 4.876 ± 0.5
4.736ValLys: 4.736 ± 0.495
5.015ValLeu: 5.015 ± 0.525
1.439ValMet: 1.439 ± 0.245
3.622ValAsn: 3.622 ± 0.389
2.368ValPro: 2.368 ± 0.297
2.6ValGln: 2.6 ± 0.36
3.622ValArg: 3.622 ± 0.529
4.318ValSer: 4.318 ± 0.431
3.668ValThr: 3.668 ± 0.512
5.34ValVal: 5.34 ± 0.489
0.697ValTrp: 0.697 ± 0.178
1.95ValTyr: 1.95 ± 0.277
0.0ValXaa: 0.0 ± 0.0
Trp
1.254TrpAla: 1.254 ± 0.201
0.139TrpCys: 0.139 ± 0.079
0.836TrpAsp: 0.836 ± 0.218
0.557TrpGlu: 0.557 ± 0.139
0.464TrpPhe: 0.464 ± 0.141
0.743TrpGly: 0.743 ± 0.195
0.093TrpHis: 0.093 ± 0.052
1.068TrpIle: 1.068 ± 0.196
0.836TrpLys: 0.836 ± 0.205
1.439TrpLeu: 1.439 ± 0.242
0.604TrpMet: 0.604 ± 0.157
0.975TrpAsn: 0.975 ± 0.23
0.557TrpPro: 0.557 ± 0.177
0.557TrpGln: 0.557 ± 0.176
0.743TrpArg: 0.743 ± 0.184
0.743TrpSer: 0.743 ± 0.186
0.743TrpThr: 0.743 ± 0.196
0.836TrpVal: 0.836 ± 0.182
0.325TrpTrp: 0.325 ± 0.15
0.743TrpTyr: 0.743 ± 0.177
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.368TyrAla: 2.368 ± 0.3
0.371TyrCys: 0.371 ± 0.14
2.136TyrAsp: 2.136 ± 0.247
1.764TyrGlu: 1.764 ± 0.273
1.997TyrPhe: 1.997 ± 0.29
3.065TyrGly: 3.065 ± 0.439
0.697TyrHis: 0.697 ± 0.182
2.229TyrIle: 2.229 ± 0.338
2.09TyrLys: 2.09 ± 0.33
1.95TyrLeu: 1.95 ± 0.35
0.789TyrMet: 0.789 ± 0.186
2.043TyrAsn: 2.043 ± 0.265
1.114TyrPro: 1.114 ± 0.242
1.857TyrGln: 1.857 ± 0.312
1.672TyrArg: 1.672 ± 0.269
2.507TyrSer: 2.507 ± 0.339
1.997TyrThr: 1.997 ± 0.288
1.95TyrVal: 1.95 ± 0.314
0.557TyrTrp: 0.557 ± 0.147
1.114TyrTyr: 1.114 ± 0.278
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 105 proteins (21537 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski