Amino acid dipepetide frequency for Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.611AlaAla: 11.611 ± 0.076	1.137AlaCys: 1.137 ± 0.014	4.787AlaAsp: 4.787 ± 0.031	5.719AlaGlu: 5.719 ± 0.04	3.076AlaPhe: 3.076 ± 0.027	6.999AlaGly: 6.999 ± 0.049	1.963AlaHis: 1.963 ± 0.02	3.946AlaIle: 3.946 ± 0.03	4.123AlaLys: 4.123 ± 0.038	8.194AlaLeu: 8.194 ± 0.046	2.092AlaMet: 2.092 ± 0.023	2.967AlaAsn: 2.967 ± 0.025	5.713AlaPro: 5.713 ± 0.045	3.65AlaGln: 3.65 ± 0.034	6.222AlaArg: 6.222 ± 0.042	7.226AlaSer: 7.226 ± 0.044	5.835AlaThr: 5.835 ± 0.037	6.195AlaVal: 6.195 ± 0.038	1.288AlaTrp: 1.288 ± 0.016	2.074AlaTyr: 2.074 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.997CysAla: 0.997 ± 0.016	0.27CysCys: 0.27 ± 0.009	0.627CysAsp: 0.627 ± 0.013	0.611CysGlu: 0.611 ± 0.012	0.505CysPhe: 0.505 ± 0.01	1.078CysGly: 1.078 ± 0.017	0.355CysHis: 0.355 ± 0.008	0.594CysIle: 0.594 ± 0.01	0.485CysLys: 0.485 ± 0.011	1.205CysLeu: 1.205 ± 0.015	0.253CysMet: 0.253 ± 0.007	0.411CysAsn: 0.411 ± 0.01	0.732CysPro: 0.732 ± 0.014	0.459CysGln: 0.459 ± 0.01	0.892CysArg: 0.892 ± 0.017	0.885CysSer: 0.885 ± 0.013	0.707CysThr: 0.707 ± 0.012	0.788CysVal: 0.788 ± 0.012	0.22CysTrp: 0.22 ± 0.006	0.327CysTyr: 0.327 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.006AspAla: 5.006 ± 0.03	0.649AspCys: 0.649 ± 0.011	4.4AspAsp: 4.4 ± 0.041	4.338AspGlu: 4.338 ± 0.037	2.118AspPhe: 2.118 ± 0.022	4.638AspGly: 4.638 ± 0.037	1.255AspHis: 1.255 ± 0.016	2.631AspIle: 2.631 ± 0.028	2.293AspLys: 2.293 ± 0.025	4.748AspLeu: 4.748 ± 0.029	1.231AspMet: 1.231 ± 0.016	1.78AspAsn: 1.78 ± 0.022	3.442AspPro: 3.442 ± 0.027	1.84AspGln: 1.84 ± 0.018	3.26AspArg: 3.26 ± 0.028	3.713AspSer: 3.713 ± 0.028	2.876AspThr: 2.876 ± 0.023	3.606AspVal: 3.606 ± 0.025	0.912AspTrp: 0.912 ± 0.013	1.487AspTyr: 1.487 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.907GluAla: 5.907 ± 0.046	0.638GluCys: 0.638 ± 0.01	4.065GluAsp: 4.065 ± 0.034	5.454GluGlu: 5.454 ± 0.055	1.838GluPhe: 1.838 ± 0.019	4.367GluGly: 4.367 ± 0.03	1.321GluHis: 1.321 ± 0.017	2.523GluIle: 2.523 ± 0.024	3.24GluLys: 3.24 ± 0.034	5.101GluLeu: 5.101 ± 0.038	1.432GluMet: 1.432 ± 0.016	1.918GluAsn: 1.918 ± 0.021	3.141GluPro: 3.141 ± 0.041	2.401GluGln: 2.401 ± 0.026	4.15GluArg: 4.15 ± 0.04	3.799GluSer: 3.799 ± 0.034	3.482GluThr: 3.482 ± 0.032	3.719GluVal: 3.719 ± 0.027	0.917GluTrp: 0.917 ± 0.014	1.508GluTyr: 1.508 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	2.968PheAla: 2.968 ± 0.025	0.515PheCys: 0.515 ± 0.01	2.183PheAsp: 2.183 ± 0.02	2.017PheGlu: 2.017 ± 0.02	1.423PhePhe: 1.423 ± 0.019	2.732PheGly: 2.732 ± 0.025	0.844PheHis: 0.844 ± 0.012	1.42PheIle: 1.42 ± 0.018	1.299PheLys: 1.299 ± 0.017	3.191PheLeu: 3.191 ± 0.028	0.672PheMet: 0.672 ± 0.011	1.25PheAsn: 1.25 ± 0.015	1.907PhePro: 1.907 ± 0.017	1.265PheGln: 1.265 ± 0.017	2.091PheArg: 2.091 ± 0.021	2.591PheSer: 2.591 ± 0.026	1.96PheThr: 1.96 ± 0.023	2.253PheVal: 2.253 ± 0.026	0.591PheTrp: 0.591 ± 0.012	0.953PheTyr: 0.953 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	6.453GlyAla: 6.453 ± 0.047	0.997GlyCys: 0.997 ± 0.016	4.106GlyAsp: 4.106 ± 0.032	4.316GlyGlu: 4.316 ± 0.035	2.722GlyPhe: 2.722 ± 0.029	8.284GlyGly: 8.284 ± 0.085	1.821GlyHis: 1.821 ± 0.023	3.154GlyIle: 3.154 ± 0.027	3.518GlyLys: 3.518 ± 0.033	6.307GlyLeu: 6.307 ± 0.04	1.679GlyMet: 1.679 ± 0.021	2.617GlyAsn: 2.617 ± 0.028	4.072GlyPro: 4.072 ± 0.038	2.739GlyGln: 2.739 ± 0.03	5.132GlyArg: 5.132 ± 0.037	5.928GlySer: 5.928 ± 0.046	4.214GlyThr: 4.214 ± 0.033	4.873GlyVal: 4.873 ± 0.034	1.286GlyTrp: 1.286 ± 0.018	2.028GlyTyr: 2.028 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.006HisAla: 2.006 ± 0.021	0.333HisCys: 0.333 ± 0.009	1.296HisAsp: 1.296 ± 0.015	1.225HisGlu: 1.225 ± 0.016	0.882HisPhe: 0.882 ± 0.013	1.869HisGly: 1.869 ± 0.022	1.096HisHis: 1.096 ± 0.022	1.122HisIle: 1.122 ± 0.014	0.863HisLys: 0.863 ± 0.014	2.242HisLeu: 2.242 ± 0.024	0.482HisMet: 0.482 ± 0.011	0.82HisAsn: 0.82 ± 0.013	1.941HisPro: 1.941 ± 0.017	1.094HisGln: 1.094 ± 0.016	1.752HisArg: 1.752 ± 0.021	1.704HisSer: 1.704 ± 0.019	1.296HisThr: 1.296 ± 0.016	1.369HisVal: 1.369 ± 0.017	0.356HisTrp: 0.356 ± 0.008	0.639HisTyr: 0.639 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.72IleAla: 3.72 ± 0.032	0.619IleCys: 0.619 ± 0.012	2.454IleAsp: 2.454 ± 0.023	2.474IleGlu: 2.474 ± 0.025	1.527IlePhe: 1.527 ± 0.02	2.734IleGly: 2.734 ± 0.026	1.098IleHis: 1.098 ± 0.014	1.95IleIle: 1.95 ± 0.024	1.884IleLys: 1.884 ± 0.018	3.798IleLeu: 3.798 ± 0.032	0.843IleMet: 0.843 ± 0.014	1.503IleAsn: 1.503 ± 0.017	2.812IlePro: 2.812 ± 0.025	1.677IleGln: 1.677 ± 0.019	2.677IleArg: 2.677 ± 0.022	3.099IleSer: 3.099 ± 0.025	2.587IleThr: 2.587 ± 0.023	2.648IleVal: 2.648 ± 0.023	0.605IleTrp: 0.605 ± 0.011	1.124IleTyr: 1.124 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	4.326LysAla: 4.326 ± 0.043	0.44LysCys: 0.44 ± 0.011	2.38LysAsp: 2.38 ± 0.028	2.973LysGlu: 2.973 ± 0.034	1.276LysPhe: 1.276 ± 0.019	2.992LysGly: 2.992 ± 0.025	1.035LysHis: 1.035 ± 0.013	1.893LysIle: 1.893 ± 0.022	3.061LysLys: 3.061 ± 0.038	3.749LysLeu: 3.749 ± 0.03	0.921LysMet: 0.921 ± 0.013	1.447LysAsn: 1.447 ± 0.017	2.75LysPro: 2.75 ± 0.028	1.686LysGln: 1.686 ± 0.019	3.34LysArg: 3.34 ± 0.03	3.003LysSer: 3.003 ± 0.032	2.754LysThr: 2.754 ± 0.026	2.59LysVal: 2.59 ± 0.026	0.629LysTrp: 0.629 ± 0.011	1.151LysTyr: 1.151 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	8.554LeuAla: 8.554 ± 0.052	1.163LeuCys: 1.163 ± 0.015	5.036LeuAsp: 5.036 ± 0.039	5.272LeuGlu: 5.272 ± 0.036	3.038LeuPhe: 3.038 ± 0.028	6.149LeuGly: 6.149 ± 0.037	2.178LeuHis: 2.178 ± 0.022	3.266LeuIle: 3.266 ± 0.029	3.751LeuLys: 3.751 ± 0.031	8.133LeuLeu: 8.133 ± 0.068	1.652LeuMet: 1.652 ± 0.018	2.768LeuAsn: 2.768 ± 0.023	5.866LeuPro: 5.866 ± 0.036	3.693LeuGln: 3.693 ± 0.028	6.251LeuArg: 6.251 ± 0.037	6.572LeuSer: 6.572 ± 0.034	4.821LeuThr: 4.821 ± 0.036	5.433LeuVal: 5.433 ± 0.034	1.241LeuTrp: 1.241 ± 0.017	2.054LeuTyr: 2.054 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.385MetAla: 2.385 ± 0.023	0.223MetCys: 0.223 ± 0.006	1.229MetAsp: 1.229 ± 0.014	1.223MetGlu: 1.223 ± 0.016	0.66MetPhe: 0.66 ± 0.012	1.551MetGly: 1.551 ± 0.019	0.465MetHis: 0.465 ± 0.009	0.781MetIle: 0.781 ± 0.014	0.86MetLys: 0.86 ± 0.014	1.787MetLeu: 1.787 ± 0.018	0.543MetMet: 0.543 ± 0.012	0.643MetAsn: 0.643 ± 0.01	1.306MetPro: 1.306 ± 0.016	0.77MetGln: 0.77 ± 0.012	1.323MetArg: 1.323 ± 0.014	1.632MetSer: 1.632 ± 0.02	1.228MetThr: 1.228 ± 0.016	1.382MetVal: 1.382 ± 0.016	0.267MetTrp: 0.267 ± 0.008	0.464MetTyr: 0.464 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.906AsnAla: 2.906 ± 0.03	0.396AsnCys: 0.396 ± 0.01	1.698AsnAsp: 1.698 ± 0.02	1.689AsnGlu: 1.689 ± 0.02	1.156AsnPhe: 1.156 ± 0.015	2.954AsnGly: 2.954 ± 0.03	0.866AsnHis: 0.866 ± 0.014	1.648AsnIle: 1.648 ± 0.018	1.419AsnLys: 1.419 ± 0.017	2.926AsnLeu: 2.926 ± 0.026	0.743AsnMet: 0.743 ± 0.013	1.527AsnAsn: 1.527 ± 0.027	2.643AsnPro: 2.643 ± 0.025	1.277AsnGln: 1.277 ± 0.016	2.018AsnArg: 2.018 ± 0.02	2.323AsnSer: 2.323 ± 0.027	2.091AsnThr: 2.091 ± 0.023	1.957AsnVal: 1.957 ± 0.018	0.524AsnTrp: 0.524 ± 0.01	0.892AsnTyr: 0.892 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	6.574ProAla: 6.574 ± 0.052	0.647ProCys: 0.647 ± 0.012	3.436ProAsp: 3.436 ± 0.025	3.933ProGlu: 3.933 ± 0.034	1.979ProPhe: 1.979 ± 0.023	4.861ProGly: 4.861 ± 0.037	1.533ProHis: 1.533 ± 0.019	2.369ProIle: 2.369 ± 0.02	2.562ProLys: 2.562 ± 0.026	5.093ProLeu: 5.093 ± 0.037	1.105ProMet: 1.105 ± 0.017	2.247ProAsn: 2.247 ± 0.025	6.683ProPro: 6.683 ± 0.076	2.752ProGln: 2.752 ± 0.034	4.244ProArg: 4.244 ± 0.032	6.212ProSer: 6.212 ± 0.051	4.771ProThr: 4.771 ± 0.038	3.916ProVal: 3.916 ± 0.031	0.828ProTrp: 0.828 ± 0.013	1.402ProTyr: 1.402 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.691GlnAla: 3.691 ± 0.033	0.431GlnCys: 0.431 ± 0.008	1.962GlnAsp: 1.962 ± 0.02	2.346GlnGlu: 2.346 ± 0.028	1.214GlnPhe: 1.214 ± 0.016	2.691GlnGly: 2.691 ± 0.029	1.154GlnHis: 1.154 ± 0.018	1.638GlnIle: 1.638 ± 0.018	1.737GlnLys: 1.737 ± 0.023	3.417GlnLeu: 3.417 ± 0.027	0.823GlnMet: 0.823 ± 0.015	1.33GlnAsn: 1.33 ± 0.015	3.003GlnPro: 3.003 ± 0.032	2.972GlnGln: 2.972 ± 0.056	2.888GlnArg: 2.888 ± 0.026	2.741GlnSer: 2.741 ± 0.025	2.333GlnThr: 2.333 ± 0.023	2.134GlnVal: 2.134 ± 0.025	0.582GlnTrp: 0.582 ± 0.011	1.038GlnTyr: 1.038 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	5.794ArgAla: 5.794 ± 0.034	0.881ArgCys: 0.881 ± 0.015	3.76ArgAsp: 3.76 ± 0.036	4.231ArgGlu: 4.231 ± 0.038	2.266ArgPhe: 2.266 ± 0.022	4.756ArgGly: 4.756 ± 0.039	1.843ArgHis: 1.843 ± 0.018	2.729ArgIle: 2.729 ± 0.022	3.279ArgLys: 3.279 ± 0.034	6.027ArgLeu: 6.027 ± 0.042	1.397ArgMet: 1.397 ± 0.017	2.281ArgAsn: 2.281 ± 0.022	4.3ArgPro: 4.3 ± 0.033	2.863ArgGln: 2.863 ± 0.024	6.246ArgArg: 6.246 ± 0.053	4.864ArgSer: 4.864 ± 0.038	3.605ArgThr: 3.605 ± 0.029	3.916ArgVal: 3.916 ± 0.031	1.134ArgTrp: 1.134 ± 0.016	1.638ArgTyr: 1.638 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.691SerAla: 6.691 ± 0.039	0.846SerCys: 0.846 ± 0.013	3.823SerAsp: 3.823 ± 0.028	3.747SerGlu: 3.747 ± 0.032	2.601SerPhe: 2.601 ± 0.022	5.78SerGly: 5.78 ± 0.044	1.81SerHis: 1.81 ± 0.019	3.141SerIle: 3.141 ± 0.028	3.031SerLys: 3.031 ± 0.029	6.435SerLeu: 6.435 ± 0.036	1.523SerMet: 1.523 ± 0.02	2.496SerAsn: 2.496 ± 0.022	5.802SerPro: 5.802 ± 0.053	3.032SerGln: 3.032 ± 0.028	5.134SerArg: 5.134 ± 0.04	7.613SerSer: 7.613 ± 0.066	5.153SerThr: 5.153 ± 0.038	4.239SerVal: 4.239 ± 0.03	1.081SerTrp: 1.081 ± 0.016	1.742SerTyr: 1.742 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	6.009ThrAla: 6.009 ± 0.039	0.749ThrCys: 0.749 ± 0.013	2.776ThrAsp: 2.776 ± 0.024	3.042ThrGlu: 3.042 ± 0.027	2.02ThrPhe: 2.02 ± 0.018	4.328ThrGly: 4.328 ± 0.038	1.325ThrHis: 1.325 ± 0.016	2.714ThrIle: 2.714 ± 0.022	2.493ThrLys: 2.493 ± 0.026	5.157ThrLeu: 5.157 ± 0.036	1.117ThrMet: 1.117 ± 0.013	2.081ThrAsn: 2.081 ± 0.019	5.071ThrPro: 5.071 ± 0.038	2.109ThrGln: 2.109 ± 0.022	3.615ThrArg: 3.615 ± 0.028	4.919ThrSer: 4.919 ± 0.034	5.172ThrThr: 5.172 ± 0.047	3.762ThrVal: 3.762 ± 0.027	0.842ThrTrp: 0.842 ± 0.012	1.397ThrTyr: 1.397 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.861ValAla: 5.861 ± 0.035	0.851ValCys: 0.851 ± 0.013	3.754ValAsp: 3.754 ± 0.028	4.045ValGlu: 4.045 ± 0.033	2.299ValPhe: 2.299 ± 0.021	4.471ValGly: 4.471 ± 0.035	1.364ValHis: 1.364 ± 0.017	2.575ValIle: 2.575 ± 0.023	2.749ValLys: 2.749 ± 0.026	5.626ValLeu: 5.626 ± 0.04	1.321ValMet: 1.321 ± 0.016	2.024ValAsn: 2.024 ± 0.023	3.846ValPro: 3.846 ± 0.03	2.265ValGln: 2.265 ± 0.021	3.872ValArg: 3.872 ± 0.032	4.247ValSer: 4.247 ± 0.033	3.467ValThr: 3.467 ± 0.027	4.874ValVal: 4.874 ± 0.036	0.936ValTrp: 0.936 ± 0.013	1.605ValTyr: 1.605 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.305TrpAla: 1.305 ± 0.016	0.225TrpCys: 0.225 ± 0.006	0.944TrpAsp: 0.944 ± 0.015	0.908TrpGlu: 0.908 ± 0.012	0.522TrpPhe: 0.522 ± 0.01	1.021TrpGly: 1.021 ± 0.017	0.365TrpHis: 0.365 ± 0.009	0.652TrpIle: 0.652 ± 0.011	0.8TrpLys: 0.8 ± 0.013	1.384TrpLeu: 1.384 ± 0.017	0.365TrpMet: 0.365 ± 0.008	0.562TrpAsn: 0.562 ± 0.01	0.691TrpPro: 0.691 ± 0.012	0.577TrpGln: 0.577 ± 0.011	1.091TrpArg: 1.091 ± 0.016	0.976TrpSer: 0.976 ± 0.013	0.904TrpThr: 0.904 ± 0.014	0.969TrpVal: 0.969 ± 0.013	0.298TrpTrp: 0.298 ± 0.007	0.395TrpTyr: 0.395 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.053TyrAla: 2.053 ± 0.02	0.391TyrCys: 0.391 ± 0.008	1.51TyrAsp: 1.51 ± 0.018	1.358TyrGlu: 1.358 ± 0.016	1.003TyrPhe: 1.003 ± 0.016	1.988TyrGly: 1.988 ± 0.024	0.697TyrHis: 0.697 ± 0.012	1.084TyrIle: 1.084 ± 0.016	0.947TyrLys: 0.947 ± 0.014	2.373TyrLeu: 2.373 ± 0.024	0.529TyrMet: 0.529 ± 0.01	0.98TyrAsn: 0.98 ± 0.016	1.423TyrPro: 1.423 ± 0.017	1.006TyrGln: 1.006 ± 0.016	1.612TyrArg: 1.612 ± 0.018	1.674TyrSer: 1.674 ± 0.019	1.442TyrThr: 1.442 ± 0.016	1.432TyrVal: 1.432 ± 0.017	0.417TyrTrp: 0.417 ± 0.01	0.818TyrTyr: 0.818 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.133XaaXaa: 0.133 ± 0.102

Statistics based on 11042 proteins (5473786 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---