Amino acid dipepetide frequency for Rhizobium sp. Root482

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.667AlaAla: 15.667 ± 0.157	0.965AlaCys: 0.965 ± 0.03	6.851AlaAsp: 6.851 ± 0.071	7.364AlaGlu: 7.364 ± 0.092	4.705AlaPhe: 4.705 ± 0.057	10.663AlaGly: 10.663 ± 0.087	2.119AlaHis: 2.119 ± 0.037	6.812AlaIle: 6.812 ± 0.08	4.11AlaLys: 4.11 ± 0.062	12.593AlaLeu: 12.593 ± 0.133	3.595AlaMet: 3.595 ± 0.055	3.004AlaAsn: 3.004 ± 0.052	4.605AlaPro: 4.605 ± 0.059	3.421AlaGln: 3.421 ± 0.057	8.047AlaArg: 8.047 ± 0.089	6.455AlaSer: 6.455 ± 0.066	5.729AlaThr: 5.729 ± 0.066	8.59AlaVal: 8.59 ± 0.087	1.333AlaTrp: 1.333 ± 0.035	2.58AlaTyr: 2.58 ± 0.045	0.001AlaXaa: 0.001 ± 0.001
Cys	0.897CysAla: 0.897 ± 0.023	0.086CysCys: 0.086 ± 0.009	0.542CysAsp: 0.542 ± 0.022	0.446CysGlu: 0.446 ± 0.018	0.318CysPhe: 0.318 ± 0.015	0.943CysGly: 0.943 ± 0.027	0.215CysHis: 0.215 ± 0.012	0.433CysIle: 0.433 ± 0.018	0.186CysLys: 0.186 ± 0.011	0.818CysLeu: 0.818 ± 0.025	0.176CysMet: 0.176 ± 0.01	0.206CysAsn: 0.206 ± 0.013	0.377CysPro: 0.377 ± 0.018	0.218CysGln: 0.218 ± 0.012	0.585CysArg: 0.585 ± 0.02	0.441CysSer: 0.441 ± 0.016	0.367CysThr: 0.367 ± 0.018	0.577CysVal: 0.577 ± 0.019	0.103CysTrp: 0.103 ± 0.008	0.198CysTyr: 0.198 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.595AspAla: 6.595 ± 0.078	0.519AspCys: 0.519 ± 0.021	3.313AspAsp: 3.313 ± 0.076	3.6AspGlu: 3.6 ± 0.054	2.483AspPhe: 2.483 ± 0.034	5.319AspGly: 5.319 ± 0.078	1.317AspHis: 1.317 ± 0.032	3.708AspIle: 3.708 ± 0.052	1.817AspLys: 1.817 ± 0.042	5.993AspLeu: 5.993 ± 0.071	1.608AspMet: 1.608 ± 0.037	1.512AspAsn: 1.512 ± 0.034	3.287AspPro: 3.287 ± 0.048	1.724AspGln: 1.724 ± 0.036	4.325AspArg: 4.325 ± 0.06	2.128AspSer: 2.128 ± 0.038	2.631AspThr: 2.631 ± 0.053	4.002AspVal: 4.002 ± 0.054	0.916AspTrp: 0.916 ± 0.024	1.565AspTyr: 1.565 ± 0.035	0.001AspXaa: 0.001 ± 0.001
Glu	7.468GluAla: 7.468 ± 0.074	0.338GluCys: 0.338 ± 0.016	2.986GluAsp: 2.986 ± 0.052	3.462GluGlu: 3.462 ± 0.062	1.854GluPhe: 1.854 ± 0.035	4.385GluGly: 4.385 ± 0.062	1.118GluHis: 1.118 ± 0.027	4.001GluIle: 4.001 ± 0.056	2.814GluLys: 2.814 ± 0.048	5.056GluLeu: 5.056 ± 0.064	1.666GluMet: 1.666 ± 0.036	1.963GluAsn: 1.963 ± 0.038	2.666GluPro: 2.666 ± 0.045	2.067GluGln: 2.067 ± 0.043	4.735GluArg: 4.735 ± 0.076	2.341GluSer: 2.341 ± 0.039	3.979GluThr: 3.979 ± 0.055	3.552GluVal: 3.552 ± 0.054	0.674GluTrp: 0.674 ± 0.021	1.003GluTyr: 1.003 ± 0.026	0.001GluXaa: 0.001 ± 0.001
Phe	4.53PheAla: 4.53 ± 0.054	0.438PheCys: 0.438 ± 0.019	2.805PheAsp: 2.805 ± 0.048	2.284PheGlu: 2.284 ± 0.044	1.55PhePhe: 1.55 ± 0.036	3.729PheGly: 3.729 ± 0.051	0.812PheHis: 0.812 ± 0.026	1.983PheIle: 1.983 ± 0.038	1.169PheLys: 1.169 ± 0.033	3.747PheLeu: 3.747 ± 0.056	0.883PheMet: 0.883 ± 0.024	1.177PheAsn: 1.177 ± 0.029	1.62PhePro: 1.62 ± 0.034	1.14PheGln: 1.14 ± 0.032	2.307PheArg: 2.307 ± 0.035	2.724PheSer: 2.724 ± 0.041	1.997PheThr: 1.997 ± 0.038	2.848PheVal: 2.848 ± 0.045	0.547PheTrp: 0.547 ± 0.021	0.959PheTyr: 0.959 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.645GlyAla: 8.645 ± 0.086	0.821GlyCys: 0.821 ± 0.028	4.558GlyAsp: 4.558 ± 0.077	5.116GlyGlu: 5.116 ± 0.071	3.765GlyPhe: 3.765 ± 0.053	7.137GlyGly: 7.137 ± 0.106	1.883GlyHis: 1.883 ± 0.038	5.09GlyIle: 5.09 ± 0.065	3.724GlyLys: 3.724 ± 0.056	9.005GlyLeu: 9.005 ± 0.085	2.392GlyMet: 2.392 ± 0.044	2.48GlyAsn: 2.48 ± 0.065	3.101GlyPro: 3.101 ± 0.047	2.788GlyGln: 2.788 ± 0.045	5.783GlyArg: 5.783 ± 0.073	4.654GlySer: 4.654 ± 0.053	4.681GlyThr: 4.681 ± 0.059	5.614GlyVal: 5.614 ± 0.058	1.234GlyTrp: 1.234 ± 0.03	2.357GlyTyr: 2.357 ± 0.045	0.001GlyXaa: 0.001 ± 0.001
His	2.256HisAla: 2.256 ± 0.045	0.22HisCys: 0.22 ± 0.013	1.253HisAsp: 1.253 ± 0.032	1.047HisGlu: 1.047 ± 0.026	0.933HisPhe: 0.933 ± 0.029	1.922HisGly: 1.922 ± 0.041	0.535HisHis: 0.535 ± 0.026	1.04HisIle: 1.04 ± 0.024	0.494HisLys: 0.494 ± 0.019	2.039HisLeu: 2.039 ± 0.04	0.565HisMet: 0.565 ± 0.017	0.46HisAsn: 0.46 ± 0.021	1.273HisPro: 1.273 ± 0.029	0.616HisGln: 0.616 ± 0.02	1.393HisArg: 1.393 ± 0.033	1.001HisSer: 1.001 ± 0.028	0.774HisThr: 0.774 ± 0.023	1.511HisVal: 1.511 ± 0.032	0.282HisTrp: 0.282 ± 0.012	0.537HisTyr: 0.537 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.764IleAla: 7.764 ± 0.072	0.591IleCys: 0.591 ± 0.02	4.039IleAsp: 4.039 ± 0.052	3.813IleGlu: 3.813 ± 0.059	2.056IlePhe: 2.056 ± 0.043	5.554IleGly: 5.554 ± 0.065	1.003IleHis: 1.003 ± 0.025	2.813IleIle: 2.813 ± 0.044	1.588IleLys: 1.588 ± 0.038	5.247IleLeu: 5.247 ± 0.07	1.152IleMet: 1.152 ± 0.03	1.594IleAsn: 1.594 ± 0.034	2.395IlePro: 2.395 ± 0.037	1.246IleGln: 1.246 ± 0.034	3.666IleArg: 3.666 ± 0.05	3.445IleSer: 3.445 ± 0.05	2.823IleThr: 2.823 ± 0.049	4.605IleVal: 4.605 ± 0.058	0.614IleTrp: 0.614 ± 0.019	1.271IleTyr: 1.271 ± 0.03	0.001IleXaa: 0.001 ± 0.001
Lys	4.755LysAla: 4.755 ± 0.066	0.175LysCys: 0.175 ± 0.01	2.034LysAsp: 2.034 ± 0.041	1.796LysGlu: 1.796 ± 0.036	1.029LysPhe: 1.029 ± 0.03	2.875LysGly: 2.875 ± 0.048	0.656LysHis: 0.656 ± 0.018	2.113LysIle: 2.113 ± 0.043	1.464LysLys: 1.464 ± 0.035	3.463LysLeu: 3.463 ± 0.052	0.905LysMet: 0.905 ± 0.025	1.025LysAsn: 1.025 ± 0.028	2.219LysPro: 2.219 ± 0.045	1.1LysGln: 1.1 ± 0.029	2.472LysArg: 2.472 ± 0.039	2.237LysSer: 2.237 ± 0.04	2.304LysThr: 2.304 ± 0.037	2.426LysVal: 2.426 ± 0.042	0.378LysTrp: 0.378 ± 0.015	0.677LysTyr: 0.677 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	12.797LeuAla: 12.797 ± 0.118	0.887LeuCys: 0.887 ± 0.026	5.968LeuAsp: 5.968 ± 0.071	5.43LeuGlu: 5.43 ± 0.067	3.886LeuPhe: 3.886 ± 0.059	7.922LeuGly: 7.922 ± 0.082	1.84LeuHis: 1.84 ± 0.037	5.206LeuIle: 5.206 ± 0.067	4.149LeuLys: 4.149 ± 0.064	9.332LeuLeu: 9.332 ± 0.118	2.44LeuMet: 2.44 ± 0.042	2.616LeuAsn: 2.616 ± 0.043	5.273LeuPro: 5.273 ± 0.073	2.86LeuGln: 2.86 ± 0.043	6.173LeuArg: 6.173 ± 0.066	7.187LeuSer: 7.187 ± 0.08	5.537LeuThr: 5.537 ± 0.068	7.492LeuVal: 7.492 ± 0.09	1.085LeuTrp: 1.085 ± 0.029	2.108LeuTyr: 2.108 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.281MetAla: 3.281 ± 0.053	0.144MetCys: 0.144 ± 0.011	1.224MetAsp: 1.224 ± 0.029	1.308MetGlu: 1.308 ± 0.027	0.74MetPhe: 0.74 ± 0.026	1.801MetGly: 1.801 ± 0.031	0.453MetHis: 0.453 ± 0.019	1.606MetIle: 1.606 ± 0.03	1.175MetLys: 1.175 ± 0.031	2.67MetLeu: 2.67 ± 0.049	0.748MetMet: 0.748 ± 0.025	0.881MetAsn: 0.881 ± 0.024	1.578MetPro: 1.578 ± 0.034	0.835MetGln: 0.835 ± 0.026	1.849MetArg: 1.849 ± 0.037	1.724MetSer: 1.724 ± 0.037	2.059MetThr: 2.059 ± 0.036	1.775MetVal: 1.775 ± 0.031	0.204MetTrp: 0.204 ± 0.011	0.292MetTyr: 0.292 ± 0.015	0.001MetXaa: 0.001 ± 0.001
Asn	3.229AsnAla: 3.229 ± 0.052	0.244AsnCys: 0.244 ± 0.013	1.579AsnAsp: 1.579 ± 0.058	1.377AsnGlu: 1.377 ± 0.03	1.081AsnPhe: 1.081 ± 0.028	2.63AsnGly: 2.63 ± 0.048	0.533AsnHis: 0.533 ± 0.019	1.636AsnIle: 1.636 ± 0.034	0.722AsnLys: 0.722 ± 0.022	2.685AsnLeu: 2.685 ± 0.045	0.678AsnMet: 0.678 ± 0.02	0.759AsnAsn: 0.759 ± 0.029	1.857AsnPro: 1.857 ± 0.042	0.78AsnGln: 0.78 ± 0.025	2.012AsnArg: 2.012 ± 0.038	1.463AsnSer: 1.463 ± 0.032	1.374AsnThr: 1.374 ± 0.042	1.935AsnVal: 1.935 ± 0.045	0.461AsnTrp: 0.461 ± 0.017	0.7AsnTyr: 0.7 ± 0.024	0.001AsnXaa: 0.001 ± 0.001
Pro	5.687ProAla: 5.687 ± 0.077	0.292ProCys: 0.292 ± 0.013	3.536ProAsp: 3.536 ± 0.055	3.387ProGlu: 3.387 ± 0.057	1.977ProPhe: 1.977 ± 0.037	4.139ProGly: 4.139 ± 0.056	1.035ProHis: 1.035 ± 0.026	2.315ProIle: 2.315 ± 0.041	1.733ProLys: 1.733 ± 0.035	4.605ProLeu: 4.605 ± 0.064	1.17ProMet: 1.17 ± 0.03	1.218ProAsn: 1.218 ± 0.028	2.04ProPro: 2.04 ± 0.043	1.693ProGln: 1.693 ± 0.032	2.523ProArg: 2.523 ± 0.048	2.704ProSer: 2.704 ± 0.038	2.261ProThr: 2.261 ± 0.041	4.151ProVal: 4.151 ± 0.057	0.589ProTrp: 0.589 ± 0.021	1.167ProTyr: 1.167 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.072GlnAla: 4.072 ± 0.062	0.188GlnCys: 0.188 ± 0.011	1.435GlnAsp: 1.435 ± 0.03	1.544GlnGlu: 1.544 ± 0.035	1.071GlnPhe: 1.071 ± 0.029	2.21GlnGly: 2.21 ± 0.041	0.598GlnHis: 0.598 ± 0.023	1.849GlnIle: 1.849 ± 0.037	1.203GlnLys: 1.203 ± 0.032	2.843GlnLeu: 2.843 ± 0.051	0.962GlnMet: 0.962 ± 0.026	0.857GlnAsn: 0.857 ± 0.031	1.72GlnPro: 1.72 ± 0.035	1.197GlnGln: 1.197 ± 0.039	2.214GlnArg: 2.214 ± 0.045	1.887GlnSer: 1.887 ± 0.034	1.782GlnThr: 1.782 ± 0.035	2.117GlnVal: 2.117 ± 0.044	0.381GlnTrp: 0.381 ± 0.018	0.567GlnTyr: 0.567 ± 0.019	0.001GlnXaa: 0.001 ± 0.001
Arg	7.012ArgAla: 7.012 ± 0.079	0.436ArgCys: 0.436 ± 0.017	3.999ArgAsp: 3.999 ± 0.052	3.955ArgGlu: 3.955 ± 0.058	2.879ArgPhe: 2.879 ± 0.046	4.429ArgGly: 4.429 ± 0.058	1.712ArgHis: 1.712 ± 0.036	4.246ArgIle: 4.246 ± 0.057	2.666ArgLys: 2.666 ± 0.047	7.469ArgLeu: 7.469 ± 0.09	1.932ArgMet: 1.932 ± 0.037	2.059ArgAsn: 2.059 ± 0.042	3.241ArgPro: 3.241 ± 0.059	2.601ArgGln: 2.601 ± 0.045	5.226ArgArg: 5.226 ± 0.068	3.711ArgSer: 3.711 ± 0.054	3.253ArgThr: 3.253 ± 0.049	4.221ArgVal: 4.221 ± 0.057	0.86ArgTrp: 0.86 ± 0.027	1.643ArgTyr: 1.643 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.265SerAla: 6.265 ± 0.071	0.402SerCys: 0.402 ± 0.02	3.221SerAsp: 3.221 ± 0.047	3.032SerGlu: 3.032 ± 0.044	2.501SerPhe: 2.501 ± 0.042	5.881SerGly: 5.881 ± 0.069	1.176SerHis: 1.176 ± 0.031	3.213SerIle: 3.213 ± 0.043	1.783SerLys: 1.783 ± 0.036	5.921SerLeu: 5.921 ± 0.063	1.475SerMet: 1.475 ± 0.034	1.503SerAsn: 1.503 ± 0.03	2.819SerPro: 2.819 ± 0.045	1.809SerGln: 1.809 ± 0.035	3.815SerArg: 3.815 ± 0.06	3.239SerSer: 3.239 ± 0.049	2.852SerThr: 2.852 ± 0.045	4.184SerVal: 4.184 ± 0.054	0.73SerTrp: 0.73 ± 0.021	1.345SerTyr: 1.345 ± 0.035	0.001SerXaa: 0.001 ± 0.001
Thr	6.302ThrAla: 6.302 ± 0.063	0.413ThrCys: 0.413 ± 0.019	3.026ThrAsp: 3.026 ± 0.056	2.844ThrGlu: 2.844 ± 0.05	1.97ThrPhe: 1.97 ± 0.04	5.256ThrGly: 5.256 ± 0.057	0.962ThrHis: 0.962 ± 0.024	3.285ThrIle: 3.285 ± 0.051	1.592ThrLys: 1.592 ± 0.032	5.594ThrLeu: 5.594 ± 0.063	1.284ThrMet: 1.284 ± 0.029	1.373ThrAsn: 1.373 ± 0.031	2.939ThrPro: 2.939 ± 0.042	1.399ThrGln: 1.399 ± 0.032	3.227ThrArg: 3.227 ± 0.045	3.017ThrSer: 3.017 ± 0.045	2.855ThrThr: 2.855 ± 0.05	4.478ThrVal: 4.478 ± 0.055	0.629ThrTrp: 0.629 ± 0.021	1.184ThrTyr: 1.184 ± 0.029	0.001ThrXaa: 0.001 ± 0.001
Val	8.485ValAla: 8.485 ± 0.078	0.591ValCys: 0.591 ± 0.021	3.97ValAsp: 3.97 ± 0.056	4.526ValGlu: 4.526 ± 0.057	2.943ValPhe: 2.943 ± 0.046	5.132ValGly: 5.132 ± 0.068	1.385ValHis: 1.385 ± 0.033	4.231ValIle: 4.231 ± 0.056	2.51ValLys: 2.51 ± 0.043	7.28ValLeu: 7.28 ± 0.079	1.869ValMet: 1.869 ± 0.035	1.98ValAsn: 1.98 ± 0.035	3.481ValPro: 3.481 ± 0.044	1.893ValGln: 1.893 ± 0.037	4.515ValArg: 4.515 ± 0.057	4.773ValSer: 4.773 ± 0.061	4.562ValThr: 4.562 ± 0.053	5.664ValVal: 5.664 ± 0.072	0.801ValTrp: 0.801 ± 0.025	1.495ValTyr: 1.495 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.136TrpAla: 1.136 ± 0.03	0.132TrpCys: 0.132 ± 0.01	0.559TrpAsp: 0.559 ± 0.02	0.554TrpGlu: 0.554 ± 0.019	0.52TrpPhe: 0.52 ± 0.018	0.774TrpGly: 0.774 ± 0.028	0.302TrpHis: 0.302 ± 0.016	0.662TrpIle: 0.662 ± 0.023	0.527TrpLys: 0.527 ± 0.02	1.516TrpLeu: 1.516 ± 0.036	0.359TrpMet: 0.359 ± 0.016	0.451TrpAsn: 0.451 ± 0.016	0.631TrpPro: 0.631 ± 0.022	0.559TrpGln: 0.559 ± 0.02	0.955TrpArg: 0.955 ± 0.027	0.812TrpSer: 0.812 ± 0.024	0.728TrpThr: 0.728 ± 0.024	0.714TrpVal: 0.714 ± 0.023	0.218TrpTrp: 0.218 ± 0.011	0.277TrpTyr: 0.277 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.366TyrAla: 2.366 ± 0.038	0.248TyrCys: 0.248 ± 0.013	1.464TyrAsp: 1.464 ± 0.031	1.241TyrGlu: 1.241 ± 0.032	0.99TyrPhe: 0.99 ± 0.024	2.127TyrGly: 2.127 ± 0.041	0.497TyrHis: 0.497 ± 0.018	1.036TyrIle: 1.036 ± 0.027	0.676TyrLys: 0.676 ± 0.02	2.311TyrLeu: 2.311 ± 0.036	0.489TyrMet: 0.489 ± 0.016	0.619TyrAsn: 0.619 ± 0.02	1.1TyrPro: 1.1 ± 0.026	0.752TyrGln: 0.752 ± 0.021	1.726TyrArg: 1.726 ± 0.037	1.223TyrSer: 1.223 ± 0.032	1.085TyrThr: 1.085 ± 0.03	1.632TyrVal: 1.632 ± 0.033	0.344TyrTrp: 0.344 ± 0.014	0.61TyrTyr: 0.61 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4853 proteins (1502100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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