Amino acid dipepetide frequency for Campylobacter phage CP30A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.189AlaAla: 1.189 ± 0.203
0.413AlaCys: 0.413 ± 0.099
2.184AlaAsp: 2.184 ± 0.233
1.99AlaGlu: 1.99 ± 0.278
1.626AlaPhe: 1.626 ± 0.249
1.553AlaGly: 1.553 ± 0.242
0.461AlaHis: 0.461 ± 0.101
3.228AlaIle: 3.228 ± 0.264
2.985AlaLys: 2.985 ± 0.309
3.276AlaLeu: 3.276 ± 0.339
0.898AlaMet: 0.898 ± 0.142
2.767AlaAsn: 2.767 ± 0.317
0.922AlaPro: 0.922 ± 0.157
0.898AlaGln: 0.898 ± 0.146
1.311AlaArg: 1.311 ± 0.137
2.403AlaSer: 2.403 ± 0.209
1.82AlaThr: 1.82 ± 0.306
2.087AlaVal: 2.087 ± 0.278
0.194AlaTrp: 0.194 ± 0.064
1.456AlaTyr: 1.456 ± 0.174
0.0AlaXaa: 0.0 ± 0.0
Cys
0.631CysAla: 0.631 ± 0.108
0.218CysCys: 0.218 ± 0.086
1.238CysAsp: 1.238 ± 0.223
1.286CysGlu: 1.286 ± 0.268
0.364CysPhe: 0.364 ± 0.09
1.141CysGly: 1.141 ± 0.149
0.073CysHis: 0.073 ± 0.043
1.456CysIle: 1.456 ± 0.204
2.378CysLys: 2.378 ± 0.36
1.335CysLeu: 1.335 ± 0.223
0.34CysMet: 0.34 ± 0.097
1.942CysAsn: 1.942 ± 0.274
1.432CysPro: 1.432 ± 0.342
0.315CysGln: 0.315 ± 0.093
0.461CysArg: 0.461 ± 0.092
1.092CysSer: 1.092 ± 0.176
0.655CysThr: 0.655 ± 0.136
0.971CysVal: 0.971 ± 0.149
0.024CysTrp: 0.024 ± 0.023
0.971CysTyr: 0.971 ± 0.136
0.0CysXaa: 0.0 ± 0.0
Asp
2.039AspAla: 2.039 ± 0.216
0.946AspCys: 0.946 ± 0.155
5.096AspAsp: 5.096 ± 0.469
4.927AspGlu: 4.927 ± 0.345
3.883AspPhe: 3.883 ± 0.296
2.864AspGly: 2.864 ± 0.207
0.534AspHis: 0.534 ± 0.113
7.111AspIle: 7.111 ± 0.476
6.261AspLys: 6.261 ± 0.409
5.412AspLeu: 5.412 ± 0.342
1.238AspMet: 1.238 ± 0.179
5.922AspAsn: 5.922 ± 0.437
1.553AspPro: 1.553 ± 0.177
1.044AspGln: 1.044 ± 0.172
1.626AspArg: 1.626 ± 0.183
3.252AspSer: 3.252 ± 0.281
2.524AspThr: 2.524 ± 0.229
3.034AspVal: 3.034 ± 0.314
0.631AspTrp: 0.631 ± 0.119
3.592AspTyr: 3.592 ± 0.264
0.0AspXaa: 0.0 ± 0.0
Glu
2.184GluAla: 2.184 ± 0.221
1.65GluCys: 1.65 ± 0.33
3.082GluAsp: 3.082 ± 0.288
3.568GluGlu: 3.568 ± 0.305
3.834GluPhe: 3.834 ± 0.321
2.136GluGly: 2.136 ± 0.277
1.165GluHis: 1.165 ± 0.163
6.553GluIle: 6.553 ± 0.403
7.863GluLys: 7.863 ± 0.55
7.426GluLeu: 7.426 ± 0.487
1.238GluMet: 1.238 ± 0.171
6.358GluAsn: 6.358 ± 0.378
1.238GluPro: 1.238 ± 0.197
1.383GluGln: 1.383 ± 0.158
1.626GluArg: 1.626 ± 0.222
4.635GluSer: 4.635 ± 0.328
3.155GluThr: 3.155 ± 0.297
4.271GluVal: 4.271 ± 0.316
0.607GluTrp: 0.607 ± 0.116
4.32GluTyr: 4.32 ± 0.304
0.0GluXaa: 0.0 ± 0.0
Phe
1.602PheAla: 1.602 ± 0.203
0.946PheCys: 0.946 ± 0.166
3.932PheAsp: 3.932 ± 0.323
4.029PheGlu: 4.029 ± 0.266
1.82PhePhe: 1.82 ± 0.222
2.378PheGly: 2.378 ± 0.264
0.655PheHis: 0.655 ± 0.121
4.15PheIle: 4.15 ± 0.29
6.795PheLys: 6.795 ± 0.543
3.737PheLeu: 3.737 ± 0.322
1.189PheMet: 1.189 ± 0.191
3.98PheAsn: 3.98 ± 0.35
0.922PhePro: 0.922 ± 0.171
1.044PheGln: 1.044 ± 0.18
1.432PheArg: 1.432 ± 0.197
3.592PheSer: 3.592 ± 0.266
3.349PheThr: 3.349 ± 0.313
2.233PheVal: 2.233 ± 0.221
0.243PheTrp: 0.243 ± 0.07
2.451PheTyr: 2.451 ± 0.263
0.0PheXaa: 0.0 ± 0.0
Gly
2.16GlyAla: 2.16 ± 0.262
0.655GlyCys: 0.655 ± 0.127
3.325GlyAsp: 3.325 ± 0.296
2.16GlyGlu: 2.16 ± 0.215
3.009GlyPhe: 3.009 ± 0.319
2.16GlyGly: 2.16 ± 0.253
1.772GlyHis: 1.772 ± 0.415
4.417GlyIle: 4.417 ± 0.353
4.684GlyLys: 4.684 ± 0.392
3.495GlyLeu: 3.495 ± 0.319
1.019GlyMet: 1.019 ± 0.145
3.956GlyAsn: 3.956 ± 0.299
0.413GlyPro: 0.413 ± 0.087
1.335GlyGln: 1.335 ± 0.17
1.383GlyArg: 1.383 ± 0.223
4.344GlySer: 4.344 ± 0.391
2.67GlyThr: 2.67 ± 0.265
2.645GlyVal: 2.645 ± 0.229
0.17GlyTrp: 0.17 ± 0.069
3.713GlyTyr: 3.713 ± 0.441
0.0GlyXaa: 0.0 ± 0.0
His
0.413HisAla: 0.413 ± 0.104
0.218HisCys: 0.218 ± 0.074
0.825HisAsp: 0.825 ± 0.164
0.655HisGlu: 0.655 ± 0.16
0.752HisPhe: 0.752 ± 0.138
0.655HisGly: 0.655 ± 0.118
0.291HisHis: 0.291 ± 0.091
2.257HisIle: 2.257 ± 0.318
1.747HisLys: 1.747 ± 0.239
1.723HisLeu: 1.723 ± 0.244
0.218HisMet: 0.218 ± 0.073
1.262HisAsn: 1.262 ± 0.19
0.34HisPro: 0.34 ± 0.105
0.218HisGln: 0.218 ± 0.077
0.34HisArg: 0.34 ± 0.098
1.092HisSer: 1.092 ± 0.179
0.995HisThr: 0.995 ± 0.162
1.044HisVal: 1.044 ± 0.21
0.146HisTrp: 0.146 ± 0.057
0.971HisTyr: 0.971 ± 0.165
0.0HisXaa: 0.0 ± 0.0
Ile
2.742IleAla: 2.742 ± 0.259
1.772IleCys: 1.772 ± 0.259
6.286IleAsp: 6.286 ± 0.38
5.946IleGlu: 5.946 ± 0.339
4.271IlePhe: 4.271 ± 0.317
3.519IleGly: 3.519 ± 0.351
1.213IleHis: 1.213 ± 0.19
8.009IleIle: 8.009 ± 0.458
10.193IleLys: 10.193 ± 0.507
7.96IleLeu: 7.96 ± 0.507
2.063IleMet: 2.063 ± 0.207
8.858IleAsn: 8.858 ± 0.49
3.131IlePro: 3.131 ± 0.291
2.864IleGln: 2.864 ± 0.26
2.16IleArg: 2.16 ± 0.214
7.111IleSer: 7.111 ± 0.447
5.436IleThr: 5.436 ± 0.404
4.635IleVal: 4.635 ± 0.399
0.874IleTrp: 0.874 ± 0.142
3.47IleTyr: 3.47 ± 0.289
0.0IleXaa: 0.0 ± 0.0
Lys
3.082LysAla: 3.082 ± 0.318
2.451LysCys: 2.451 ± 0.438
7.014LysAsp: 7.014 ± 0.335
7.815LysGlu: 7.815 ± 0.553
4.563LysPhe: 4.563 ± 0.319
4.951LysGly: 4.951 ± 0.4
2.136LysHis: 2.136 ± 0.244
8.907LysIle: 8.907 ± 0.378
7.669LysLys: 7.669 ± 0.504
9.586LysLeu: 9.586 ± 0.47
2.257LysMet: 2.257 ± 0.241
9.853LysAsn: 9.853 ± 0.518
2.548LysPro: 2.548 ± 0.262
3.276LysGln: 3.276 ± 0.278
2.912LysArg: 2.912 ± 0.304
5.873LysSer: 5.873 ± 0.386
5.509LysThr: 5.509 ± 0.442
4.684LysVal: 4.684 ± 0.298
1.019LysTrp: 1.019 ± 0.17
6.383LysTyr: 6.383 ± 0.429
0.0LysXaa: 0.0 ± 0.0
Leu
3.203LeuAla: 3.203 ± 0.295
1.82LeuCys: 1.82 ± 0.214
5.703LeuAsp: 5.703 ± 0.374
7.232LeuGlu: 7.232 ± 0.524
3.106LeuPhe: 3.106 ± 0.281
5.606LeuGly: 5.606 ± 0.536
1.553LeuHis: 1.553 ± 0.187
6.456LeuIle: 6.456 ± 0.397
10.023LeuLys: 10.023 ± 0.518
7.669LeuLeu: 7.669 ± 0.482
2.281LeuMet: 2.281 ± 0.232
7.038LeuAsn: 7.038 ± 0.436
2.985LeuPro: 2.985 ± 0.261
2.67LeuGln: 2.67 ± 0.296
2.184LeuArg: 2.184 ± 0.236
6.043LeuSer: 6.043 ± 0.392
3.81LeuThr: 3.81 ± 0.325
3.301LeuVal: 3.301 ± 0.263
0.461LeuTrp: 0.461 ± 0.101
4.174LeuTyr: 4.174 ± 0.332
0.0LeuXaa: 0.0 ± 0.0
Met
1.383MetAla: 1.383 ± 0.172
0.534MetCys: 0.534 ± 0.123
1.189MetAsp: 1.189 ± 0.178
1.286MetGlu: 1.286 ± 0.189
1.408MetPhe: 1.408 ± 0.168
1.165MetGly: 1.165 ± 0.154
0.218MetHis: 0.218 ± 0.074
1.432MetIle: 1.432 ± 0.164
2.451MetLys: 2.451 ± 0.225
2.33MetLeu: 2.33 ± 0.277
0.267MetMet: 0.267 ± 0.071
1.626MetAsn: 1.626 ± 0.163
0.485MetPro: 0.485 ± 0.115
0.51MetGln: 0.51 ± 0.115
0.534MetArg: 0.534 ± 0.111
1.553MetSer: 1.553 ± 0.181
0.752MetThr: 0.752 ± 0.127
0.922MetVal: 0.922 ± 0.126
0.218MetTrp: 0.218 ± 0.073
0.971MetTyr: 0.971 ± 0.152
0.0MetXaa: 0.0 ± 0.0
Asn
2.208AsnAla: 2.208 ± 0.246
1.602AsnCys: 1.602 ± 0.241
4.514AsnAsp: 4.514 ± 0.358
5.679AsnGlu: 5.679 ± 0.408
4.004AsnPhe: 4.004 ± 0.28
5.655AsnGly: 5.655 ± 0.455
1.626AsnHis: 1.626 ± 0.224
10.314AsnIle: 10.314 ± 0.607
8.64AsnLys: 8.64 ± 0.469
7.451AsnLeu: 7.451 ± 0.549
2.087AsnMet: 2.087 ± 0.21
7.62AsnAsn: 7.62 ± 0.489
2.208AsnPro: 2.208 ± 0.298
2.16AsnGln: 2.16 ± 0.234
2.233AsnArg: 2.233 ± 0.231
5.169AsnSer: 5.169 ± 0.319
4.004AsnThr: 4.004 ± 0.378
4.393AsnVal: 4.393 ± 0.308
0.485AsnTrp: 0.485 ± 0.101
4.077AsnTyr: 4.077 ± 0.302
0.0AsnXaa: 0.0 ± 0.0
Pro
0.68ProAla: 0.68 ± 0.127
0.218ProCys: 0.218 ± 0.072
1.529ProAsp: 1.529 ± 0.178
1.966ProGlu: 1.966 ± 0.182
1.383ProPhe: 1.383 ± 0.178
1.383ProGly: 1.383 ± 0.162
0.364ProHis: 0.364 ± 0.099
2.718ProIle: 2.718 ± 0.25
2.621ProLys: 2.621 ± 0.285
1.893ProLeu: 1.893 ± 0.228
0.364ProMet: 0.364 ± 0.099
2.354ProAsn: 2.354 ± 0.209
0.607ProPro: 0.607 ± 0.139
0.704ProGln: 0.704 ± 0.16
0.655ProArg: 0.655 ± 0.104
2.645ProSer: 2.645 ± 0.308
1.553ProThr: 1.553 ± 0.202
1.238ProVal: 1.238 ± 0.183
0.17ProTrp: 0.17 ± 0.058
1.359ProTyr: 1.359 ± 0.194
0.0ProXaa: 0.0 ± 0.0
Gln
1.189GlnAla: 1.189 ± 0.167
0.388GlnCys: 0.388 ± 0.08
1.116GlnAsp: 1.116 ± 0.183
1.942GlnGlu: 1.942 ± 0.226
1.48GlnPhe: 1.48 ± 0.185
1.602GlnGly: 1.602 ± 0.227
0.315GlnHis: 0.315 ± 0.088
1.699GlnIle: 1.699 ± 0.231
2.233GlnLys: 2.233 ± 0.267
3.155GlnLeu: 3.155 ± 0.271
0.607GlnMet: 0.607 ± 0.125
1.966GlnAsn: 1.966 ± 0.185
0.68GlnPro: 0.68 ± 0.125
1.311GlnGln: 1.311 ± 0.191
0.849GlnArg: 0.849 ± 0.138
1.456GlnSer: 1.456 ± 0.174
1.238GlnThr: 1.238 ± 0.171
1.189GlnVal: 1.189 ± 0.183
0.146GlnTrp: 0.146 ± 0.052
1.408GlnTyr: 1.408 ± 0.191
0.0GlnXaa: 0.0 ± 0.0
Arg
1.044ArgAla: 1.044 ± 0.135
0.388ArgCys: 0.388 ± 0.116
1.529ArgAsp: 1.529 ± 0.19
1.699ArgGlu: 1.699 ± 0.223
1.408ArgPhe: 1.408 ± 0.158
1.311ArgGly: 1.311 ± 0.166
0.291ArgHis: 0.291 ± 0.094
1.966ArgIle: 1.966 ± 0.24
2.937ArgLys: 2.937 ± 0.237
2.403ArgLeu: 2.403 ± 0.208
0.461ArgMet: 0.461 ± 0.097
1.942ArgAsn: 1.942 ± 0.234
0.558ArgPro: 0.558 ± 0.139
1.116ArgGln: 1.116 ± 0.169
0.728ArgArg: 0.728 ± 0.132
1.456ArgSer: 1.456 ± 0.174
1.723ArgThr: 1.723 ± 0.222
1.48ArgVal: 1.48 ± 0.166
0.218ArgTrp: 0.218 ± 0.061
1.359ArgTyr: 1.359 ± 0.193
0.0ArgXaa: 0.0 ± 0.0
Ser
2.208SerAla: 2.208 ± 0.259
0.874SerCys: 0.874 ± 0.179
4.757SerAsp: 4.757 ± 0.334
4.514SerGlu: 4.514 ± 0.337
4.126SerPhe: 4.126 ± 0.34
3.349SerGly: 3.349 ± 0.361
1.116SerHis: 1.116 ± 0.148
6.868SerIle: 6.868 ± 0.388
7.305SerLys: 7.305 ± 0.354
6.48SerLeu: 6.48 ± 0.378
1.675SerMet: 1.675 ± 0.191
5.533SerAsn: 5.533 ± 0.425
1.408SerPro: 1.408 ± 0.204
1.456SerGln: 1.456 ± 0.181
1.505SerArg: 1.505 ± 0.215
4.83SerSer: 4.83 ± 0.439
3.373SerThr: 3.373 ± 0.294
3.519SerVal: 3.519 ± 0.358
0.68SerTrp: 0.68 ± 0.12
3.446SerTyr: 3.446 ± 0.26
0.0SerXaa: 0.0 ± 0.0
Thr
1.65ThrAla: 1.65 ± 0.227
0.971ThrCys: 0.971 ± 0.135
3.252ThrAsp: 3.252 ± 0.32
3.713ThrGlu: 3.713 ± 0.227
3.034ThrPhe: 3.034 ± 0.309
2.815ThrGly: 2.815 ± 0.285
0.631ThrHis: 0.631 ± 0.12
4.732ThrIle: 4.732 ± 0.378
4.32ThrLys: 4.32 ± 0.415
4.199ThrLeu: 4.199 ± 0.335
0.704ThrMet: 0.704 ± 0.133
3.932ThrAsn: 3.932 ± 0.345
2.475ThrPro: 2.475 ± 0.249
1.553ThrGln: 1.553 ± 0.249
1.165ThrArg: 1.165 ± 0.155
3.131ThrSer: 3.131 ± 0.289
2.573ThrThr: 2.573 ± 0.251
2.961ThrVal: 2.961 ± 0.284
0.437ThrTrp: 0.437 ± 0.112
2.937ThrTyr: 2.937 ± 0.253
0.0ThrXaa: 0.0 ± 0.0
Val
2.039ValAla: 2.039 ± 0.28
1.019ValCys: 1.019 ± 0.167
2.888ValAsp: 2.888 ± 0.398
3.907ValGlu: 3.907 ± 0.288
2.961ValPhe: 2.961 ± 0.29
2.378ValGly: 2.378 ± 0.269
0.461ValHis: 0.461 ± 0.094
4.66ValIle: 4.66 ± 0.293
5.509ValLys: 5.509 ± 0.347
3.713ValLeu: 3.713 ± 0.269
0.728ValMet: 0.728 ± 0.123
3.568ValAsn: 3.568 ± 0.27
1.116ValPro: 1.116 ± 0.159
0.898ValGln: 0.898 ± 0.132
1.359ValArg: 1.359 ± 0.152
4.223ValSer: 4.223 ± 0.382
2.912ValThr: 2.912 ± 0.293
3.034ValVal: 3.034 ± 0.276
0.801ValTrp: 0.801 ± 0.142
2.548ValTyr: 2.548 ± 0.231
0.0ValXaa: 0.0 ± 0.0
Trp
0.364TrpAla: 0.364 ± 0.109
0.243TrpCys: 0.243 ± 0.088
0.68TrpAsp: 0.68 ± 0.126
0.825TrpGlu: 0.825 ± 0.126
0.315TrpPhe: 0.315 ± 0.079
0.364TrpGly: 0.364 ± 0.106
0.34TrpHis: 0.34 ± 0.083
0.655TrpIle: 0.655 ± 0.146
0.51TrpLys: 0.51 ± 0.1
0.534TrpLeu: 0.534 ± 0.117
0.267TrpMet: 0.267 ± 0.086
0.704TrpAsn: 0.704 ± 0.124
0.024TrpPro: 0.024 ± 0.021
0.121TrpGln: 0.121 ± 0.051
0.194TrpArg: 0.194 ± 0.072
0.461TrpSer: 0.461 ± 0.117
0.388TrpThr: 0.388 ± 0.081
0.582TrpVal: 0.582 ± 0.115
0.049TrpTrp: 0.049 ± 0.037
0.461TrpTyr: 0.461 ± 0.108
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.65TyrAla: 1.65 ± 0.236
0.995TyrCys: 0.995 ± 0.152
3.349TyrAsp: 3.349 ± 0.299
3.155TyrGlu: 3.155 ± 0.282
3.131TyrPhe: 3.131 ± 0.328
2.5TyrGly: 2.5 ± 0.249
0.946TyrHis: 0.946 ± 0.175
4.927TyrIle: 4.927 ± 0.395
5.363TyrLys: 5.363 ± 0.362
3.543TyrLeu: 3.543 ± 0.303
1.311TyrMet: 1.311 ± 0.164
4.975TyrAsn: 4.975 ± 0.347
1.359TyrPro: 1.359 ± 0.176
1.092TyrGln: 1.092 ± 0.157
1.359TyrArg: 1.359 ± 0.186
4.66TyrSer: 4.66 ± 0.392
2.742TyrThr: 2.742 ± 0.248
2.5TyrVal: 2.5 ± 0.259
0.51TyrTrp: 0.51 ± 0.094
2.961TyrTyr: 2.961 ± 0.251
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 162 proteins (41206 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski