Amino acid dipepetide frequency for Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.139AlaAla: 18.139 ± 0.165	1.323AlaCys: 1.323 ± 0.032	6.778AlaAsp: 6.778 ± 0.089	8.798AlaGlu: 8.798 ± 0.107	3.998AlaPhe: 3.998 ± 0.065	10.743AlaGly: 10.743 ± 0.112	2.384AlaHis: 2.384 ± 0.049	5.594AlaIle: 5.594 ± 0.071	4.694AlaLys: 4.694 ± 0.073	13.545AlaLeu: 13.545 ± 0.189	3.724AlaMet: 3.724 ± 0.064	2.906AlaAsn: 2.906 ± 0.061	5.625AlaPro: 5.625 ± 0.093	4.022AlaGln: 4.022 ± 0.063	8.641AlaArg: 8.641 ± 0.113	6.181AlaSer: 6.181 ± 0.077	5.928AlaThr: 5.928 ± 0.136	9.447AlaVal: 9.447 ± 0.083	1.674AlaTrp: 1.674 ± 0.041	2.29AlaTyr: 2.29 ± 0.042	0.001AlaXaa: 0.001 ± 0.001
Cys	1.007CysAla: 1.007 ± 0.029	0.15CysCys: 0.15 ± 0.011	0.606CysAsp: 0.606 ± 0.023	0.456CysGlu: 0.456 ± 0.017	0.346CysPhe: 0.346 ± 0.016	1.048CysGly: 1.048 ± 0.027	0.322CysHis: 0.322 ± 0.019	0.407CysIle: 0.407 ± 0.018	0.283CysLys: 0.283 ± 0.015	0.983CysLeu: 0.983 ± 0.032	0.192CysMet: 0.192 ± 0.012	0.227CysAsn: 0.227 ± 0.013	0.644CysPro: 0.644 ± 0.022	0.27CysGln: 0.27 ± 0.013	0.912CysArg: 0.912 ± 0.026	0.552CysSer: 0.552 ± 0.023	0.51CysThr: 0.51 ± 0.018	0.644CysVal: 0.644 ± 0.028	0.147CysTrp: 0.147 ± 0.011	0.21CysTyr: 0.21 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.06AspAla: 6.06 ± 0.072	0.597AspCys: 0.597 ± 0.021	3.213AspAsp: 3.213 ± 0.062	3.43AspGlu: 3.43 ± 0.056	2.042AspPhe: 2.042 ± 0.036	5.768AspGly: 5.768 ± 0.136	1.326AspHis: 1.326 ± 0.031	2.882AspIle: 2.882 ± 0.058	1.91AspLys: 1.91 ± 0.044	6.208AspLeu: 6.208 ± 0.078	1.415AspMet: 1.415 ± 0.032	1.347AspAsn: 1.347 ± 0.037	3.141AspPro: 3.141 ± 0.052	1.885AspGln: 1.885 ± 0.046	4.006AspArg: 4.006 ± 0.068	2.789AspSer: 2.789 ± 0.084	2.627AspThr: 2.627 ± 0.075	3.904AspVal: 3.904 ± 0.063	0.894AspTrp: 0.894 ± 0.024	1.261AspTyr: 1.261 ± 0.031	0.001AspXaa: 0.001 ± 0.001
Glu	8.037GluAla: 8.037 ± 0.108	0.444GluCys: 0.444 ± 0.02	2.889GluAsp: 2.889 ± 0.073	3.264GluGlu: 3.264 ± 0.071	1.734GluPhe: 1.734 ± 0.04	4.344GluGly: 4.344 ± 0.064	1.22GluHis: 1.22 ± 0.03	3.38GluIle: 3.38 ± 0.06	2.219GluLys: 2.219 ± 0.049	5.246GluLeu: 5.246 ± 0.068	1.797GluMet: 1.797 ± 0.04	1.238GluAsn: 1.238 ± 0.032	2.5GluPro: 2.5 ± 0.066	2.013GluGln: 2.013 ± 0.043	4.658GluArg: 4.658 ± 0.074	2.643GluSer: 2.643 ± 0.041	3.301GluThr: 3.301 ± 0.054	4.449GluVal: 4.449 ± 0.064	0.726GluTrp: 0.726 ± 0.025	0.997GluTyr: 0.997 ± 0.031	0.001GluXaa: 0.001 ± 0.001
Phe	4.261PheAla: 4.261 ± 0.059	0.413PheCys: 0.413 ± 0.018	2.262PheAsp: 2.262 ± 0.044	1.885PheGlu: 1.885 ± 0.044	1.244PhePhe: 1.244 ± 0.034	3.188PheGly: 3.188 ± 0.052	0.736PheHis: 0.736 ± 0.024	1.425PheIle: 1.425 ± 0.033	1.184PheLys: 1.184 ± 0.031	3.261PheLeu: 3.261 ± 0.053	0.735PheMet: 0.735 ± 0.024	0.954PheAsn: 0.954 ± 0.027	1.499PhePro: 1.499 ± 0.038	1.02PheGln: 1.02 ± 0.028	2.092PheArg: 2.092 ± 0.038	2.067PheSer: 2.067 ± 0.035	2.071PheThr: 2.071 ± 0.079	2.421PheVal: 2.421 ± 0.046	0.44PheTrp: 0.44 ± 0.018	0.759PheTyr: 0.759 ± 0.026	0.001PheXaa: 0.001 ± 0.001
Gly	9.272GlyAla: 9.272 ± 0.108	1.045GlyCys: 1.045 ± 0.035	4.66GlyAsp: 4.66 ± 0.072	4.96GlyGlu: 4.96 ± 0.109	3.17GlyPhe: 3.17 ± 0.055	7.876GlyGly: 7.876 ± 0.12	2.082GlyHis: 2.082 ± 0.045	4.537GlyIle: 4.537 ± 0.056	3.676GlyLys: 3.676 ± 0.065	9.407GlyLeu: 9.407 ± 0.113	2.563GlyMet: 2.563 ± 0.041	2.288GlyAsn: 2.288 ± 0.08	3.404GlyPro: 3.404 ± 0.058	2.941GlyGln: 2.941 ± 0.05	6.576GlyArg: 6.576 ± 0.095	4.616GlySer: 4.616 ± 0.12	4.95GlyThr: 4.95 ± 0.213	5.915GlyVal: 5.915 ± 0.072	1.426GlyTrp: 1.426 ± 0.039	2.007GlyTyr: 2.007 ± 0.043	0.001GlyXaa: 0.001 ± 0.001
His	2.393HisAla: 2.393 ± 0.048	0.285HisCys: 0.285 ± 0.014	1.291HisAsp: 1.291 ± 0.035	1.041HisGlu: 1.041 ± 0.03	0.816HisPhe: 0.816 ± 0.027	2.06HisGly: 2.06 ± 0.045	0.71HisHis: 0.71 ± 0.027	0.865HisIle: 0.865 ± 0.025	0.557HisLys: 0.557 ± 0.022	2.383HisLeu: 2.383 ± 0.045	0.524HisMet: 0.524 ± 0.021	0.434HisAsn: 0.434 ± 0.02	1.428HisPro: 1.428 ± 0.036	0.708HisGln: 0.708 ± 0.024	1.482HisArg: 1.482 ± 0.037	1.006HisSer: 1.006 ± 0.026	0.861HisThr: 0.861 ± 0.024	1.601HisVal: 1.601 ± 0.048	0.341HisTrp: 0.341 ± 0.015	0.566HisTyr: 0.566 ± 0.023	0.001HisXaa: 0.001 ± 0.001
Ile	6.178IleAla: 6.178 ± 0.061	0.529IleCys: 0.529 ± 0.02	3.098IleAsp: 3.098 ± 0.046	2.985IleGlu: 2.985 ± 0.053	1.36IlePhe: 1.36 ± 0.031	4.505IleGly: 4.505 ± 0.057	1.031IleHis: 1.031 ± 0.033	2.011IleIle: 2.011 ± 0.04	1.678IleLys: 1.678 ± 0.034	4.174IleLeu: 4.174 ± 0.071	0.984IleMet: 0.984 ± 0.028	1.501IleAsn: 1.501 ± 0.032	2.322IlePro: 2.322 ± 0.048	1.247IleGln: 1.247 ± 0.032	3.319IleArg: 3.319 ± 0.057	2.822IleSer: 2.822 ± 0.056	2.69IleThr: 2.69 ± 0.053	3.237IleVal: 3.237 ± 0.054	0.506IleTrp: 0.506 ± 0.019	0.888IleTyr: 0.888 ± 0.027	0.001IleXaa: 0.001 ± 0.001
Lys	4.914LysAla: 4.914 ± 0.071	0.229LysCys: 0.229 ± 0.015	1.996LysAsp: 1.996 ± 0.041	1.661LysGlu: 1.661 ± 0.039	0.933LysPhe: 0.933 ± 0.027	3.162LysGly: 3.162 ± 0.054	0.578LysHis: 0.578 ± 0.021	1.612LysIle: 1.612 ± 0.039	1.393LysLys: 1.393 ± 0.048	3.265LysLeu: 3.265 ± 0.054	0.976LysMet: 0.976 ± 0.031	0.821LysAsn: 0.821 ± 0.026	2.164LysPro: 2.164 ± 0.052	0.912LysGln: 0.912 ± 0.028	2.361LysArg: 2.361 ± 0.045	1.896LysSer: 1.896 ± 0.038	2.016LysThr: 2.016 ± 0.047	3.083LysVal: 3.083 ± 0.051	0.455LysTrp: 0.455 ± 0.036	0.67LysTyr: 0.67 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.723LeuAla: 14.723 ± 0.146	0.985LeuCys: 0.985 ± 0.03	6.335LeuAsp: 6.335 ± 0.079	5.48LeuGlu: 5.48 ± 0.074	3.351LeuPhe: 3.351 ± 0.056	9.097LeuGly: 9.097 ± 0.101	1.915LeuHis: 1.915 ± 0.041	4.344LeuIle: 4.344 ± 0.06	3.744LeuLys: 3.744 ± 0.065	9.762LeuLeu: 9.762 ± 0.136	2.53LeuMet: 2.53 ± 0.048	2.574LeuAsn: 2.574 ± 0.098	5.692LeuPro: 5.692 ± 0.092	2.379LeuGln: 2.379 ± 0.044	6.738LeuArg: 6.738 ± 0.094	6.61LeuSer: 6.61 ± 0.146	5.44LeuThr: 5.44 ± 0.162	7.734LeuVal: 7.734 ± 0.087	1.251LeuTrp: 1.251 ± 0.034	1.916LeuTyr: 1.916 ± 0.042	0.001LeuXaa: 0.001 ± 0.001
Met	3.708MetAla: 3.708 ± 0.057	0.182MetCys: 0.182 ± 0.011	1.372MetAsp: 1.372 ± 0.03	1.461MetGlu: 1.461 ± 0.035	0.705MetPhe: 0.705 ± 0.026	2.209MetGly: 2.209 ± 0.05	0.392MetHis: 0.392 ± 0.016	1.293MetIle: 1.293 ± 0.032	1.016MetLys: 1.016 ± 0.025	2.53MetLeu: 2.53 ± 0.041	0.712MetMet: 0.712 ± 0.024	0.724MetAsn: 0.724 ± 0.019	1.555MetPro: 1.555 ± 0.036	0.662MetGln: 0.662 ± 0.021	1.759MetArg: 1.759 ± 0.039	1.714MetSer: 1.714 ± 0.034	1.877MetThr: 1.877 ± 0.051	2.313MetVal: 2.313 ± 0.043	0.216MetTrp: 0.216 ± 0.012	0.276MetTyr: 0.276 ± 0.014	0.001MetXaa: 0.001 ± 0.001
Asn	3.055AsnAla: 3.055 ± 0.089	0.252AsnCys: 0.252 ± 0.013	1.563AsnAsp: 1.563 ± 0.105	1.105AsnGlu: 1.105 ± 0.029	0.811AsnPhe: 0.811 ± 0.028	2.294AsnGly: 2.294 ± 0.08	0.54AsnHis: 0.54 ± 0.022	1.189AsnIle: 1.189 ± 0.031	0.688AsnLys: 0.688 ± 0.025	2.596AsnLeu: 2.596 ± 0.049	0.586AsnMet: 0.586 ± 0.022	0.684AsnAsn: 0.684 ± 0.04	1.678AsnPro: 1.678 ± 0.034	0.81AsnGln: 0.81 ± 0.028	1.746AsnArg: 1.746 ± 0.035	1.272AsnSer: 1.272 ± 0.035	1.241AsnThr: 1.241 ± 0.045	1.865AsnVal: 1.865 ± 0.056	0.369AsnTrp: 0.369 ± 0.018	0.546AsnTyr: 0.546 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.649ProAla: 6.649 ± 0.093	0.447ProCys: 0.447 ± 0.018	3.443ProAsp: 3.443 ± 0.054	3.591ProGlu: 3.591 ± 0.076	1.806ProPhe: 1.806 ± 0.037	4.642ProGly: 4.642 ± 0.082	1.119ProHis: 1.119 ± 0.026	1.989ProIle: 1.989 ± 0.047	1.761ProLys: 1.761 ± 0.047	5.063ProLeu: 5.063 ± 0.079	1.349ProMet: 1.349 ± 0.031	1.187ProAsn: 1.187 ± 0.033	3.501ProPro: 3.501 ± 0.106	1.537ProGln: 1.537 ± 0.038	2.893ProArg: 2.893 ± 0.059	2.841ProSer: 2.841 ± 0.05	2.297ProThr: 2.297 ± 0.045	4.276ProVal: 4.276 ± 0.067	0.757ProTrp: 0.757 ± 0.028	1.036ProTyr: 1.036 ± 0.029	0.001ProXaa: 0.001 ± 0.001
Gln	4.553GlnAla: 4.553 ± 0.091	0.288GlnCys: 0.288 ± 0.014	1.398GlnAsp: 1.398 ± 0.03	1.453GlnGlu: 1.453 ± 0.048	0.939GlnPhe: 0.939 ± 0.026	2.692GlnGly: 2.692 ± 0.052	0.568GlnHis: 0.568 ± 0.022	1.586GlnIle: 1.586 ± 0.055	0.956GlnLys: 0.956 ± 0.025	2.778GlnLeu: 2.778 ± 0.062	0.934GlnMet: 0.934 ± 0.026	0.674GlnAsn: 0.674 ± 0.022	1.712GlnPro: 1.712 ± 0.039	1.009GlnGln: 1.009 ± 0.034	2.144GlnArg: 2.144 ± 0.045	1.716GlnSer: 1.716 ± 0.03	1.71GlnThr: 1.71 ± 0.036	2.8GlnVal: 2.8 ± 0.097	0.448GlnTrp: 0.448 ± 0.016	0.573GlnTyr: 0.573 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.52ArgAla: 7.52 ± 0.091	0.622ArgCys: 0.622 ± 0.023	3.968ArgAsp: 3.968 ± 0.068	3.727ArgGlu: 3.727 ± 0.063	2.71ArgPhe: 2.71 ± 0.047	4.493ArgGly: 4.493 ± 0.068	1.981ArgHis: 1.981 ± 0.041	3.653ArgIle: 3.653 ± 0.057	2.397ArgLys: 2.397 ± 0.05	8.578ArgLeu: 8.578 ± 0.126	2.052ArgMet: 2.052 ± 0.039	1.741ArgAsn: 1.741 ± 0.038	3.919ArgPro: 3.919 ± 0.073	2.645ArgGln: 2.645 ± 0.057	6.219ArgArg: 6.219 ± 0.086	3.616ArgSer: 3.616 ± 0.059	3.214ArgThr: 3.214 ± 0.051	4.74ArgVal: 4.74 ± 0.077	1.023ArgTrp: 1.023 ± 0.027	1.519ArgTyr: 1.519 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.481SerAla: 6.481 ± 0.11	0.526SerCys: 0.526 ± 0.022	2.883SerAsp: 2.883 ± 0.064	2.626SerGlu: 2.626 ± 0.046	2.089SerPhe: 2.089 ± 0.046	5.518SerGly: 5.518 ± 0.122	1.242SerHis: 1.242 ± 0.031	2.432SerIle: 2.432 ± 0.044	1.681SerLys: 1.681 ± 0.038	5.785SerLeu: 5.785 ± 0.083	1.475SerMet: 1.475 ± 0.045	1.373SerAsn: 1.373 ± 0.055	2.998SerPro: 2.998 ± 0.052	1.667SerGln: 1.667 ± 0.035	3.817SerArg: 3.817 ± 0.061	3.125SerSer: 3.125 ± 0.074	2.85SerThr: 2.85 ± 0.157	4.098SerVal: 4.098 ± 0.064	0.795SerTrp: 0.795 ± 0.023	1.213SerTyr: 1.213 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.171ThrAla: 6.171 ± 0.125	0.468ThrCys: 0.468 ± 0.02	2.759ThrAsp: 2.759 ± 0.098	2.704ThrGlu: 2.704 ± 0.048	1.981ThrPhe: 1.981 ± 0.089	5.114ThrGly: 5.114 ± 0.114	0.924ThrHis: 0.924 ± 0.024	2.794ThrIle: 2.794 ± 0.117	1.576ThrLys: 1.576 ± 0.044	5.787ThrLeu: 5.787 ± 0.105	1.248ThrMet: 1.248 ± 0.03	1.318ThrAsn: 1.318 ± 0.051	3.104ThrPro: 3.104 ± 0.051	1.751ThrGln: 1.751 ± 0.177	3.133ThrArg: 3.133 ± 0.058	2.893ThrSer: 2.893 ± 0.113	3.142ThrThr: 3.142 ± 0.373	4.46ThrVal: 4.46 ± 0.102	0.675ThrTrp: 0.675 ± 0.023	1.072ThrTyr: 1.072 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.808ValAla: 9.808 ± 0.088	0.719ValCys: 0.719 ± 0.025	4.236ValAsp: 4.236 ± 0.059	4.875ValGlu: 4.875 ± 0.069	2.618ValPhe: 2.618 ± 0.048	5.723ValGly: 5.723 ± 0.071	1.415ValHis: 1.415 ± 0.029	3.74ValIle: 3.74 ± 0.062	2.615ValLys: 2.615 ± 0.049	7.604ValLeu: 7.604 ± 0.087	2.086ValMet: 2.086 ± 0.043	1.976ValAsn: 1.976 ± 0.054	3.658ValPro: 3.658 ± 0.055	2.213ValGln: 2.213 ± 0.085	4.852ValArg: 4.852 ± 0.062	4.339ValSer: 4.339 ± 0.06	4.657ValThr: 4.657 ± 0.129	6.727ValVal: 6.727 ± 0.091	0.925ValTrp: 0.925 ± 0.025	1.337ValTyr: 1.337 ± 0.032	0.001ValXaa: 0.001 ± 0.001
Trp	1.377TrpAla: 1.377 ± 0.033	0.163TrpCys: 0.163 ± 0.012	0.655TrpAsp: 0.655 ± 0.023	0.635TrpGlu: 0.635 ± 0.022	0.46TrpPhe: 0.46 ± 0.019	0.992TrpGly: 0.992 ± 0.027	0.351TrpHis: 0.351 ± 0.02	0.587TrpIle: 0.587 ± 0.023	0.48TrpLys: 0.48 ± 0.02	1.606TrpLeu: 1.606 ± 0.037	0.379TrpMet: 0.379 ± 0.016	0.41TrpAsn: 0.41 ± 0.018	0.669TrpPro: 0.669 ± 0.024	0.548TrpGln: 0.548 ± 0.02	1.282TrpArg: 1.282 ± 0.034	0.854TrpSer: 0.854 ± 0.04	0.732TrpThr: 0.732 ± 0.023	0.947TrpVal: 0.947 ± 0.027	0.235TrpTrp: 0.235 ± 0.015	0.271TrpTyr: 0.271 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.127TyrAla: 2.127 ± 0.038	0.249TyrCys: 0.249 ± 0.014	1.3TyrAsp: 1.3 ± 0.031	0.966TyrGlu: 0.966 ± 0.031	0.803TyrPhe: 0.803 ± 0.026	1.903TyrGly: 1.903 ± 0.04	0.515TyrHis: 0.515 ± 0.02	0.745TyrIle: 0.745 ± 0.023	0.589TyrLys: 0.589 ± 0.024	2.038TyrLeu: 2.038 ± 0.049	0.412TyrMet: 0.412 ± 0.017	0.513TyrAsn: 0.513 ± 0.022	0.972TyrPro: 0.972 ± 0.025	0.695TyrGln: 0.695 ± 0.023	1.709TyrArg: 1.709 ± 0.039	1.123TyrSer: 1.123 ± 0.03	0.959TyrThr: 0.959 ± 0.032	1.462TyrVal: 1.462 ± 0.038	0.329TyrTrp: 0.329 ± 0.016	0.488TyrTyr: 0.488 ± 0.02	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4515 proteins (1451216 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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