Amino acid dipepetide frequency for Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.864AlaAla: 5.864 ± 0.14
0.989AlaCys: 0.989 ± 0.043
4.375AlaAsp: 4.375 ± 0.092
5.106AlaGlu: 5.106 ± 0.104
2.727AlaPhe: 2.727 ± 0.076
6.247AlaGly: 6.247 ± 0.111
1.316AlaHis: 1.316 ± 0.051
5.723AlaIle: 5.723 ± 0.111
3.817AlaLys: 3.817 ± 0.096
6.452AlaLeu: 6.452 ± 0.126
2.02AlaMet: 2.02 ± 0.055
2.8AlaAsn: 2.8 ± 0.071
2.118AlaPro: 2.118 ± 0.065
1.757AlaGln: 1.757 ± 0.061
3.361AlaArg: 3.361 ± 0.083
4.726AlaSer: 4.726 ± 0.095
4.026AlaThr: 4.026 ± 0.104
5.15AlaVal: 5.15 ± 0.097
0.497AlaTrp: 0.497 ± 0.033
2.157AlaTyr: 2.157 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.906CysAla: 0.906 ± 0.043
0.215CysCys: 0.215 ± 0.023
0.79CysAsp: 0.79 ± 0.045
0.89CysGlu: 0.89 ± 0.042
0.388CysPhe: 0.388 ± 0.028
1.484CysGly: 1.484 ± 0.06
0.358CysHis: 0.358 ± 0.035
0.933CysIle: 0.933 ± 0.047
0.663CysLys: 0.663 ± 0.036
0.863CysLeu: 0.863 ± 0.044
0.348CysMet: 0.348 ± 0.023
0.593CysAsn: 0.593 ± 0.034
0.867CysPro: 0.867 ± 0.051
0.315CysGln: 0.315 ± 0.025
0.656CysArg: 0.656 ± 0.035
0.844CysSer: 0.844 ± 0.036
0.702CysThr: 0.702 ± 0.034
0.768CysVal: 0.768 ± 0.038
0.078CysTrp: 0.078 ± 0.012
0.382CysTyr: 0.382 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
4.188AspAla: 4.188 ± 0.091
0.75AspCys: 0.75 ± 0.033
3.168AspAsp: 3.168 ± 0.096
5.05AspGlu: 5.05 ± 0.112
2.635AspPhe: 2.635 ± 0.064
3.948AspGly: 3.948 ± 0.109
1.033AspHis: 1.033 ± 0.043
6.193AspIle: 6.193 ± 0.098
3.302AspLys: 3.302 ± 0.076
5.214AspLeu: 5.214 ± 0.114
2.086AspMet: 2.086 ± 0.064
2.684AspAsn: 2.684 ± 0.083
2.606AspPro: 2.606 ± 0.092
1.245AspGln: 1.245 ± 0.049
2.796AspArg: 2.796 ± 0.071
4.032AspSer: 4.032 ± 0.092
3.239AspThr: 3.239 ± 0.081
5.252AspVal: 5.252 ± 0.111
0.561AspTrp: 0.561 ± 0.033
2.232AspTyr: 2.232 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
4.858GluAla: 4.858 ± 0.102
0.829GluCys: 0.829 ± 0.036
4.819GluAsp: 4.819 ± 0.11
6.768GluGlu: 6.768 ± 0.126
2.503GluPhe: 2.503 ± 0.074
5.191GluGly: 5.191 ± 0.105
1.323GluHis: 1.323 ± 0.045
6.359GluIle: 6.359 ± 0.111
6.537GluLys: 6.537 ± 0.128
6.371GluLeu: 6.371 ± 0.123
2.696GluMet: 2.696 ± 0.07
4.295GluAsn: 4.295 ± 0.098
2.169GluPro: 2.169 ± 0.069
2.072GluGln: 2.072 ± 0.062
3.149GluArg: 3.149 ± 0.08
4.09GluSer: 4.09 ± 0.094
3.685GluThr: 3.685 ± 0.088
5.357GluVal: 5.357 ± 0.1
0.707GluTrp: 0.707 ± 0.039
2.813GluTyr: 2.813 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.83PheAla: 2.83 ± 0.078
0.519PheCys: 0.519 ± 0.032
2.555PheAsp: 2.555 ± 0.078
2.923PheGlu: 2.923 ± 0.07
1.53PhePhe: 1.53 ± 0.06
2.974PheGly: 2.974 ± 0.078
0.648PheHis: 0.648 ± 0.033
2.728PheIle: 2.728 ± 0.072
1.875PheLys: 1.875 ± 0.054
3.439PheLeu: 3.439 ± 0.098
1.034PheMet: 1.034 ± 0.042
1.648PheAsn: 1.648 ± 0.06
1.268PhePro: 1.268 ± 0.048
0.848PheGln: 0.848 ± 0.039
1.531PheArg: 1.531 ± 0.051
2.735PheSer: 2.735 ± 0.07
2.213PheThr: 2.213 ± 0.068
2.91PheVal: 2.91 ± 0.065
0.332PheTrp: 0.332 ± 0.025
1.296PheTyr: 1.296 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.979GlyAla: 4.979 ± 0.122
1.195GlyCys: 1.195 ± 0.056
4.251GlyAsp: 4.251 ± 0.125
4.972GlyGlu: 4.972 ± 0.102
3.04GlyPhe: 3.04 ± 0.076
5.272GlyGly: 5.272 ± 0.119
1.489GlyHis: 1.489 ± 0.052
6.749GlyIle: 6.749 ± 0.114
5.135GlyLys: 5.135 ± 0.107
6.093GlyLeu: 6.093 ± 0.108
2.438GlyMet: 2.438 ± 0.072
3.412GlyAsn: 3.412 ± 0.118
2.133GlyPro: 2.133 ± 0.068
1.881GlyGln: 1.881 ± 0.061
3.096GlyArg: 3.096 ± 0.08
4.509GlySer: 4.509 ± 0.102
4.166GlyThr: 4.166 ± 0.101
5.297GlyVal: 5.297 ± 0.118
0.731GlyTrp: 0.731 ± 0.04
3.005GlyTyr: 3.005 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.307HisAla: 1.307 ± 0.052
0.351HisCys: 0.351 ± 0.022
1.099HisAsp: 1.099 ± 0.043
1.306HisGlu: 1.306 ± 0.049
0.772HisPhe: 0.772 ± 0.043
1.448HisGly: 1.448 ± 0.055
0.419HisHis: 0.419 ± 0.026
1.665HisIle: 1.665 ± 0.052
0.911HisLys: 0.911 ± 0.041
1.762HisLeu: 1.762 ± 0.06
0.566HisMet: 0.566 ± 0.031
0.775HisAsn: 0.775 ± 0.041
1.14HisPro: 1.14 ± 0.048
0.485HisGln: 0.485 ± 0.031
0.938HisArg: 0.938 ± 0.042
1.267HisSer: 1.267 ± 0.048
0.95HisThr: 0.95 ± 0.038
1.384HisVal: 1.384 ± 0.047
0.187HisTrp: 0.187 ± 0.017
0.692HisTyr: 0.692 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
6.247IleAla: 6.247 ± 0.114
1.053IleCys: 1.053 ± 0.043
5.423IleAsp: 5.423 ± 0.105
6.311IleGlu: 6.311 ± 0.111
2.898IlePhe: 2.898 ± 0.085
6.003IleGly: 6.003 ± 0.103
1.613IleHis: 1.613 ± 0.056
5.888IleIle: 5.888 ± 0.132
4.492IleLys: 4.492 ± 0.095
7.027IleLeu: 7.027 ± 0.144
2.037IleMet: 2.037 ± 0.062
3.393IleAsn: 3.393 ± 0.077
3.693IlePro: 3.693 ± 0.076
2.052IleGln: 2.052 ± 0.065
3.49IleArg: 3.49 ± 0.082
5.67IleSer: 5.67 ± 0.099
4.299IleThr: 4.299 ± 0.095
5.509IleVal: 5.509 ± 0.093
0.588IleTrp: 0.588 ± 0.034
2.437IleTyr: 2.437 ± 0.074
0.0IleXaa: 0.0 ± 0.0
Lys
4.209LysAla: 4.209 ± 0.094
0.77LysCys: 0.77 ± 0.042
3.641LysAsp: 3.641 ± 0.084
5.321LysGlu: 5.321 ± 0.127
1.818LysPhe: 1.818 ± 0.064
4.292LysGly: 4.292 ± 0.091
1.089LysHis: 1.089 ± 0.043
4.648LysIle: 4.648 ± 0.087
4.957LysLys: 4.957 ± 0.121
4.884LysLeu: 4.884 ± 0.096
1.908LysMet: 1.908 ± 0.054
3.023LysAsn: 3.023 ± 0.082
2.342LysPro: 2.342 ± 0.068
2.009LysGln: 2.009 ± 0.064
2.786LysArg: 2.786 ± 0.078
3.442LysSer: 3.442 ± 0.094
3.146LysThr: 3.146 ± 0.071
3.968LysVal: 3.968 ± 0.097
0.551LysTrp: 0.551 ± 0.032
2.316LysTyr: 2.316 ± 0.072
0.0LysXaa: 0.0 ± 0.0
Leu
6.713LeuAla: 6.713 ± 0.122
0.984LeuCys: 0.984 ± 0.04
5.621LeuAsp: 5.621 ± 0.105
7.056LeuGlu: 7.056 ± 0.122
3.503LeuPhe: 3.503 ± 0.096
6.11LeuGly: 6.11 ± 0.11
1.692LeuHis: 1.692 ± 0.048
6.31LeuIle: 6.31 ± 0.125
5.877LeuLys: 5.877 ± 0.111
8.239LeuLeu: 8.239 ± 0.173
2.501LeuMet: 2.501 ± 0.068
3.81LeuAsn: 3.81 ± 0.083
3.549LeuPro: 3.549 ± 0.076
2.644LeuGln: 2.644 ± 0.071
3.678LeuArg: 3.678 ± 0.086
5.994LeuSer: 5.994 ± 0.108
4.183LeuThr: 4.183 ± 0.091
5.927LeuVal: 5.927 ± 0.106
0.61LeuTrp: 0.61 ± 0.034
2.618LeuTyr: 2.618 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.245MetAla: 2.245 ± 0.077
0.353MetCys: 0.353 ± 0.025
2.067MetAsp: 2.067 ± 0.067
2.499MetGlu: 2.499 ± 0.072
0.931MetPhe: 0.931 ± 0.043
2.444MetGly: 2.444 ± 0.074
0.526MetHis: 0.526 ± 0.03
1.913MetIle: 1.913 ± 0.057
1.945MetLys: 1.945 ± 0.064
2.557MetLeu: 2.557 ± 0.067
0.828MetMet: 0.828 ± 0.039
1.243MetAsn: 1.243 ± 0.046
1.129MetPro: 1.129 ± 0.049
1.034MetGln: 1.034 ± 0.04
1.219MetArg: 1.219 ± 0.044
1.73MetSer: 1.73 ± 0.055
1.487MetThr: 1.487 ± 0.05
2.104MetVal: 2.104 ± 0.064
0.22MetTrp: 0.22 ± 0.022
0.799MetTyr: 0.799 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.983AsnAla: 2.983 ± 0.079
0.59AsnCys: 0.59 ± 0.032
2.377AsnAsp: 2.377 ± 0.076
2.801AsnGlu: 2.801 ± 0.073
1.599AsnPhe: 1.599 ± 0.052
2.867AsnGly: 2.867 ± 0.1
0.858AsnHis: 0.858 ± 0.041
4.2AsnIle: 4.2 ± 0.097
2.413AsnLys: 2.413 ± 0.073
4.087AsnLeu: 4.087 ± 0.092
1.316AsnMet: 1.316 ± 0.054
2.164AsnAsn: 2.164 ± 0.124
2.357AsnPro: 2.357 ± 0.065
1.184AsnGln: 1.184 ± 0.056
1.992AsnArg: 1.992 ± 0.063
2.683AsnSer: 2.683 ± 0.093
2.613AsnThr: 2.613 ± 0.102
3.554AsnVal: 3.554 ± 0.112
0.427AsnTrp: 0.427 ± 0.027
1.552AsnTyr: 1.552 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
3.057ProAla: 3.057 ± 0.079
0.514ProCys: 0.514 ± 0.03
2.85ProAsp: 2.85 ± 0.083
3.78ProGlu: 3.78 ± 0.097
1.623ProPhe: 1.623 ± 0.058
2.725ProGly: 2.725 ± 0.081
0.841ProHis: 0.841 ± 0.037
2.557ProIle: 2.557 ± 0.068
1.669ProLys: 1.669 ± 0.055
3.542ProLeu: 3.542 ± 0.085
0.912ProMet: 0.912 ± 0.037
1.25ProAsn: 1.25 ± 0.042
1.319ProPro: 1.319 ± 0.058
1.299ProGln: 1.299 ± 0.051
1.462ProArg: 1.462 ± 0.054
2.501ProSer: 2.501 ± 0.067
1.918ProThr: 1.918 ± 0.064
3.395ProVal: 3.395 ± 0.075
0.302ProTrp: 0.302 ± 0.024
1.363ProTyr: 1.363 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
1.943GlnAla: 1.943 ± 0.06
0.336GlnCys: 0.336 ± 0.022
1.477GlnAsp: 1.477 ± 0.053
1.996GlnGlu: 1.996 ± 0.068
0.943GlnPhe: 0.943 ± 0.045
1.613GlnGly: 1.613 ± 0.056
0.56GlnHis: 0.56 ± 0.036
2.194GlnIle: 2.194 ± 0.061
2.091GlnLys: 2.091 ± 0.069
2.561GlnLeu: 2.561 ± 0.075
0.946GlnMet: 0.946 ± 0.043
1.304GlnAsn: 1.304 ± 0.047
0.967GlnPro: 0.967 ± 0.039
1.097GlnGln: 1.097 ± 0.053
1.387GlnArg: 1.387 ± 0.05
1.594GlnSer: 1.594 ± 0.05
1.446GlnThr: 1.446 ± 0.053
1.818GlnVal: 1.818 ± 0.055
0.29GlnTrp: 0.29 ± 0.02
1.011GlnTyr: 1.011 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.884ArgAla: 2.884 ± 0.074
0.633ArgCys: 0.633 ± 0.034
2.874ArgAsp: 2.874 ± 0.074
3.405ArgGlu: 3.405 ± 0.095
1.638ArgPhe: 1.638 ± 0.063
2.932ArgGly: 2.932 ± 0.077
0.906ArgHis: 0.906 ± 0.04
3.748ArgIle: 3.748 ± 0.094
3.32ArgLys: 3.32 ± 0.072
3.829ArgLeu: 3.829 ± 0.083
1.399ArgMet: 1.399 ± 0.043
2.098ArgAsn: 2.098 ± 0.055
1.441ArgPro: 1.441 ± 0.051
1.66ArgGln: 1.66 ± 0.052
2.143ArgArg: 2.143 ± 0.079
2.413ArgSer: 2.413 ± 0.066
2.106ArgThr: 2.106 ± 0.06
2.847ArgVal: 2.847 ± 0.074
0.451ArgTrp: 0.451 ± 0.027
1.626ArgTyr: 1.626 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
4.292SerAla: 4.292 ± 0.091
0.727SerCys: 0.727 ± 0.044
3.876SerAsp: 3.876 ± 0.1
4.321SerGlu: 4.321 ± 0.095
2.608SerPhe: 2.608 ± 0.082
5.206SerGly: 5.206 ± 0.098
1.448SerHis: 1.448 ± 0.052
5.314SerIle: 5.314 ± 0.112
3.52SerLys: 3.52 ± 0.082
5.691SerLeu: 5.691 ± 0.107
1.828SerMet: 1.828 ± 0.052
2.811SerAsn: 2.811 ± 0.097
2.501SerPro: 2.501 ± 0.067
1.814SerGln: 1.814 ± 0.064
3.183SerArg: 3.183 ± 0.084
4.802SerSer: 4.802 ± 0.14
3.62SerThr: 3.62 ± 0.094
4.351SerVal: 4.351 ± 0.097
0.526SerTrp: 0.526 ± 0.035
2.125SerTyr: 2.125 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
3.7ThrAla: 3.7 ± 0.088
0.661ThrCys: 0.661 ± 0.034
3.286ThrAsp: 3.286 ± 0.099
3.391ThrGlu: 3.391 ± 0.082
2.04ThrPhe: 2.04 ± 0.073
4.887ThrGly: 4.887 ± 0.145
1.039ThrHis: 1.039 ± 0.044
4.407ThrIle: 4.407 ± 0.109
2.442ThrLys: 2.442 ± 0.061
4.731ThrLeu: 4.731 ± 0.102
1.277ThrMet: 1.277 ± 0.043
2.164ThrAsn: 2.164 ± 0.092
2.605ThrPro: 2.605 ± 0.067
1.245ThrGln: 1.245 ± 0.053
2.291ThrArg: 2.291 ± 0.064
3.642ThrSer: 3.642 ± 0.099
3.096ThrThr: 3.096 ± 0.09
3.893ThrVal: 3.893 ± 0.089
0.343ThrTrp: 0.343 ± 0.028
1.92ThrTyr: 1.92 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
5.369ValAla: 5.369 ± 0.118
1.017ValCys: 1.017 ± 0.047
4.828ValAsp: 4.828 ± 0.088
5.586ValGlu: 5.586 ± 0.097
2.856ValPhe: 2.856 ± 0.067
4.977ValGly: 4.977 ± 0.105
1.406ValHis: 1.406 ± 0.053
5.555ValIle: 5.555 ± 0.111
4.102ValLys: 4.102 ± 0.087
6.374ValLeu: 6.374 ± 0.097
1.942ValMet: 1.942 ± 0.057
2.983ValAsn: 2.983 ± 0.085
2.832ValPro: 2.832 ± 0.066
1.76ValGln: 1.76 ± 0.054
3.069ValArg: 3.069 ± 0.078
4.967ValSer: 4.967 ± 0.1
3.924ValThr: 3.924 ± 0.129
5.603ValVal: 5.603 ± 0.112
0.585ValTrp: 0.585 ± 0.047
2.232ValTyr: 2.232 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.529TrpAla: 0.529 ± 0.032
0.095TrpCys: 0.095 ± 0.015
0.607TrpAsp: 0.607 ± 0.032
0.571TrpGlu: 0.571 ± 0.036
0.365TrpPhe: 0.365 ± 0.028
0.585TrpGly: 0.585 ± 0.026
0.161TrpHis: 0.161 ± 0.016
0.675TrpIle: 0.675 ± 0.038
0.585TrpLys: 0.585 ± 0.037
0.75TrpLeu: 0.75 ± 0.041
0.293TrpMet: 0.293 ± 0.03
0.451TrpAsn: 0.451 ± 0.027
0.229TrpPro: 0.229 ± 0.024
0.305TrpGln: 0.305 ± 0.021
0.327TrpArg: 0.327 ± 0.024
0.431TrpSer: 0.431 ± 0.033
0.444TrpThr: 0.444 ± 0.037
0.592TrpVal: 0.592 ± 0.035
0.107TrpTrp: 0.107 ± 0.014
0.346TrpTyr: 0.346 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.121TyrAla: 2.121 ± 0.058
0.463TyrCys: 0.463 ± 0.032
2.226TyrAsp: 2.226 ± 0.068
2.538TyrGlu: 2.538 ± 0.079
1.423TyrPhe: 1.423 ± 0.052
2.64TyrGly: 2.64 ± 0.066
0.699TyrHis: 0.699 ± 0.032
2.364TyrIle: 2.364 ± 0.078
1.467TyrLys: 1.467 ± 0.055
3.156TyrLeu: 3.156 ± 0.08
0.897TyrMet: 0.897 ± 0.038
1.716TyrAsn: 1.716 ± 0.092
1.614TyrPro: 1.614 ± 0.06
0.867TyrGln: 0.867 ± 0.045
1.797TyrArg: 1.797 ± 0.054
2.493TyrSer: 2.493 ± 0.074
1.797TyrThr: 1.797 ± 0.064
2.286TyrVal: 2.286 ± 0.077
0.354TyrTrp: 0.354 ± 0.022
1.312TyrTyr: 1.312 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1986 proteins (589724 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski