Amino acid dipepetide frequency for Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.729AlaAla: 7.729 ± 0.059	0.928AlaCys: 0.928 ± 0.016	3.797AlaAsp: 3.797 ± 0.031	4.752AlaGlu: 4.752 ± 0.046	2.773AlaPhe: 2.773 ± 0.031	5.29AlaGly: 5.29 ± 0.044	1.645AlaHis: 1.645 ± 0.023	4.016AlaIle: 4.016 ± 0.038	3.989AlaLys: 3.989 ± 0.038	6.918AlaLeu: 6.918 ± 0.047	1.695AlaMet: 1.695 ± 0.021	3.007AlaAsn: 3.007 ± 0.029	4.127AlaPro: 4.127 ± 0.039	2.977AlaGln: 2.977 ± 0.04	4.545AlaArg: 4.545 ± 0.037	6.819AlaSer: 6.819 ± 0.048	4.824AlaThr: 4.824 ± 0.041	4.954AlaVal: 4.954 ± 0.042	0.916AlaTrp: 0.916 ± 0.018	1.832AlaTyr: 1.832 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.861CysAla: 0.861 ± 0.016	0.244CysCys: 0.244 ± 0.01	0.606CysAsp: 0.606 ± 0.013	0.621CysGlu: 0.621 ± 0.013	0.52CysPhe: 0.52 ± 0.013	0.932CysGly: 0.932 ± 0.017	0.349CysHis: 0.349 ± 0.011	0.706CysIle: 0.706 ± 0.013	0.553CysLys: 0.553 ± 0.013	1.26CysLeu: 1.26 ± 0.017	0.253CysMet: 0.253 ± 0.008	0.443CysAsn: 0.443 ± 0.012	0.703CysPro: 0.703 ± 0.015	0.49CysGln: 0.49 ± 0.012	0.8CysArg: 0.8 ± 0.015	1.012CysSer: 1.012 ± 0.015	0.647CysThr: 0.647 ± 0.015	0.741CysVal: 0.741 ± 0.012	0.191CysTrp: 0.191 ± 0.007	0.35CysTyr: 0.35 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.112AspAla: 4.112 ± 0.03	0.604AspCys: 0.604 ± 0.013	4.15AspAsp: 4.15 ± 0.052	4.286AspGlu: 4.286 ± 0.043	2.094AspPhe: 2.094 ± 0.023	4.07AspGly: 4.07 ± 0.041	1.191AspHis: 1.191 ± 0.017	3.325AspIle: 3.325 ± 0.028	2.372AspLys: 2.372 ± 0.029	4.816AspLeu: 4.816 ± 0.038	1.254AspMet: 1.254 ± 0.017	2.014AspAsn: 2.014 ± 0.023	3.256AspPro: 3.256 ± 0.029	1.755AspGln: 1.755 ± 0.023	3.11AspArg: 3.11 ± 0.04	4.204AspSer: 4.204 ± 0.039	2.799AspThr: 2.799 ± 0.028	3.557AspVal: 3.557 ± 0.031	0.738AspTrp: 0.738 ± 0.014	1.461AspTyr: 1.461 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.803GluAla: 4.803 ± 0.043	0.654GluCys: 0.654 ± 0.013	4.003GluAsp: 4.003 ± 0.036	5.616GluGlu: 5.616 ± 0.062	2.012GluPhe: 2.012 ± 0.024	3.826GluGly: 3.826 ± 0.036	1.343GluHis: 1.343 ± 0.021	3.296GluIle: 3.296 ± 0.031	3.943GluLys: 3.943 ± 0.04	5.281GluLeu: 5.281 ± 0.047	1.518GluMet: 1.518 ± 0.023	2.694GluAsn: 2.694 ± 0.03	2.705GluPro: 2.705 ± 0.037	2.432GluGln: 2.432 ± 0.029	4.156GluArg: 4.156 ± 0.037	4.439GluSer: 4.439 ± 0.038	3.381GluThr: 3.381 ± 0.033	3.415GluVal: 3.415 ± 0.034	0.841GluTrp: 0.841 ± 0.015	1.638GluTyr: 1.638 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.702PheAla: 2.702 ± 0.032	0.573PheCys: 0.573 ± 0.012	2.178PheAsp: 2.178 ± 0.026	2.155PheGlu: 2.155 ± 0.023	1.493PhePhe: 1.493 ± 0.025	2.621PheGly: 2.621 ± 0.04	0.944PheHis: 0.944 ± 0.015	1.817PheIle: 1.817 ± 0.025	1.576PheLys: 1.576 ± 0.02	3.417PheLeu: 3.417 ± 0.033	0.722PheMet: 0.722 ± 0.015	1.481PheAsn: 1.481 ± 0.022	2.139PhePro: 2.139 ± 0.028	1.414PheGln: 1.414 ± 0.017	2.068PheArg: 2.068 ± 0.023	3.277PheSer: 3.277 ± 0.031	2.054PheThr: 2.054 ± 0.022	2.278PheVal: 2.278 ± 0.029	0.556PheTrp: 0.556 ± 0.011	1.06PheTyr: 1.06 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	4.682GlyAla: 4.682 ± 0.041	0.844GlyCys: 0.844 ± 0.016	3.709GlyAsp: 3.709 ± 0.041	3.946GlyGlu: 3.946 ± 0.036	2.61GlyPhe: 2.61 ± 0.033	5.982GlyGly: 5.982 ± 0.072	1.608GlyHis: 1.608 ± 0.025	3.6GlyIle: 3.6 ± 0.039	3.677GlyLys: 3.677 ± 0.033	5.518GlyLeu: 5.518 ± 0.047	1.585GlyMet: 1.585 ± 0.021	2.805GlyAsn: 2.805 ± 0.033	3.127GlyPro: 3.127 ± 0.03	2.437GlyGln: 2.437 ± 0.03	4.247GlyArg: 4.247 ± 0.038	5.779GlySer: 5.779 ± 0.046	3.75GlyThr: 3.75 ± 0.032	4.231GlyVal: 4.231 ± 0.046	1.055GlyTrp: 1.055 ± 0.018	1.973GlyTyr: 1.973 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.717HisAla: 1.717 ± 0.02	0.334HisCys: 0.334 ± 0.01	1.268HisAsp: 1.268 ± 0.017	1.281HisGlu: 1.281 ± 0.017	0.936HisPhe: 0.936 ± 0.017	1.675HisGly: 1.675 ± 0.023	0.995HisHis: 0.995 ± 0.021	1.357HisIle: 1.357 ± 0.02	0.975HisLys: 0.975 ± 0.017	2.304HisLeu: 2.304 ± 0.027	0.48HisMet: 0.48 ± 0.01	0.952HisAsn: 0.952 ± 0.016	1.923HisPro: 1.923 ± 0.024	1.15HisGln: 1.15 ± 0.021	1.609HisArg: 1.609 ± 0.023	2.159HisSer: 2.159 ± 0.025	1.328HisThr: 1.328 ± 0.019	1.391HisVal: 1.391 ± 0.018	0.306HisTrp: 0.306 ± 0.009	0.679HisTyr: 0.679 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.944IleAla: 3.944 ± 0.035	0.794IleCys: 0.794 ± 0.013	2.92IleAsp: 2.92 ± 0.028	2.934IleGlu: 2.934 ± 0.026	2.107IlePhe: 2.107 ± 0.027	3.069IleGly: 3.069 ± 0.034	1.339IleHis: 1.339 ± 0.019	2.666IleIle: 2.666 ± 0.029	2.303IleLys: 2.303 ± 0.026	4.847IleLeu: 4.847 ± 0.044	0.994IleMet: 0.994 ± 0.016	1.969IleAsn: 1.969 ± 0.024	3.514IlePro: 3.514 ± 0.029	2.023IleGln: 2.023 ± 0.025	3.048IleArg: 3.048 ± 0.03	4.664IleSer: 4.664 ± 0.037	2.91IleThr: 2.91 ± 0.026	3.084IleVal: 3.084 ± 0.031	0.664IleTrp: 0.664 ± 0.014	1.513IleTyr: 1.513 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.966LysAla: 3.966 ± 0.039	0.556LysCys: 0.556 ± 0.014	2.705LysAsp: 2.705 ± 0.03	3.6LysGlu: 3.6 ± 0.038	1.637LysPhe: 1.637 ± 0.023	3.207LysGly: 3.207 ± 0.027	1.209LysHis: 1.209 ± 0.02	2.564LysIle: 2.564 ± 0.028	3.464LysLys: 3.464 ± 0.047	4.417LysLeu: 4.417 ± 0.04	1.099LysMet: 1.099 ± 0.017	1.958LysAsn: 1.958 ± 0.023	2.954LysPro: 2.954 ± 0.031	2.012LysGln: 2.012 ± 0.023	3.836LysArg: 3.836 ± 0.034	4.034LysSer: 4.034 ± 0.036	2.817LysThr: 2.817 ± 0.03	2.803LysVal: 2.803 ± 0.026	0.669LysTrp: 0.669 ± 0.014	1.437LysTyr: 1.437 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.043LeuAla: 7.043 ± 0.048	1.189LeuCys: 1.189 ± 0.018	4.942LeuAsp: 4.942 ± 0.038	5.557LeuGlu: 5.557 ± 0.044	3.258LeuPhe: 3.258 ± 0.037	5.489LeuGly: 5.489 ± 0.04	2.293LeuHis: 2.293 ± 0.024	4.046LeuIle: 4.046 ± 0.041	4.538LeuLys: 4.538 ± 0.044	8.317LeuLeu: 8.317 ± 0.067	1.669LeuMet: 1.669 ± 0.022	3.378LeuAsn: 3.378 ± 0.026	5.636LeuPro: 5.636 ± 0.043	3.881LeuGln: 3.881 ± 0.039	5.875LeuArg: 5.875 ± 0.048	7.925LeuSer: 7.925 ± 0.047	4.771LeuThr: 4.771 ± 0.035	5.086LeuVal: 5.086 ± 0.04	1.078LeuTrp: 1.078 ± 0.019	2.237LeuTyr: 2.237 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.004MetAla: 2.004 ± 0.022	0.232MetCys: 0.232 ± 0.008	1.235MetAsp: 1.235 ± 0.017	1.384MetGlu: 1.384 ± 0.02	0.709MetPhe: 0.709 ± 0.015	1.428MetGly: 1.428 ± 0.02	0.442MetHis: 0.442 ± 0.012	0.983MetIle: 0.983 ± 0.015	1.1MetLys: 1.1 ± 0.018	1.753MetLeu: 1.753 ± 0.026	0.527MetMet: 0.527 ± 0.012	0.834MetAsn: 0.834 ± 0.014	1.186MetPro: 1.186 ± 0.018	0.804MetGln: 0.804 ± 0.015	1.249MetArg: 1.249 ± 0.018	1.854MetSer: 1.854 ± 0.021	1.239MetThr: 1.239 ± 0.019	1.247MetVal: 1.247 ± 0.019	0.242MetTrp: 0.242 ± 0.008	0.474MetTyr: 0.474 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.062AsnAla: 3.062 ± 0.029	0.5AsnCys: 0.5 ± 0.011	2.197AsnAsp: 2.197 ± 0.022	2.241AsnGlu: 2.241 ± 0.023	1.453AsnPhe: 1.453 ± 0.02	3.183AsnGly: 3.183 ± 0.037	1.029AsnHis: 1.029 ± 0.015	2.322AsnIle: 2.322 ± 0.027	1.774AsnLys: 1.774 ± 0.022	3.472AsnLeu: 3.472 ± 0.029	0.852AsnMet: 0.852 ± 0.015	2.022AsnAsn: 2.022 ± 0.043	2.847AsnPro: 2.847 ± 0.031	1.514AsnGln: 1.514 ± 0.021	2.279AsnArg: 2.279 ± 0.024	3.368AsnSer: 3.368 ± 0.037	2.356AsnThr: 2.356 ± 0.026	2.394AsnVal: 2.394 ± 0.025	0.5AsnTrp: 0.5 ± 0.011	1.065AsnTyr: 1.065 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	4.797ProAla: 4.797 ± 0.047	0.574ProCys: 0.574 ± 0.012	3.095ProAsp: 3.095 ± 0.029	3.641ProGlu: 3.641 ± 0.037	2.146ProPhe: 2.146 ± 0.024	3.789ProGly: 3.789 ± 0.037	1.553ProHis: 1.553 ± 0.022	2.803ProIle: 2.803 ± 0.03	2.822ProLys: 2.822 ± 0.031	5.058ProLeu: 5.058 ± 0.045	1.029ProMet: 1.029 ± 0.015	2.521ProAsn: 2.521 ± 0.028	5.783ProPro: 5.783 ± 0.087	2.726ProGln: 2.726 ± 0.039	3.504ProArg: 3.504 ± 0.038	6.807ProSer: 6.807 ± 0.054	4.201ProThr: 4.201 ± 0.048	3.475ProVal: 3.475 ± 0.033	0.667ProTrp: 0.667 ± 0.014	1.523ProTyr: 1.523 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	2.986GlnAla: 2.986 ± 0.034	0.455GlnCys: 0.455 ± 0.01	1.9GlnAsp: 1.9 ± 0.02	2.371GlnGlu: 2.371 ± 0.027	1.321GlnPhe: 1.321 ± 0.021	2.314GlnGly: 2.314 ± 0.028	1.218GlnHis: 1.218 ± 0.021	2.0GlnIle: 2.0 ± 0.023	2.141GlnLys: 2.141 ± 0.022	3.544GlnLeu: 3.544 ± 0.034	0.866GlnMet: 0.866 ± 0.015	1.803GlnAsn: 1.803 ± 0.024	2.747GlnPro: 2.747 ± 0.037	3.146GlnGln: 3.146 ± 0.082	2.812GlnArg: 2.812 ± 0.03	3.402GlnSer: 3.402 ± 0.034	2.388GlnThr: 2.388 ± 0.025	2.047GlnVal: 2.047 ± 0.026	0.484GlnTrp: 0.484 ± 0.012	1.1GlnTyr: 1.1 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.471ArgAla: 4.471 ± 0.03	0.774ArgCys: 0.774 ± 0.014	3.409ArgAsp: 3.409 ± 0.039	4.132ArgGlu: 4.132 ± 0.039	2.179ArgPhe: 2.179 ± 0.021	3.977ArgGly: 3.977 ± 0.041	1.628ArgHis: 1.628 ± 0.023	3.173ArgIle: 3.173 ± 0.027	3.858ArgLys: 3.858 ± 0.033	5.475ArgLeu: 5.475 ± 0.042	1.378ArgMet: 1.378 ± 0.02	2.675ArgAsn: 2.675 ± 0.026	3.527ArgPro: 3.527 ± 0.042	2.74ArgGln: 2.74 ± 0.025	5.509ArgArg: 5.509 ± 0.049	5.293ArgSer: 5.293 ± 0.043	3.378ArgThr: 3.378 ± 0.027	3.424ArgVal: 3.424 ± 0.03	0.863ArgTrp: 0.863 ± 0.016	1.673ArgTyr: 1.673 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	6.408SerAla: 6.408 ± 0.05	0.98SerCys: 0.98 ± 0.018	4.229SerAsp: 4.229 ± 0.033	4.292SerGlu: 4.292 ± 0.04	3.246SerPhe: 3.246 ± 0.032	5.818SerGly: 5.818 ± 0.049	2.277SerHis: 2.277 ± 0.028	4.356SerIle: 4.356 ± 0.033	4.271SerLys: 4.271 ± 0.035	7.709SerLeu: 7.709 ± 0.056	1.748SerMet: 1.748 ± 0.02	3.615SerAsn: 3.615 ± 0.036	6.395SerPro: 6.395 ± 0.064	3.721SerGln: 3.721 ± 0.036	5.699SerArg: 5.699 ± 0.051	10.391SerSer: 10.391 ± 0.099	6.042SerThr: 6.042 ± 0.053	4.669SerVal: 4.669 ± 0.033	1.056SerTrp: 1.056 ± 0.016	2.084SerTyr: 2.084 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	4.816ThrAla: 4.816 ± 0.041	0.717ThrCys: 0.717 ± 0.014	2.818ThrAsp: 2.818 ± 0.025	3.002ThrGlu: 3.002 ± 0.031	2.147ThrPhe: 2.147 ± 0.023	3.925ThrGly: 3.925 ± 0.036	1.348ThrHis: 1.348 ± 0.018	3.104ThrIle: 3.104 ± 0.028	2.697ThrLys: 2.697 ± 0.027	5.148ThrLeu: 5.148 ± 0.043	1.116ThrMet: 1.116 ± 0.017	2.319ThrAsn: 2.319 ± 0.028	4.496ThrPro: 4.496 ± 0.042	2.067ThrGln: 2.067 ± 0.025	3.191ThrArg: 3.191 ± 0.03	5.814ThrSer: 5.814 ± 0.05	4.504ThrThr: 4.504 ± 0.059	3.472ThrVal: 3.472 ± 0.034	0.693ThrTrp: 0.693 ± 0.014	1.474ThrTyr: 1.474 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.611ValAla: 4.611 ± 0.035	0.778ValCys: 0.778 ± 0.014	3.67ValAsp: 3.67 ± 0.034	3.893ValGlu: 3.893 ± 0.037	2.266ValPhe: 2.266 ± 0.028	3.901ValGly: 3.901 ± 0.042	1.336ValHis: 1.336 ± 0.019	3.009ValIle: 3.009 ± 0.032	3.016ValLys: 3.016 ± 0.031	5.218ValLeu: 5.218 ± 0.044	1.241ValMet: 1.241 ± 0.018	2.292ValAsn: 2.292 ± 0.03	3.407ValPro: 3.407 ± 0.031	2.208ValGln: 2.208 ± 0.022	3.45ValArg: 3.45 ± 0.034	4.751ValSer: 4.751 ± 0.035	3.275ValThr: 3.275 ± 0.033	4.018ValVal: 4.018 ± 0.035	0.754ValTrp: 0.754 ± 0.015	1.496ValTyr: 1.496 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	0.959TrpAla: 0.959 ± 0.014	0.167TrpCys: 0.167 ± 0.006	0.793TrpAsp: 0.793 ± 0.019	0.806TrpGlu: 0.806 ± 0.015	0.461TrpPhe: 0.461 ± 0.01	0.804TrpGly: 0.804 ± 0.017	0.312TrpHis: 0.312 ± 0.01	0.698TrpIle: 0.698 ± 0.015	0.781TrpLys: 0.781 ± 0.015	1.171TrpLeu: 1.171 ± 0.016	0.34TrpMet: 0.34 ± 0.01	0.597TrpAsn: 0.597 ± 0.013	0.508TrpPro: 0.508 ± 0.014	0.491TrpGln: 0.491 ± 0.01	0.924TrpArg: 0.924 ± 0.015	0.925TrpSer: 0.925 ± 0.016	0.747TrpThr: 0.747 ± 0.014	0.78TrpVal: 0.78 ± 0.014	0.24TrpTrp: 0.24 ± 0.009	0.355TrpTyr: 0.355 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.861TyrAla: 1.861 ± 0.026	0.385TyrCys: 0.385 ± 0.01	1.544TyrAsp: 1.544 ± 0.018	1.488TyrGlu: 1.488 ± 0.019	1.157TyrPhe: 1.157 ± 0.018	1.864TyrGly: 1.864 ± 0.026	0.762TyrHis: 0.762 ± 0.014	1.463TyrIle: 1.463 ± 0.023	1.094TyrLys: 1.094 ± 0.019	2.565TyrLeu: 2.565 ± 0.031	0.557TyrMet: 0.557 ± 0.01	1.052TyrAsn: 1.052 ± 0.017	1.532TyrPro: 1.532 ± 0.026	1.058TyrGln: 1.058 ± 0.016	1.625TyrArg: 1.625 ± 0.022	2.088TyrSer: 2.088 ± 0.028	1.46TyrThr: 1.46 ± 0.019	1.524TyrVal: 1.524 ± 0.023	0.345TyrTrp: 0.345 ± 0.009	0.863TyrTyr: 0.863 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8811 proteins (3951676 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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