Amino acid dipepetide frequency for Mycobacterium virus Avani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.393AlaAla: 14.393 ± 1.703
1.028AlaCys: 1.028 ± 0.25
6.511AlaAsp: 6.511 ± 0.718
7.939AlaGlu: 7.939 ± 0.92
3.199AlaPhe: 3.199 ± 0.427
8.853AlaGly: 8.853 ± 1.173
1.599AlaHis: 1.599 ± 0.308
4.398AlaIle: 4.398 ± 0.476
4.455AlaLys: 4.455 ± 0.513
10.224AlaLeu: 10.224 ± 0.891
3.313AlaMet: 3.313 ± 0.429
3.598AlaAsn: 3.598 ± 0.505
4.569AlaPro: 4.569 ± 0.428
4.798AlaGln: 4.798 ± 0.576
6.968AlaArg: 6.968 ± 0.946
5.369AlaSer: 5.369 ± 0.57
5.655AlaThr: 5.655 ± 0.61
7.597AlaVal: 7.597 ± 0.739
2.627AlaTrp: 2.627 ± 0.428
2.056AlaTyr: 2.056 ± 0.343
0.0AlaXaa: 0.0 ± 0.0
Cys
1.199CysAla: 1.199 ± 0.294
0.228CysCys: 0.228 ± 0.105
0.971CysAsp: 0.971 ± 0.267
1.085CysGlu: 1.085 ± 0.258
0.343CysPhe: 0.343 ± 0.143
1.714CysGly: 1.714 ± 0.402
0.4CysHis: 0.4 ± 0.144
0.4CysIle: 0.4 ± 0.143
0.571CysLys: 0.571 ± 0.166
0.743CysLeu: 0.743 ± 0.26
0.171CysMet: 0.171 ± 0.107
0.343CysAsn: 0.343 ± 0.129
0.914CysPro: 0.914 ± 0.242
0.4CysGln: 0.4 ± 0.184
0.743CysArg: 0.743 ± 0.239
0.743CysSer: 0.743 ± 0.212
0.685CysThr: 0.685 ± 0.213
0.743CysVal: 0.743 ± 0.215
0.343CysTrp: 0.343 ± 0.142
0.4CysTyr: 0.4 ± 0.135
0.0CysXaa: 0.0 ± 0.0
Asp
7.597AspAla: 7.597 ± 0.68
0.743AspCys: 0.743 ± 0.193
4.398AspAsp: 4.398 ± 0.696
4.798AspGlu: 4.798 ± 0.672
2.228AspPhe: 2.228 ± 0.366
5.026AspGly: 5.026 ± 0.528
1.428AspHis: 1.428 ± 0.335
3.027AspIle: 3.027 ± 0.512
1.714AspLys: 1.714 ± 0.359
4.112AspLeu: 4.112 ± 0.567
1.428AspMet: 1.428 ± 0.298
1.599AspAsn: 1.599 ± 0.329
4.227AspPro: 4.227 ± 0.585
1.828AspGln: 1.828 ± 0.326
4.284AspArg: 4.284 ± 0.521
2.856AspSer: 2.856 ± 0.389
3.256AspThr: 3.256 ± 0.415
4.684AspVal: 4.684 ± 0.444
1.485AspTrp: 1.485 ± 0.275
1.771AspTyr: 1.771 ± 0.328
0.0AspXaa: 0.0 ± 0.0
Glu
6.626GluAla: 6.626 ± 0.674
1.542GluCys: 1.542 ± 0.326
3.77GluAsp: 3.77 ± 0.552
2.856GluGlu: 2.856 ± 0.558
2.285GluPhe: 2.285 ± 0.387
4.17GluGly: 4.17 ± 0.593
1.542GluHis: 1.542 ± 0.317
2.399GluIle: 2.399 ± 0.375
2.228GluLys: 2.228 ± 0.387
6.111GluLeu: 6.111 ± 0.607
1.028GluMet: 1.028 ± 0.235
1.942GluAsn: 1.942 ± 0.301
3.598GluPro: 3.598 ± 0.509
2.456GluGln: 2.456 ± 0.343
4.055GluArg: 4.055 ± 0.667
3.655GluSer: 3.655 ± 0.459
3.141GluThr: 3.141 ± 0.429
4.626GluVal: 4.626 ± 0.476
1.257GluTrp: 1.257 ± 0.226
1.485GluTyr: 1.485 ± 0.303
0.0GluXaa: 0.0 ± 0.0
Phe
3.027PheAla: 3.027 ± 0.329
0.457PheCys: 0.457 ± 0.151
1.942PheAsp: 1.942 ± 0.41
1.828PheGlu: 1.828 ± 0.331
0.685PhePhe: 0.685 ± 0.192
2.684PheGly: 2.684 ± 0.435
0.571PheHis: 0.571 ± 0.195
1.485PheIle: 1.485 ± 0.254
1.142PheLys: 1.142 ± 0.281
2.285PheLeu: 2.285 ± 0.385
0.857PheMet: 0.857 ± 0.212
1.028PheAsn: 1.028 ± 0.184
1.428PhePro: 1.428 ± 0.24
0.743PheGln: 0.743 ± 0.216
1.485PheArg: 1.485 ± 0.29
2.113PheSer: 2.113 ± 0.306
2.399PheThr: 2.399 ± 0.321
1.885PheVal: 1.885 ± 0.34
0.571PheTrp: 0.571 ± 0.167
0.628PheTyr: 0.628 ± 0.179
0.0PheXaa: 0.0 ± 0.0
Gly
8.453GlyAla: 8.453 ± 1.117
0.8GlyCys: 0.8 ± 0.299
4.912GlyAsp: 4.912 ± 0.527
4.569GlyGlu: 4.569 ± 0.494
2.513GlyPhe: 2.513 ± 0.434
9.596GlyGly: 9.596 ± 1.57
2.17GlyHis: 2.17 ± 0.287
3.655GlyIle: 3.655 ± 0.526
3.484GlyLys: 3.484 ± 0.443
5.883GlyLeu: 5.883 ± 0.675
1.714GlyMet: 1.714 ± 0.358
3.027GlyAsn: 3.027 ± 0.428
3.598GlyPro: 3.598 ± 0.454
3.541GlyGln: 3.541 ± 0.571
4.912GlyArg: 4.912 ± 0.45
5.597GlySer: 5.597 ± 0.958
6.74GlyThr: 6.74 ± 0.75
7.025GlyVal: 7.025 ± 0.728
2.113GlyTrp: 2.113 ± 0.35
2.228GlyTyr: 2.228 ± 0.4
0.0GlyXaa: 0.0 ± 0.0
His
1.599HisAla: 1.599 ± 0.305
0.4HisCys: 0.4 ± 0.143
1.428HisAsp: 1.428 ± 0.287
0.857HisGlu: 0.857 ± 0.233
0.4HisPhe: 0.4 ± 0.122
1.714HisGly: 1.714 ± 0.299
0.857HisHis: 0.857 ± 0.242
1.257HisIle: 1.257 ± 0.303
0.914HisLys: 0.914 ± 0.192
2.342HisLeu: 2.342 ± 0.361
0.514HisMet: 0.514 ± 0.173
0.857HisAsn: 0.857 ± 0.23
1.485HisPro: 1.485 ± 0.252
0.685HisGln: 0.685 ± 0.188
1.999HisArg: 1.999 ± 0.44
1.314HisSer: 1.314 ± 0.252
1.199HisThr: 1.199 ± 0.291
1.485HisVal: 1.485 ± 0.334
0.457HisTrp: 0.457 ± 0.187
0.685HisTyr: 0.685 ± 0.218
0.0HisXaa: 0.0 ± 0.0
Ile
5.712IleAla: 5.712 ± 0.68
0.685IleCys: 0.685 ± 0.245
3.541IleAsp: 3.541 ± 0.533
3.199IleGlu: 3.199 ± 0.382
0.743IlePhe: 0.743 ± 0.21
4.227IleGly: 4.227 ± 0.549
1.199IleHis: 1.199 ± 0.295
1.885IleIle: 1.885 ± 0.329
1.371IleLys: 1.371 ± 0.267
2.056IleLeu: 2.056 ± 0.449
0.914IleMet: 0.914 ± 0.23
2.113IleAsn: 2.113 ± 0.408
2.57IlePro: 2.57 ± 0.467
1.656IleGln: 1.656 ± 0.301
3.541IleArg: 3.541 ± 0.47
1.942IleSer: 1.942 ± 0.415
4.227IleThr: 4.227 ± 0.573
2.97IleVal: 2.97 ± 0.354
0.628IleTrp: 0.628 ± 0.225
0.857IleTyr: 0.857 ± 0.206
0.0IleXaa: 0.0 ± 0.0
Lys
3.998LysAla: 3.998 ± 0.552
0.171LysCys: 0.171 ± 0.095
1.714LysAsp: 1.714 ± 0.279
1.599LysGlu: 1.599 ± 0.367
0.8LysPhe: 0.8 ± 0.204
2.342LysGly: 2.342 ± 0.379
0.743LysHis: 0.743 ± 0.206
1.885LysIle: 1.885 ± 0.322
1.428LysLys: 1.428 ± 0.383
2.627LysLeu: 2.627 ± 0.357
0.914LysMet: 0.914 ± 0.206
0.971LysAsn: 0.971 ± 0.258
2.57LysPro: 2.57 ± 0.38
1.885LysGln: 1.885 ± 0.397
3.313LysArg: 3.313 ± 0.538
2.17LysSer: 2.17 ± 0.424
1.714LysThr: 1.714 ± 0.343
2.456LysVal: 2.456 ± 0.287
1.142LysTrp: 1.142 ± 0.247
0.857LysTyr: 0.857 ± 0.274
0.0LysXaa: 0.0 ± 0.0
Leu
9.424LeuAla: 9.424 ± 0.943
0.8LeuCys: 0.8 ± 0.258
5.083LeuAsp: 5.083 ± 0.602
3.541LeuGlu: 3.541 ± 0.438
1.999LeuPhe: 1.999 ± 0.359
6.34LeuGly: 6.34 ± 0.624
1.428LeuHis: 1.428 ± 0.276
3.541LeuIle: 3.541 ± 0.599
3.37LeuLys: 3.37 ± 0.419
5.54LeuLeu: 5.54 ± 0.684
1.314LeuMet: 1.314 ± 0.343
2.456LeuAsn: 2.456 ± 0.413
5.597LeuPro: 5.597 ± 0.7
2.799LeuGln: 2.799 ± 0.472
5.141LeuArg: 5.141 ± 0.566
5.255LeuSer: 5.255 ± 0.531
5.483LeuThr: 5.483 ± 0.598
5.141LeuVal: 5.141 ± 0.522
1.085LeuTrp: 1.085 ± 0.345
1.771LeuTyr: 1.771 ± 0.284
0.0LeuXaa: 0.0 ± 0.0
Met
2.399MetAla: 2.399 ± 0.388
0.4MetCys: 0.4 ± 0.21
0.914MetAsp: 0.914 ± 0.208
0.914MetGlu: 0.914 ± 0.254
0.8MetPhe: 0.8 ± 0.26
1.599MetGly: 1.599 ± 0.346
0.228MetHis: 0.228 ± 0.121
0.914MetIle: 0.914 ± 0.214
0.628MetLys: 0.628 ± 0.197
1.942MetLeu: 1.942 ± 0.341
0.343MetMet: 0.343 ± 0.141
0.914MetAsn: 0.914 ± 0.225
1.314MetPro: 1.314 ± 0.222
0.228MetGln: 0.228 ± 0.105
1.485MetArg: 1.485 ± 0.294
2.627MetSer: 2.627 ± 0.389
2.056MetThr: 2.056 ± 0.351
1.371MetVal: 1.371 ± 0.255
0.4MetTrp: 0.4 ± 0.185
0.457MetTyr: 0.457 ± 0.166
0.0MetXaa: 0.0 ± 0.0
Asn
3.199AsnAla: 3.199 ± 0.558
0.4AsnCys: 0.4 ± 0.165
1.485AsnAsp: 1.485 ± 0.264
1.714AsnGlu: 1.714 ± 0.339
0.685AsnPhe: 0.685 ± 0.18
4.912AsnGly: 4.912 ± 0.545
0.8AsnHis: 0.8 ± 0.241
1.257AsnIle: 1.257 ± 0.267
0.914AsnLys: 0.914 ± 0.202
3.084AsnLeu: 3.084 ± 0.407
0.8AsnMet: 0.8 ± 0.234
1.199AsnAsn: 1.199 ± 0.285
2.627AsnPro: 2.627 ± 0.433
0.8AsnGln: 0.8 ± 0.2
1.542AsnArg: 1.542 ± 0.317
2.228AsnSer: 2.228 ± 0.3
2.17AsnThr: 2.17 ± 0.373
1.999AsnVal: 1.999 ± 0.294
0.571AsnTrp: 0.571 ± 0.166
0.8AsnTyr: 0.8 ± 0.203
0.0AsnXaa: 0.0 ± 0.0
Pro
5.54ProAla: 5.54 ± 0.643
0.743ProCys: 0.743 ± 0.207
5.026ProAsp: 5.026 ± 0.553
4.912ProGlu: 4.912 ± 0.632
1.999ProPhe: 1.999 ± 0.296
5.769ProGly: 5.769 ± 0.732
1.542ProHis: 1.542 ± 0.265
1.942ProIle: 1.942 ± 0.307
2.113ProLys: 2.113 ± 0.328
3.598ProLeu: 3.598 ± 0.434
1.085ProMet: 1.085 ± 0.204
2.17ProAsn: 2.17 ± 0.37
3.655ProPro: 3.655 ± 0.602
1.714ProGln: 1.714 ± 0.297
3.313ProArg: 3.313 ± 0.445
2.684ProSer: 2.684 ± 0.376
3.541ProThr: 3.541 ± 0.5
4.112ProVal: 4.112 ± 0.579
0.971ProTrp: 0.971 ± 0.218
1.714ProTyr: 1.714 ± 0.277
0.0ProXaa: 0.0 ± 0.0
Gln
3.541GlnAla: 3.541 ± 0.527
0.571GlnCys: 0.571 ± 0.225
1.485GlnAsp: 1.485 ± 0.255
1.771GlnGlu: 1.771 ± 0.284
1.257GlnPhe: 1.257 ± 0.269
3.084GlnGly: 3.084 ± 0.426
1.085GlnHis: 1.085 ± 0.233
2.285GlnIle: 2.285 ± 0.376
1.942GlnLys: 1.942 ± 0.386
2.97GlnLeu: 2.97 ± 0.383
1.199GlnMet: 1.199 ± 0.258
1.142GlnAsn: 1.142 ± 0.334
2.285GlnPro: 2.285 ± 0.454
1.485GlnGln: 1.485 ± 0.344
2.228GlnArg: 2.228 ± 0.384
2.342GlnSer: 2.342 ± 0.32
1.885GlnThr: 1.885 ± 0.284
1.999GlnVal: 1.999 ± 0.365
0.571GlnTrp: 0.571 ± 0.195
1.028GlnTyr: 1.028 ± 0.243
0.0GlnXaa: 0.0 ± 0.0
Arg
6.968ArgAla: 6.968 ± 0.706
1.085ArgCys: 1.085 ± 0.291
3.884ArgAsp: 3.884 ± 0.485
4.626ArgGlu: 4.626 ± 0.661
2.342ArgPhe: 2.342 ± 0.426
3.884ArgGly: 3.884 ± 0.437
1.371ArgHis: 1.371 ± 0.277
3.941ArgIle: 3.941 ± 0.561
2.113ArgLys: 2.113 ± 0.389
5.483ArgLeu: 5.483 ± 0.609
1.714ArgMet: 1.714 ± 0.365
2.113ArgAsn: 2.113 ± 0.38
3.713ArgPro: 3.713 ± 0.533
2.799ArgGln: 2.799 ± 0.46
6.454ArgArg: 6.454 ± 1.009
3.998ArgSer: 3.998 ± 0.472
2.97ArgThr: 2.97 ± 0.503
4.512ArgVal: 4.512 ± 0.586
2.228ArgTrp: 2.228 ± 0.287
1.885ArgTyr: 1.885 ± 0.341
0.0ArgXaa: 0.0 ± 0.0
Ser
6.911SerAla: 6.911 ± 1.068
0.457SerCys: 0.457 ± 0.155
3.884SerAsp: 3.884 ± 0.456
3.199SerGlu: 3.199 ± 0.454
1.542SerPhe: 1.542 ± 0.378
6.511SerGly: 6.511 ± 0.962
1.142SerHis: 1.142 ± 0.33
2.684SerIle: 2.684 ± 0.37
1.714SerLys: 1.714 ± 0.367
4.17SerLeu: 4.17 ± 0.564
1.656SerMet: 1.656 ± 0.251
2.17SerAsn: 2.17 ± 0.387
2.97SerPro: 2.97 ± 0.386
2.113SerGln: 2.113 ± 0.308
3.77SerArg: 3.77 ± 0.602
2.97SerSer: 2.97 ± 0.547
4.455SerThr: 4.455 ± 0.496
4.569SerVal: 4.569 ± 0.728
1.314SerTrp: 1.314 ± 0.303
1.142SerTyr: 1.142 ± 0.248
0.0SerXaa: 0.0 ± 0.0
Thr
6.854ThrAla: 6.854 ± 0.692
0.628ThrCys: 0.628 ± 0.19
4.055ThrAsp: 4.055 ± 0.516
3.655ThrGlu: 3.655 ± 0.432
1.485ThrPhe: 1.485 ± 0.329
5.312ThrGly: 5.312 ± 0.693
1.314ThrHis: 1.314 ± 0.235
3.598ThrIle: 3.598 ± 0.587
1.599ThrLys: 1.599 ± 0.287
4.741ThrLeu: 4.741 ± 0.572
0.971ThrMet: 0.971 ± 0.215
2.342ThrAsn: 2.342 ± 0.368
5.026ThrPro: 5.026 ± 0.619
2.056ThrGln: 2.056 ± 0.39
4.341ThrArg: 4.341 ± 0.555
4.227ThrSer: 4.227 ± 0.465
4.055ThrThr: 4.055 ± 0.624
4.569ThrVal: 4.569 ± 0.59
1.771ThrTrp: 1.771 ± 0.407
1.028ThrTyr: 1.028 ± 0.228
0.0ThrXaa: 0.0 ± 0.0
Val
7.711ValAla: 7.711 ± 0.574
1.142ValCys: 1.142 ± 0.259
3.998ValAsp: 3.998 ± 0.598
5.255ValGlu: 5.255 ± 0.621
2.17ValPhe: 2.17 ± 0.35
4.969ValGly: 4.969 ± 0.645
2.056ValHis: 2.056 ± 0.358
3.256ValIle: 3.256 ± 0.498
2.342ValLys: 2.342 ± 0.374
5.083ValLeu: 5.083 ± 0.657
0.914ValMet: 0.914 ± 0.269
1.885ValAsn: 1.885 ± 0.318
3.998ValPro: 3.998 ± 0.377
2.285ValGln: 2.285 ± 0.326
4.569ValArg: 4.569 ± 0.554
4.741ValSer: 4.741 ± 0.668
4.626ValThr: 4.626 ± 0.668
5.712ValVal: 5.712 ± 0.721
1.942ValTrp: 1.942 ± 0.297
1.885ValTyr: 1.885 ± 0.361
0.0ValXaa: 0.0 ± 0.0
Trp
1.771TrpAla: 1.771 ± 0.299
0.514TrpCys: 0.514 ± 0.18
1.885TrpAsp: 1.885 ± 0.399
0.914TrpGlu: 0.914 ± 0.297
0.743TrpPhe: 0.743 ± 0.191
1.428TrpGly: 1.428 ± 0.331
0.343TrpHis: 0.343 ± 0.126
1.485TrpIle: 1.485 ± 0.246
0.685TrpLys: 0.685 ± 0.198
2.17TrpLeu: 2.17 ± 0.393
0.685TrpMet: 0.685 ± 0.234
0.571TrpAsn: 0.571 ± 0.152
1.142TrpPro: 1.142 ± 0.283
1.028TrpGln: 1.028 ± 0.198
1.428TrpArg: 1.428 ± 0.294
1.485TrpSer: 1.485 ± 0.31
1.599TrpThr: 1.599 ± 0.332
1.371TrpVal: 1.371 ± 0.293
0.8TrpTrp: 0.8 ± 0.22
0.743TrpTyr: 0.743 ± 0.189
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.228TyrAla: 2.228 ± 0.341
0.343TyrCys: 0.343 ± 0.127
1.599TyrAsp: 1.599 ± 0.268
1.599TyrGlu: 1.599 ± 0.303
1.028TyrPhe: 1.028 ± 0.262
2.399TyrGly: 2.399 ± 0.515
0.628TyrHis: 0.628 ± 0.19
0.743TyrIle: 0.743 ± 0.167
0.571TyrLys: 0.571 ± 0.226
1.942TyrLeu: 1.942 ± 0.309
0.343TyrMet: 0.343 ± 0.124
0.743TyrAsn: 0.743 ± 0.172
0.857TyrPro: 0.857 ± 0.21
0.857TyrGln: 0.857 ± 0.237
2.513TyrArg: 2.513 ± 0.413
1.028TyrSer: 1.028 ± 0.252
1.771TyrThr: 1.771 ± 0.326
1.714TyrVal: 1.714 ± 0.289
0.514TyrTrp: 0.514 ± 0.173
0.571TyrTyr: 0.571 ± 0.165
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 107 proteins (17509 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski