Amino acid dipepetide frequency for European elk papillomavirus (EEPV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.179AlaAla: 6.179 ± 1.361
1.716AlaCys: 1.716 ± 0.818
2.746AlaAsp: 2.746 ± 0.854
3.433AlaGlu: 3.433 ± 1.068
2.746AlaPhe: 2.746 ± 0.823
6.179AlaGly: 6.179 ± 1.671
1.373AlaHis: 1.373 ± 0.648
1.03AlaIle: 1.03 ± 0.391
2.746AlaLys: 2.746 ± 0.921
4.119AlaLeu: 4.119 ± 0.882
0.687AlaMet: 0.687 ± 0.356
1.373AlaAsn: 1.373 ± 0.551
5.836AlaPro: 5.836 ± 1.587
2.403AlaGln: 2.403 ± 1.037
6.866AlaArg: 6.866 ± 1.853
3.776AlaSer: 3.776 ± 1.969
4.463AlaThr: 4.463 ± 1.493
5.493AlaVal: 5.493 ± 1.097
0.687AlaTrp: 0.687 ± 0.497
2.06AlaTyr: 2.06 ± 1.154
0.0AlaXaa: 0.0 ± 0.0
Cys
2.06CysAla: 2.06 ± 0.674
0.687CysCys: 0.687 ± 0.458
0.687CysAsp: 0.687 ± 0.553
1.03CysGlu: 1.03 ± 0.928
0.343CysPhe: 0.343 ± 0.305
0.687CysGly: 0.687 ± 1.108
0.687CysHis: 0.687 ± 0.673
1.716CysIle: 1.716 ± 0.749
1.716CysLys: 1.716 ± 0.571
3.433CysLeu: 3.433 ± 1.325
0.687CysMet: 0.687 ± 0.58
0.687CysAsn: 0.687 ± 0.553
1.373CysPro: 1.373 ± 0.551
0.0CysGln: 0.0 ± 0.0
1.373CysArg: 1.373 ± 0.737
4.806CysSer: 4.806 ± 1.606
1.373CysThr: 1.373 ± 1.036
1.373CysVal: 1.373 ± 0.772
0.687CysTrp: 0.687 ± 0.356
2.403CysTyr: 2.403 ± 1.583
0.0CysXaa: 0.0 ± 0.0
Asp
4.806AspAla: 4.806 ± 1.179
1.373AspCys: 1.373 ± 0.871
1.716AspAsp: 1.716 ± 0.803
3.09AspGlu: 3.09 ± 1.519
1.373AspPhe: 1.373 ± 0.683
2.06AspGly: 2.06 ± 0.783
1.716AspHis: 1.716 ± 0.781
3.09AspIle: 3.09 ± 1.343
2.403AspLys: 2.403 ± 0.582
3.776AspLeu: 3.776 ± 0.694
0.343AspMet: 0.343 ± 0.293
2.746AspAsn: 2.746 ± 0.581
2.06AspPro: 2.06 ± 0.852
1.716AspGln: 1.716 ± 0.6
1.716AspArg: 1.716 ± 0.744
5.149AspSer: 5.149 ± 1.579
3.09AspThr: 3.09 ± 0.895
2.746AspVal: 2.746 ± 0.746
1.03AspTrp: 1.03 ± 0.696
0.343AspTyr: 0.343 ± 0.293
0.0AspXaa: 0.0 ± 0.0
Glu
2.746GluAla: 2.746 ± 0.837
1.373GluCys: 1.373 ± 0.743
3.776GluAsp: 3.776 ± 1.059
2.746GluGlu: 2.746 ± 1.066
0.687GluPhe: 0.687 ± 0.651
3.433GluGly: 3.433 ± 1.509
1.03GluHis: 1.03 ± 0.432
2.06GluIle: 2.06 ± 0.683
2.403GluLys: 2.403 ± 1.016
3.433GluLeu: 3.433 ± 0.698
1.03GluMet: 1.03 ± 0.581
2.403GluAsn: 2.403 ± 1.007
3.776GluPro: 3.776 ± 1.345
2.06GluGln: 2.06 ± 0.561
6.179GluArg: 6.179 ± 1.252
2.403GluSer: 2.403 ± 0.683
6.179GluThr: 6.179 ± 0.915
3.776GluVal: 3.776 ± 1.307
0.0GluTrp: 0.0 ± 0.0
1.716GluTyr: 1.716 ± 0.866
0.0GluXaa: 0.0 ± 0.0
Phe
2.06PheAla: 2.06 ± 0.634
1.373PheCys: 1.373 ± 0.932
1.373PheAsp: 1.373 ± 0.892
2.403PheGlu: 2.403 ± 0.8
2.06PhePhe: 2.06 ± 0.979
3.433PheGly: 3.433 ± 0.874
0.0PheHis: 0.0 ± 0.0
1.03PheIle: 1.03 ± 0.645
2.06PheLys: 2.06 ± 0.75
4.463PheLeu: 4.463 ± 1.257
1.03PheMet: 1.03 ± 0.694
1.716PheAsn: 1.716 ± 0.565
1.373PhePro: 1.373 ± 0.967
2.403PheGln: 2.403 ± 0.815
3.433PheArg: 3.433 ± 1.052
2.403PheSer: 2.403 ± 1.168
0.687PheThr: 0.687 ± 0.529
1.716PheVal: 1.716 ± 0.613
2.06PheTrp: 2.06 ± 0.652
1.03PheTyr: 1.03 ± 0.595
0.0PheXaa: 0.0 ± 0.0
Gly
4.806GlyAla: 4.806 ± 1.395
2.746GlyCys: 2.746 ± 1.147
2.403GlyAsp: 2.403 ± 1.008
4.119GlyGlu: 4.119 ± 0.889
2.403GlyPhe: 2.403 ± 0.786
6.522GlyGly: 6.522 ± 1.537
2.403GlyHis: 2.403 ± 1.05
4.806GlyIle: 4.806 ± 1.908
3.433GlyLys: 3.433 ± 1.054
5.836GlyLeu: 5.836 ± 1.643
2.746GlyMet: 2.746 ± 0.95
2.746GlyAsn: 2.746 ± 0.884
4.463GlyPro: 4.463 ± 1.385
2.06GlyGln: 2.06 ± 0.673
3.09GlyArg: 3.09 ± 1.227
7.552GlySer: 7.552 ± 1.198
6.179GlyThr: 6.179 ± 1.398
3.776GlyVal: 3.776 ± 1.062
0.687GlyTrp: 0.687 ± 0.403
0.687GlyTyr: 0.687 ± 0.372
0.0GlyXaa: 0.0 ± 0.0
His
1.03HisAla: 1.03 ± 0.593
1.03HisCys: 1.03 ± 0.64
0.343HisAsp: 0.343 ± 0.299
1.03HisGlu: 1.03 ± 0.738
0.343HisPhe: 0.343 ± 0.305
3.09HisGly: 3.09 ± 1.303
1.373HisHis: 1.373 ± 0.883
1.03HisIle: 1.03 ± 0.432
1.373HisLys: 1.373 ± 1.106
3.776HisLeu: 3.776 ± 0.931
0.687HisMet: 0.687 ± 0.467
0.687HisAsn: 0.687 ± 0.458
3.09HisPro: 3.09 ± 1.247
1.373HisGln: 1.373 ± 0.964
1.716HisArg: 1.716 ± 0.916
3.09HisSer: 3.09 ± 1.195
0.687HisThr: 0.687 ± 0.62
0.687HisVal: 0.687 ± 0.451
0.687HisTrp: 0.687 ± 0.413
1.03HisTyr: 1.03 ± 0.392
0.0HisXaa: 0.0 ± 0.0
Ile
5.149IleAla: 5.149 ± 1.304
1.716IleCys: 1.716 ± 0.744
1.716IleAsp: 1.716 ± 0.82
2.403IleGlu: 2.403 ± 0.728
0.687IlePhe: 0.687 ± 0.592
2.746IleGly: 2.746 ± 1.152
0.343IleHis: 0.343 ± 0.299
1.03IleIle: 1.03 ± 0.577
2.06IleLys: 2.06 ± 0.713
4.119IleLeu: 4.119 ± 1.33
0.343IleMet: 0.343 ± 0.305
2.06IleAsn: 2.06 ± 0.627
3.09IlePro: 3.09 ± 1.51
0.687IleGln: 0.687 ± 0.663
2.403IleArg: 2.403 ± 1.092
2.746IleSer: 2.746 ± 1.121
2.746IleThr: 2.746 ± 0.757
2.746IleVal: 2.746 ± 0.514
0.687IleTrp: 0.687 ± 0.565
1.03IleTyr: 1.03 ± 0.745
0.0IleXaa: 0.0 ± 0.0
Lys
2.06LysAla: 2.06 ± 0.713
1.716LysCys: 1.716 ± 0.614
2.746LysAsp: 2.746 ± 0.79
4.119LysGlu: 4.119 ± 1.317
2.06LysPhe: 2.06 ± 0.904
3.776LysGly: 3.776 ± 1.026
2.403LysHis: 2.403 ± 1.302
1.373LysIle: 1.373 ± 0.708
3.433LysLys: 3.433 ± 1.97
2.746LysLeu: 2.746 ± 0.791
2.06LysMet: 2.06 ± 1.035
1.03LysAsn: 1.03 ± 0.554
3.776LysPro: 3.776 ± 0.99
2.403LysGln: 2.403 ± 0.848
4.806LysArg: 4.806 ± 0.83
2.06LysSer: 2.06 ± 0.933
3.09LysThr: 3.09 ± 0.732
4.119LysVal: 4.119 ± 1.143
0.0LysTrp: 0.0 ± 0.0
0.687LysTyr: 0.687 ± 0.409
0.0LysXaa: 0.0 ± 0.0
Leu
6.179LeuAla: 6.179 ± 1.605
2.403LeuCys: 2.403 ± 0.961
3.776LeuAsp: 3.776 ± 0.828
6.179LeuGlu: 6.179 ± 1.701
5.836LeuPhe: 5.836 ± 1.695
5.149LeuGly: 5.149 ± 1.427
1.716LeuHis: 1.716 ± 0.918
2.746LeuIle: 2.746 ± 0.54
5.836LeuLys: 5.836 ± 1.547
13.388LeuLeu: 13.388 ± 3.453
1.373LeuMet: 1.373 ± 0.874
1.373LeuAsn: 1.373 ± 0.712
5.836LeuPro: 5.836 ± 1.659
4.463LeuGln: 4.463 ± 0.904
2.403LeuArg: 2.403 ± 0.918
7.552LeuSer: 7.552 ± 1.369
7.896LeuThr: 7.896 ± 1.663
4.119LeuVal: 4.119 ± 1.211
0.687LeuTrp: 0.687 ± 0.425
4.806LeuTyr: 4.806 ± 1.289
0.0LeuXaa: 0.0 ± 0.0
Met
2.403MetAla: 2.403 ± 1.034
0.343MetCys: 0.343 ± 0.554
0.687MetAsp: 0.687 ± 0.586
0.687MetGlu: 0.687 ± 0.552
0.687MetPhe: 0.687 ± 0.565
1.03MetGly: 1.03 ± 0.455
1.03MetHis: 1.03 ± 0.696
0.687MetIle: 0.687 ± 0.491
1.03MetLys: 1.03 ± 0.627
1.373MetLeu: 1.373 ± 0.783
0.343MetMet: 0.343 ± 0.293
0.687MetAsn: 0.687 ± 0.356
1.03MetPro: 1.03 ± 0.879
1.716MetGln: 1.716 ± 0.841
0.343MetArg: 0.343 ± 0.307
1.716MetSer: 1.716 ± 0.771
0.687MetThr: 0.687 ± 0.491
2.06MetVal: 2.06 ± 0.934
0.0MetTrp: 0.0 ± 0.0
0.687MetTyr: 0.687 ± 0.565
0.0MetXaa: 0.0 ± 0.0
Asn
2.403AsnAla: 2.403 ± 1.107
0.343AsnCys: 0.343 ± 0.305
1.03AsnAsp: 1.03 ± 0.745
0.343AsnGlu: 0.343 ± 0.305
1.373AsnPhe: 1.373 ± 0.622
3.09AsnGly: 3.09 ± 1.37
1.716AsnHis: 1.716 ± 0.848
1.03AsnIle: 1.03 ± 0.612
1.03AsnLys: 1.03 ± 0.551
1.373AsnLeu: 1.373 ± 0.981
1.373AsnMet: 1.373 ± 0.634
1.03AsnAsn: 1.03 ± 0.595
1.373AsnPro: 1.373 ± 0.666
2.06AsnGln: 2.06 ± 0.883
1.373AsnArg: 1.373 ± 0.952
2.403AsnSer: 2.403 ± 0.645
2.06AsnThr: 2.06 ± 1.19
3.09AsnVal: 3.09 ± 1.046
0.687AsnTrp: 0.687 ± 0.455
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
4.463ProAla: 4.463 ± 0.728
2.746ProCys: 2.746 ± 0.818
4.119ProAsp: 4.119 ± 1.264
4.463ProGlu: 4.463 ± 1.618
1.716ProPhe: 1.716 ± 1.251
6.179ProGly: 6.179 ± 1.676
1.03ProHis: 1.03 ± 0.687
3.09ProIle: 3.09 ± 0.613
3.09ProLys: 3.09 ± 0.871
7.896ProLeu: 7.896 ± 1.429
0.343ProMet: 0.343 ± 0.293
1.716ProAsn: 1.716 ± 0.551
7.552ProPro: 7.552 ± 1.828
0.343ProGln: 0.343 ± 0.487
3.776ProArg: 3.776 ± 1.425
5.149ProSer: 5.149 ± 1.66
4.463ProThr: 4.463 ± 1.567
4.806ProVal: 4.806 ± 1.078
1.716ProTrp: 1.716 ± 0.829
2.403ProTyr: 2.403 ± 1.028
0.0ProXaa: 0.0 ± 0.0
Gln
4.119GlnAla: 4.119 ± 1.706
0.687GlnCys: 0.687 ± 0.36
1.03GlnAsp: 1.03 ± 0.528
1.716GlnGlu: 1.716 ± 0.7
1.03GlnPhe: 1.03 ± 0.697
3.433GlnGly: 3.433 ± 1.29
0.687GlnHis: 0.687 ± 0.441
1.373GlnIle: 1.373 ± 0.454
1.03GlnLys: 1.03 ± 0.752
3.433GlnLeu: 3.433 ± 1.3
1.03GlnMet: 1.03 ± 0.523
1.373GlnAsn: 1.373 ± 0.841
2.403GlnPro: 2.403 ± 0.734
2.746GlnGln: 2.746 ± 1.002
2.746GlnArg: 2.746 ± 0.978
2.746GlnSer: 2.746 ± 1.075
3.09GlnThr: 3.09 ± 1.006
2.403GlnVal: 2.403 ± 0.679
0.687GlnTrp: 0.687 ± 0.611
1.373GlnTyr: 1.373 ± 0.523
0.0GlnXaa: 0.0 ± 0.0
Arg
3.09ArgAla: 3.09 ± 1.072
2.403ArgCys: 2.403 ± 1.84
3.433ArgAsp: 3.433 ± 1.083
2.403ArgGlu: 2.403 ± 0.897
2.746ArgPhe: 2.746 ± 1.422
5.493ArgGly: 5.493 ± 1.629
4.119ArgHis: 4.119 ± 2.151
3.09ArgIle: 3.09 ± 0.959
5.149ArgLys: 5.149 ± 1.583
5.836ArgLeu: 5.836 ± 1.253
0.687ArgMet: 0.687 ± 0.43
2.746ArgAsn: 2.746 ± 0.914
4.119ArgPro: 4.119 ± 1.544
2.403ArgGln: 2.403 ± 1.086
7.209ArgArg: 7.209 ± 1.848
4.806ArgSer: 4.806 ± 1.332
5.149ArgThr: 5.149 ± 1.825
4.119ArgVal: 4.119 ± 0.778
1.03ArgTrp: 1.03 ± 0.654
2.403ArgTyr: 2.403 ± 0.628
0.0ArgXaa: 0.0 ± 0.0
Ser
2.403SerAla: 2.403 ± 0.935
0.687SerCys: 0.687 ± 0.565
5.836SerAsp: 5.836 ± 2.097
2.403SerGlu: 2.403 ± 0.713
2.06SerPhe: 2.06 ± 0.928
6.522SerGly: 6.522 ± 1.339
1.716SerHis: 1.716 ± 0.563
2.746SerIle: 2.746 ± 0.76
5.493SerLys: 5.493 ± 1.391
7.552SerLeu: 7.552 ± 1.798
1.716SerMet: 1.716 ± 0.685
1.373SerAsn: 1.373 ± 0.507
8.239SerPro: 8.239 ± 1.633
2.403SerGln: 2.403 ± 0.645
8.582SerArg: 8.582 ± 1.476
6.522SerSer: 6.522 ± 1.709
5.493SerThr: 5.493 ± 1.751
3.433SerVal: 3.433 ± 1.227
1.03SerTrp: 1.03 ± 0.593
1.373SerTyr: 1.373 ± 0.453
0.0SerXaa: 0.0 ± 0.0
Thr
3.433ThrAla: 3.433 ± 1.561
2.06ThrCys: 2.06 ± 0.932
4.119ThrAsp: 4.119 ± 1.566
4.463ThrGlu: 4.463 ± 1.034
2.403ThrPhe: 2.403 ± 0.895
6.179ThrGly: 6.179 ± 1.463
1.03ThrHis: 1.03 ± 0.612
4.463ThrIle: 4.463 ± 1.405
2.746ThrLys: 2.746 ± 1.151
5.493ThrLeu: 5.493 ± 1.524
1.03ThrMet: 1.03 ± 0.659
1.373ThrAsn: 1.373 ± 1.001
5.149ThrPro: 5.149 ± 0.915
2.06ThrGln: 2.06 ± 0.529
4.806ThrArg: 4.806 ± 1.479
4.806ThrSer: 4.806 ± 1.344
2.746ThrThr: 2.746 ± 0.868
5.836ThrVal: 5.836 ± 1.506
1.373ThrTrp: 1.373 ± 0.883
1.03ThrTyr: 1.03 ± 0.49
0.0ThrXaa: 0.0 ± 0.0
Val
3.433ValAla: 3.433 ± 1.057
1.373ValCys: 1.373 ± 0.617
2.06ValAsp: 2.06 ± 0.972
3.433ValGlu: 3.433 ± 1.079
4.119ValPhe: 4.119 ± 1.105
3.433ValGly: 3.433 ± 0.74
2.06ValHis: 2.06 ± 0.784
2.06ValIle: 2.06 ± 0.949
2.403ValLys: 2.403 ± 0.787
4.806ValLeu: 4.806 ± 0.995
1.373ValMet: 1.373 ± 1.027
1.716ValAsn: 1.716 ± 0.728
5.149ValPro: 5.149 ± 1.319
3.09ValGln: 3.09 ± 1.124
5.493ValArg: 5.493 ± 1.117
4.806ValSer: 4.806 ± 2.093
4.806ValThr: 4.806 ± 1.8
2.403ValVal: 2.403 ± 0.67
0.687ValTrp: 0.687 ± 0.491
2.746ValTyr: 2.746 ± 1.228
0.0ValXaa: 0.0 ± 0.0
Trp
1.373TrpAla: 1.373 ± 0.505
0.343TrpCys: 0.343 ± 0.554
0.687TrpAsp: 0.687 ± 0.491
1.716TrpGlu: 1.716 ± 0.693
1.373TrpPhe: 1.373 ± 0.648
0.343TrpGly: 0.343 ± 0.307
0.343TrpHis: 0.343 ± 0.417
0.687TrpIle: 0.687 ± 0.577
0.343TrpLys: 0.343 ± 0.305
2.06TrpLeu: 2.06 ± 0.897
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.687TrpGln: 0.687 ± 0.48
1.373TrpArg: 1.373 ± 0.738
2.06TrpSer: 2.06 ± 1.228
1.03TrpThr: 1.03 ± 0.666
0.687TrpVal: 0.687 ± 0.577
0.687TrpTrp: 0.687 ± 0.506
0.343TrpTyr: 0.343 ± 0.307
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.716TyrAla: 1.716 ± 0.597
0.687TyrCys: 0.687 ± 0.58
2.06TyrAsp: 2.06 ± 0.606
1.03TyrGlu: 1.03 ± 0.744
2.403TyrPhe: 2.403 ± 0.8
0.687TyrGly: 0.687 ± 0.494
1.373TyrHis: 1.373 ± 0.536
1.373TyrIle: 1.373 ± 0.551
0.687TyrLys: 0.687 ± 0.565
4.806TyrLeu: 4.806 ± 1.68
0.0TyrMet: 0.0 ± 0.0
0.343TyrAsn: 0.343 ± 0.305
1.373TyrPro: 1.373 ± 0.504
2.06TyrGln: 2.06 ± 0.697
2.746TyrArg: 2.746 ± 1.108
1.03TyrSer: 1.03 ± 0.695
0.687TyrThr: 0.687 ± 0.403
2.06TyrVal: 2.06 ± 0.875
1.03TyrTrp: 1.03 ± 0.647
1.373TyrTyr: 1.373 ± 0.618
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2914 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski