Amino acid dipepetide frequency for Human T-cell leukemia virus type I

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.217AlaAla: 5.217 ± 1.535
1.304AlaCys: 1.304 ± 0.316
0.978AlaAsp: 0.978 ± 0.48
1.304AlaGlu: 1.304 ± 0.316
3.587AlaPhe: 3.587 ± 0.385
2.934AlaGly: 2.934 ± 0.735
2.282AlaHis: 2.282 ± 0.319
2.934AlaIle: 2.934 ± 0.845
2.934AlaLys: 2.934 ± 0.735
13.368AlaLeu: 13.368 ± 1.343
0.652AlaMet: 0.652 ± 0.555
2.282AlaAsn: 2.282 ± 0.601
7.173AlaPro: 7.173 ± 1.159
2.608AlaGln: 2.608 ± 0.492
3.261AlaArg: 3.261 ± 0.75
7.173AlaSer: 7.173 ± 0.779
2.282AlaThr: 2.282 ± 0.806
2.608AlaVal: 2.608 ± 0.492
0.978AlaTrp: 0.978 ± 0.505
2.282AlaTyr: 2.282 ± 0.601
0.0AlaXaa: 0.0 ± 0.0
Cys
0.326CysAla: 0.326 ± 0.201
0.326CysCys: 0.326 ± 0.539
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.978CysPhe: 0.978 ± 0.318
1.956CysGly: 1.956 ± 0.507
0.978CysHis: 0.978 ± 0.505
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.956CysLeu: 1.956 ± 0.519
0.652CysMet: 0.652 ± 0.555
0.978CysAsn: 0.978 ± 0.48
5.869CysPro: 5.869 ± 2.135
4.565CysGln: 4.565 ± 1.132
0.652CysArg: 0.652 ± 0.401
2.282CysSer: 2.282 ± 1.169
1.63CysThr: 1.63 ± 0.453
0.652CysVal: 0.652 ± 0.555
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.608AspAla: 2.608 ± 0.746
3.261AspCys: 3.261 ± 0.914
0.326AspAsp: 0.326 ± 0.201
0.0AspGlu: 0.0 ± 0.0
0.978AspPhe: 0.978 ± 0.318
0.978AspGly: 0.978 ± 0.505
0.978AspHis: 0.978 ± 0.399
1.63AspIle: 1.63 ± 0.424
1.63AspLys: 1.63 ± 0.424
5.869AspLeu: 5.869 ± 1.125
1.63AspMet: 1.63 ± 0.464
0.978AspAsn: 0.978 ± 0.318
9.455AspPro: 9.455 ± 1.162
0.652AspGln: 0.652 ± 0.5
0.0AspArg: 0.0 ± 0.0
2.608AspSer: 2.608 ± 0.74
2.282AspThr: 2.282 ± 0.951
0.326AspVal: 0.326 ± 0.539
0.652AspTrp: 0.652 ± 0.555
0.326AspTyr: 0.326 ± 0.539
0.0AspXaa: 0.0 ± 0.0
Glu
3.587GluAla: 3.587 ± 1.118
0.978GluCys: 0.978 ± 0.318
1.956GluAsp: 1.956 ± 0.339
2.608GluGlu: 2.608 ± 0.558
0.0GluPhe: 0.0 ± 0.0
0.978GluGly: 0.978 ± 0.318
1.304GluHis: 1.304 ± 0.476
2.282GluIle: 2.282 ± 0.706
0.0GluLys: 0.0 ± 0.0
1.63GluLeu: 1.63 ± 0.625
0.326GluMet: 0.326 ± 0.201
0.326GluAsn: 0.326 ± 0.201
6.195GluPro: 6.195 ± 1.378
0.0GluGln: 0.0 ± 0.0
1.304GluArg: 1.304 ± 0.316
0.0GluSer: 0.0 ± 0.0
2.282GluThr: 2.282 ± 0.601
1.304GluVal: 1.304 ± 0.536
0.0GluTrp: 0.0 ± 0.0
0.978GluTyr: 0.978 ± 0.318
0.0GluXaa: 0.0 ± 0.0
Phe
1.304PheAla: 1.304 ± 0.316
1.304PheCys: 1.304 ± 0.928
0.978PheAsp: 0.978 ± 0.318
0.326PheGlu: 0.326 ± 0.201
0.652PhePhe: 0.652 ± 0.5
2.608PheGly: 2.608 ± 2.218
0.978PheHis: 0.978 ± 0.318
0.652PheIle: 0.652 ± 0.401
1.63PheLys: 1.63 ± 0.741
5.543PheLeu: 5.543 ± 1.269
0.978PheMet: 0.978 ± 0.318
0.326PheAsn: 0.326 ± 0.201
3.587PhePro: 3.587 ± 1.522
2.934PheGln: 2.934 ± 1.186
2.934PheArg: 2.934 ± 0.846
2.934PheSer: 2.934 ± 0.838
1.304PheThr: 1.304 ± 0.64
0.978PheVal: 0.978 ± 0.318
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
5.543GlyAla: 5.543 ± 0.417
0.326GlyCys: 0.326 ± 0.539
3.261GlyAsp: 3.261 ± 0.98
0.652GlyGlu: 0.652 ± 0.401
1.304GlyPhe: 1.304 ± 0.753
3.587GlyGly: 3.587 ± 1.337
3.261GlyHis: 3.261 ± 0.349
0.978GlyIle: 0.978 ± 0.318
1.304GlyLys: 1.304 ± 0.536
7.499GlyLeu: 7.499 ± 0.737
0.0GlyMet: 0.0 ± 0.0
0.326GlyAsn: 0.326 ± 0.201
5.543GlyPro: 5.543 ± 1.434
4.891GlyGln: 4.891 ± 1.154
2.934GlyArg: 2.934 ± 0.525
3.587GlySer: 3.587 ± 0.779
2.934GlyThr: 2.934 ± 1.142
0.978GlyVal: 0.978 ± 0.48
0.0GlyTrp: 0.0 ± 0.0
3.913GlyTyr: 3.913 ± 1.41
0.0GlyXaa: 0.0 ± 0.0
His
2.608HisAla: 2.608 ± 0.477
0.326HisCys: 0.326 ± 0.201
1.304HisAsp: 1.304 ± 0.316
0.326HisGlu: 0.326 ± 0.201
1.956HisPhe: 1.956 ± 0.612
1.63HisGly: 1.63 ± 0.424
2.934HisHis: 2.934 ± 0.72
2.608HisIle: 2.608 ± 0.949
0.326HisLys: 0.326 ± 0.201
3.261HisLeu: 3.261 ± 0.783
0.0HisMet: 0.0 ± 0.0
0.326HisAsn: 0.326 ± 0.201
3.587HisPro: 3.587 ± 0.435
2.934HisGln: 2.934 ± 0.42
2.608HisArg: 2.608 ± 0.313
1.304HisSer: 1.304 ± 0.64
2.608HisThr: 2.608 ± 0.411
1.304HisVal: 1.304 ± 0.532
3.261HisTrp: 3.261 ± 0.941
0.652HisTyr: 0.652 ± 0.347
0.0HisXaa: 0.0 ± 0.0
Ile
2.608IleAla: 2.608 ± 0.74
0.978IleCys: 0.978 ± 0.318
1.304IleAsp: 1.304 ± 0.532
1.63IleGlu: 1.63 ± 0.456
1.956IlePhe: 1.956 ± 0.339
1.956IleGly: 1.956 ± 0.705
0.652IleHis: 0.652 ± 0.401
1.956IleIle: 1.956 ± 0.519
2.282IleLys: 2.282 ± 0.457
8.803IleLeu: 8.803 ± 0.914
0.652IleMet: 0.652 ± 0.489
1.63IleAsn: 1.63 ± 0.453
7.173IlePro: 7.173 ± 1.158
2.282IleGln: 2.282 ± 0.602
2.608IleArg: 2.608 ± 0.746
4.891IleSer: 4.891 ± 0.822
3.913IleThr: 3.913 ± 1.281
0.652IleVal: 0.652 ± 0.291
0.326IleTrp: 0.326 ± 0.201
0.326IleTyr: 0.326 ± 0.201
0.0IleXaa: 0.0 ± 0.0
Lys
3.261LysAla: 3.261 ± 0.469
0.652LysCys: 0.652 ± 1.077
5.217LysAsp: 5.217 ± 1.535
1.304LysGlu: 1.304 ± 0.316
1.956LysPhe: 1.956 ± 0.944
1.956LysGly: 1.956 ± 0.498
0.326LysHis: 0.326 ± 0.201
1.63LysIle: 1.63 ± 0.457
2.608LysLys: 2.608 ± 0.602
1.956LysLeu: 1.956 ± 0.498
0.0LysMet: 0.0 ± 0.0
3.587LysAsn: 3.587 ± 1.118
2.608LysPro: 2.608 ± 1.071
1.63LysGln: 1.63 ± 0.424
2.608LysArg: 2.608 ± 0.695
0.652LysSer: 0.652 ± 0.347
3.587LysThr: 3.587 ± 0.534
2.282LysVal: 2.282 ± 0.319
0.0LysTrp: 0.0 ± 0.0
1.63LysTyr: 1.63 ± 0.625
0.0LysXaa: 0.0 ± 0.0
Leu
8.803LeuAla: 8.803 ± 1.196
2.934LeuCys: 2.934 ± 0.42
5.217LeuAsp: 5.217 ± 1.001
3.913LeuGlu: 3.913 ± 1.016
4.239LeuPhe: 4.239 ± 1.741
6.195LeuGly: 6.195 ± 0.988
5.869LeuHis: 5.869 ± 0.865
4.891LeuIle: 4.891 ± 1.075
5.543LeuLys: 5.543 ± 0.637
15.65LeuLeu: 15.65 ± 1.845
1.304LeuMet: 1.304 ± 0.43
3.913LeuAsn: 3.913 ± 0.678
18.585LeuPro: 18.585 ± 2.204
13.042LeuGln: 13.042 ± 1.066
6.195LeuArg: 6.195 ± 0.917
4.565LeuSer: 4.565 ± 1.608
7.499LeuThr: 7.499 ± 1.702
4.239LeuVal: 4.239 ± 0.782
2.282LeuTrp: 2.282 ± 0.319
4.239LeuTyr: 4.239 ± 1.386
0.0LeuXaa: 0.0 ± 0.0
Met
1.304MetAla: 1.304 ± 0.801
0.0MetCys: 0.0 ± 0.0
0.326MetAsp: 0.326 ± 0.201
0.978MetGlu: 0.978 ± 0.571
0.0MetPhe: 0.0 ± 0.0
1.304MetGly: 1.304 ± 0.536
0.978MetHis: 0.978 ± 0.318
0.0MetIle: 0.0 ± 0.0
0.978MetLys: 0.978 ± 0.318
1.304MetLeu: 1.304 ± 0.316
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.978MetPro: 0.978 ± 0.455
1.304MetGln: 1.304 ± 0.316
0.652MetArg: 0.652 ± 0.555
0.0MetSer: 0.0 ± 0.0
0.652MetThr: 0.652 ± 0.291
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.652MetTyr: 0.652 ± 0.555
0.0MetXaa: 0.0 ± 0.0
Asn
2.282AsnAla: 2.282 ± 0.397
0.326AsnCys: 0.326 ± 0.201
0.0AsnAsp: 0.0 ± 0.0
0.978AsnGlu: 0.978 ± 0.318
1.304AsnPhe: 1.304 ± 0.536
2.282AsnGly: 2.282 ± 0.568
1.63AsnHis: 1.63 ± 0.424
2.934AsnIle: 2.934 ± 0.463
1.304AsnLys: 1.304 ± 0.316
2.608AsnLeu: 2.608 ± 1.011
0.0AsnMet: 0.0 ± 0.0
2.282AsnAsn: 2.282 ± 0.602
3.913AsnPro: 3.913 ± 0.678
2.282AsnGln: 2.282 ± 0.706
0.326AsnArg: 0.326 ± 0.539
1.956AsnSer: 1.956 ± 0.597
2.608AsnThr: 2.608 ± 1.061
0.652AsnVal: 0.652 ± 0.555
0.652AsnTrp: 0.652 ± 0.291
1.304AsnTyr: 1.304 ± 0.316
0.0AsnXaa: 0.0 ± 0.0
Pro
3.587ProAla: 3.587 ± 0.851
3.587ProCys: 3.587 ± 1.45
2.282ProAsp: 2.282 ± 0.319
7.173ProGlu: 7.173 ± 0.871
1.63ProPhe: 1.63 ± 0.456
8.803ProGly: 8.803 ± 1.126
3.913ProHis: 3.913 ± 0.707
9.129ProIle: 9.129 ± 1.232
6.195ProLys: 6.195 ± 1.449
10.108ProLeu: 10.108 ± 0.965
0.978ProMet: 0.978 ± 0.571
4.565ProAsn: 4.565 ± 0.711
17.607ProPro: 17.607 ± 2.908
5.869ProGln: 5.869 ± 0.858
6.521ProArg: 6.521 ± 0.806
7.499ProSer: 7.499 ± 1.214
11.086ProThr: 11.086 ± 1.537
9.129ProVal: 9.129 ± 1.105
1.956ProTrp: 1.956 ± 0.447
4.239ProTyr: 4.239 ± 1.389
0.0ProXaa: 0.0 ± 0.0
Gln
10.76GlnAla: 10.76 ± 0.925
1.63GlnCys: 1.63 ± 0.741
3.587GlnAsp: 3.587 ± 0.809
1.63GlnGlu: 1.63 ± 0.621
4.239GlnPhe: 4.239 ± 0.216
4.565GlnGly: 4.565 ± 0.608
1.63GlnHis: 1.63 ± 0.504
4.565GlnIle: 4.565 ± 0.574
1.304GlnLys: 1.304 ± 0.316
6.195GlnLeu: 6.195 ± 0.746
1.304GlnMet: 1.304 ± 0.316
1.956GlnAsn: 1.956 ± 0.992
5.869GlnPro: 5.869 ± 0.913
7.499GlnGln: 7.499 ± 1.531
1.956GlnArg: 1.956 ± 0.845
1.956GlnSer: 1.956 ± 0.735
6.847GlnThr: 6.847 ± 1.886
2.608GlnVal: 2.608 ± 0.752
0.652GlnTrp: 0.652 ± 0.401
1.63GlnTyr: 1.63 ± 0.464
0.0GlnXaa: 0.0 ± 0.0
Arg
1.956ArgAla: 1.956 ± 0.583
1.304ArgCys: 1.304 ± 0.316
2.934ArgAsp: 2.934 ± 0.735
0.978ArgGlu: 0.978 ± 0.318
0.652ArgPhe: 0.652 ± 0.401
4.239ArgGly: 4.239 ± 1.031
0.978ArgHis: 0.978 ± 0.505
0.978ArgIle: 0.978 ± 0.837
2.282ArgLys: 2.282 ± 0.915
8.477ArgLeu: 8.477 ± 0.532
0.326ArgMet: 0.326 ± 0.369
0.978ArgAsn: 0.978 ± 0.837
7.499ArgPro: 7.499 ± 1.929
1.304ArgGln: 1.304 ± 0.56
3.261ArgArg: 3.261 ± 1.111
5.543ArgSer: 5.543 ± 0.768
1.63ArgThr: 1.63 ± 0.456
2.608ArgVal: 2.608 ± 0.558
0.326ArgTrp: 0.326 ± 0.201
0.326ArgTyr: 0.326 ± 0.201
0.0ArgXaa: 0.0 ± 0.0
Ser
5.217SerAla: 5.217 ± 0.955
1.304SerCys: 1.304 ± 0.473
1.956SerAsp: 1.956 ± 0.451
1.956SerGlu: 1.956 ± 0.583
3.261SerPhe: 3.261 ± 2.129
1.304SerGly: 1.304 ± 0.476
1.956SerHis: 1.956 ± 0.93
1.956SerIle: 1.956 ± 0.635
2.608SerLys: 2.608 ± 1.117
11.086SerLeu: 11.086 ± 0.892
0.0SerMet: 0.0 ± 0.0
2.282SerAsn: 2.282 ± 0.706
8.477SerPro: 8.477 ± 0.862
3.913SerGln: 3.913 ± 0.948
5.869SerArg: 5.869 ± 1.28
7.825SerSer: 7.825 ± 1.727
1.63SerThr: 1.63 ± 0.456
1.63SerVal: 1.63 ± 0.456
1.956SerTrp: 1.956 ± 0.944
2.282SerTyr: 2.282 ± 1.469
0.0SerXaa: 0.0 ± 0.0
Thr
3.587ThrAla: 3.587 ± 0.385
1.304ThrCys: 1.304 ± 0.809
1.63ThrAsp: 1.63 ± 0.424
0.326ThrGlu: 0.326 ± 0.201
1.304ThrPhe: 1.304 ± 0.803
3.587ThrGly: 3.587 ± 0.347
3.261ThrHis: 3.261 ± 0.349
4.565ThrIle: 4.565 ± 0.919
1.956ThrLys: 1.956 ± 0.635
9.129ThrLeu: 9.129 ± 3.111
0.326ThrMet: 0.326 ± 0.201
2.282ThrAsn: 2.282 ± 0.319
7.173ThrPro: 7.173 ± 0.938
6.521ThrGln: 6.521 ± 0.453
1.63ThrArg: 1.63 ± 0.314
4.891ThrSer: 4.891 ± 1.49
5.217ThrThr: 5.217 ± 1.403
1.63ThrVal: 1.63 ± 0.741
2.934ThrTrp: 2.934 ± 0.846
0.652ThrTyr: 0.652 ± 0.5
0.0ThrXaa: 0.0 ± 0.0
Val
0.978ValAla: 0.978 ± 0.318
0.978ValCys: 0.978 ± 0.837
1.63ValAsp: 1.63 ± 0.668
1.956ValGlu: 1.956 ± 0.635
1.63ValPhe: 1.63 ± 0.625
0.326ValGly: 0.326 ± 0.539
0.0ValHis: 0.0 ± 0.0
3.587ValIle: 3.587 ± 0.977
1.304ValLys: 1.304 ± 0.532
8.151ValLeu: 8.151 ± 2.066
0.978ValMet: 0.978 ± 0.318
1.304ValAsn: 1.304 ± 0.536
1.956ValPro: 1.956 ± 0.762
4.565ValGln: 4.565 ± 0.574
0.652ValArg: 0.652 ± 0.401
2.608ValSer: 2.608 ± 1.412
0.652ValThr: 0.652 ± 0.555
2.282ValVal: 2.282 ± 0.319
1.63ValTrp: 1.63 ± 0.424
0.978ValTyr: 0.978 ± 0.505
0.0ValXaa: 0.0 ± 0.0
Trp
2.282TrpAla: 2.282 ± 0.41
0.652TrpCys: 0.652 ± 0.555
0.978TrpAsp: 0.978 ± 0.505
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.978TrpGly: 0.978 ± 0.505
0.0TrpHis: 0.0 ± 0.0
1.304TrpIle: 1.304 ± 0.536
1.63TrpLys: 1.63 ± 0.453
2.282TrpLeu: 2.282 ± 0.601
0.0TrpMet: 0.0 ± 0.0
0.326TrpAsn: 0.326 ± 0.201
0.978TrpPro: 0.978 ± 0.505
1.956TrpGln: 1.956 ± 0.339
0.978TrpArg: 0.978 ± 0.399
1.304TrpSer: 1.304 ± 0.513
1.63TrpThr: 1.63 ± 1.026
0.652TrpVal: 0.652 ± 0.401
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.326TyrAla: 0.326 ± 0.201
0.326TyrCys: 0.326 ± 0.201
1.304TyrAsp: 1.304 ± 0.316
0.0TyrGlu: 0.0 ± 0.0
0.326TyrPhe: 0.326 ± 0.201
0.652TyrGly: 0.652 ± 0.401
1.956TyrHis: 1.956 ± 0.944
0.326TyrIle: 0.326 ± 0.201
1.63TyrLys: 1.63 ± 1.041
4.239TyrLeu: 4.239 ± 0.789
0.978TyrMet: 0.978 ± 0.505
0.978TyrAsn: 0.978 ± 0.318
1.63TyrPro: 1.63 ± 0.457
1.63TyrGln: 1.63 ± 0.457
1.63TyrArg: 1.63 ± 0.593
4.891TyrSer: 4.891 ± 2.735
1.63TyrThr: 1.63 ± 0.716
1.63TyrVal: 1.63 ± 0.457
0.326TyrTrp: 0.326 ± 0.539
0.326TyrTyr: 0.326 ± 0.539
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (3068 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski