Amino acid dipepetide frequency for Mycobacterium montefiorense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.563AlaAla: 19.563 ± 0.178	1.05AlaCys: 1.05 ± 0.029	8.011AlaAsp: 8.011 ± 0.07	7.386AlaGlu: 7.386 ± 0.072	3.527AlaPhe: 3.527 ± 0.052	11.652AlaGly: 11.652 ± 0.101	2.609AlaHis: 2.609 ± 0.039	5.661AlaIle: 5.661 ± 0.056	3.083AlaLys: 3.083 ± 0.052	12.592AlaLeu: 12.592 ± 0.113	3.033AlaMet: 3.033 ± 0.049	2.92AlaAsn: 2.92 ± 0.047	6.173AlaPro: 6.173 ± 0.086	4.296AlaGln: 4.296 ± 0.053	8.228AlaArg: 8.228 ± 0.092	6.26AlaSer: 6.26 ± 0.066	7.096AlaThr: 7.096 ± 0.077	11.024AlaVal: 11.024 ± 0.098	1.629AlaTrp: 1.629 ± 0.035	2.325AlaTyr: 2.325 ± 0.038	0.001AlaXaa: 0.001 ± 0.001
Cys	1.116CysAla: 1.116 ± 0.031	0.108CysCys: 0.108 ± 0.01	0.605CysAsp: 0.605 ± 0.019	0.44CysGlu: 0.44 ± 0.015	0.238CysPhe: 0.238 ± 0.012	0.995CysGly: 0.995 ± 0.026	0.205CysHis: 0.205 ± 0.011	0.298CysIle: 0.298 ± 0.014	0.157CysLys: 0.157 ± 0.01	0.707CysLeu: 0.707 ± 0.024	0.134CysMet: 0.134 ± 0.009	0.195CysAsn: 0.195 ± 0.011	0.538CysPro: 0.538 ± 0.018	0.246CysGln: 0.246 ± 0.012	0.589CysArg: 0.589 ± 0.017	0.519CysSer: 0.519 ± 0.018	0.514CysThr: 0.514 ± 0.02	0.703CysVal: 0.703 ± 0.02	0.148CysTrp: 0.148 ± 0.008	0.201CysTyr: 0.201 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.497AspAla: 7.497 ± 0.079	0.482AspCys: 0.482 ± 0.017	4.13AspAsp: 4.13 ± 0.055	3.992AspGlu: 3.992 ± 0.052	1.858AspPhe: 1.858 ± 0.038	5.561AspGly: 5.561 ± 0.056	1.466AspHis: 1.466 ± 0.03	2.745AspIle: 2.745 ± 0.037	1.362AspLys: 1.362 ± 0.032	5.979AspLeu: 5.979 ± 0.062	1.078AspMet: 1.078 ± 0.029	1.33AspAsn: 1.33 ± 0.034	4.252AspPro: 4.252 ± 0.049	1.887AspGln: 1.887 ± 0.032	4.298AspArg: 4.298 ± 0.052	2.997AspSer: 2.997 ± 0.044	3.117AspThr: 3.117 ± 0.042	5.133AspVal: 5.133 ± 0.061	0.997AspTrp: 0.997 ± 0.028	1.497AspTyr: 1.497 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	5.854GluAla: 5.854 ± 0.063	0.373GluCys: 0.373 ± 0.015	2.326GluAsp: 2.326 ± 0.043	2.427GluGlu: 2.427 ± 0.046	1.888GluPhe: 1.888 ± 0.034	3.234GluGly: 3.234 ± 0.043	1.534GluHis: 1.534 ± 0.033	2.84GluIle: 2.84 ± 0.044	1.289GluLys: 1.289 ± 0.033	6.581GluLeu: 6.581 ± 0.069	1.139GluMet: 1.139 ± 0.027	1.145GluAsn: 1.145 ± 0.023	2.855GluPro: 2.855 ± 0.039	2.267GluGln: 2.267 ± 0.039	4.137GluArg: 4.137 ± 0.052	2.81GluSer: 2.81 ± 0.037	2.588GluThr: 2.588 ± 0.035	4.224GluVal: 4.224 ± 0.051	0.729GluTrp: 0.729 ± 0.021	1.126GluTyr: 1.126 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.066PheAla: 4.066 ± 0.053	0.346PheCys: 0.346 ± 0.014	2.509PheAsp: 2.509 ± 0.038	1.647PheGlu: 1.647 ± 0.031	1.052PhePhe: 1.052 ± 0.026	3.517PheGly: 3.517 ± 0.04	0.669PheHis: 0.669 ± 0.019	1.165PheIle: 1.165 ± 0.029	0.587PheLys: 0.587 ± 0.02	2.539PheLeu: 2.539 ± 0.043	0.55PheMet: 0.55 ± 0.018	0.806PheAsn: 0.806 ± 0.021	1.475PhePro: 1.475 ± 0.035	0.695PheGln: 0.695 ± 0.02	1.681PheArg: 1.681 ± 0.03	1.872PheSer: 1.872 ± 0.032	2.08PheThr: 2.08 ± 0.038	2.687PheVal: 2.687 ± 0.041	0.465PheTrp: 0.465 ± 0.015	0.741PheTyr: 0.741 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.936GlyAla: 9.936 ± 0.08	0.843GlyCys: 0.843 ± 0.025	4.859GlyAsp: 4.859 ± 0.049	4.261GlyGlu: 4.261 ± 0.05	3.105GlyPhe: 3.105 ± 0.042	7.561GlyGly: 7.561 ± 0.104	2.083GlyHis: 2.083 ± 0.034	4.344GlyIle: 4.344 ± 0.049	2.434GlyLys: 2.434 ± 0.042	8.509GlyLeu: 8.509 ± 0.081	2.227GlyMet: 2.227 ± 0.04	2.047GlyAsn: 2.047 ± 0.036	4.637GlyPro: 4.637 ± 0.061	2.964GlyGln: 2.964 ± 0.047	6.026GlyArg: 6.026 ± 0.065	5.404GlySer: 5.404 ± 0.059	5.064GlyThr: 5.064 ± 0.063	7.349GlyVal: 7.349 ± 0.069	1.626GlyTrp: 1.626 ± 0.036	2.449GlyTyr: 2.449 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.516HisAla: 2.516 ± 0.038	0.245HisCys: 0.245 ± 0.011	1.385HisAsp: 1.385 ± 0.03	1.092HisGlu: 1.092 ± 0.026	0.708HisPhe: 0.708 ± 0.018	2.144HisGly: 2.144 ± 0.036	0.714HisHis: 0.714 ± 0.027	0.905HisIle: 0.905 ± 0.022	0.398HisLys: 0.398 ± 0.017	2.135HisLeu: 2.135 ± 0.037	0.383HisMet: 0.383 ± 0.015	0.551HisAsn: 0.551 ± 0.017	1.709HisPro: 1.709 ± 0.029	0.787HisGln: 0.787 ± 0.024	1.849HisArg: 1.849 ± 0.036	1.216HisSer: 1.216 ± 0.026	1.208HisThr: 1.208 ± 0.031	1.751HisVal: 1.751 ± 0.036	0.412HisTrp: 0.412 ± 0.015	0.598HisTyr: 0.598 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.596IleAla: 6.596 ± 0.062	0.475IleCys: 0.475 ± 0.017	3.582IleAsp: 3.582 ± 0.046	2.771IleGlu: 2.771 ± 0.038	1.202IlePhe: 1.202 ± 0.028	4.66IleGly: 4.66 ± 0.061	0.848IleHis: 0.848 ± 0.021	1.566IleIle: 1.566 ± 0.033	0.983IleLys: 0.983 ± 0.029	3.107IleLeu: 3.107 ± 0.04	0.699IleMet: 0.699 ± 0.02	1.31IleAsn: 1.31 ± 0.028	2.506IlePro: 2.506 ± 0.04	1.053IleGln: 1.053 ± 0.023	2.756IleArg: 2.756 ± 0.036	2.581IleSer: 2.581 ± 0.039	2.916IleThr: 2.916 ± 0.041	3.859IleVal: 3.859 ± 0.047	0.529IleTrp: 0.529 ± 0.018	0.893IleTyr: 0.893 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.72LysAla: 2.72 ± 0.049	0.116LysCys: 0.116 ± 0.008	1.142LysAsp: 1.142 ± 0.031	0.994LysGlu: 0.994 ± 0.026	0.719LysPhe: 0.719 ± 0.021	1.53LysGly: 1.53 ± 0.038	0.543LysHis: 0.543 ± 0.02	1.061LysIle: 1.061 ± 0.026	0.653LysLys: 0.653 ± 0.027	2.37LysLeu: 2.37 ± 0.046	0.53LysMet: 0.53 ± 0.018	0.511LysAsn: 0.511 ± 0.018	1.572LysPro: 1.572 ± 0.032	0.764LysGln: 0.764 ± 0.022	1.618LysArg: 1.618 ± 0.034	1.401LysSer: 1.401 ± 0.034	1.409LysThr: 1.409 ± 0.032	1.943LysVal: 1.943 ± 0.037	0.321LysTrp: 0.321 ± 0.014	0.537LysTyr: 0.537 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.792LeuAla: 13.792 ± 0.1	0.929LeuCys: 0.929 ± 0.022	6.366LeuAsp: 6.366 ± 0.075	4.351LeuGlu: 4.351 ± 0.053	2.726LeuPhe: 2.726 ± 0.044	8.764LeuGly: 8.764 ± 0.078	2.112LeuHis: 2.112 ± 0.033	4.304LeuIle: 4.304 ± 0.053	1.927LeuLys: 1.927 ± 0.038	9.845LeuLeu: 9.845 ± 0.086	1.849LeuMet: 1.849 ± 0.034	2.314LeuAsn: 2.314 ± 0.04	5.883LeuPro: 5.883 ± 0.06	2.752LeuGln: 2.752 ± 0.04	7.496LeuArg: 7.496 ± 0.077	5.911LeuSer: 5.911 ± 0.06	6.236LeuThr: 6.236 ± 0.065	8.211LeuVal: 8.211 ± 0.081	1.237LeuTrp: 1.237 ± 0.027	1.688LeuTyr: 1.688 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.728MetAla: 2.728 ± 0.043	0.192MetCys: 0.192 ± 0.009	0.953MetAsp: 0.953 ± 0.025	0.684MetGlu: 0.684 ± 0.019	0.683MetPhe: 0.683 ± 0.021	1.559MetGly: 1.559 ± 0.034	0.455MetHis: 0.455 ± 0.018	0.995MetIle: 0.995 ± 0.026	0.477MetLys: 0.477 ± 0.017	2.274MetLeu: 2.274 ± 0.038	0.449MetMet: 0.449 ± 0.017	0.545MetAsn: 0.545 ± 0.017	1.317MetPro: 1.317 ± 0.029	0.625MetGln: 0.625 ± 0.02	1.574MetArg: 1.574 ± 0.03	1.622MetSer: 1.622 ± 0.029	1.843MetThr: 1.843 ± 0.029	1.674MetVal: 1.674 ± 0.035	0.292MetTrp: 0.292 ± 0.012	0.394MetTyr: 0.394 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.914AsnAla: 2.914 ± 0.049	0.206AsnCys: 0.206 ± 0.012	1.352AsnAsp: 1.352 ± 0.03	1.103AsnGlu: 1.103 ± 0.024	0.786AsnPhe: 0.786 ± 0.021	2.219AsnGly: 2.219 ± 0.042	0.55AsnHis: 0.55 ± 0.018	1.082AsnIle: 1.082 ± 0.024	0.5AsnLys: 0.5 ± 0.02	2.236AsnLeu: 2.236 ± 0.042	0.494AsnMet: 0.494 ± 0.017	0.654AsnAsn: 0.654 ± 0.02	1.861AsnPro: 1.861 ± 0.036	0.752AsnGln: 0.752 ± 0.024	1.632AsnArg: 1.632 ± 0.03	1.33AsnSer: 1.33 ± 0.032	1.417AsnThr: 1.417 ± 0.028	1.865AsnVal: 1.865 ± 0.033	0.433AsnTrp: 0.433 ± 0.015	0.622AsnTyr: 0.622 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.164ProAla: 7.164 ± 0.083	0.332ProCys: 0.332 ± 0.016	4.311ProAsp: 4.311 ± 0.044	3.507ProGlu: 3.507 ± 0.048	1.67ProPhe: 1.67 ± 0.031	5.724ProGly: 5.724 ± 0.069	1.27ProHis: 1.27 ± 0.027	2.36ProIle: 2.36 ± 0.041	1.364ProLys: 1.364 ± 0.027	4.975ProLeu: 4.975 ± 0.053	1.236ProMet: 1.236 ± 0.028	1.467ProAsn: 1.467 ± 0.031	3.799ProPro: 3.799 ± 0.093	1.937ProGln: 1.937 ± 0.034	3.304ProArg: 3.304 ± 0.055	3.211ProSer: 3.211 ± 0.04	3.375ProThr: 3.375 ± 0.058	4.726ProVal: 4.726 ± 0.05	0.87ProTrp: 0.87 ± 0.026	1.188ProTyr: 1.188 ± 0.028	0.001ProXaa: 0.001 ± 0.001
Gln	3.86GlnAla: 3.86 ± 0.05	0.249GlnCys: 0.249 ± 0.011	1.326GlnAsp: 1.326 ± 0.027	1.152GlnGlu: 1.152 ± 0.026	1.061GlnPhe: 1.061 ± 0.024	2.127GlnGly: 2.127 ± 0.042	0.858GlnHis: 0.858 ± 0.023	1.636GlnIle: 1.636 ± 0.028	0.63GlnLys: 0.63 ± 0.022	3.92GlnLeu: 3.92 ± 0.042	0.755GlnMet: 0.755 ± 0.023	0.668GlnAsn: 0.668 ± 0.021	1.979GlnPro: 1.979 ± 0.04	1.507GlnGln: 1.507 ± 0.037	2.911GlnArg: 2.911 ± 0.042	1.66GlnSer: 1.66 ± 0.031	1.749GlnThr: 1.749 ± 0.032	2.651GlnVal: 2.651 ± 0.042	0.601GlnTrp: 0.601 ± 0.018	0.714GlnTyr: 0.714 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.932ArgAla: 7.932 ± 0.075	0.599ArgCys: 0.599 ± 0.019	4.159ArgAsp: 4.159 ± 0.053	3.683ArgGlu: 3.683 ± 0.056	2.395ArgPhe: 2.395 ± 0.035	5.038ArgGly: 5.038 ± 0.062	1.717ArgHis: 1.717 ± 0.031	3.446ArgIle: 3.446 ± 0.048	1.628ArgLys: 1.628 ± 0.035	7.486ArgLeu: 7.486 ± 0.085	1.736ArgMet: 1.736 ± 0.03	1.721ArgAsn: 1.721 ± 0.033	3.789ArgPro: 3.789 ± 0.052	2.341ArgGln: 2.341 ± 0.04	6.211ArgArg: 6.211 ± 0.084	3.982ArgSer: 3.982 ± 0.051	3.924ArgThr: 3.924 ± 0.05	5.338ArgVal: 5.338 ± 0.056	1.293ArgTrp: 1.293 ± 0.028	1.92ArgTyr: 1.92 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	7.116SerAla: 7.116 ± 0.073	0.461SerCys: 0.461 ± 0.017	3.41SerAsp: 3.41 ± 0.047	2.767SerGlu: 2.767 ± 0.048	1.735SerPhe: 1.735 ± 0.034	5.835SerGly: 5.835 ± 0.061	1.165SerHis: 1.165 ± 0.029	2.395SerIle: 2.395 ± 0.04	1.254SerLys: 1.254 ± 0.03	5.09SerLeu: 5.09 ± 0.053	1.451SerMet: 1.451 ± 0.03	1.336SerAsn: 1.336 ± 0.03	3.109SerPro: 3.109 ± 0.044	1.755SerGln: 1.755 ± 0.033	3.793SerArg: 3.793 ± 0.053	3.424SerSer: 3.424 ± 0.057	3.404SerThr: 3.404 ± 0.054	4.642SerVal: 4.642 ± 0.056	0.985SerTrp: 0.985 ± 0.023	1.38SerTyr: 1.38 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	7.611ThrAla: 7.611 ± 0.073	0.439ThrCys: 0.439 ± 0.019	3.542ThrAsp: 3.542 ± 0.044	3.038ThrGlu: 3.038 ± 0.046	1.808ThrPhe: 1.808 ± 0.032	5.641ThrGly: 5.641 ± 0.05	1.174ThrHis: 1.174 ± 0.026	2.591ThrIle: 2.591 ± 0.038	1.326ThrLys: 1.326 ± 0.027	5.517ThrLeu: 5.517 ± 0.062	1.274ThrMet: 1.274 ± 0.026	1.368ThrAsn: 1.368 ± 0.028	3.712ThrPro: 3.712 ± 0.055	1.685ThrGln: 1.685 ± 0.031	3.523ThrArg: 3.523 ± 0.047	3.254ThrSer: 3.254 ± 0.046	3.851ThrThr: 3.851 ± 0.06	5.522ThrVal: 5.522 ± 0.053	0.855ThrTrp: 0.855 ± 0.023	1.303ThrTyr: 1.303 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.11ValAla: 11.11 ± 0.101	0.798ValCys: 0.798 ± 0.022	5.516ValAsp: 5.516 ± 0.062	4.334ValGlu: 4.334 ± 0.054	2.628ValPhe: 2.628 ± 0.04	6.833ValGly: 6.833 ± 0.068	1.836ValHis: 1.836 ± 0.036	4.073ValIle: 4.073 ± 0.056	1.706ValLys: 1.706 ± 0.037	8.572ValLeu: 8.572 ± 0.083	1.64ValMet: 1.64 ± 0.028	2.177ValAsn: 2.177 ± 0.04	4.465ValPro: 4.465 ± 0.052	2.209ValGln: 2.209 ± 0.034	5.549ValArg: 5.549 ± 0.063	4.84ValSer: 4.84 ± 0.056	5.185ValThr: 5.185 ± 0.061	8.215ValVal: 8.215 ± 0.095	1.042ValTrp: 1.042 ± 0.022	1.545ValTyr: 1.545 ± 0.03	0.001ValXaa: 0.001 ± 0.001
Trp	1.551TrpAla: 1.551 ± 0.036	0.169TrpCys: 0.169 ± 0.011	0.806TrpAsp: 0.806 ± 0.023	0.67TrpGlu: 0.67 ± 0.019	0.512TrpPhe: 0.512 ± 0.017	1.041TrpGly: 1.041 ± 0.027	0.383TrpHis: 0.383 ± 0.015	0.686TrpIle: 0.686 ± 0.021	0.339TrpLys: 0.339 ± 0.015	1.797TrpLeu: 1.797 ± 0.034	0.358TrpMet: 0.358 ± 0.016	0.431TrpAsn: 0.431 ± 0.018	0.86TrpPro: 0.86 ± 0.026	0.674TrpGln: 0.674 ± 0.022	1.266TrpArg: 1.266 ± 0.03	0.987TrpSer: 0.987 ± 0.023	0.871TrpThr: 0.871 ± 0.024	1.115TrpVal: 1.115 ± 0.029	0.329TrpTrp: 0.329 ± 0.013	0.337TrpTyr: 0.337 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.478TyrAla: 2.478 ± 0.034	0.243TyrCys: 0.243 ± 0.012	1.368TyrAsp: 1.368 ± 0.031	1.067TyrGlu: 1.067 ± 0.026	0.848TyrPhe: 0.848 ± 0.025	2.093TyrGly: 2.093 ± 0.041	0.518TyrHis: 0.518 ± 0.02	0.737TyrIle: 0.737 ± 0.022	0.357TyrLys: 0.357 ± 0.014	2.461TyrLeu: 2.461 ± 0.04	0.32TyrMet: 0.32 ± 0.016	0.512TyrAsn: 0.512 ± 0.02	1.297TyrPro: 1.297 ± 0.027	0.819TyrGln: 0.819 ± 0.02	1.896TyrArg: 1.896 ± 0.026	1.228TyrSer: 1.228 ± 0.03	1.187TyrThr: 1.187 ± 0.028	1.641TyrVal: 1.641 ± 0.034	0.39TyrTrp: 0.39 ± 0.014	0.529TyrTyr: 0.529 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.106XaaXaa: 0.106 ± 0.072

Statistics based on 5384 proteins (1725077 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---