Amino acid dipepetide frequency for Roseovarius albus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.511AlaAla: 12.511 ± 0.127	1.093AlaCys: 1.093 ± 0.036	6.128AlaAsp: 6.128 ± 0.066	7.268AlaGlu: 7.268 ± 0.093	4.126AlaPhe: 4.126 ± 0.07	8.893AlaGly: 8.893 ± 0.105	2.185AlaHis: 2.185 ± 0.042	5.988AlaIle: 5.988 ± 0.076	4.259AlaLys: 4.259 ± 0.067	11.645AlaLeu: 11.645 ± 0.114	3.416AlaMet: 3.416 ± 0.056	3.109AlaAsn: 3.109 ± 0.051	4.663AlaPro: 4.663 ± 0.066	4.447AlaGln: 4.447 ± 0.073	6.516AlaArg: 6.516 ± 0.087	5.506AlaSer: 5.506 ± 0.074	5.307AlaThr: 5.307 ± 0.065	7.276AlaVal: 7.276 ± 0.084	1.28AlaTrp: 1.28 ± 0.029	2.571AlaTyr: 2.571 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.075CysAla: 1.075 ± 0.031	0.162CysCys: 0.162 ± 0.012	0.668CysAsp: 0.668 ± 0.026	0.567CysGlu: 0.567 ± 0.022	0.408CysPhe: 0.408 ± 0.018	1.034CysGly: 1.034 ± 0.029	0.287CysHis: 0.287 ± 0.018	0.529CysIle: 0.529 ± 0.023	0.291CysLys: 0.291 ± 0.018	1.0CysLeu: 1.0 ± 0.03	0.208CysMet: 0.208 ± 0.012	0.292CysAsn: 0.292 ± 0.014	0.527CysPro: 0.527 ± 0.02	0.301CysGln: 0.301 ± 0.016	0.552CysArg: 0.552 ± 0.02	0.603CysSer: 0.603 ± 0.021	0.554CysThr: 0.554 ± 0.021	0.737CysVal: 0.737 ± 0.026	0.136CysTrp: 0.136 ± 0.011	0.287CysTyr: 0.287 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.285AspAla: 6.285 ± 0.078	0.594AspCys: 0.594 ± 0.024	3.441AspAsp: 3.441 ± 0.068	3.802AspGlu: 3.802 ± 0.059	2.395AspPhe: 2.395 ± 0.049	5.217AspGly: 5.217 ± 0.082	1.418AspHis: 1.418 ± 0.032	3.432AspIle: 3.432 ± 0.06	2.053AspLys: 2.053 ± 0.044	6.339AspLeu: 6.339 ± 0.08	1.693AspMet: 1.693 ± 0.039	1.642AspAsn: 1.642 ± 0.04	3.331AspPro: 3.331 ± 0.063	2.295AspGln: 2.295 ± 0.041	3.551AspArg: 3.551 ± 0.057	2.468AspSer: 2.468 ± 0.05	3.038AspThr: 3.038 ± 0.053	4.466AspVal: 4.466 ± 0.067	1.172AspTrp: 1.172 ± 0.033	1.655AspTyr: 1.655 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.387GluAla: 7.387 ± 0.085	0.484GluCys: 0.484 ± 0.02	3.553GluAsp: 3.553 ± 0.059	3.944GluGlu: 3.944 ± 0.062	2.187GluPhe: 2.187 ± 0.043	4.778GluGly: 4.778 ± 0.071	1.363GluHis: 1.363 ± 0.038	3.96GluIle: 3.96 ± 0.065	2.552GluLys: 2.552 ± 0.046	5.81GluLeu: 5.81 ± 0.073	1.891GluMet: 1.891 ± 0.042	2.283GluAsn: 2.283 ± 0.042	2.478GluPro: 2.478 ± 0.048	2.331GluGln: 2.331 ± 0.039	4.13GluArg: 4.13 ± 0.056	2.628GluSer: 2.628 ± 0.051	3.838GluThr: 3.838 ± 0.058	4.44GluVal: 4.44 ± 0.061	0.859GluTrp: 0.859 ± 0.028	1.314GluTyr: 1.314 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.252PheAla: 4.252 ± 0.066	0.506PheCys: 0.506 ± 0.02	2.916PheAsp: 2.916 ± 0.053	2.588PheGlu: 2.588 ± 0.049	1.585PhePhe: 1.585 ± 0.04	3.742PheGly: 3.742 ± 0.059	0.8PheHis: 0.8 ± 0.029	1.892PheIle: 1.892 ± 0.045	1.195PheLys: 1.195 ± 0.032	3.576PheLeu: 3.576 ± 0.062	1.026PheMet: 1.026 ± 0.024	1.298PheAsn: 1.298 ± 0.035	1.595PhePro: 1.595 ± 0.035	1.147PheGln: 1.147 ± 0.029	2.004PheArg: 2.004 ± 0.037	2.541PheSer: 2.541 ± 0.051	2.166PheThr: 2.166 ± 0.039	2.811PheVal: 2.811 ± 0.051	0.592PheTrp: 0.592 ± 0.026	1.126PheTyr: 1.126 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.364GlyAla: 8.364 ± 0.111	0.914GlyCys: 0.914 ± 0.031	4.629GlyAsp: 4.629 ± 0.098	4.591GlyGlu: 4.591 ± 0.067	3.703GlyPhe: 3.703 ± 0.067	7.184GlyGly: 7.184 ± 0.335	2.025GlyHis: 2.025 ± 0.044	4.54GlyIle: 4.54 ± 0.064	3.399GlyLys: 3.399 ± 0.059	8.405GlyLeu: 8.405 ± 0.087	2.485GlyMet: 2.485 ± 0.043	2.543GlyAsn: 2.543 ± 0.08	3.277GlyPro: 3.277 ± 0.049	3.22GlyGln: 3.22 ± 0.047	4.763GlyArg: 4.763 ± 0.063	4.432GlySer: 4.432 ± 0.097	4.426GlyThr: 4.426 ± 0.082	6.212GlyVal: 6.212 ± 0.075	1.389GlyTrp: 1.389 ± 0.034	2.466GlyTyr: 2.466 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.21HisAla: 2.21 ± 0.047	0.304HisCys: 0.304 ± 0.013	1.291HisAsp: 1.291 ± 0.035	1.182HisGlu: 1.182 ± 0.031	0.983HisPhe: 0.983 ± 0.026	1.922HisGly: 1.922 ± 0.044	0.622HisHis: 0.622 ± 0.027	1.122HisIle: 1.122 ± 0.028	0.708HisLys: 0.708 ± 0.025	2.192HisLeu: 2.192 ± 0.047	0.608HisMet: 0.608 ± 0.022	0.605HisAsn: 0.605 ± 0.021	1.397HisPro: 1.397 ± 0.038	0.758HisGln: 0.758 ± 0.026	1.276HisArg: 1.276 ± 0.032	1.18HisSer: 1.18 ± 0.031	0.925HisThr: 0.925 ± 0.026	1.557HisVal: 1.557 ± 0.037	0.391HisTrp: 0.391 ± 0.016	0.63HisTyr: 0.63 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.756IleAla: 6.756 ± 0.071	0.737IleCys: 0.737 ± 0.027	3.751IleAsp: 3.751 ± 0.06	3.97IleGlu: 3.97 ± 0.064	2.012IlePhe: 2.012 ± 0.045	4.994IleGly: 4.994 ± 0.071	1.014IleHis: 1.014 ± 0.029	2.737IleIle: 2.737 ± 0.056	1.968IleLys: 1.968 ± 0.043	5.09IleLeu: 5.09 ± 0.075	1.272IleMet: 1.272 ± 0.036	1.824IleAsn: 1.824 ± 0.042	2.537IlePro: 2.537 ± 0.049	1.47IleGln: 1.47 ± 0.032	3.048IleArg: 3.048 ± 0.047	3.7IleSer: 3.7 ± 0.058	3.268IleThr: 3.268 ± 0.049	3.832IleVal: 3.832 ± 0.058	0.829IleTrp: 0.829 ± 0.026	1.428IleTyr: 1.428 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.265LysAla: 4.265 ± 0.058	0.269LysCys: 0.269 ± 0.015	2.114LysAsp: 2.114 ± 0.045	2.034LysGlu: 2.034 ± 0.044	1.231LysPhe: 1.231 ± 0.031	3.0LysGly: 3.0 ± 0.051	0.862LysHis: 0.862 ± 0.027	2.21LysIle: 2.21 ± 0.042	1.544LysLys: 1.544 ± 0.043	3.672LysLeu: 3.672 ± 0.057	1.077LysMet: 1.077 ± 0.029	1.183LysAsn: 1.183 ± 0.028	1.997LysPro: 1.997 ± 0.04	1.259LysGln: 1.259 ± 0.032	2.506LysArg: 2.506 ± 0.048	2.333LysSer: 2.333 ± 0.049	2.278LysThr: 2.278 ± 0.041	2.577LysVal: 2.577 ± 0.045	0.481LysTrp: 0.481 ± 0.02	0.855LysTyr: 0.855 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	10.781LeuAla: 10.781 ± 0.13	1.071LeuCys: 1.071 ± 0.029	5.646LeuAsp: 5.646 ± 0.08	5.841LeuGlu: 5.841 ± 0.07	3.655LeuPhe: 3.655 ± 0.06	7.79LeuGly: 7.79 ± 0.067	1.976LeuHis: 1.976 ± 0.045	5.576LeuIle: 5.576 ± 0.079	3.99LeuLys: 3.99 ± 0.069	8.567LeuLeu: 8.567 ± 0.111	2.662LeuMet: 2.662 ± 0.049	3.376LeuAsn: 3.376 ± 0.057	5.112LeuPro: 5.112 ± 0.078	3.144LeuGln: 3.144 ± 0.048	5.999LeuArg: 5.999 ± 0.074	7.152LeuSer: 7.152 ± 0.08	5.747LeuThr: 5.747 ± 0.07	6.339LeuVal: 6.339 ± 0.07	1.286LeuTrp: 1.286 ± 0.034	2.107LeuTyr: 2.107 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.189MetAla: 3.189 ± 0.049	0.238MetCys: 0.238 ± 0.013	1.472MetAsp: 1.472 ± 0.034	1.383MetGlu: 1.383 ± 0.033	0.943MetPhe: 0.943 ± 0.028	2.235MetGly: 2.235 ± 0.044	0.533MetHis: 0.533 ± 0.022	1.663MetIle: 1.663 ± 0.041	1.224MetLys: 1.224 ± 0.028	2.623MetLeu: 2.623 ± 0.043	0.79MetMet: 0.79 ± 0.026	0.997MetAsn: 0.997 ± 0.029	1.509MetPro: 1.509 ± 0.037	1.14MetGln: 1.14 ± 0.028	1.791MetArg: 1.791 ± 0.039	1.92MetSer: 1.92 ± 0.04	1.918MetThr: 1.918 ± 0.039	1.838MetVal: 1.838 ± 0.039	0.259MetTrp: 0.259 ± 0.016	0.436MetTyr: 0.436 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.512AsnAla: 3.512 ± 0.055	0.366AsnCys: 0.366 ± 0.018	1.914AsnAsp: 1.914 ± 0.057	1.721AsnGlu: 1.721 ± 0.036	1.227AsnPhe: 1.227 ± 0.032	2.805AsnGly: 2.805 ± 0.077	0.658AsnHis: 0.658 ± 0.021	1.832AsnIle: 1.832 ± 0.041	1.055AsnLys: 1.055 ± 0.028	3.016AsnLeu: 3.016 ± 0.049	0.834AsnMet: 0.834 ± 0.029	0.945AsnAsn: 0.945 ± 0.032	2.091AsnPro: 2.091 ± 0.037	1.021AsnGln: 1.021 ± 0.03	1.85AsnArg: 1.85 ± 0.039	1.657AsnSer: 1.657 ± 0.036	1.761AsnThr: 1.761 ± 0.037	2.235AsnVal: 2.235 ± 0.047	0.587AsnTrp: 0.587 ± 0.023	0.826AsnTyr: 0.826 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.465ProAla: 4.465 ± 0.066	0.395ProCys: 0.395 ± 0.017	3.671ProAsp: 3.671 ± 0.055	4.172ProGlu: 4.172 ± 0.063	1.928ProPhe: 1.928 ± 0.04	3.733ProGly: 3.733 ± 0.056	1.045ProHis: 1.045 ± 0.03	2.517ProIle: 2.517 ± 0.041	1.953ProLys: 1.953 ± 0.042	4.324ProLeu: 4.324 ± 0.066	1.269ProMet: 1.269 ± 0.034	1.68ProAsn: 1.68 ± 0.038	1.892ProPro: 1.892 ± 0.046	1.575ProGln: 1.575 ± 0.034	2.205ProArg: 2.205 ± 0.044	2.638ProSer: 2.638 ± 0.047	2.477ProThr: 2.477 ± 0.045	3.776ProVal: 3.776 ± 0.055	0.628ProTrp: 0.628 ± 0.024	1.256ProTyr: 1.256 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.074GlnAla: 4.074 ± 0.066	0.289GlnCys: 0.289 ± 0.018	1.896GlnAsp: 1.896 ± 0.044	1.921GlnGlu: 1.921 ± 0.041	1.315GlnPhe: 1.315 ± 0.035	2.594GlnGly: 2.594 ± 0.047	0.785GlnHis: 0.785 ± 0.024	2.313GlnIle: 2.313 ± 0.037	1.34GlnLys: 1.34 ± 0.035	3.079GlnLeu: 3.079 ± 0.053	1.277GlnMet: 1.277 ± 0.037	1.232GlnAsn: 1.232 ± 0.029	1.575GlnPro: 1.575 ± 0.035	1.275GlnGln: 1.275 ± 0.034	2.101GlnArg: 2.101 ± 0.04	2.248GlnSer: 2.248 ± 0.058	2.057GlnThr: 2.057 ± 0.045	2.537GlnVal: 2.537 ± 0.045	0.437GlnTrp: 0.437 ± 0.019	0.769GlnTyr: 0.769 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	6.237ArgAla: 6.237 ± 0.084	0.532ArgCys: 0.532 ± 0.019	3.733ArgAsp: 3.733 ± 0.054	3.709ArgGlu: 3.709 ± 0.061	2.416ArgPhe: 2.416 ± 0.047	3.819ArgGly: 3.819 ± 0.057	1.406ArgHis: 1.406 ± 0.039	3.446ArgIle: 3.446 ± 0.055	2.491ArgLys: 2.491 ± 0.051	6.162ArgLeu: 6.162 ± 0.075	1.668ArgMet: 1.668 ± 0.036	1.921ArgAsn: 1.921 ± 0.041	2.667ArgPro: 2.667 ± 0.049	2.211ArgGln: 2.211 ± 0.04	3.852ArgArg: 3.852 ± 0.065	3.176ArgSer: 3.176 ± 0.053	2.67ArgThr: 2.67 ± 0.052	4.047ArgVal: 4.047 ± 0.057	0.859ArgTrp: 0.859 ± 0.029	1.57ArgTyr: 1.57 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.916SerAla: 5.916 ± 0.073	0.537SerCys: 0.537 ± 0.023	3.79SerAsp: 3.79 ± 0.06	3.573SerGlu: 3.573 ± 0.055	2.481SerPhe: 2.481 ± 0.047	5.719SerGly: 5.719 ± 0.096	1.25SerHis: 1.25 ± 0.032	3.095SerIle: 3.095 ± 0.062	2.165SerLys: 2.165 ± 0.043	5.31SerLeu: 5.31 ± 0.073	1.502SerMet: 1.502 ± 0.032	1.938SerAsn: 1.938 ± 0.039	2.574SerPro: 2.574 ± 0.047	1.9SerGln: 1.9 ± 0.037	3.052SerArg: 3.052 ± 0.054	3.181SerSer: 3.181 ± 0.061	3.023SerThr: 3.023 ± 0.05	4.063SerVal: 4.063 ± 0.069	0.804SerTrp: 0.804 ± 0.028	1.504SerTyr: 1.504 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.525ThrAla: 5.525 ± 0.077	0.557ThrCys: 0.557 ± 0.021	3.115ThrAsp: 3.115 ± 0.056	3.133ThrGlu: 3.133 ± 0.054	2.16ThrPhe: 2.16 ± 0.043	5.081ThrGly: 5.081 ± 0.08	1.191ThrHis: 1.191 ± 0.032	3.01ThrIle: 3.01 ± 0.046	1.791ThrLys: 1.791 ± 0.034	5.902ThrLeu: 5.902 ± 0.083	1.347ThrMet: 1.347 ± 0.034	1.578ThrAsn: 1.578 ± 0.037	3.288ThrPro: 3.288 ± 0.058	1.863ThrGln: 1.863 ± 0.038	3.122ThrArg: 3.122 ± 0.056	3.134ThrSer: 3.134 ± 0.044	2.841ThrThr: 2.841 ± 0.053	3.947ThrVal: 3.947 ± 0.062	0.698ThrTrp: 0.698 ± 0.029	1.418ThrTyr: 1.418 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.518ValAla: 7.518 ± 0.086	0.715ValCys: 0.715 ± 0.024	4.004ValAsp: 4.004 ± 0.048	4.56ValGlu: 4.56 ± 0.064	2.888ValPhe: 2.888 ± 0.046	5.204ValGly: 5.204 ± 0.081	1.417ValHis: 1.417 ± 0.035	4.411ValIle: 4.411 ± 0.067	2.451ValLys: 2.451 ± 0.048	7.008ValLeu: 7.008 ± 0.077	2.1ValMet: 2.1 ± 0.044	2.185ValAsn: 2.185 ± 0.044	3.261ValPro: 3.261 ± 0.052	2.277ValGln: 2.277 ± 0.051	3.757ValArg: 3.757 ± 0.056	4.639ValSer: 4.639 ± 0.064	4.428ValThr: 4.428 ± 0.066	5.412ValVal: 5.412 ± 0.078	0.918ValTrp: 0.918 ± 0.028	1.526ValTyr: 1.526 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.367TrpAla: 1.367 ± 0.03	0.163TrpCys: 0.163 ± 0.011	0.774TrpAsp: 0.774 ± 0.027	0.74TrpGlu: 0.74 ± 0.023	0.64TrpPhe: 0.64 ± 0.025	1.078TrpGly: 1.078 ± 0.038	0.39TrpHis: 0.39 ± 0.019	0.812TrpIle: 0.812 ± 0.028	0.52TrpLys: 0.52 ± 0.02	1.614TrpLeu: 1.614 ± 0.042	0.423TrpMet: 0.423 ± 0.018	0.508TrpAsn: 0.508 ± 0.019	0.669TrpPro: 0.669 ± 0.022	0.617TrpGln: 0.617 ± 0.024	0.952TrpArg: 0.952 ± 0.027	0.856TrpSer: 0.856 ± 0.024	0.705TrpThr: 0.705 ± 0.023	0.926TrpVal: 0.926 ± 0.029	0.222TrpTrp: 0.222 ± 0.013	0.304TrpTyr: 0.304 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.499TyrAla: 2.499 ± 0.044	0.292TyrCys: 0.292 ± 0.015	1.782TyrAsp: 1.782 ± 0.041	1.509TyrGlu: 1.509 ± 0.039	1.072TyrPhe: 1.072 ± 0.031	2.147TyrGly: 2.147 ± 0.041	0.637TyrHis: 0.637 ± 0.022	1.153TyrIle: 1.153 ± 0.032	0.797TyrLys: 0.797 ± 0.024	2.487TyrLeu: 2.487 ± 0.047	0.552TyrMet: 0.552 ± 0.018	0.776TyrAsn: 0.776 ± 0.026	1.16TyrPro: 1.16 ± 0.03	0.865TyrGln: 0.865 ± 0.025	1.566TyrArg: 1.566 ± 0.037	1.384TyrSer: 1.384 ± 0.034	1.275TyrThr: 1.275 ± 0.029	1.647TyrVal: 1.647 ± 0.034	0.449TyrTrp: 0.449 ± 0.018	0.712TyrTyr: 0.712 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4169 proteins (1280323 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---