Amino acid dipepetide frequency for Hericium alpestre

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.762AlaAla: 9.762 ± 0.066	1.149AlaCys: 1.149 ± 0.017	4.945AlaAsp: 4.945 ± 0.04	5.622AlaGlu: 5.622 ± 0.047	3.42AlaPhe: 3.42 ± 0.034	5.808AlaGly: 5.808 ± 0.041	2.34AlaHis: 2.34 ± 0.025	4.228AlaIle: 4.228 ± 0.035	4.295AlaLys: 4.295 ± 0.039	8.894AlaLeu: 8.894 ± 0.053	2.14AlaMet: 2.14 ± 0.024	2.751AlaAsn: 2.751 ± 0.025	5.694AlaPro: 5.694 ± 0.051	3.599AlaGln: 3.599 ± 0.031	5.662AlaArg: 5.662 ± 0.043	7.609AlaSer: 7.609 ± 0.053	5.081AlaThr: 5.081 ± 0.039	5.785AlaVal: 5.785 ± 0.038	1.228AlaTrp: 1.228 ± 0.017	2.268AlaTyr: 2.268 ± 0.025	0.122AlaXaa: 0.122 ± 0.007
Cys	0.992CysAla: 0.992 ± 0.017	0.226CysCys: 0.226 ± 0.008	0.665CysAsp: 0.665 ± 0.012	0.594CysGlu: 0.594 ± 0.013	0.5CysPhe: 0.5 ± 0.011	0.812CysGly: 0.812 ± 0.018	0.349CysHis: 0.349 ± 0.009	0.669CysIle: 0.669 ± 0.012	0.546CysLys: 0.546 ± 0.011	1.16CysLeu: 1.16 ± 0.017	0.312CysMet: 0.312 ± 0.008	0.392CysAsn: 0.392 ± 0.01	0.699CysPro: 0.699 ± 0.015	0.449CysGln: 0.449 ± 0.011	0.724CysArg: 0.724 ± 0.014	0.891CysSer: 0.891 ± 0.016	0.703CysThr: 0.703 ± 0.015	0.763CysVal: 0.763 ± 0.016	0.19CysTrp: 0.19 ± 0.007	0.305CysTyr: 0.305 ± 0.009	0.018CysXaa: 0.018 ± 0.002
Asp	5.724AspAla: 5.724 ± 0.038	0.639AspCys: 0.639 ± 0.013	4.522AspAsp: 4.522 ± 0.047	4.837AspGlu: 4.837 ± 0.049	2.206AspPhe: 2.206 ± 0.023	4.079AspGly: 4.079 ± 0.031	1.311AspHis: 1.311 ± 0.019	3.211AspIle: 3.211 ± 0.026	2.38AspLys: 2.38 ± 0.028	5.386AspLeu: 5.386 ± 0.039	1.405AspMet: 1.405 ± 0.019	1.737AspAsn: 1.737 ± 0.022	3.602AspPro: 3.602 ± 0.032	1.699AspGln: 1.699 ± 0.022	2.976AspArg: 2.976 ± 0.029	3.961AspSer: 3.961 ± 0.033	3.048AspThr: 3.048 ± 0.028	4.438AspVal: 4.438 ± 0.033	0.966AspTrp: 0.966 ± 0.015	1.489AspTyr: 1.489 ± 0.017	0.087AspXaa: 0.087 ± 0.006
Glu	5.561GluAla: 5.561 ± 0.042	0.612GluCys: 0.612 ± 0.014	4.618GluAsp: 4.618 ± 0.046	5.822GluGlu: 5.822 ± 0.068	2.004GluPhe: 2.004 ± 0.023	3.879GluGly: 3.879 ± 0.037	1.655GluHis: 1.655 ± 0.02	2.79GluIle: 2.79 ± 0.03	3.324GluLys: 3.324 ± 0.034	5.603GluLeu: 5.603 ± 0.045	1.467GluMet: 1.467 ± 0.018	1.877GluAsn: 1.877 ± 0.023	2.943GluPro: 2.943 ± 0.031	2.53GluGln: 2.53 ± 0.027	4.035GluArg: 4.035 ± 0.041	3.775GluSer: 3.775 ± 0.035	3.049GluThr: 3.049 ± 0.027	3.767GluVal: 3.767 ± 0.031	0.95GluTrp: 0.95 ± 0.014	1.57GluTyr: 1.57 ± 0.021	0.073GluXaa: 0.073 ± 0.005
Phe	3.268PheAla: 3.268 ± 0.03	0.544PheCys: 0.544 ± 0.012	2.412PheAsp: 2.412 ± 0.022	2.102PheGlu: 2.102 ± 0.022	1.585PhePhe: 1.585 ± 0.024	2.673PheGly: 2.673 ± 0.028	0.94PheHis: 0.94 ± 0.014	1.848PheIle: 1.848 ± 0.021	1.534PheLys: 1.534 ± 0.021	3.487PheLeu: 3.487 ± 0.031	0.864PheMet: 0.864 ± 0.015	1.365PheAsn: 1.365 ± 0.018	1.966PhePro: 1.966 ± 0.024	1.216PheGln: 1.216 ± 0.016	1.931PheArg: 1.931 ± 0.018	2.991PheSer: 2.991 ± 0.03	2.137PheThr: 2.137 ± 0.023	2.606PheVal: 2.606 ± 0.026	0.589PheTrp: 0.589 ± 0.011	1.058PheTyr: 1.058 ± 0.016	0.046PheXaa: 0.046 ± 0.004
Gly	5.278GlyAla: 5.278 ± 0.037	0.752GlyCys: 0.752 ± 0.015	3.547GlyAsp: 3.547 ± 0.033	3.551GlyGlu: 3.551 ± 0.03	2.511GlyPhe: 2.511 ± 0.024	5.096GlyGly: 5.096 ± 0.064	1.693GlyHis: 1.693 ± 0.022	3.172GlyIle: 3.172 ± 0.03	3.458GlyLys: 3.458 ± 0.031	5.662GlyLeu: 5.662 ± 0.043	1.522GlyMet: 1.522 ± 0.022	2.062GlyAsn: 2.062 ± 0.024	3.415GlyPro: 3.415 ± 0.03	2.312GlyGln: 2.312 ± 0.027	3.923GlyArg: 3.923 ± 0.031	5.121GlySer: 5.121 ± 0.043	3.729GlyThr: 3.729 ± 0.031	4.083GlyVal: 4.083 ± 0.036	1.067GlyTrp: 1.067 ± 0.015	1.799GlyTyr: 1.799 ± 0.024	0.093GlyXaa: 0.093 ± 0.006
His	2.477HisAla: 2.477 ± 0.027	0.335HisCys: 0.335 ± 0.009	1.442HisAsp: 1.442 ± 0.017	1.441HisGlu: 1.441 ± 0.018	1.063HisPhe: 1.063 ± 0.016	1.728HisGly: 1.728 ± 0.017	0.794HisHis: 0.794 ± 0.015	1.416HisIle: 1.416 ± 0.019	0.984HisLys: 0.984 ± 0.016	2.603HisLeu: 2.603 ± 0.028	0.556HisMet: 0.556 ± 0.012	0.799HisAsn: 0.799 ± 0.013	1.921HisPro: 1.921 ± 0.02	0.847HisGln: 0.847 ± 0.015	1.6HisArg: 1.6 ± 0.02	1.822HisSer: 1.822 ± 0.023	1.437HisThr: 1.437 ± 0.018	1.891HisVal: 1.891 ± 0.022	0.388HisTrp: 0.388 ± 0.01	0.683HisTyr: 0.683 ± 0.013	0.03HisXaa: 0.03 ± 0.003
Ile	4.254IleAla: 4.254 ± 0.033	0.719IleCys: 0.719 ± 0.013	2.895IleAsp: 2.895 ± 0.027	2.689IleGlu: 2.689 ± 0.027	1.909IlePhe: 1.909 ± 0.022	2.884IleGly: 2.884 ± 0.028	1.262IleHis: 1.262 ± 0.016	2.443IleIle: 2.443 ± 0.027	2.055IleLys: 2.055 ± 0.023	4.457IleLeu: 4.457 ± 0.037	1.013IleMet: 1.013 ± 0.017	1.616IleAsn: 1.616 ± 0.019	3.138IlePro: 3.138 ± 0.027	1.759IleGln: 1.759 ± 0.019	2.71IleArg: 2.71 ± 0.024	3.623IleSer: 3.623 ± 0.031	2.719IleThr: 2.719 ± 0.027	3.376IleVal: 3.376 ± 0.03	0.683IleTrp: 0.683 ± 0.012	1.283IleTyr: 1.283 ± 0.021	0.058IleXaa: 0.058 ± 0.005
Lys	4.713LysAla: 4.713 ± 0.049	0.485LysCys: 0.485 ± 0.012	2.75LysAsp: 2.75 ± 0.028	3.316LysGlu: 3.316 ± 0.032	1.381LysPhe: 1.381 ± 0.019	2.967LysGly: 2.967 ± 0.031	1.207LysHis: 1.207 ± 0.016	2.035LysIle: 2.035 ± 0.023	3.236LysLys: 3.236 ± 0.047	3.979LysLeu: 3.979 ± 0.028	0.962LysMet: 0.962 ± 0.016	1.491LysAsn: 1.491 ± 0.022	2.679LysPro: 2.679 ± 0.025	1.769LysGln: 1.769 ± 0.023	3.36LysArg: 3.36 ± 0.035	3.029LysSer: 3.029 ± 0.033	2.603LysThr: 2.603 ± 0.029	2.805LysVal: 2.805 ± 0.026	0.69LysTrp: 0.69 ± 0.014	1.262LysTyr: 1.262 ± 0.019	0.074LysXaa: 0.074 ± 0.005
Leu	8.349LeuAla: 8.349 ± 0.049	1.23LeuCys: 1.23 ± 0.02	5.571LeuAsp: 5.571 ± 0.041	5.612LeuGlu: 5.612 ± 0.046	3.41LeuPhe: 3.41 ± 0.032	5.388LeuGly: 5.388 ± 0.035	2.597LeuHis: 2.597 ± 0.027	3.85LeuIle: 3.85 ± 0.034	4.247LeuLys: 4.247 ± 0.035	8.616LeuLeu: 8.616 ± 0.06	1.829LeuMet: 1.829 ± 0.02	3.05LeuAsn: 3.05 ± 0.027	6.125LeuPro: 6.125 ± 0.037	3.817LeuGln: 3.817 ± 0.034	6.089LeuArg: 6.089 ± 0.042	7.524LeuSer: 7.524 ± 0.044	5.216LeuThr: 5.216 ± 0.037	5.687LeuVal: 5.687 ± 0.044	1.216LeuTrp: 1.216 ± 0.017	2.355LeuTyr: 2.355 ± 0.025	0.117LeuXaa: 0.117 ± 0.008
Met	2.05MetAla: 2.05 ± 0.021	0.25MetCys: 0.25 ± 0.007	1.34MetAsp: 1.34 ± 0.02	1.275MetGlu: 1.275 ± 0.015	0.776MetPhe: 0.776 ± 0.015	1.257MetGly: 1.257 ± 0.02	0.653MetHis: 0.653 ± 0.012	0.943MetIle: 0.943 ± 0.016	0.99MetLys: 0.99 ± 0.018	2.101MetLeu: 2.101 ± 0.023	0.556MetMet: 0.556 ± 0.013	0.71MetAsn: 0.71 ± 0.015	1.512MetPro: 1.512 ± 0.021	1.006MetGln: 1.006 ± 0.017	1.38MetArg: 1.38 ± 0.018	2.007MetSer: 2.007 ± 0.023	1.266MetThr: 1.266 ± 0.018	1.227MetVal: 1.227 ± 0.017	0.263MetTrp: 0.263 ± 0.008	0.533MetTyr: 0.533 ± 0.013	0.031MetXaa: 0.031 ± 0.003
Asn	3.166AsnAla: 3.166 ± 0.028	0.346AsnCys: 0.346 ± 0.01	1.754AsnAsp: 1.754 ± 0.022	1.801AsnGlu: 1.801 ± 0.023	1.266AsnPhe: 1.266 ± 0.017	2.497AsnGly: 2.497 ± 0.027	0.773AsnHis: 0.773 ± 0.014	1.795AsnIle: 1.795 ± 0.02	1.332AsnLys: 1.332 ± 0.019	2.966AsnLeu: 2.966 ± 0.028	0.747AsnMet: 0.747 ± 0.012	1.147AsnAsn: 1.147 ± 0.019	2.116AsnPro: 2.116 ± 0.023	1.024AsnGln: 1.024 ± 0.015	1.61AsnArg: 1.61 ± 0.018	2.171AsnSer: 2.171 ± 0.024	1.87AsnThr: 1.87 ± 0.022	2.427AsnVal: 2.427 ± 0.021	0.492AsnTrp: 0.492 ± 0.011	0.894AsnTyr: 0.894 ± 0.014	0.046AsnXaa: 0.046 ± 0.004
Pro	6.319ProAla: 6.319 ± 0.056	0.526ProCys: 0.526 ± 0.012	3.588ProAsp: 3.588 ± 0.028	3.863ProGlu: 3.863 ± 0.029	2.233ProPhe: 2.233 ± 0.023	3.732ProGly: 3.732 ± 0.033	1.606ProHis: 1.606 ± 0.021	2.681ProIle: 2.681 ± 0.027	2.507ProLys: 2.507 ± 0.027	5.13ProLeu: 5.13 ± 0.039	1.172ProMet: 1.172 ± 0.017	2.008ProAsn: 2.008 ± 0.022	5.927ProPro: 5.927 ± 0.073	2.287ProGln: 2.287 ± 0.03	3.406ProArg: 3.406 ± 0.034	6.773ProSer: 6.773 ± 0.06	4.084ProThr: 4.084 ± 0.045	3.912ProVal: 3.912 ± 0.034	0.738ProTrp: 0.738 ± 0.014	1.517ProTyr: 1.517 ± 0.023	0.095ProXaa: 0.095 ± 0.007
Gln	3.574GlnAla: 3.574 ± 0.031	0.431GlnCys: 0.431 ± 0.01	2.101GlnAsp: 2.101 ± 0.025	2.265GlnGlu: 2.265 ± 0.026	1.284GlnPhe: 1.284 ± 0.02	2.168GlnGly: 2.168 ± 0.023	1.116GlnHis: 1.116 ± 0.019	1.765GlnIle: 1.765 ± 0.02	1.748GlnLys: 1.748 ± 0.022	3.475GlnLeu: 3.475 ± 0.028	0.862GlnMet: 0.862 ± 0.018	1.256GlnAsn: 1.256 ± 0.019	2.403GlnPro: 2.403 ± 0.031	1.949GlnGln: 1.949 ± 0.036	2.441GlnArg: 2.441 ± 0.024	2.751GlnSer: 2.751 ± 0.03	2.152GlnThr: 2.152 ± 0.021	2.131GlnVal: 2.131 ± 0.023	0.549GlnTrp: 0.549 ± 0.012	1.086GlnTyr: 1.086 ± 0.015	0.048GlnXaa: 0.048 ± 0.004
Arg	5.502ArgAla: 5.502 ± 0.042	0.718ArgCys: 0.718 ± 0.016	3.412ArgAsp: 3.412 ± 0.031	3.796ArgGlu: 3.796 ± 0.035	2.068ArgPhe: 2.068 ± 0.023	3.501ArgGly: 3.501 ± 0.034	1.655ArgHis: 1.655 ± 0.02	2.995ArgIle: 2.995 ± 0.026	3.303ArgLys: 3.303 ± 0.03	5.617ArgLeu: 5.617 ± 0.041	1.411ArgMet: 1.411 ± 0.019	1.923ArgAsn: 1.923 ± 0.02	3.515ArgPro: 3.515 ± 0.037	2.31ArgGln: 2.31 ± 0.024	4.957ArgArg: 4.957 ± 0.046	4.547ArgSer: 4.547 ± 0.039	3.433ArgThr: 3.433 ± 0.028	3.672ArgVal: 3.672 ± 0.03	0.946ArgTrp: 0.946 ± 0.015	1.546ArgTyr: 1.546 ± 0.018	0.09ArgXaa: 0.09 ± 0.006
Ser	7.183SerAla: 7.183 ± 0.049	0.85SerCys: 0.85 ± 0.015	4.427SerAsp: 4.427 ± 0.038	4.002SerGlu: 4.002 ± 0.035	2.944SerPhe: 2.944 ± 0.026	5.093SerGly: 5.093 ± 0.043	1.934SerHis: 1.934 ± 0.025	3.715SerIle: 3.715 ± 0.029	3.447SerLys: 3.447 ± 0.038	7.135SerLeu: 7.135 ± 0.044	1.772SerMet: 1.772 ± 0.022	2.474SerAsn: 2.474 ± 0.028	5.735SerPro: 5.735 ± 0.056	2.944SerGln: 2.944 ± 0.032	4.618SerArg: 4.618 ± 0.038	8.509SerSer: 8.509 ± 0.076	5.238SerThr: 5.238 ± 0.046	4.855SerVal: 4.855 ± 0.036	1.009SerTrp: 1.009 ± 0.016	1.899SerTyr: 1.899 ± 0.021	0.102SerXaa: 0.102 ± 0.006
Thr	5.164ThrAla: 5.164 ± 0.034	0.707ThrCys: 0.707 ± 0.014	2.904ThrAsp: 2.904 ± 0.029	2.865ThrGlu: 2.865 ± 0.028	2.359ThrPhe: 2.359 ± 0.026	3.771ThrGly: 3.771 ± 0.027	1.485ThrHis: 1.485 ± 0.019	2.897ThrIle: 2.897 ± 0.026	2.377ThrLys: 2.377 ± 0.025	5.481ThrLeu: 5.481 ± 0.044	1.211ThrMet: 1.211 ± 0.016	1.818ThrAsn: 1.818 ± 0.021	4.331ThrPro: 4.331 ± 0.038	1.95ThrGln: 1.95 ± 0.025	3.145ThrArg: 3.145 ± 0.025	5.116ThrSer: 5.116 ± 0.039	3.693ThrThr: 3.693 ± 0.037	3.728ThrVal: 3.728 ± 0.027	0.801ThrTrp: 0.801 ± 0.015	1.55ThrTyr: 1.55 ± 0.019	0.076ThrXaa: 0.076 ± 0.006
Val	5.514ValAla: 5.514 ± 0.038	0.842ValCys: 0.842 ± 0.017	4.093ValAsp: 4.093 ± 0.034	4.035ValGlu: 4.035 ± 0.035	2.558ValPhe: 2.558 ± 0.029	3.76ValGly: 3.76 ± 0.033	1.732ValHis: 1.732 ± 0.02	2.979ValIle: 2.979 ± 0.028	3.096ValLys: 3.096 ± 0.031	6.198ValLeu: 6.198 ± 0.048	1.332ValMet: 1.332 ± 0.018	2.188ValAsn: 2.188 ± 0.026	4.126ValPro: 4.126 ± 0.032	2.597ValGln: 2.597 ± 0.025	3.795ValArg: 3.795 ± 0.03	4.73ValSer: 4.73 ± 0.037	3.472ValThr: 3.472 ± 0.03	4.491ValVal: 4.491 ± 0.039	0.937ValTrp: 0.937 ± 0.017	1.727ValTyr: 1.727 ± 0.022	0.091ValXaa: 0.091 ± 0.006
Trp	1.128TrpAla: 1.128 ± 0.017	0.2TrpCys: 0.2 ± 0.007	0.957TrpAsp: 0.957 ± 0.015	0.834TrpGlu: 0.834 ± 0.014	0.547TrpPhe: 0.547 ± 0.013	0.841TrpGly: 0.841 ± 0.016	0.406TrpHis: 0.406 ± 0.01	0.742TrpIle: 0.742 ± 0.013	0.798TrpLys: 0.798 ± 0.016	1.303TrpLeu: 1.303 ± 0.017	0.373TrpMet: 0.373 ± 0.01	0.589TrpAsn: 0.589 ± 0.012	0.652TrpPro: 0.652 ± 0.012	0.531TrpGln: 0.531 ± 0.011	0.966TrpArg: 0.966 ± 0.015	1.062TrpSer: 1.062 ± 0.019	0.908TrpThr: 0.908 ± 0.014	0.837TrpVal: 0.837 ± 0.015	0.262TrpTrp: 0.262 ± 0.008	0.421TrpTyr: 0.421 ± 0.009	0.015TrpXaa: 0.015 ± 0.002
Tyr	2.285TyrAla: 2.285 ± 0.026	0.379TyrCys: 0.379 ± 0.01	1.667TyrAsp: 1.667 ± 0.02	1.493TyrGlu: 1.493 ± 0.017	1.094TyrPhe: 1.094 ± 0.016	1.82TyrGly: 1.82 ± 0.025	0.71TyrHis: 0.71 ± 0.012	1.318TyrIle: 1.318 ± 0.019	1.07TyrLys: 1.07 ± 0.018	2.515TyrLeu: 2.515 ± 0.024	0.594TyrMet: 0.594 ± 0.012	0.958TyrAsn: 0.958 ± 0.016	1.512TyrPro: 1.512 ± 0.021	0.908TyrGln: 0.908 ± 0.014	1.509TyrArg: 1.509 ± 0.021	1.777TyrSer: 1.777 ± 0.021	1.523TyrThr: 1.523 ± 0.022	1.719TyrVal: 1.719 ± 0.024	0.387TyrTrp: 0.387 ± 0.009	0.82TyrTyr: 0.82 ± 0.015	0.037TyrXaa: 0.037 ± 0.003
Xaa	0.139XaaAla: 0.139 ± 0.008	0.018XaaCys: 0.018 ± 0.003	0.094XaaAsp: 0.094 ± 0.006	0.088XaaGlu: 0.088 ± 0.007	0.045XaaPhe: 0.045 ± 0.004	0.093XaaGly: 0.093 ± 0.006	0.038XaaHis: 0.038 ± 0.003	0.054XaaIle: 0.054 ± 0.004	0.063XaaLys: 0.063 ± 0.006	0.126XaaLeu: 0.126 ± 0.009	0.027XaaMet: 0.027 ± 0.003	0.031XaaAsn: 0.031 ± 0.003	0.091XaaPro: 0.091 ± 0.007	0.05XaaGln: 0.05 ± 0.004	0.079XaaArg: 0.079 ± 0.006	0.099XaaSer: 0.099 ± 0.006	0.07XaaThr: 0.07 ± 0.005	0.091XaaVal: 0.091 ± 0.006	0.021XaaTrp: 0.021 ± 0.002	0.029XaaTyr: 0.029 ± 0.003	0.173XaaXaa: 0.173 ± 0.014

Statistics based on 11000 proteins (4291909 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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