Amino acid dipepetide frequency for Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.209AlaAla: 7.209 ± 0.099	0.905AlaCys: 0.905 ± 0.028	4.4AlaAsp: 4.4 ± 0.063	4.962AlaGlu: 4.962 ± 0.062	3.665AlaPhe: 3.665 ± 0.057	5.583AlaGly: 5.583 ± 0.08	1.718AlaHis: 1.718 ± 0.037	5.811AlaIle: 5.811 ± 0.068	4.605AlaLys: 4.605 ± 0.068	10.03AlaLeu: 10.03 ± 0.095	2.49AlaMet: 2.49 ± 0.048	3.447AlaAsn: 3.447 ± 0.052	2.947AlaPro: 2.947 ± 0.054	3.436AlaGln: 3.436 ± 0.061	3.605AlaArg: 3.605 ± 0.051	5.875AlaSer: 5.875 ± 0.067	4.509AlaThr: 4.509 ± 0.07	5.618AlaVal: 5.618 ± 0.074	0.931AlaTrp: 0.931 ± 0.028	2.428AlaTyr: 2.428 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.79CysAla: 0.79 ± 0.029	0.146CysCys: 0.146 ± 0.011	0.645CysAsp: 0.645 ± 0.022	0.587CysGlu: 0.587 ± 0.019	0.491CysPhe: 0.491 ± 0.021	0.85CysGly: 0.85 ± 0.026	0.322CysHis: 0.322 ± 0.015	0.619CysIle: 0.619 ± 0.021	0.381CysLys: 0.381 ± 0.018	1.134CysLeu: 1.134 ± 0.028	0.205CysMet: 0.205 ± 0.012	0.321CysAsn: 0.321 ± 0.018	0.39CysPro: 0.39 ± 0.015	0.386CysGln: 0.386 ± 0.017	0.468CysArg: 0.468 ± 0.019	0.712CysSer: 0.712 ± 0.024	0.46CysThr: 0.46 ± 0.019	0.695CysVal: 0.695 ± 0.022	0.111CysTrp: 0.111 ± 0.008	0.356CysTyr: 0.356 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.761AspAla: 4.761 ± 0.06	0.494AspCys: 0.494 ± 0.018	3.276AspAsp: 3.276 ± 0.063	4.112AspGlu: 4.112 ± 0.07	2.322AspPhe: 2.322 ± 0.044	3.712AspGly: 3.712 ± 0.076	1.216AspHis: 1.216 ± 0.034	4.118AspIle: 4.118 ± 0.055	2.898AspLys: 2.898 ± 0.049	5.63AspLeu: 5.63 ± 0.068	1.391AspMet: 1.391 ± 0.032	2.132AspAsn: 2.132 ± 0.045	2.083AspPro: 2.083 ± 0.039	2.309AspGln: 2.309 ± 0.037	2.517AspArg: 2.517 ± 0.046	3.758AspSer: 3.758 ± 0.061	2.868AspThr: 2.868 ± 0.055	4.291AspVal: 4.291 ± 0.068	0.892AspTrp: 0.892 ± 0.025	1.956AspTyr: 1.956 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.609GluAla: 5.609 ± 0.072	0.516GluCys: 0.516 ± 0.021	3.232GluAsp: 3.232 ± 0.06	4.448GluGlu: 4.448 ± 0.073	2.509GluPhe: 2.509 ± 0.039	3.907GluGly: 3.907 ± 0.058	1.649GluHis: 1.649 ± 0.039	3.737GluIle: 3.737 ± 0.072	3.982GluLys: 3.982 ± 0.065	6.967GluLeu: 6.967 ± 0.08	1.605GluMet: 1.605 ± 0.034	2.78GluAsn: 2.78 ± 0.052	1.956GluPro: 1.956 ± 0.055	3.406GluGln: 3.406 ± 0.054	3.602GluArg: 3.602 ± 0.071	4.53GluSer: 4.53 ± 0.061	3.518GluThr: 3.518 ± 0.054	4.2GluVal: 4.2 ± 0.063	0.798GluTrp: 0.798 ± 0.027	1.802GluTyr: 1.802 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.307PheAla: 3.307 ± 0.054	0.523PheCys: 0.523 ± 0.022	2.827PheAsp: 2.827 ± 0.049	2.708PheGlu: 2.708 ± 0.049	1.808PhePhe: 1.808 ± 0.044	3.179PheGly: 3.179 ± 0.055	0.814PheHis: 0.814 ± 0.027	2.762PheIle: 2.762 ± 0.05	2.04PheLys: 2.04 ± 0.04	3.723PheLeu: 3.723 ± 0.06	1.032PheMet: 1.032 ± 0.027	1.873PheAsn: 1.873 ± 0.043	1.541PhePro: 1.541 ± 0.035	1.329PheGln: 1.329 ± 0.032	1.574PheArg: 1.574 ± 0.031	3.595PheSer: 3.595 ± 0.056	2.057PheThr: 2.057 ± 0.043	2.916PheVal: 2.916 ± 0.046	0.54PheTrp: 0.54 ± 0.023	1.367PheTyr: 1.367 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.481GlyAla: 5.481 ± 0.073	0.858GlyCys: 0.858 ± 0.024	3.705GlyAsp: 3.705 ± 0.064	4.173GlyGlu: 4.173 ± 0.066	3.305GlyPhe: 3.305 ± 0.051	4.685GlyGly: 4.685 ± 0.082	1.507GlyHis: 1.507 ± 0.037	4.542GlyIle: 4.542 ± 0.058	3.756GlyLys: 3.756 ± 0.059	6.931GlyLeu: 6.931 ± 0.084	1.954GlyMet: 1.954 ± 0.044	2.425GlyAsn: 2.425 ± 0.059	1.692GlyPro: 1.692 ± 0.034	2.577GlyGln: 2.577 ± 0.043	3.14GlyArg: 3.14 ± 0.056	4.208GlySer: 4.208 ± 0.07	3.363GlyThr: 3.363 ± 0.054	5.502GlyVal: 5.502 ± 0.072	0.934GlyTrp: 0.934 ± 0.032	2.436GlyTyr: 2.436 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.682HisAla: 1.682 ± 0.038	0.317HisCys: 0.317 ± 0.016	1.159HisAsp: 1.159 ± 0.038	1.207HisGlu: 1.207 ± 0.033	1.122HisPhe: 1.122 ± 0.03	1.397HisGly: 1.397 ± 0.036	0.674HisHis: 0.674 ± 0.024	1.452HisIle: 1.452 ± 0.035	1.051HisLys: 1.051 ± 0.032	2.329HisLeu: 2.329 ± 0.045	0.502HisMet: 0.502 ± 0.019	0.84HisAsn: 0.84 ± 0.027	1.116HisPro: 1.116 ± 0.034	0.997HisGln: 0.997 ± 0.029	1.006HisArg: 1.006 ± 0.031	1.527HisSer: 1.527 ± 0.031	1.095HisThr: 1.095 ± 0.029	1.284HisVal: 1.284 ± 0.029	0.36HisTrp: 0.36 ± 0.017	0.849HisTyr: 0.849 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.101IleAla: 6.101 ± 0.078	0.669IleCys: 0.669 ± 0.024	4.283IleAsp: 4.283 ± 0.061	4.966IleGlu: 4.966 ± 0.058	2.138IlePhe: 2.138 ± 0.047	4.661IleGly: 4.661 ± 0.061	1.241IleHis: 1.241 ± 0.028	3.37IleIle: 3.37 ± 0.059	3.314IleLys: 3.314 ± 0.052	5.375IleLeu: 5.375 ± 0.072	1.366IleMet: 1.366 ± 0.036	2.839IleAsn: 2.839 ± 0.051	2.627IlePro: 2.627 ± 0.044	2.433IleGln: 2.433 ± 0.042	2.985IleArg: 2.985 ± 0.051	4.804IleSer: 4.804 ± 0.069	3.486IleThr: 3.486 ± 0.064	4.274IleVal: 4.274 ± 0.06	0.702IleTrp: 0.702 ± 0.027	1.552IleTyr: 1.552 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.863LysAla: 4.863 ± 0.066	0.351LysCys: 0.351 ± 0.018	2.949LysAsp: 2.949 ± 0.049	3.839LysGlu: 3.839 ± 0.064	1.433LysPhe: 1.433 ± 0.034	3.62LysGly: 3.62 ± 0.056	1.319LysHis: 1.319 ± 0.035	2.782LysIle: 2.782 ± 0.047	3.28LysLys: 3.28 ± 0.065	4.99LysLeu: 4.99 ± 0.066	1.319LysMet: 1.319 ± 0.031	2.254LysAsn: 2.254 ± 0.047	2.067LysPro: 2.067 ± 0.041	2.563LysGln: 2.563 ± 0.044	3.076LysArg: 3.076 ± 0.056	3.6LysSer: 3.6 ± 0.053	3.068LysThr: 3.068 ± 0.054	3.926LysVal: 3.926 ± 0.062	0.593LysTrp: 0.593 ± 0.021	1.339LysTyr: 1.339 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	9.119LeuAla: 9.119 ± 0.088	1.116LeuCys: 1.116 ± 0.032	6.07LeuAsp: 6.07 ± 0.07	6.709LeuGlu: 6.709 ± 0.088	4.295LeuPhe: 4.295 ± 0.063	6.981LeuGly: 6.981 ± 0.09	1.942LeuHis: 1.942 ± 0.045	6.567LeuIle: 6.567 ± 0.084	5.717LeuLys: 5.717 ± 0.077	10.308LeuLeu: 10.308 ± 0.127	2.586LeuMet: 2.586 ± 0.045	4.831LeuAsn: 4.831 ± 0.07	4.786LeuPro: 4.786 ± 0.063	3.442LeuGln: 3.442 ± 0.054	4.227LeuArg: 4.227 ± 0.06	8.904LeuSer: 8.904 ± 0.106	5.947LeuThr: 5.947 ± 0.079	6.987LeuVal: 6.987 ± 0.075	1.032LeuTrp: 1.032 ± 0.031	2.811LeuTyr: 2.811 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.338MetAla: 2.338 ± 0.051	0.201MetCys: 0.201 ± 0.012	1.311MetAsp: 1.311 ± 0.031	1.284MetGlu: 1.284 ± 0.031	0.879MetPhe: 0.879 ± 0.027	1.706MetGly: 1.706 ± 0.038	0.462MetHis: 0.462 ± 0.019	1.508MetIle: 1.508 ± 0.033	1.5MetLys: 1.5 ± 0.033	2.567MetLeu: 2.567 ± 0.045	0.734MetMet: 0.734 ± 0.024	1.086MetAsn: 1.086 ± 0.026	1.22MetPro: 1.22 ± 0.035	1.005MetGln: 1.005 ± 0.029	1.168MetArg: 1.168 ± 0.032	2.172MetSer: 2.172 ± 0.045	1.654MetThr: 1.654 ± 0.036	1.654MetVal: 1.654 ± 0.041	0.208MetTrp: 0.208 ± 0.013	0.524MetTyr: 0.524 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.707AsnAla: 3.707 ± 0.059	0.386AsnCys: 0.386 ± 0.018	2.481AsnAsp: 2.481 ± 0.049	2.636AsnGlu: 2.636 ± 0.05	1.424AsnPhe: 1.424 ± 0.032	2.935AsnGly: 2.935 ± 0.061	0.933AsnHis: 0.933 ± 0.028	2.681AsnIle: 2.681 ± 0.051	2.144AsnLys: 2.144 ± 0.046	3.919AsnLeu: 3.919 ± 0.05	0.954AsnMet: 0.954 ± 0.025	1.818AsnAsn: 1.818 ± 0.042	1.914AsnPro: 1.914 ± 0.042	1.885AsnGln: 1.885 ± 0.035	2.085AsnArg: 2.085 ± 0.039	2.632AsnSer: 2.632 ± 0.053	2.538AsnThr: 2.538 ± 0.047	2.833AsnVal: 2.833 ± 0.041	0.601AsnTrp: 0.601 ± 0.024	1.249AsnTyr: 1.249 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	2.804ProAla: 2.804 ± 0.045	0.285ProCys: 0.285 ± 0.014	2.431ProAsp: 2.431 ± 0.043	3.073ProGlu: 3.073 ± 0.067	1.77ProPhe: 1.77 ± 0.037	2.073ProGly: 2.073 ± 0.045	0.877ProHis: 0.877 ± 0.028	2.761ProIle: 2.761 ± 0.043	2.135ProLys: 2.135 ± 0.042	3.92ProLeu: 3.92 ± 0.056	1.041ProMet: 1.041 ± 0.029	1.978ProAsn: 1.978 ± 0.044	1.243ProPro: 1.243 ± 0.038	1.3ProGln: 1.3 ± 0.034	1.341ProArg: 1.341 ± 0.037	2.92ProSer: 2.92 ± 0.056	2.204ProThr: 2.204 ± 0.043	2.792ProVal: 2.792 ± 0.049	0.459ProTrp: 0.459 ± 0.019	1.295ProTyr: 1.295 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.732GlnAla: 3.732 ± 0.057	0.38GlnCys: 0.38 ± 0.019	1.972GlnAsp: 1.972 ± 0.038	2.297GlnGlu: 2.297 ± 0.045	1.627GlnPhe: 1.627 ± 0.036	2.674GlnGly: 2.674 ± 0.044	1.018GlnHis: 1.018 ± 0.028	2.392GlnIle: 2.392 ± 0.041	2.159GlnLys: 2.159 ± 0.049	4.367GlnLeu: 4.367 ± 0.066	0.952GlnMet: 0.952 ± 0.028	1.654GlnAsn: 1.654 ± 0.039	1.471GlnPro: 1.471 ± 0.03	2.013GlnGln: 2.013 ± 0.049	2.113GlnArg: 2.113 ± 0.04	3.101GlnSer: 3.101 ± 0.058	2.344GlnThr: 2.344 ± 0.044	2.844GlnVal: 2.844 ± 0.049	0.572GlnTrp: 0.572 ± 0.02	1.289GlnTyr: 1.289 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.445ArgAla: 3.445 ± 0.05	0.451ArgCys: 0.451 ± 0.02	2.356ArgAsp: 2.356 ± 0.046	2.898ArgGlu: 2.898 ± 0.05	2.29ArgPhe: 2.29 ± 0.044	2.535ArgGly: 2.535 ± 0.051	1.132ArgHis: 1.132 ± 0.031	3.076ArgIle: 3.076 ± 0.05	2.462ArgLys: 2.462 ± 0.053	5.277ArgLeu: 5.277 ± 0.066	1.258ArgMet: 1.258 ± 0.034	1.822ArgAsn: 1.822 ± 0.038	1.693ArgPro: 1.693 ± 0.037	2.057ArgGln: 2.057 ± 0.04	2.399ArgArg: 2.399 ± 0.049	3.041ArgSer: 3.041 ± 0.048	2.222ArgThr: 2.222 ± 0.038	3.182ArgVal: 3.182 ± 0.054	0.644ArgTrp: 0.644 ± 0.025	1.805ArgTyr: 1.805 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.825SerAla: 5.825 ± 0.081	0.604SerCys: 0.604 ± 0.021	4.32SerAsp: 4.32 ± 0.078	4.698SerGlu: 4.698 ± 0.069	3.126SerPhe: 3.126 ± 0.05	5.241SerGly: 5.241 ± 0.063	1.619SerHis: 1.619 ± 0.036	4.825SerIle: 4.825 ± 0.067	3.768SerLys: 3.768 ± 0.06	7.972SerLeu: 7.972 ± 0.086	1.862SerMet: 1.862 ± 0.042	3.161SerAsn: 3.161 ± 0.051	2.712SerPro: 2.712 ± 0.044	2.887SerGln: 2.887 ± 0.049	3.085SerArg: 3.085 ± 0.051	5.618SerSer: 5.618 ± 0.091	3.807SerThr: 3.807 ± 0.063	5.334SerVal: 5.334 ± 0.071	0.883SerTrp: 0.883 ± 0.027	2.144SerTyr: 2.144 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.184ThrAla: 4.184 ± 0.061	0.465ThrCys: 0.465 ± 0.02	2.923ThrAsp: 2.923 ± 0.059	3.208ThrGlu: 3.208 ± 0.046	2.183ThrPhe: 2.183 ± 0.036	3.881ThrGly: 3.881 ± 0.066	1.243ThrHis: 1.243 ± 0.032	3.225ThrIle: 3.225 ± 0.056	2.529ThrLys: 2.529 ± 0.047	6.784ThrLeu: 6.784 ± 0.078	1.088ThrMet: 1.088 ± 0.027	2.016ThrAsn: 2.016 ± 0.045	2.908ThrPro: 2.908 ± 0.063	2.442ThrGln: 2.442 ± 0.043	2.245ThrArg: 2.245 ± 0.041	3.837ThrSer: 3.837 ± 0.067	3.07ThrThr: 3.07 ± 0.068	3.742ThrVal: 3.742 ± 0.071	0.592ThrTrp: 0.592 ± 0.019	1.556ThrTyr: 1.556 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	6.182ValAla: 6.182 ± 0.081	0.851ValCys: 0.851 ± 0.026	3.998ValAsp: 3.998 ± 0.06	4.586ValGlu: 4.586 ± 0.062	3.082ValPhe: 3.082 ± 0.048	4.71ValGly: 4.71 ± 0.07	1.211ValHis: 1.211 ± 0.031	4.618ValIle: 4.618 ± 0.059	3.499ValLys: 3.499 ± 0.051	7.061ValLeu: 7.061 ± 0.092	1.875ValMet: 1.875 ± 0.044	2.946ValAsn: 2.946 ± 0.05	2.626ValPro: 2.626 ± 0.044	2.219ValGln: 2.219 ± 0.035	3.004ValArg: 3.004 ± 0.056	5.708ValSer: 5.708 ± 0.076	4.005ValThr: 4.005 ± 0.078	5.377ValVal: 5.377 ± 0.075	0.763ValTrp: 0.763 ± 0.024	1.922ValTyr: 1.922 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.839TrpAla: 0.839 ± 0.027	0.156TrpCys: 0.156 ± 0.011	0.634TrpAsp: 0.634 ± 0.022	0.574TrpGlu: 0.574 ± 0.018	0.576TrpPhe: 0.576 ± 0.019	0.755TrpGly: 0.755 ± 0.027	0.346TrpHis: 0.346 ± 0.017	0.684TrpIle: 0.684 ± 0.026	0.576TrpLys: 0.576 ± 0.021	1.675TrpLeu: 1.675 ± 0.039	0.345TrpMet: 0.345 ± 0.015	0.502TrpAsn: 0.502 ± 0.021	0.443TrpPro: 0.443 ± 0.019	0.713TrpGln: 0.713 ± 0.028	0.69TrpArg: 0.69 ± 0.025	0.838TrpSer: 0.838 ± 0.025	0.496TrpThr: 0.496 ± 0.019	0.894TrpVal: 0.894 ± 0.023	0.191TrpTrp: 0.191 ± 0.013	0.362TrpTyr: 0.362 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.196TyrAla: 2.196 ± 0.038	0.394TyrCys: 0.394 ± 0.017	1.763TyrAsp: 1.763 ± 0.052	1.79TyrGlu: 1.79 ± 0.043	1.469TyrPhe: 1.469 ± 0.033	2.09TyrGly: 2.09 ± 0.035	0.725TyrHis: 0.725 ± 0.023	1.658TyrIle: 1.658 ± 0.035	1.432TyrLys: 1.432 ± 0.031	3.415TyrLeu: 3.415 ± 0.057	0.621TyrMet: 0.621 ± 0.022	1.027TyrAsn: 1.027 ± 0.026	1.265TyrPro: 1.265 ± 0.029	1.573TyrGln: 1.573 ± 0.031	1.716TyrArg: 1.716 ± 0.034	2.11TyrSer: 2.11 ± 0.04	1.413TyrThr: 1.413 ± 0.039	1.898TyrVal: 1.898 ± 0.041	0.482TyrTrp: 0.482 ± 0.02	0.988TyrTyr: 0.988 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4118 proteins (1345423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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