Amino acid dipepetide frequency for Halomicrobium zhouii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.146AlaAla: 13.146 ± 0.158	0.67AlaCys: 0.67 ± 0.025	10.121AlaAsp: 10.121 ± 0.09	8.071AlaGlu: 8.071 ± 0.106	3.963AlaPhe: 3.963 ± 0.068	9.656AlaGly: 9.656 ± 0.11	1.823AlaHis: 1.823 ± 0.039	4.682AlaIle: 4.682 ± 0.082	1.719AlaLys: 1.719 ± 0.038	10.197AlaLeu: 10.197 ± 0.122	2.059AlaMet: 2.059 ± 0.045	2.536AlaAsn: 2.536 ± 0.051	3.936AlaPro: 3.936 ± 0.065	2.274AlaGln: 2.274 ± 0.054	5.948AlaArg: 5.948 ± 0.071	5.897AlaSer: 5.897 ± 0.074	7.477AlaThr: 7.477 ± 0.094	11.019AlaVal: 11.019 ± 0.125	1.179AlaTrp: 1.179 ± 0.033	2.661AlaTyr: 2.661 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.558CysAla: 0.558 ± 0.024	0.09CysCys: 0.09 ± 0.009	0.591CysAsp: 0.591 ± 0.025	0.611CysGlu: 0.611 ± 0.027	0.205CysPhe: 0.205 ± 0.015	0.797CysGly: 0.797 ± 0.028	0.182CysHis: 0.182 ± 0.013	0.228CysIle: 0.228 ± 0.014	0.108CysLys: 0.108 ± 0.009	0.525CysLeu: 0.525 ± 0.022	0.102CysMet: 0.102 ± 0.01	0.163CysAsn: 0.163 ± 0.013	0.487CysPro: 0.487 ± 0.02	0.191CysGln: 0.191 ± 0.014	0.425CysArg: 0.425 ± 0.019	0.436CysSer: 0.436 ± 0.022	0.376CysThr: 0.376 ± 0.021	0.482CysVal: 0.482 ± 0.02	0.09CysTrp: 0.09 ± 0.009	0.195CysTyr: 0.195 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	10.372AspAla: 10.372 ± 0.118	0.657AspCys: 0.657 ± 0.025	8.634AspAsp: 8.634 ± 0.116	8.343AspGlu: 8.343 ± 0.12	1.964AspPhe: 1.964 ± 0.044	9.296AspGly: 9.296 ± 0.135	2.042AspHis: 2.042 ± 0.046	2.368AspIle: 2.368 ± 0.045	0.859AspLys: 0.859 ± 0.031	7.086AspLeu: 7.086 ± 0.084	1.236AspMet: 1.236 ± 0.033	1.352AspAsn: 1.352 ± 0.043	4.796AspPro: 4.796 ± 0.073	2.233AspGln: 2.233 ± 0.052	6.437AspArg: 6.437 ± 0.075	4.013AspSer: 4.013 ± 0.072	3.928AspThr: 3.928 ± 0.095	9.499AspVal: 9.499 ± 0.094	1.139AspTrp: 1.139 ± 0.032	1.977AspTyr: 1.977 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.311GluAla: 8.311 ± 0.108	0.523GluCys: 0.523 ± 0.021	5.95GluAsp: 5.95 ± 0.095	6.437GluGlu: 6.437 ± 0.103	2.953GluPhe: 2.953 ± 0.05	5.493GluGly: 5.493 ± 0.068	1.891GluHis: 1.891 ± 0.041	3.335GluIle: 3.335 ± 0.062	1.703GluLys: 1.703 ± 0.05	7.007GluLeu: 7.007 ± 0.096	1.851GluMet: 1.851 ± 0.038	2.366GluAsn: 2.366 ± 0.053	3.775GluPro: 3.775 ± 0.062	2.754GluGln: 2.754 ± 0.064	7.507GluArg: 7.507 ± 0.109	5.268GluSer: 5.268 ± 0.074	6.652GluThr: 6.652 ± 0.15	5.477GluVal: 5.477 ± 0.075	1.249GluTrp: 1.249 ± 0.035	2.628GluTyr: 2.628 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.716PheAla: 3.716 ± 0.069	0.261PheCys: 0.261 ± 0.014	3.462PheAsp: 3.462 ± 0.058	3.126PheGlu: 3.126 ± 0.055	1.071PhePhe: 1.071 ± 0.033	3.169PheGly: 3.169 ± 0.052	0.68PheHis: 0.68 ± 0.02	0.812PheIle: 0.812 ± 0.031	0.44PheLys: 0.44 ± 0.021	3.008PheLeu: 3.008 ± 0.059	0.492PheMet: 0.492 ± 0.02	0.667PheAsn: 0.667 ± 0.026	1.357PhePro: 1.357 ± 0.035	0.877PheGln: 0.877 ± 0.028	1.808PheArg: 1.808 ± 0.047	1.718PheSer: 1.718 ± 0.04	1.842PheThr: 1.842 ± 0.039	3.55PheVal: 3.55 ± 0.061	0.435PheTrp: 0.435 ± 0.021	0.865PheTyr: 0.865 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.332GlyAla: 8.332 ± 0.091	0.711GlyCys: 0.711 ± 0.029	7.6GlyAsp: 7.6 ± 0.095	7.318GlyGlu: 7.318 ± 0.09	3.092GlyPhe: 3.092 ± 0.052	7.828GlyGly: 7.828 ± 0.121	1.734GlyHis: 1.734 ± 0.043	3.768GlyIle: 3.768 ± 0.063	1.779GlyLys: 1.779 ± 0.052	7.432GlyLeu: 7.432 ± 0.103	1.701GlyMet: 1.701 ± 0.042	2.146GlyAsn: 2.146 ± 0.05	3.578GlyPro: 3.578 ± 0.056	2.229GlyGln: 2.229 ± 0.047	4.724GlyArg: 4.724 ± 0.075	5.452GlySer: 5.452 ± 0.087	6.059GlyThr: 6.059 ± 0.084	7.775GlyVal: 7.775 ± 0.103	1.196GlyTrp: 1.196 ± 0.037	2.556GlyTyr: 2.556 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.028HisAla: 2.028 ± 0.045	0.199HisCys: 0.199 ± 0.013	1.891HisAsp: 1.891 ± 0.043	1.708HisGlu: 1.708 ± 0.04	0.585HisPhe: 0.585 ± 0.02	1.905HisGly: 1.905 ± 0.048	0.541HisHis: 0.541 ± 0.026	0.527HisIle: 0.527 ± 0.024	0.26HisLys: 0.26 ± 0.015	1.741HisLeu: 1.741 ± 0.04	0.267HisMet: 0.267 ± 0.016	0.429HisAsn: 0.429 ± 0.02	1.217HisPro: 1.217 ± 0.033	0.508HisGln: 0.508 ± 0.022	1.347HisArg: 1.347 ± 0.034	0.913HisSer: 0.913 ± 0.032	0.961HisThr: 0.961 ± 0.028	2.116HisVal: 2.116 ± 0.05	0.276HisTrp: 0.276 ± 0.012	0.589HisTyr: 0.589 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.137IleAla: 4.137 ± 0.068	0.229IleCys: 0.229 ± 0.014	3.503IleAsp: 3.503 ± 0.057	3.606IleGlu: 3.606 ± 0.056	0.867IlePhe: 0.867 ± 0.031	3.348IleGly: 3.348 ± 0.051	0.749IleHis: 0.749 ± 0.025	1.099IleIle: 1.099 ± 0.039	0.589IleLys: 0.589 ± 0.025	2.823IleLeu: 2.823 ± 0.057	0.442IleMet: 0.442 ± 0.019	0.815IleAsn: 0.815 ± 0.027	1.855IlePro: 1.855 ± 0.045	1.106IleGln: 1.106 ± 0.03	2.252IleArg: 2.252 ± 0.045	1.986IleSer: 1.986 ± 0.044	2.103IleThr: 2.103 ± 0.04	3.323IleVal: 3.323 ± 0.063	0.303IleTrp: 0.303 ± 0.015	0.85IleTyr: 0.85 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	1.552LysAla: 1.552 ± 0.041	0.101LysCys: 0.101 ± 0.01	0.944LysAsp: 0.944 ± 0.035	1.175LysGlu: 1.175 ± 0.034	0.518LysPhe: 0.518 ± 0.019	1.265LysGly: 1.265 ± 0.037	0.428LysHis: 0.428 ± 0.023	0.669LysIle: 0.669 ± 0.027	0.425LysLys: 0.425 ± 0.025	1.589LysLeu: 1.589 ± 0.041	0.332LysMet: 0.332 ± 0.018	0.473LysAsn: 0.473 ± 0.023	0.798LysPro: 0.798 ± 0.026	0.697LysGln: 0.697 ± 0.03	1.436LysArg: 1.436 ± 0.038	1.046LysSer: 1.046 ± 0.033	1.143LysThr: 1.143 ± 0.034	1.138LysVal: 1.138 ± 0.029	0.235LysTrp: 0.235 ± 0.015	0.526LysTyr: 0.526 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	11.307LeuAla: 11.307 ± 0.142	0.522LeuCys: 0.522 ± 0.023	7.6LeuAsp: 7.6 ± 0.085	6.359LeuGlu: 6.359 ± 0.09	3.269LeuPhe: 3.269 ± 0.064	7.487LeuGly: 7.487 ± 0.088	1.501LeuHis: 1.501 ± 0.034	2.563LeuIle: 2.563 ± 0.05	1.28LeuLys: 1.28 ± 0.036	8.393LeuLeu: 8.393 ± 0.126	1.199LeuMet: 1.199 ± 0.029	1.703LeuAsn: 1.703 ± 0.041	4.11LeuPro: 4.11 ± 0.06	2.213LeuGln: 2.213 ± 0.046	5.29LeuArg: 5.29 ± 0.063	5.317LeuSer: 5.317 ± 0.07	5.281LeuThr: 5.281 ± 0.063	9.045LeuVal: 9.045 ± 0.116	0.908LeuTrp: 0.908 ± 0.025	2.214LeuTyr: 2.214 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.94MetAla: 1.94 ± 0.046	0.108MetCys: 0.108 ± 0.01	1.293MetAsp: 1.293 ± 0.039	1.059MetGlu: 1.059 ± 0.031	0.491MetPhe: 0.491 ± 0.019	1.489MetGly: 1.489 ± 0.037	0.321MetHis: 0.321 ± 0.018	0.621MetIle: 0.621 ± 0.023	0.409MetLys: 0.409 ± 0.018	1.417MetLeu: 1.417 ± 0.035	0.28MetMet: 0.28 ± 0.016	0.572MetAsn: 0.572 ± 0.022	0.815MetPro: 0.815 ± 0.027	0.481MetGln: 0.481 ± 0.02	1.043MetArg: 1.043 ± 0.029	1.349MetSer: 1.349 ± 0.034	1.512MetThr: 1.512 ± 0.036	1.327MetVal: 1.327 ± 0.032	0.161MetTrp: 0.161 ± 0.011	0.345MetTyr: 0.345 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.474AsnAla: 2.474 ± 0.046	0.196AsnCys: 0.196 ± 0.015	1.853AsnAsp: 1.853 ± 0.049	1.967AsnGlu: 1.967 ± 0.057	0.674AsnPhe: 0.674 ± 0.023	2.113AsnGly: 2.113 ± 0.054	0.525AsnHis: 0.525 ± 0.022	0.724AsnIle: 0.724 ± 0.026	0.353AsnLys: 0.353 ± 0.019	1.915AsnLeu: 1.915 ± 0.041	0.395AsnMet: 0.395 ± 0.019	0.521AsnAsn: 0.521 ± 0.024	1.451AsnPro: 1.451 ± 0.036	0.7AsnGln: 0.7 ± 0.029	1.532AsnArg: 1.532 ± 0.041	1.042AsnSer: 1.042 ± 0.036	1.189AsnThr: 1.189 ± 0.033	2.439AsnVal: 2.439 ± 0.055	0.362AsnTrp: 0.362 ± 0.02	0.721AsnTyr: 0.721 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.862ProAla: 4.862 ± 0.062	0.239ProCys: 0.239 ± 0.014	4.887ProAsp: 4.887 ± 0.064	4.276ProGlu: 4.276 ± 0.06	1.623ProPhe: 1.623 ± 0.04	4.052ProGly: 4.052 ± 0.063	0.828ProHis: 0.828 ± 0.026	1.682ProIle: 1.682 ± 0.036	0.73ProLys: 0.73 ± 0.025	3.671ProLeu: 3.671 ± 0.072	0.824ProMet: 0.824 ± 0.028	1.082ProAsn: 1.082 ± 0.027	2.232ProPro: 2.232 ± 0.051	1.031ProGln: 1.031 ± 0.033	2.323ProArg: 2.323 ± 0.041	2.742ProSer: 2.742 ± 0.054	3.213ProThr: 3.213 ± 0.051	4.383ProVal: 4.383 ± 0.066	0.566ProTrp: 0.566 ± 0.023	1.122ProTyr: 1.122 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.689GlnAla: 2.689 ± 0.053	0.191GlnCys: 0.191 ± 0.013	1.58GlnAsp: 1.58 ± 0.043	1.868GlnGlu: 1.868 ± 0.05	1.151GlnPhe: 1.151 ± 0.029	1.789GlnGly: 1.789 ± 0.041	0.563GlnHis: 0.563 ± 0.021	1.173GlnIle: 1.173 ± 0.031	0.544GlnLys: 0.544 ± 0.024	2.299GlnLeu: 2.299 ± 0.047	0.55GlnMet: 0.55 ± 0.022	0.784GlnAsn: 0.784 ± 0.031	1.19GlnPro: 1.19 ± 0.033	1.109GlnGln: 1.109 ± 0.041	2.185GlnArg: 2.185 ± 0.046	1.827GlnSer: 1.827 ± 0.055	1.826GlnThr: 1.826 ± 0.043	2.057GlnVal: 2.057 ± 0.042	0.435GlnTrp: 0.435 ± 0.019	0.868GlnTyr: 0.868 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.212ArgAla: 6.212 ± 0.078	0.467ArgCys: 0.467 ± 0.021	5.337ArgAsp: 5.337 ± 0.076	6.333ArgGlu: 6.333 ± 0.083	2.347ArgPhe: 2.347 ± 0.044	4.24ArgGly: 4.24 ± 0.058	1.256ArgHis: 1.256 ± 0.035	2.767ArgIle: 2.767 ± 0.053	1.318ArgLys: 1.318 ± 0.037	5.813ArgLeu: 5.813 ± 0.072	1.248ArgMet: 1.248 ± 0.031	1.634ArgAsn: 1.634 ± 0.039	2.666ArgPro: 2.666 ± 0.054	1.947ArgGln: 1.947 ± 0.041	4.912ArgArg: 4.912 ± 0.076	3.685ArgSer: 3.685 ± 0.062	3.909ArgThr: 3.909 ± 0.061	5.308ArgVal: 5.308 ± 0.073	0.851ArgTrp: 0.851 ± 0.026	2.007ArgTyr: 2.007 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.466SerAla: 5.466 ± 0.078	0.308SerCys: 0.308 ± 0.015	4.782SerAsp: 4.782 ± 0.088	4.331SerGlu: 4.331 ± 0.064	1.993SerPhe: 1.993 ± 0.041	5.613SerGly: 5.613 ± 0.074	1.099SerHis: 1.099 ± 0.033	2.292SerIle: 2.292 ± 0.046	1.11SerLys: 1.11 ± 0.035	5.034SerLeu: 5.034 ± 0.071	1.105SerMet: 1.105 ± 0.028	1.382SerAsn: 1.382 ± 0.034	2.692SerPro: 2.692 ± 0.051	1.515SerGln: 1.515 ± 0.041	3.182SerArg: 3.182 ± 0.056	3.193SerSer: 3.193 ± 0.062	3.695SerThr: 3.695 ± 0.059	5.204SerVal: 5.204 ± 0.074	0.669SerTrp: 0.669 ± 0.024	1.458SerTyr: 1.458 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	7.001ThrAla: 7.001 ± 0.101	0.388ThrCys: 0.388 ± 0.02	5.913ThrAsp: 5.913 ± 0.103	4.97ThrGlu: 4.97 ± 0.141	2.226ThrPhe: 2.226 ± 0.047	5.925ThrGly: 5.925 ± 0.088	1.155ThrHis: 1.155 ± 0.031	2.744ThrIle: 2.744 ± 0.051	0.927ThrLys: 0.927 ± 0.029	5.548ThrLeu: 5.548 ± 0.081	1.034ThrMet: 1.034 ± 0.031	1.495ThrAsn: 1.495 ± 0.037	3.168ThrPro: 3.168 ± 0.063	1.393ThrGln: 1.393 ± 0.039	3.254ThrArg: 3.254 ± 0.049	3.095ThrSer: 3.095 ± 0.051	4.406ThrThr: 4.406 ± 0.074	7.36ThrVal: 7.36 ± 0.097	0.709ThrTrp: 0.709 ± 0.025	1.753ThrTyr: 1.753 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	11.166ValAla: 11.166 ± 0.124	0.647ValCys: 0.647 ± 0.025	8.722ValAsp: 8.722 ± 0.099	8.256ValGlu: 8.256 ± 0.093	3.006ValPhe: 3.006 ± 0.059	8.32ValGly: 8.32 ± 0.109	1.744ValHis: 1.744 ± 0.038	2.781ValIle: 2.781 ± 0.06	1.288ValLys: 1.288 ± 0.038	8.366ValLeu: 8.366 ± 0.104	1.31ValMet: 1.31 ± 0.035	2.001ValAsn: 2.001 ± 0.042	4.498ValPro: 4.498 ± 0.07	2.168ValGln: 2.168 ± 0.046	5.69ValArg: 5.69 ± 0.072	5.184ValSer: 5.184 ± 0.07	6.706ValThr: 6.706 ± 0.093	10.195ValVal: 10.195 ± 0.12	0.907ValTrp: 0.907 ± 0.029	2.224ValTyr: 2.224 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.024TrpAla: 1.024 ± 0.033	0.092TrpCys: 0.092 ± 0.01	0.88TrpAsp: 0.88 ± 0.027	0.92TrpGlu: 0.92 ± 0.03	0.489TrpPhe: 0.489 ± 0.019	0.929TrpGly: 0.929 ± 0.027	0.284TrpHis: 0.284 ± 0.017	0.536TrpIle: 0.536 ± 0.019	0.266TrpLys: 0.266 ± 0.015	1.306TrpLeu: 1.306 ± 0.042	0.22TrpMet: 0.22 ± 0.014	0.416TrpAsn: 0.416 ± 0.019	0.49TrpPro: 0.49 ± 0.022	0.448TrpGln: 0.448 ± 0.02	0.995TrpArg: 0.995 ± 0.035	0.645TrpSer: 0.645 ± 0.027	0.836TrpThr: 0.836 ± 0.025	0.906TrpVal: 0.906 ± 0.027	0.221TrpTrp: 0.221 ± 0.014	0.368TrpTyr: 0.368 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.743TyrAla: 2.743 ± 0.051	0.242TyrCys: 0.242 ± 0.015	2.687TyrAsp: 2.687 ± 0.049	2.395TyrGlu: 2.395 ± 0.045	0.868TyrPhe: 0.868 ± 0.027	2.296TyrGly: 2.296 ± 0.04	0.661TyrHis: 0.661 ± 0.024	0.615TyrIle: 0.615 ± 0.021	0.383TyrLys: 0.383 ± 0.02	2.393TyrLeu: 2.393 ± 0.043	0.385TyrMet: 0.385 ± 0.019	0.609TyrAsn: 0.609 ± 0.023	1.257TyrPro: 1.257 ± 0.033	0.803TyrGln: 0.803 ± 0.025	1.968TyrArg: 1.968 ± 0.045	1.315TyrSer: 1.315 ± 0.036	1.352TyrThr: 1.352 ± 0.035	2.576TyrVal: 2.576 ± 0.056	0.378TyrTrp: 0.378 ± 0.018	0.904TyrTyr: 0.904 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4091 proteins (1202276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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