Amino acid dipepetide frequency for Halorussus sp. MSC15.2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.544AlaAla: 12.544 ± 0.177	0.609AlaCys: 0.609 ± 0.025	10.034AlaAsp: 10.034 ± 0.126	9.103AlaGlu: 9.103 ± 0.109	4.012AlaPhe: 4.012 ± 0.064	9.043AlaGly: 9.043 ± 0.093	1.62AlaHis: 1.62 ± 0.035	3.904AlaIle: 3.904 ± 0.067	2.049AlaLys: 2.049 ± 0.046	10.016AlaLeu: 10.016 ± 0.126	1.967AlaMet: 1.967 ± 0.042	2.585AlaAsn: 2.585 ± 0.059	3.915AlaPro: 3.915 ± 0.065	2.099AlaGln: 2.099 ± 0.049	6.065AlaArg: 6.065 ± 0.091	5.843AlaSer: 5.843 ± 0.085	7.099AlaThr: 7.099 ± 0.09	10.635AlaVal: 10.635 ± 0.113	1.099AlaTrp: 1.099 ± 0.033	2.679AlaTyr: 2.679 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.553CysAla: 0.553 ± 0.022	0.09CysCys: 0.09 ± 0.01	0.548CysAsp: 0.548 ± 0.02	0.588CysGlu: 0.588 ± 0.025	0.184CysPhe: 0.184 ± 0.013	0.777CysGly: 0.777 ± 0.026	0.174CysHis: 0.174 ± 0.012	0.234CysIle: 0.234 ± 0.013	0.105CysLys: 0.105 ± 0.009	0.479CysLeu: 0.479 ± 0.022	0.113CysMet: 0.113 ± 0.01	0.179CysAsn: 0.179 ± 0.013	0.501CysPro: 0.501 ± 0.026	0.156CysGln: 0.156 ± 0.012	0.451CysArg: 0.451 ± 0.021	0.409CysSer: 0.409 ± 0.019	0.337CysThr: 0.337 ± 0.017	0.477CysVal: 0.477 ± 0.021	0.092CysTrp: 0.092 ± 0.008	0.175CysTyr: 0.175 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	10.294AspAla: 10.294 ± 0.126	0.689AspCys: 0.689 ± 0.03	7.425AspAsp: 7.425 ± 0.118	8.193AspGlu: 8.193 ± 0.115	2.262AspPhe: 2.262 ± 0.046	7.777AspGly: 7.777 ± 0.114	1.859AspHis: 1.859 ± 0.039	2.71AspIle: 2.71 ± 0.058	1.107AspLys: 1.107 ± 0.034	6.847AspLeu: 6.847 ± 0.092	1.172AspMet: 1.172 ± 0.034	1.38AspAsn: 1.38 ± 0.044	4.538AspPro: 4.538 ± 0.075	1.523AspGln: 1.523 ± 0.042	6.274AspArg: 6.274 ± 0.095	4.156AspSer: 4.156 ± 0.062	3.835AspThr: 3.835 ± 0.069	7.415AspVal: 7.415 ± 0.084	1.135AspTrp: 1.135 ± 0.033	2.099AspTyr: 2.099 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.954GluAla: 7.954 ± 0.102	0.556GluCys: 0.556 ± 0.024	5.992GluAsp: 5.992 ± 0.098	7.025GluGlu: 7.025 ± 0.114	3.23GluPhe: 3.23 ± 0.056	5.75GluGly: 5.75 ± 0.075	1.585GluHis: 1.585 ± 0.043	3.516GluIle: 3.516 ± 0.064	2.119GluLys: 2.119 ± 0.046	7.194GluLeu: 7.194 ± 0.092	2.039GluMet: 2.039 ± 0.046	2.729GluAsn: 2.729 ± 0.053	3.11GluPro: 3.11 ± 0.056	2.836GluGln: 2.836 ± 0.052	7.891GluArg: 7.891 ± 0.103	5.849GluSer: 5.849 ± 0.083	7.046GluThr: 7.046 ± 0.099	6.439GluVal: 6.439 ± 0.08	1.169GluTrp: 1.169 ± 0.032	2.8GluTyr: 2.8 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.871PheAla: 3.871 ± 0.061	0.263PheCys: 0.263 ± 0.016	3.289PheAsp: 3.289 ± 0.059	3.4PheGlu: 3.4 ± 0.056	1.048PhePhe: 1.048 ± 0.031	3.404PheGly: 3.404 ± 0.06	0.675PheHis: 0.675 ± 0.024	0.837PheIle: 0.837 ± 0.032	0.507PheLys: 0.507 ± 0.021	2.926PheLeu: 2.926 ± 0.063	0.449PheMet: 0.449 ± 0.021	0.708PheAsn: 0.708 ± 0.028	1.392PhePro: 1.392 ± 0.039	0.808PheGln: 0.808 ± 0.025	2.029PheArg: 2.029 ± 0.043	1.816PheSer: 1.816 ± 0.039	1.905PheThr: 1.905 ± 0.044	3.594PheVal: 3.594 ± 0.059	0.429PheTrp: 0.429 ± 0.023	0.915PheTyr: 0.915 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	7.802GlyAla: 7.802 ± 0.104	0.646GlyCys: 0.646 ± 0.025	7.034GlyAsp: 7.034 ± 0.084	7.516GlyGlu: 7.516 ± 0.088	3.161GlyPhe: 3.161 ± 0.054	7.702GlyGly: 7.702 ± 0.131	1.588GlyHis: 1.588 ± 0.039	3.499GlyIle: 3.499 ± 0.063	2.056GlyLys: 2.056 ± 0.044	7.127GlyLeu: 7.127 ± 0.102	1.627GlyMet: 1.627 ± 0.037	2.264GlyAsn: 2.264 ± 0.054	3.344GlyPro: 3.344 ± 0.058	2.147GlyGln: 2.147 ± 0.047	4.978GlyArg: 4.978 ± 0.071	5.159GlySer: 5.159 ± 0.082	5.926GlyThr: 5.926 ± 0.088	8.226GlyVal: 8.226 ± 0.082	1.102GlyTrp: 1.102 ± 0.035	2.637GlyTyr: 2.637 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.9HisAla: 1.9 ± 0.048	0.18HisCys: 0.18 ± 0.013	1.698HisAsp: 1.698 ± 0.04	1.623HisGlu: 1.623 ± 0.038	0.646HisPhe: 0.646 ± 0.027	1.827HisGly: 1.827 ± 0.042	0.557HisHis: 0.557 ± 0.027	0.53HisIle: 0.53 ± 0.026	0.294HisLys: 0.294 ± 0.017	1.73HisLeu: 1.73 ± 0.037	0.259HisMet: 0.259 ± 0.015	0.457HisAsn: 0.457 ± 0.02	1.139HisPro: 1.139 ± 0.035	0.429HisGln: 0.429 ± 0.022	1.248HisArg: 1.248 ± 0.036	0.819HisSer: 0.819 ± 0.027	0.958HisThr: 0.958 ± 0.032	1.844HisVal: 1.844 ± 0.041	0.24HisTrp: 0.24 ± 0.015	0.568HisTyr: 0.568 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	3.829IleAla: 3.829 ± 0.056	0.212IleCys: 0.212 ± 0.015	3.251IleAsp: 3.251 ± 0.056	3.352IleGlu: 3.352 ± 0.066	0.832IlePhe: 0.832 ± 0.027	2.887IleGly: 2.887 ± 0.062	0.676IleHis: 0.676 ± 0.023	1.078IleIle: 1.078 ± 0.033	0.636IleLys: 0.636 ± 0.024	2.681IleLeu: 2.681 ± 0.052	0.4IleMet: 0.4 ± 0.022	0.832IleAsn: 0.832 ± 0.029	1.886IlePro: 1.886 ± 0.038	0.944IleGln: 0.944 ± 0.035	2.363IleArg: 2.363 ± 0.047	1.916IleSer: 1.916 ± 0.041	2.049IleThr: 2.049 ± 0.042	2.913IleVal: 2.913 ± 0.056	0.276IleTrp: 0.276 ± 0.016	0.817IleTyr: 0.817 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	1.95LysAla: 1.95 ± 0.048	0.144LysCys: 0.144 ± 0.011	1.189LysAsp: 1.189 ± 0.036	1.468LysGlu: 1.468 ± 0.035	0.682LysPhe: 0.682 ± 0.024	1.499LysGly: 1.499 ± 0.036	0.467LysHis: 0.467 ± 0.021	0.874LysIle: 0.874 ± 0.034	0.653LysLys: 0.653 ± 0.032	1.864LysLeu: 1.864 ± 0.041	0.449LysMet: 0.449 ± 0.024	0.683LysAsn: 0.683 ± 0.026	0.989LysPro: 0.989 ± 0.033	0.865LysGln: 0.865 ± 0.029	1.731LysArg: 1.731 ± 0.037	1.36LysSer: 1.36 ± 0.036	1.453LysThr: 1.453 ± 0.038	1.474LysVal: 1.474 ± 0.042	0.31LysTrp: 0.31 ± 0.016	0.745LysTyr: 0.745 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	10.904LeuAla: 10.904 ± 0.143	0.486LeuCys: 0.486 ± 0.021	7.572LeuAsp: 7.572 ± 0.088	5.768LeuGlu: 5.768 ± 0.086	3.057LeuPhe: 3.057 ± 0.078	7.663LeuGly: 7.663 ± 0.097	1.436LeuHis: 1.436 ± 0.037	2.078LeuIle: 2.078 ± 0.055	1.741LeuLys: 1.741 ± 0.041	8.55LeuLeu: 8.55 ± 0.141	1.214LeuMet: 1.214 ± 0.033	2.007LeuAsn: 2.007 ± 0.044	4.046LeuPro: 4.046 ± 0.059	1.975LeuGln: 1.975 ± 0.044	5.852LeuArg: 5.852 ± 0.072	5.697LeuSer: 5.697 ± 0.065	5.134LeuThr: 5.134 ± 0.075	8.438LeuVal: 8.438 ± 0.121	0.864LeuTrp: 0.864 ± 0.029	2.286LeuTyr: 2.286 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.804MetAla: 1.804 ± 0.039	0.091MetCys: 0.091 ± 0.01	1.24MetAsp: 1.24 ± 0.041	1.15MetGlu: 1.15 ± 0.031	0.496MetPhe: 0.496 ± 0.024	1.344MetGly: 1.344 ± 0.038	0.335MetHis: 0.335 ± 0.016	0.546MetIle: 0.546 ± 0.023	0.495MetLys: 0.495 ± 0.021	1.506MetLeu: 1.506 ± 0.039	0.297MetMet: 0.297 ± 0.016	0.681MetAsn: 0.681 ± 0.023	0.777MetPro: 0.777 ± 0.027	0.483MetGln: 0.483 ± 0.022	1.118MetArg: 1.118 ± 0.033	1.407MetSer: 1.407 ± 0.034	1.455MetThr: 1.455 ± 0.041	1.311MetVal: 1.311 ± 0.034	0.162MetTrp: 0.162 ± 0.012	0.399MetTyr: 0.399 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.725AsnAla: 2.725 ± 0.05	0.251AsnCys: 0.251 ± 0.014	1.876AsnAsp: 1.876 ± 0.041	1.905AsnGlu: 1.905 ± 0.049	0.834AsnPhe: 0.834 ± 0.029	2.135AsnGly: 2.135 ± 0.056	0.575AsnHis: 0.575 ± 0.023	0.835AsnIle: 0.835 ± 0.03	0.485AsnLys: 0.485 ± 0.02	2.308AsnLeu: 2.308 ± 0.042	0.416AsnMet: 0.416 ± 0.017	0.653AsnAsn: 0.653 ± 0.031	1.773AsnPro: 1.773 ± 0.039	0.777AsnGln: 0.777 ± 0.028	1.85AsnArg: 1.85 ± 0.04	1.272AsnSer: 1.272 ± 0.035	1.319AsnThr: 1.319 ± 0.037	2.719AsnVal: 2.719 ± 0.059	0.358AsnTrp: 0.358 ± 0.018	0.83AsnTyr: 0.83 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.277ProAla: 4.277 ± 0.059	0.221ProCys: 0.221 ± 0.014	4.957ProAsp: 4.957 ± 0.078	4.852ProGlu: 4.852 ± 0.071	1.542ProPhe: 1.542 ± 0.039	3.624ProGly: 3.624 ± 0.064	0.895ProHis: 0.895 ± 0.027	1.538ProIle: 1.538 ± 0.042	1.026ProLys: 1.026 ± 0.03	3.351ProLeu: 3.351 ± 0.057	0.782ProMet: 0.782 ± 0.023	1.265ProAsn: 1.265 ± 0.031	2.098ProPro: 2.098 ± 0.047	0.921ProGln: 0.921 ± 0.029	2.379ProArg: 2.379 ± 0.045	2.723ProSer: 2.723 ± 0.055	3.223ProThr: 3.223 ± 0.057	3.983ProVal: 3.983 ± 0.058	0.513ProTrp: 0.513 ± 0.02	1.1ProTyr: 1.1 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.233GlnAla: 2.233 ± 0.05	0.155GlnCys: 0.155 ± 0.013	1.278GlnAsp: 1.278 ± 0.04	1.493GlnGlu: 1.493 ± 0.037	1.189GlnPhe: 1.189 ± 0.029	1.577GlnGly: 1.577 ± 0.047	0.529GlnHis: 0.529 ± 0.02	1.049GlnIle: 1.049 ± 0.031	0.753GlnLys: 0.753 ± 0.03	2.204GlnLeu: 2.204 ± 0.044	0.612GlnMet: 0.612 ± 0.024	0.935GlnAsn: 0.935 ± 0.035	0.978GlnPro: 0.978 ± 0.026	1.162GlnGln: 1.162 ± 0.044	1.979GlnArg: 1.979 ± 0.043	1.848GlnSer: 1.848 ± 0.046	1.853GlnThr: 1.853 ± 0.049	1.943GlnVal: 1.943 ± 0.04	0.352GlnTrp: 0.352 ± 0.016	0.833GlnTyr: 0.833 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	6.277ArgAla: 6.277 ± 0.085	0.409ArgCys: 0.409 ± 0.019	5.404ArgAsp: 5.404 ± 0.074	7.079ArgGlu: 7.079 ± 0.104	2.308ArgPhe: 2.308 ± 0.043	4.752ArgGly: 4.752 ± 0.075	1.273ArgHis: 1.273 ± 0.034	2.76ArgIle: 2.76 ± 0.055	1.713ArgLys: 1.713 ± 0.035	5.728ArgLeu: 5.728 ± 0.079	1.252ArgMet: 1.252 ± 0.03	1.934ArgAsn: 1.934 ± 0.048	2.745ArgPro: 2.745 ± 0.059	1.778ArgGln: 1.778 ± 0.041	5.279ArgArg: 5.279 ± 0.082	3.63ArgSer: 3.63 ± 0.059	4.443ArgThr: 4.443 ± 0.074	5.603ArgVal: 5.603 ± 0.074	0.884ArgTrp: 0.884 ± 0.032	1.847ArgTyr: 1.847 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.242SerAla: 6.242 ± 0.089	0.32SerCys: 0.32 ± 0.018	4.866SerAsp: 4.866 ± 0.074	4.719SerGlu: 4.719 ± 0.073	1.992SerPhe: 1.992 ± 0.048	5.959SerGly: 5.959 ± 0.087	1.028SerHis: 1.028 ± 0.031	2.089SerIle: 2.089 ± 0.046	1.421SerLys: 1.421 ± 0.035	4.974SerLeu: 4.974 ± 0.067	1.086SerMet: 1.086 ± 0.03	1.616SerAsn: 1.616 ± 0.042	2.805SerPro: 2.805 ± 0.055	1.483SerGln: 1.483 ± 0.039	3.232SerArg: 3.232 ± 0.053	3.484SerSer: 3.484 ± 0.074	3.324SerThr: 3.324 ± 0.057	5.659SerVal: 5.659 ± 0.086	0.706SerTrp: 0.706 ± 0.029	1.461SerTyr: 1.461 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.971ThrAla: 6.971 ± 0.095	0.347ThrCys: 0.347 ± 0.019	5.998ThrAsp: 5.998 ± 0.079	5.075ThrGlu: 5.075 ± 0.084	2.301ThrPhe: 2.301 ± 0.047	5.916ThrGly: 5.916 ± 0.075	1.145ThrHis: 1.145 ± 0.033	2.362ThrIle: 2.362 ± 0.044	1.255ThrLys: 1.255 ± 0.035	5.468ThrLeu: 5.468 ± 0.082	1.021ThrMet: 1.021 ± 0.031	1.592ThrAsn: 1.592 ± 0.044	3.297ThrPro: 3.297 ± 0.051	1.409ThrGln: 1.409 ± 0.039	3.366ThrArg: 3.366 ± 0.066	3.123ThrSer: 3.123 ± 0.065	5.117ThrThr: 5.117 ± 0.17	7.085ThrVal: 7.085 ± 0.106	0.654ThrTrp: 0.654 ± 0.027	1.865ThrTyr: 1.865 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	10.976ValAla: 10.976 ± 0.135	0.625ValCys: 0.625 ± 0.024	5.493ValAsp: 5.493 ± 0.084	9.14ValGlu: 9.14 ± 0.099	3.053ValPhe: 3.053 ± 0.058	8.631ValGly: 8.631 ± 0.119	1.65ValHis: 1.65 ± 0.041	2.402ValIle: 2.402 ± 0.05	1.633ValLys: 1.633 ± 0.042	8.01ValLeu: 8.01 ± 0.113	1.354ValMet: 1.354 ± 0.033	2.276ValAsn: 2.276 ± 0.051	4.196ValPro: 4.196 ± 0.063	2.062ValGln: 2.062 ± 0.051	6.044ValArg: 6.044 ± 0.076	5.895ValSer: 5.895 ± 0.089	6.559ValThr: 6.559 ± 0.101	9.843ValVal: 9.843 ± 0.131	0.919ValTrp: 0.919 ± 0.027	2.295ValTyr: 2.295 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.963TrpAla: 0.963 ± 0.03	0.088TrpCys: 0.088 ± 0.008	0.805TrpAsp: 0.805 ± 0.028	0.853TrpGlu: 0.853 ± 0.031	0.524TrpPhe: 0.524 ± 0.021	0.863TrpGly: 0.863 ± 0.028	0.238TrpHis: 0.238 ± 0.014	0.386TrpIle: 0.386 ± 0.016	0.333TrpLys: 0.333 ± 0.018	1.225TrpLeu: 1.225 ± 0.034	0.225TrpMet: 0.225 ± 0.015	0.402TrpAsn: 0.402 ± 0.016	0.455TrpPro: 0.455 ± 0.023	0.412TrpGln: 0.412 ± 0.017	0.904TrpArg: 0.904 ± 0.027	0.737TrpSer: 0.737 ± 0.025	0.892TrpThr: 0.892 ± 0.03	0.948TrpVal: 0.948 ± 0.032	0.2TrpTrp: 0.2 ± 0.013	0.402TrpTyr: 0.402 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.85TyrAla: 2.85 ± 0.049	0.238TyrCys: 0.238 ± 0.014	2.744TyrAsp: 2.744 ± 0.055	2.527TyrGlu: 2.527 ± 0.055	0.909TyrPhe: 0.909 ± 0.034	2.408TyrGly: 2.408 ± 0.048	0.643TyrHis: 0.643 ± 0.023	0.602TyrIle: 0.602 ± 0.026	0.469TyrLys: 0.469 ± 0.02	2.581TyrLeu: 2.581 ± 0.054	0.359TyrMet: 0.359 ± 0.018	0.722TyrAsn: 0.722 ± 0.027	1.284TyrPro: 1.284 ± 0.033	0.688TyrGln: 0.688 ± 0.022	2.064TyrArg: 2.064 ± 0.042	1.326TyrSer: 1.326 ± 0.035	1.44TyrThr: 1.44 ± 0.039	2.507TyrVal: 2.507 ± 0.052	0.391TyrTrp: 0.391 ± 0.018	0.932TyrTyr: 0.932 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4072 proteins (1157722 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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