Amino acid dipepetide frequency for Pseudomonas taeanensis MS-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.209AlaAla: 13.209 ± 0.127
1.324AlaCys: 1.324 ± 0.031
5.757AlaAsp: 5.757 ± 0.068
7.924AlaGlu: 7.924 ± 0.083
3.86AlaPhe: 3.86 ± 0.057
9.065AlaGly: 9.065 ± 0.077
2.269AlaHis: 2.269 ± 0.04
5.254AlaIle: 5.254 ± 0.065
3.802AlaLys: 3.802 ± 0.058
14.129AlaLeu: 14.129 ± 0.138
2.897AlaMet: 2.897 ± 0.052
2.901AlaAsn: 2.901 ± 0.049
4.523AlaPro: 4.523 ± 0.061
5.463AlaGln: 5.463 ± 0.072
6.847AlaArg: 6.847 ± 0.078
6.282AlaSer: 6.282 ± 0.064
4.673AlaThr: 4.673 ± 0.065
7.472AlaVal: 7.472 ± 0.066
1.631AlaTrp: 1.631 ± 0.037
2.642AlaTyr: 2.642 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.208CysAla: 1.208 ± 0.03
0.16CysCys: 0.16 ± 0.009
0.549CysAsp: 0.549 ± 0.023
0.609CysGlu: 0.609 ± 0.021
0.353CysPhe: 0.353 ± 0.017
1.028CysGly: 1.028 ± 0.03
0.324CysHis: 0.324 ± 0.016
0.458CysIle: 0.458 ± 0.019
0.291CysLys: 0.291 ± 0.015
1.193CysLeu: 1.193 ± 0.03
0.215CysMet: 0.215 ± 0.012
0.299CysAsn: 0.299 ± 0.015
0.562CysPro: 0.562 ± 0.02
0.461CysGln: 0.461 ± 0.017
0.665CysArg: 0.665 ± 0.023
0.621CysSer: 0.621 ± 0.02
0.474CysThr: 0.474 ± 0.019
0.71CysVal: 0.71 ± 0.024
0.162CysTrp: 0.162 ± 0.011
0.28CysTyr: 0.28 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
5.579AspAla: 5.579 ± 0.065
0.586AspCys: 0.586 ± 0.021
2.737AspAsp: 2.737 ± 0.053
3.497AspGlu: 3.497 ± 0.054
2.09AspPhe: 2.09 ± 0.038
4.303AspGly: 4.303 ± 0.057
1.041AspHis: 1.041 ± 0.03
2.53AspIle: 2.53 ± 0.043
1.875AspLys: 1.875 ± 0.04
5.81AspLeu: 5.81 ± 0.065
1.188AspMet: 1.188 ± 0.034
1.501AspAsn: 1.501 ± 0.033
2.685AspPro: 2.685 ± 0.044
2.181AspGln: 2.181 ± 0.039
2.847AspArg: 2.847 ± 0.042
3.184AspSer: 3.184 ± 0.048
2.198AspThr: 2.198 ± 0.04
3.253AspVal: 3.253 ± 0.051
1.008AspTrp: 1.008 ± 0.031
1.724AspTyr: 1.724 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
6.598GluAla: 6.598 ± 0.076
0.465GluCys: 0.465 ± 0.017
2.55GluAsp: 2.55 ± 0.044
3.192GluGlu: 3.192 ± 0.055
1.936GluPhe: 1.936 ± 0.043
3.887GluGly: 3.887 ± 0.052
1.698GluHis: 1.698 ± 0.04
2.81GluIle: 2.81 ± 0.047
1.966GluLys: 1.966 ± 0.041
7.87GluLeu: 7.87 ± 0.09
1.338GluMet: 1.338 ± 0.031
1.408GluAsn: 1.408 ± 0.033
2.462GluPro: 2.462 ± 0.04
4.374GluGln: 4.374 ± 0.06
5.011GluArg: 5.011 ± 0.061
2.787GluSer: 2.787 ± 0.045
2.539GluThr: 2.539 ± 0.043
4.555GluVal: 4.555 ± 0.058
0.722GluTrp: 0.722 ± 0.026
1.229GluTyr: 1.229 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.28PheAla: 4.28 ± 0.06
0.432PheCys: 0.432 ± 0.017
2.459PheAsp: 2.459 ± 0.044
2.089PheGlu: 2.089 ± 0.035
1.455PhePhe: 1.455 ± 0.04
3.213PheGly: 3.213 ± 0.052
0.731PheHis: 0.731 ± 0.024
1.873PheIle: 1.873 ± 0.041
1.237PheLys: 1.237 ± 0.032
3.321PheLeu: 3.321 ± 0.051
0.799PheMet: 0.799 ± 0.026
1.346PheAsn: 1.346 ± 0.032
1.44PhePro: 1.44 ± 0.032
1.256PheGln: 1.256 ± 0.029
1.897PheArg: 1.897 ± 0.036
2.602PheSer: 2.602 ± 0.046
1.763PheThr: 1.763 ± 0.033
2.531PheVal: 2.531 ± 0.046
0.559PheTrp: 0.559 ± 0.022
1.066PheTyr: 1.066 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
7.346GlyAla: 7.346 ± 0.07
1.001GlyCys: 1.001 ± 0.029
3.793GlyAsp: 3.793 ± 0.054
4.99GlyGlu: 4.99 ± 0.069
3.316GlyPhe: 3.316 ± 0.049
6.053GlyGly: 6.053 ± 0.081
1.883GlyHis: 1.883 ± 0.036
4.161GlyIle: 4.161 ± 0.063
3.296GlyLys: 3.296 ± 0.05
9.566GlyLeu: 9.566 ± 0.091
2.208GlyMet: 2.208 ± 0.04
2.246GlyAsn: 2.246 ± 0.042
2.585GlyPro: 2.585 ± 0.043
3.793GlyGln: 3.793 ± 0.051
4.842GlyArg: 4.842 ± 0.064
4.585GlySer: 4.585 ± 0.053
3.447GlyThr: 3.447 ± 0.058
5.939GlyVal: 5.939 ± 0.066
1.295GlyTrp: 1.295 ± 0.03
2.48GlyTyr: 2.48 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.335HisAla: 2.335 ± 0.039
0.395HisCys: 0.395 ± 0.016
1.182HisAsp: 1.182 ± 0.03
1.243HisGlu: 1.243 ± 0.029
1.004HisPhe: 1.004 ± 0.026
1.98HisGly: 1.98 ± 0.041
0.624HisHis: 0.624 ± 0.026
1.042HisIle: 1.042 ± 0.024
0.71HisLys: 0.71 ± 0.021
2.64HisLeu: 2.64 ± 0.048
0.494HisMet: 0.494 ± 0.019
0.705HisAsn: 0.705 ± 0.019
1.408HisPro: 1.408 ± 0.031
1.006HisGln: 1.006 ± 0.027
1.39HisArg: 1.39 ± 0.03
1.405HisSer: 1.405 ± 0.036
0.941HisThr: 0.941 ± 0.028
1.3HisVal: 1.3 ± 0.025
0.471HisTrp: 0.471 ± 0.02
0.792HisTyr: 0.792 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.887IleAla: 5.887 ± 0.068
0.55IleCys: 0.55 ± 0.019
3.242IleAsp: 3.242 ± 0.048
3.43IleGlu: 3.43 ± 0.05
1.467IlePhe: 1.467 ± 0.036
4.444IleGly: 4.444 ± 0.06
0.975IleHis: 0.975 ± 0.027
2.078IleIle: 2.078 ± 0.04
1.719IleLys: 1.719 ± 0.034
4.245IleLeu: 4.245 ± 0.058
0.812IleMet: 0.812 ± 0.029
1.697IleAsn: 1.697 ± 0.034
2.224IlePro: 2.224 ± 0.039
1.709IleGln: 1.709 ± 0.036
2.897IleArg: 2.897 ± 0.045
2.978IleSer: 2.978 ± 0.048
2.358IleThr: 2.358 ± 0.042
3.057IleVal: 3.057 ± 0.052
0.492IleTrp: 0.492 ± 0.02
1.151IleTyr: 1.151 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
3.837LysAla: 3.837 ± 0.061
0.198LysCys: 0.198 ± 0.012
1.631LysAsp: 1.631 ± 0.037
1.574LysGlu: 1.574 ± 0.035
0.871LysPhe: 0.871 ± 0.022
2.499LysGly: 2.499 ± 0.05
0.807LysHis: 0.807 ± 0.021
1.551LysIle: 1.551 ± 0.036
1.206LysLys: 1.206 ± 0.036
3.879LysLeu: 3.879 ± 0.056
0.696LysMet: 0.696 ± 0.025
0.973LysAsn: 0.973 ± 0.026
1.973LysPro: 1.973 ± 0.044
1.663LysGln: 1.663 ± 0.034
2.377LysArg: 2.377 ± 0.038
1.769LysSer: 1.769 ± 0.038
1.75LysThr: 1.75 ± 0.038
2.647LysVal: 2.647 ± 0.048
0.313LysTrp: 0.313 ± 0.014
0.703LysTyr: 0.703 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
15.0LeuAla: 15.0 ± 0.128
1.32LeuCys: 1.32 ± 0.03
6.869LeuAsp: 6.869 ± 0.076
6.82LeuGlu: 6.82 ± 0.074
4.335LeuPhe: 4.335 ± 0.066
9.543LeuGly: 9.543 ± 0.101
2.689LeuHis: 2.689 ± 0.048
5.81LeuIle: 5.81 ± 0.073
4.286LeuLys: 4.286 ± 0.057
15.07LeuLeu: 15.07 ± 0.178
2.578LeuMet: 2.578 ± 0.046
3.745LeuAsn: 3.745 ± 0.051
6.452LeuPro: 6.452 ± 0.087
5.254LeuGln: 5.254 ± 0.078
7.625LeuArg: 7.625 ± 0.089
7.861LeuSer: 7.861 ± 0.082
5.643LeuThr: 5.643 ± 0.071
7.794LeuVal: 7.794 ± 0.082
1.458LeuTrp: 1.458 ± 0.037
2.666LeuTyr: 2.666 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.666MetAla: 2.666 ± 0.047
0.17MetCys: 0.17 ± 0.011
1.004MetAsp: 1.004 ± 0.023
0.906MetGlu: 0.906 ± 0.029
0.631MetPhe: 0.631 ± 0.022
1.661MetGly: 1.661 ± 0.037
0.546MetHis: 0.546 ± 0.019
1.087MetIle: 1.087 ± 0.028
0.803MetLys: 0.803 ± 0.025
2.798MetLeu: 2.798 ± 0.051
0.482MetMet: 0.482 ± 0.02
0.802MetAsn: 0.802 ± 0.023
1.37MetPro: 1.37 ± 0.03
1.166MetGln: 1.166 ± 0.026
1.545MetArg: 1.545 ± 0.033
1.761MetSer: 1.761 ± 0.03
1.388MetThr: 1.388 ± 0.032
1.519MetVal: 1.519 ± 0.034
0.184MetTrp: 0.184 ± 0.011
0.347MetTyr: 0.347 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.018AsnAla: 3.018 ± 0.047
0.34AsnCys: 0.34 ± 0.017
1.414AsnAsp: 1.414 ± 0.036
1.428AsnGlu: 1.428 ± 0.03
1.029AsnPhe: 1.029 ± 0.028
2.375AsnGly: 2.375 ± 0.045
0.617AsnHis: 0.617 ± 0.02
1.403AsnIle: 1.403 ± 0.037
0.92AsnLys: 0.92 ± 0.024
3.559AsnLeu: 3.559 ± 0.05
0.595AsnMet: 0.595 ± 0.022
0.9AsnAsn: 0.9 ± 0.028
1.934AsnPro: 1.934 ± 0.037
1.375AsnGln: 1.375 ± 0.033
1.838AsnArg: 1.838 ± 0.036
1.638AsnSer: 1.638 ± 0.037
1.337AsnThr: 1.337 ± 0.034
1.78AsnVal: 1.78 ± 0.035
0.479AsnTrp: 0.479 ± 0.019
0.787AsnTyr: 0.787 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
5.51ProAla: 5.51 ± 0.067
0.407ProCys: 0.407 ± 0.019
2.59ProAsp: 2.59 ± 0.038
3.261ProGlu: 3.261 ± 0.047
1.79ProPhe: 1.79 ± 0.032
3.825ProGly: 3.825 ± 0.045
1.079ProHis: 1.079 ± 0.028
2.04ProIle: 2.04 ± 0.037
1.441ProLys: 1.441 ± 0.034
6.02ProLeu: 6.02 ± 0.078
1.16ProMet: 1.16 ± 0.026
1.301ProAsn: 1.301 ± 0.031
1.89ProPro: 1.89 ± 0.044
2.407ProGln: 2.407 ± 0.041
2.592ProArg: 2.592 ± 0.054
2.689ProSer: 2.689 ± 0.039
2.145ProThr: 2.145 ± 0.036
3.56ProVal: 3.56 ± 0.048
0.754ProTrp: 0.754 ± 0.022
1.183ProTyr: 1.183 ± 0.03
0.001ProXaa: 0.001 ± 0.001
Gln
6.492GlnAla: 6.492 ± 0.079
0.363GlnCys: 0.363 ± 0.016
1.95GlnAsp: 1.95 ± 0.034
2.14GlnGlu: 2.14 ± 0.042
1.448GlnPhe: 1.448 ± 0.03
3.665GlnGly: 3.665 ± 0.052
1.304GlnHis: 1.304 ± 0.032
2.132GlnIle: 2.132 ± 0.03
1.132GlnLys: 1.132 ± 0.029
6.345GlnLeu: 6.345 ± 0.084
1.041GlnMet: 1.041 ± 0.028
1.023GlnAsn: 1.023 ± 0.032
2.647GlnPro: 2.647 ± 0.046
3.255GlnGln: 3.255 ± 0.063
4.083GlnArg: 4.083 ± 0.069
2.344GlnSer: 2.344 ± 0.045
1.932GlnThr: 1.932 ± 0.041
3.849GlnVal: 3.849 ± 0.05
0.663GlnTrp: 0.663 ± 0.023
0.94GlnTyr: 0.94 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
6.219ArgAla: 6.219 ± 0.067
0.608ArgCys: 0.608 ± 0.021
3.379ArgAsp: 3.379 ± 0.048
4.391ArgGlu: 4.391 ± 0.06
2.749ArgPhe: 2.749 ± 0.045
4.087ArgGly: 4.087 ± 0.053
1.687ArgHis: 1.687 ± 0.034
3.27ArgIle: 3.27 ± 0.041
1.955ArgLys: 1.955 ± 0.039
8.743ArgLeu: 8.743 ± 0.109
1.619ArgMet: 1.619 ± 0.037
1.865ArgAsn: 1.865 ± 0.038
2.694ArgPro: 2.694 ± 0.043
3.564ArgGln: 3.564 ± 0.053
4.248ArgArg: 4.248 ± 0.06
3.478ArgSer: 3.478 ± 0.058
2.533ArgThr: 2.533 ± 0.04
4.56ArgVal: 4.56 ± 0.061
1.021ArgTrp: 1.021 ± 0.027
1.99ArgTyr: 1.99 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.38SerAla: 6.38 ± 0.063
0.562SerCys: 0.562 ± 0.018
2.878SerAsp: 2.878 ± 0.041
3.317SerGlu: 3.317 ± 0.049
2.241SerPhe: 2.241 ± 0.042
5.286SerGly: 5.286 ± 0.063
1.406SerHis: 1.406 ± 0.03
2.738SerIle: 2.738 ± 0.041
1.826SerLys: 1.826 ± 0.042
7.485SerLeu: 7.485 ± 0.08
1.396SerMet: 1.396 ± 0.03
1.815SerAsn: 1.815 ± 0.037
2.612SerPro: 2.612 ± 0.042
2.608SerGln: 2.608 ± 0.046
3.627SerArg: 3.627 ± 0.052
3.586SerSer: 3.586 ± 0.052
2.718SerThr: 2.718 ± 0.043
3.89SerVal: 3.89 ± 0.053
0.871SerTrp: 0.871 ± 0.023
1.425SerTyr: 1.425 ± 0.031
0.002SerXaa: 0.002 ± 0.001
Thr
4.944ThrAla: 4.944 ± 0.062
0.467ThrCys: 0.467 ± 0.019
2.128ThrAsp: 2.128 ± 0.037
2.314ThrGlu: 2.314 ± 0.037
1.67ThrPhe: 1.67 ± 0.035
3.792ThrGly: 3.792 ± 0.056
1.005ThrHis: 1.005 ± 0.027
1.88ThrIle: 1.88 ± 0.036
1.039ThrLys: 1.039 ± 0.032
6.409ThrLeu: 6.409 ± 0.076
0.793ThrMet: 0.793 ± 0.024
1.108ThrAsn: 1.108 ± 0.028
2.955ThrPro: 2.955 ± 0.05
2.003ThrGln: 2.003 ± 0.039
2.923ThrArg: 2.923 ± 0.042
2.581ThrSer: 2.581 ± 0.042
2.193ThrThr: 2.193 ± 0.043
3.12ThrVal: 3.12 ± 0.045
0.658ThrTrp: 0.658 ± 0.024
1.089ThrTyr: 1.089 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
7.678ValAla: 7.678 ± 0.087
0.767ValCys: 0.767 ± 0.023
3.814ValAsp: 3.814 ± 0.048
4.584ValGlu: 4.584 ± 0.058
2.56ValPhe: 2.56 ± 0.045
5.15ValGly: 5.15 ± 0.057
1.378ValHis: 1.378 ± 0.037
3.694ValIle: 3.694 ± 0.045
2.282ValLys: 2.282 ± 0.046
8.184ValLeu: 8.184 ± 0.092
1.718ValMet: 1.718 ± 0.035
2.042ValAsn: 2.042 ± 0.041
3.184ValPro: 3.184 ± 0.052
2.774ValGln: 2.774 ± 0.046
4.285ValArg: 4.285 ± 0.054
4.167ValSer: 4.167 ± 0.057
3.362ValThr: 3.362 ± 0.053
5.137ValVal: 5.137 ± 0.063
0.827ValTrp: 0.827 ± 0.023
1.551ValTyr: 1.551 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.21TrpAla: 1.21 ± 0.03
0.17TrpCys: 0.17 ± 0.011
0.613TrpAsp: 0.613 ± 0.02
0.546TrpGlu: 0.546 ± 0.018
0.557TrpPhe: 0.557 ± 0.02
0.901TrpGly: 0.901 ± 0.029
0.403TrpHis: 0.403 ± 0.017
0.604TrpIle: 0.604 ± 0.023
0.403TrpLys: 0.403 ± 0.016
2.333TrpLeu: 2.333 ± 0.049
0.352TrpMet: 0.352 ± 0.016
0.413TrpAsn: 0.413 ± 0.016
0.669TrpPro: 0.669 ± 0.022
1.028TrpGln: 1.028 ± 0.029
1.125TrpArg: 1.125 ± 0.033
0.787TrpSer: 0.787 ± 0.023
0.581TrpThr: 0.581 ± 0.022
0.932TrpVal: 0.932 ± 0.026
0.222TrpTrp: 0.222 ± 0.013
0.351TrpTyr: 0.351 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.529TyrAla: 2.529 ± 0.041
0.338TyrCys: 0.338 ± 0.015
1.278TyrAsp: 1.278 ± 0.03
1.142TyrGlu: 1.142 ± 0.025
0.988TyrPhe: 0.988 ± 0.026
2.066TyrGly: 2.066 ± 0.04
0.599TyrHis: 0.599 ± 0.02
1.0TyrIle: 1.0 ± 0.026
0.729TyrLys: 0.729 ± 0.022
3.219TyrLeu: 3.219 ± 0.05
0.455TyrMet: 0.455 ± 0.018
0.677TyrAsn: 0.677 ± 0.022
1.372TyrPro: 1.372 ± 0.031
1.405TyrGln: 1.405 ± 0.029
1.997TyrArg: 1.997 ± 0.039
1.563TyrSer: 1.563 ± 0.034
1.095TyrThr: 1.095 ± 0.027
1.532TyrVal: 1.532 ± 0.029
0.413TyrTrp: 0.413 ± 0.018
0.733TyrTyr: 0.733 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.001XaaCys: 0.001 ± 0.001
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.001
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4573 proteins (1480677 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski