Amino acid dipepetide frequency for Streptomyces wuyuanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.258AlaAla: 22.258 ± 0.165	1.059AlaCys: 1.059 ± 0.024	8.104AlaAsp: 8.104 ± 0.063	9.044AlaGlu: 9.044 ± 0.098	3.505AlaPhe: 3.505 ± 0.039	13.957AlaGly: 13.957 ± 0.112	2.806AlaHis: 2.806 ± 0.04	3.31AlaIle: 3.31 ± 0.049	2.783AlaLys: 2.783 ± 0.051	14.29AlaLeu: 14.29 ± 0.118	2.553AlaMet: 2.553 ± 0.03	1.9AlaAsn: 1.9 ± 0.034	7.55AlaPro: 7.55 ± 0.07	3.533AlaGln: 3.533 ± 0.045	10.777AlaArg: 10.777 ± 0.091	5.985AlaSer: 5.985 ± 0.056	6.781AlaThr: 6.781 ± 0.06	12.85AlaVal: 12.85 ± 0.102	1.851AlaTrp: 1.851 ± 0.029	2.644AlaTyr: 2.644 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.116CysAla: 1.116 ± 0.025	0.1CysCys: 0.1 ± 0.007	0.475CysAsp: 0.475 ± 0.014	0.415CysGlu: 0.415 ± 0.014	0.224CysPhe: 0.224 ± 0.01	0.982CysGly: 0.982 ± 0.023	0.192CysHis: 0.192 ± 0.01	0.188CysIle: 0.188 ± 0.01	0.112CysLys: 0.112 ± 0.007	0.751CysLeu: 0.751 ± 0.018	0.127CysMet: 0.127 ± 0.006	0.13CysAsn: 0.13 ± 0.008	0.533CysPro: 0.533 ± 0.018	0.154CysGln: 0.154 ± 0.009	0.652CysArg: 0.652 ± 0.015	0.444CysSer: 0.444 ± 0.016	0.54CysThr: 0.54 ± 0.015	0.618CysVal: 0.618 ± 0.017	0.116CysTrp: 0.116 ± 0.007	0.147CysTyr: 0.147 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.676AspAla: 7.676 ± 0.071	0.433AspCys: 0.433 ± 0.014	3.584AspAsp: 3.584 ± 0.051	4.044AspGlu: 4.044 ± 0.044	1.632AspPhe: 1.632 ± 0.024	6.629AspGly: 6.629 ± 0.062	1.374AspHis: 1.374 ± 0.025	1.812AspIle: 1.812 ± 0.031	1.164AspLys: 1.164 ± 0.032	5.953AspLeu: 5.953 ± 0.057	0.809AspMet: 0.809 ± 0.016	0.924AspAsn: 0.924 ± 0.019	4.485AspPro: 4.485 ± 0.05	1.389AspGln: 1.389 ± 0.025	5.204AspArg: 5.204 ± 0.055	2.473AspSer: 2.473 ± 0.036	3.044AspThr: 3.044 ± 0.036	4.69AspVal: 4.69 ± 0.044	0.994AspTrp: 0.994 ± 0.024	1.049AspTyr: 1.049 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.629GluAla: 7.629 ± 0.08	0.393GluCys: 0.393 ± 0.013	3.031GluAsp: 3.031 ± 0.045	3.774GluGlu: 3.774 ± 0.053	1.434GluPhe: 1.434 ± 0.027	4.592GluGly: 4.592 ± 0.049	1.506GluHis: 1.506 ± 0.029	2.21GluIle: 2.21 ± 0.034	1.452GluLys: 1.452 ± 0.033	6.879GluLeu: 6.879 ± 0.071	0.876GluMet: 0.876 ± 0.019	1.011GluAsn: 1.011 ± 0.023	3.615GluPro: 3.615 ± 0.046	2.209GluGln: 2.209 ± 0.037	5.828GluArg: 5.828 ± 0.053	2.722GluSer: 2.722 ± 0.037	2.95GluThr: 2.95 ± 0.036	4.394GluVal: 4.394 ± 0.05	0.801GluTrp: 0.801 ± 0.017	1.117GluTyr: 1.117 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.688PheAla: 3.688 ± 0.044	0.263PheCys: 0.263 ± 0.011	1.891PheAsp: 1.891 ± 0.03	1.414PheGlu: 1.414 ± 0.024	0.868PhePhe: 0.868 ± 0.023	2.959PheGly: 2.959 ± 0.039	0.603PheHis: 0.603 ± 0.017	0.697PheIle: 0.697 ± 0.018	0.47PheLys: 0.47 ± 0.015	2.543PheLeu: 2.543 ± 0.04	0.389PheMet: 0.389 ± 0.014	0.543PheAsn: 0.543 ± 0.015	1.426PhePro: 1.426 ± 0.024	0.593PheGln: 0.593 ± 0.014	1.873PheArg: 1.873 ± 0.025	1.412PheSer: 1.412 ± 0.026	1.98PheThr: 1.98 ± 0.035	2.2PheVal: 2.2 ± 0.035	0.421PheTrp: 0.421 ± 0.016	0.506PheTyr: 0.506 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.718GlyAla: 11.718 ± 0.093	0.855GlyCys: 0.855 ± 0.022	5.404GlyAsp: 5.404 ± 0.051	5.428GlyGlu: 5.428 ± 0.045	2.826GlyPhe: 2.826 ± 0.04	9.402GlyGly: 9.402 ± 0.095	2.41GlyHis: 2.41 ± 0.037	3.432GlyIle: 3.432 ± 0.04	2.414GlyLys: 2.414 ± 0.037	9.542GlyLeu: 9.542 ± 0.085	1.988GlyMet: 1.988 ± 0.029	1.783GlyAsn: 1.783 ± 0.03	5.788GlyPro: 5.788 ± 0.064	2.503GlyGln: 2.503 ± 0.038	8.556GlyArg: 8.556 ± 0.07	5.541GlySer: 5.541 ± 0.061	6.664GlyThr: 6.664 ± 0.07	7.48GlyVal: 7.48 ± 0.059	1.697GlyTrp: 1.697 ± 0.03	2.18GlyTyr: 2.18 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.692HisAla: 2.692 ± 0.041	0.224HisCys: 0.224 ± 0.011	1.42HisAsp: 1.42 ± 0.027	1.264HisGlu: 1.264 ± 0.024	0.597HisPhe: 0.597 ± 0.017	2.586HisGly: 2.586 ± 0.034	0.686HisHis: 0.686 ± 0.018	0.675HisIle: 0.675 ± 0.017	0.368HisLys: 0.368 ± 0.013	2.251HisLeu: 2.251 ± 0.034	0.34HisMet: 0.34 ± 0.012	0.35HisAsn: 0.35 ± 0.013	1.738HisPro: 1.738 ± 0.03	0.594HisGln: 0.594 ± 0.018	2.154HisArg: 2.154 ± 0.032	1.046HisSer: 1.046 ± 0.022	1.33HisThr: 1.33 ± 0.026	1.657HisVal: 1.657 ± 0.029	0.373HisTrp: 0.373 ± 0.013	0.467HisTyr: 0.467 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.696IleAla: 4.696 ± 0.057	0.308IleCys: 0.308 ± 0.011	2.103IleAsp: 2.103 ± 0.039	1.997IleGlu: 1.997 ± 0.029	0.667IlePhe: 0.667 ± 0.018	3.553IleGly: 3.553 ± 0.049	0.602IleHis: 0.602 ± 0.017	0.767IleIle: 0.767 ± 0.02	0.676IleLys: 0.676 ± 0.02	2.261IleLeu: 2.261 ± 0.033	0.451IleMet: 0.451 ± 0.015	0.64IleAsn: 0.64 ± 0.019	1.711IlePro: 1.711 ± 0.028	0.662IleGln: 0.662 ± 0.019	2.24IleArg: 2.24 ± 0.032	1.543IleSer: 1.543 ± 0.026	2.156IleThr: 2.156 ± 0.029	2.707IleVal: 2.707 ± 0.036	0.35IleTrp: 0.35 ± 0.014	0.483IleTyr: 0.483 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.889LysAla: 2.889 ± 0.049	0.123LysCys: 0.123 ± 0.007	1.325LysAsp: 1.325 ± 0.03	1.225LysGlu: 1.225 ± 0.027	0.437LysPhe: 0.437 ± 0.015	1.846LysGly: 1.846 ± 0.035	0.431LysHis: 0.431 ± 0.016	0.819LysIle: 0.819 ± 0.02	0.796LysLys: 0.796 ± 0.032	1.944LysLeu: 1.944 ± 0.036	0.355LysMet: 0.355 ± 0.012	0.498LysAsn: 0.498 ± 0.016	1.337LysPro: 1.337 ± 0.029	0.675LysGln: 0.675 ± 0.02	1.472LysArg: 1.472 ± 0.026	1.109LysSer: 1.109 ± 0.027	1.223LysThr: 1.223 ± 0.032	1.809LysVal: 1.809 ± 0.034	0.264LysTrp: 0.264 ± 0.01	0.419LysTyr: 0.419 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.765LeuAla: 14.765 ± 0.107	0.844LeuCys: 0.844 ± 0.022	6.481LeuAsp: 6.481 ± 0.053	4.838LeuGlu: 4.838 ± 0.058	2.542LeuPhe: 2.542 ± 0.036	9.32LeuGly: 9.32 ± 0.067	2.301LeuHis: 2.301 ± 0.037	3.103LeuIle: 3.103 ± 0.045	1.922LeuLys: 1.922 ± 0.036	11.208LeuLeu: 11.208 ± 0.106	1.639LeuMet: 1.639 ± 0.026	1.629LeuAsn: 1.629 ± 0.028	6.447LeuPro: 6.447 ± 0.062	2.083LeuGln: 2.083 ± 0.03	8.785LeuArg: 8.785 ± 0.082	5.117LeuSer: 5.117 ± 0.053	6.571LeuThr: 6.571 ± 0.057	8.85LeuVal: 8.85 ± 0.073	1.242LeuTrp: 1.242 ± 0.025	1.804LeuTyr: 1.804 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.281MetAla: 2.281 ± 0.034	0.144MetCys: 0.144 ± 0.007	0.88MetAsp: 0.88 ± 0.021	0.775MetGlu: 0.775 ± 0.019	0.453MetPhe: 0.453 ± 0.016	1.306MetGly: 1.306 ± 0.028	0.381MetHis: 0.381 ± 0.014	0.611MetIle: 0.611 ± 0.019	0.444MetLys: 0.444 ± 0.014	1.686MetLeu: 1.686 ± 0.025	0.284MetMet: 0.284 ± 0.011	0.446MetAsn: 0.446 ± 0.015	1.112MetPro: 1.112 ± 0.025	0.432MetGln: 0.432 ± 0.013	1.464MetArg: 1.464 ± 0.023	1.308MetSer: 1.308 ± 0.024	1.557MetThr: 1.557 ± 0.027	1.248MetVal: 1.248 ± 0.025	0.214MetTrp: 0.214 ± 0.011	0.301MetTyr: 0.301 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.239AsnAla: 2.239 ± 0.035	0.169AsnCys: 0.169 ± 0.009	0.962AsnAsp: 0.962 ± 0.019	0.799AsnGlu: 0.799 ± 0.018	0.46AsnPhe: 0.46 ± 0.015	1.897AsnGly: 1.897 ± 0.035	0.374AsnHis: 0.374 ± 0.013	0.604AsnIle: 0.604 ± 0.017	0.414AsnLys: 0.414 ± 0.017	1.586AsnLeu: 1.586 ± 0.034	0.289AsnMet: 0.289 ± 0.011	0.399AsnAsn: 0.399 ± 0.015	1.315AsnPro: 1.315 ± 0.026	0.451AsnGln: 0.451 ± 0.014	1.32AsnArg: 1.32 ± 0.028	0.859AsnSer: 0.859 ± 0.021	1.032AsnThr: 1.032 ± 0.029	1.32AsnVal: 1.32 ± 0.027	0.278AsnTrp: 0.278 ± 0.011	0.363AsnTyr: 0.363 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.165ProAla: 9.165 ± 0.089	0.348ProCys: 0.348 ± 0.014	4.474ProAsp: 4.474 ± 0.045	4.5ProGlu: 4.5 ± 0.05	1.536ProPhe: 1.536 ± 0.028	7.292ProGly: 7.292 ± 0.077	1.403ProHis: 1.403 ± 0.025	1.227ProIle: 1.227 ± 0.022	1.14ProLys: 1.14 ± 0.027	5.372ProLeu: 5.372 ± 0.052	1.008ProMet: 1.008 ± 0.023	0.872ProAsn: 0.872 ± 0.018	3.863ProPro: 3.863 ± 0.062	1.751ProGln: 1.751 ± 0.037	4.205ProArg: 4.205 ± 0.053	3.293ProSer: 3.293 ± 0.043	2.914ProThr: 2.914 ± 0.042	5.845ProVal: 5.845 ± 0.057	0.936ProTrp: 0.936 ± 0.02	1.393ProTyr: 1.393 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.483GlnAla: 3.483 ± 0.046	0.167GlnCys: 0.167 ± 0.009	1.332GlnAsp: 1.332 ± 0.023	1.394GlnGlu: 1.394 ± 0.025	0.631GlnPhe: 0.631 ± 0.019	2.188GlnGly: 2.188 ± 0.035	0.598GlnHis: 0.598 ± 0.017	1.042GlnIle: 1.042 ± 0.022	0.587GlnLys: 0.587 ± 0.02	2.899GlnLeu: 2.899 ± 0.038	0.467GlnMet: 0.467 ± 0.013	0.458GlnAsn: 0.458 ± 0.017	1.616GlnPro: 1.616 ± 0.037	1.129GlnGln: 1.129 ± 0.028	2.309GlnArg: 2.309 ± 0.038	1.237GlnSer: 1.237 ± 0.021	1.274GlnThr: 1.274 ± 0.025	2.209GlnVal: 2.209 ± 0.035	0.405GlnTrp: 0.405 ± 0.013	0.563GlnTyr: 0.563 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.25ArgAla: 10.25 ± 0.102	0.632ArgCys: 0.632 ± 0.017	4.515ArgAsp: 4.515 ± 0.049	4.952ArgGlu: 4.952 ± 0.058	2.353ArgPhe: 2.353 ± 0.034	6.268ArgGly: 6.268 ± 0.057	2.215ArgHis: 2.215 ± 0.034	3.371ArgIle: 3.371 ± 0.035	1.719ArgLys: 1.719 ± 0.033	9.045ArgLeu: 9.045 ± 0.071	1.792ArgMet: 1.792 ± 0.03	1.461ArgAsn: 1.461 ± 0.029	5.405ArgPro: 5.405 ± 0.062	2.248ArgGln: 2.248 ± 0.031	8.381ArgArg: 8.381 ± 0.085	4.291ArgSer: 4.291 ± 0.04	5.685ArgThr: 5.685 ± 0.055	5.876ArgVal: 5.876 ± 0.05	1.391ArgTrp: 1.391 ± 0.024	1.785ArgTyr: 1.785 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.881SerAla: 6.881 ± 0.051	0.449SerCys: 0.449 ± 0.017	2.606SerAsp: 2.606 ± 0.039	2.564SerGlu: 2.564 ± 0.038	1.494SerPhe: 1.494 ± 0.025	6.094SerGly: 6.094 ± 0.058	1.028SerHis: 1.028 ± 0.025	1.324SerIle: 1.324 ± 0.026	0.977SerLys: 0.977 ± 0.025	4.707SerLeu: 4.707 ± 0.046	1.072SerMet: 1.072 ± 0.019	0.793SerAsn: 0.793 ± 0.019	3.21SerPro: 3.21 ± 0.039	1.227SerGln: 1.227 ± 0.026	3.848SerArg: 3.848 ± 0.044	2.718SerSer: 2.718 ± 0.042	2.904SerThr: 2.904 ± 0.038	4.325SerVal: 4.325 ± 0.044	0.873SerTrp: 0.873 ± 0.021	1.143SerTyr: 1.143 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.097ThrAla: 9.097 ± 0.083	0.402ThrCys: 0.402 ± 0.012	3.529ThrAsp: 3.529 ± 0.042	3.225ThrGlu: 3.225 ± 0.041	1.543ThrPhe: 1.543 ± 0.025	6.956ThrGly: 6.956 ± 0.066	1.136ThrHis: 1.136 ± 0.023	1.685ThrIle: 1.685 ± 0.033	1.094ThrLys: 1.094 ± 0.029	5.392ThrLeu: 5.392 ± 0.05	0.958ThrMet: 0.958 ± 0.023	0.956ThrAsn: 0.956 ± 0.024	3.989ThrPro: 3.989 ± 0.046	1.25ThrGln: 1.25 ± 0.024	3.951ThrArg: 3.951 ± 0.043	3.047ThrSer: 3.047 ± 0.041	3.724ThrThr: 3.724 ± 0.056	5.958ThrVal: 5.958 ± 0.053	0.842ThrTrp: 0.842 ± 0.022	1.261ThrTyr: 1.261 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.702ValAla: 10.702 ± 0.088	0.765ValCys: 0.765 ± 0.017	4.963ValAsp: 4.963 ± 0.049	4.757ValGlu: 4.757 ± 0.052	2.407ValPhe: 2.407 ± 0.036	6.477ValGly: 6.477 ± 0.061	2.055ValHis: 2.055 ± 0.029	2.701ValIle: 2.701 ± 0.038	1.723ValLys: 1.723 ± 0.036	9.544ValLeu: 9.544 ± 0.088	1.411ValMet: 1.411 ± 0.029	1.591ValAsn: 1.591 ± 0.032	5.588ValPro: 5.588 ± 0.059	2.001ValGln: 2.001 ± 0.03	7.41ValArg: 7.41 ± 0.05	4.268ValSer: 4.268 ± 0.042	5.467ValThr: 5.467 ± 0.058	8.216ValVal: 8.216 ± 0.08	1.147ValTrp: 1.147 ± 0.024	1.577ValTyr: 1.577 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.653TrpAla: 1.653 ± 0.027	0.162TrpCys: 0.162 ± 0.007	0.823TrpAsp: 0.823 ± 0.018	0.728TrpGlu: 0.728 ± 0.018	0.512TrpPhe: 0.512 ± 0.014	1.038TrpGly: 1.038 ± 0.022	0.351TrpHis: 0.351 ± 0.012	0.534TrpIle: 0.534 ± 0.017	0.37TrpLys: 0.37 ± 0.013	1.689TrpLeu: 1.689 ± 0.03	0.275TrpMet: 0.275 ± 0.01	0.388TrpAsn: 0.388 ± 0.015	0.781TrpPro: 0.781 ± 0.02	0.584TrpGln: 0.584 ± 0.015	1.34TrpArg: 1.34 ± 0.024	0.917TrpSer: 0.917 ± 0.022	1.057TrpThr: 1.057 ± 0.027	0.944TrpVal: 0.944 ± 0.021	0.336TrpTrp: 0.336 ± 0.013	0.366TrpTyr: 0.366 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.66TyrAla: 2.66 ± 0.036	0.177TyrCys: 0.177 ± 0.009	1.462TyrAsp: 1.462 ± 0.035	1.288TyrGlu: 1.288 ± 0.026	0.618TyrPhe: 0.618 ± 0.016	2.267TyrGly: 2.267 ± 0.039	0.36TyrHis: 0.36 ± 0.013	0.463TyrIle: 0.463 ± 0.014	0.369TyrLys: 0.369 ± 0.015	1.95TyrLeu: 1.95 ± 0.03	0.241TyrMet: 0.241 ± 0.01	0.358TyrAsn: 0.358 ± 0.015	1.028TyrPro: 1.028 ± 0.021	0.521TyrGln: 0.521 ± 0.016	1.866TyrArg: 1.866 ± 0.035	0.907TyrSer: 0.907 ± 0.021	1.139TyrThr: 1.139 ± 0.025	1.574TyrVal: 1.574 ± 0.028	0.317TyrTrp: 0.317 ± 0.012	0.415TyrTyr: 0.415 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7164 proteins (2291314 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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