Amino acid dipepetide frequency for Parasedimentitalea marina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.1AlaAla: 14.1 ± 0.148
1.063AlaCys: 1.063 ± 0.03
6.529AlaAsp: 6.529 ± 0.07
6.974AlaGlu: 6.974 ± 0.082
3.936AlaPhe: 3.936 ± 0.053
9.477AlaGly: 9.477 ± 0.11
2.15AlaHis: 2.15 ± 0.039
5.687AlaIle: 5.687 ± 0.069
4.13AlaLys: 4.13 ± 0.068
12.454AlaLeu: 12.454 ± 0.1
3.466AlaMet: 3.466 ± 0.055
3.087AlaAsn: 3.087 ± 0.053
4.889AlaPro: 4.889 ± 0.066
4.531AlaGln: 4.531 ± 0.058
6.842AlaArg: 6.842 ± 0.077
5.967AlaSer: 5.967 ± 0.079
5.698AlaThr: 5.698 ± 0.061
7.842AlaVal: 7.842 ± 0.083
1.269AlaTrp: 1.269 ± 0.031
2.439AlaTyr: 2.439 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
1.049CysAla: 1.049 ± 0.029
0.122CysCys: 0.122 ± 0.01
0.678CysAsp: 0.678 ± 0.023
0.473CysGlu: 0.473 ± 0.019
0.368CysPhe: 0.368 ± 0.015
1.009CysGly: 1.009 ± 0.032
0.316CysHis: 0.316 ± 0.015
0.486CysIle: 0.486 ± 0.02
0.298CysLys: 0.298 ± 0.013
0.916CysLeu: 0.916 ± 0.03
0.203CysMet: 0.203 ± 0.012
0.292CysAsn: 0.292 ± 0.015
0.498CysPro: 0.498 ± 0.021
0.297CysGln: 0.297 ± 0.013
0.581CysArg: 0.581 ± 0.024
0.595CysSer: 0.595 ± 0.019
0.51CysThr: 0.51 ± 0.021
0.623CysVal: 0.623 ± 0.021
0.117CysTrp: 0.117 ± 0.01
0.267CysTyr: 0.267 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.35AspAla: 6.35 ± 0.068
0.571AspCys: 0.571 ± 0.019
3.328AspAsp: 3.328 ± 0.058
3.326AspGlu: 3.326 ± 0.058
2.436AspPhe: 2.436 ± 0.045
5.42AspGly: 5.42 ± 0.073
1.518AspHis: 1.518 ± 0.038
3.435AspIle: 3.435 ± 0.053
1.841AspLys: 1.841 ± 0.041
6.638AspLeu: 6.638 ± 0.07
1.755AspMet: 1.755 ± 0.033
1.544AspAsn: 1.544 ± 0.038
3.385AspPro: 3.385 ± 0.048
2.425AspGln: 2.425 ± 0.044
3.738AspArg: 3.738 ± 0.063
2.634AspSer: 2.634 ± 0.042
3.159AspThr: 3.159 ± 0.058
4.377AspVal: 4.377 ± 0.058
1.102AspTrp: 1.102 ± 0.028
1.562AspTyr: 1.562 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
6.604GluAla: 6.604 ± 0.082
0.412GluCys: 0.412 ± 0.016
3.142GluAsp: 3.142 ± 0.05
2.97GluGlu: 2.97 ± 0.051
1.993GluPhe: 1.993 ± 0.045
4.013GluGly: 4.013 ± 0.059
1.148GluHis: 1.148 ± 0.031
3.791GluIle: 3.791 ± 0.054
2.122GluLys: 2.122 ± 0.043
5.438GluLeu: 5.438 ± 0.067
1.826GluMet: 1.826 ± 0.036
1.979GluAsn: 1.979 ± 0.04
2.295GluPro: 2.295 ± 0.041
2.33GluGln: 2.33 ± 0.043
3.417GluArg: 3.417 ± 0.056
2.229GluSer: 2.229 ± 0.042
3.831GluThr: 3.831 ± 0.055
4.125GluVal: 4.125 ± 0.054
0.676GluTrp: 0.676 ± 0.021
1.155GluTyr: 1.155 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.272PheAla: 4.272 ± 0.059
0.473PheCys: 0.473 ± 0.019
2.922PheAsp: 2.922 ± 0.05
2.324PheGlu: 2.324 ± 0.042
1.49PhePhe: 1.49 ± 0.038
3.693PheGly: 3.693 ± 0.055
0.783PheHis: 0.783 ± 0.022
1.774PheIle: 1.774 ± 0.038
1.125PheLys: 1.125 ± 0.032
3.583PheLeu: 3.583 ± 0.05
0.942PheMet: 0.942 ± 0.026
1.249PheAsn: 1.249 ± 0.032
1.527PhePro: 1.527 ± 0.032
1.286PheGln: 1.286 ± 0.034
1.979PheArg: 1.979 ± 0.038
2.606PheSer: 2.606 ± 0.034
2.159PheThr: 2.159 ± 0.042
2.648PheVal: 2.648 ± 0.048
0.607PheTrp: 0.607 ± 0.021
0.979PheTyr: 0.979 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
8.701GlyAla: 8.701 ± 0.1
0.921GlyCys: 0.921 ± 0.024
4.764GlyAsp: 4.764 ± 0.072
4.427GlyGlu: 4.427 ± 0.05
3.804GlyPhe: 3.804 ± 0.053
6.954GlyGly: 6.954 ± 0.102
1.941GlyHis: 1.941 ± 0.041
4.432GlyIle: 4.432 ± 0.058
3.346GlyLys: 3.346 ± 0.048
8.961GlyLeu: 8.961 ± 0.08
2.497GlyMet: 2.497 ± 0.044
2.46GlyAsn: 2.46 ± 0.055
3.257GlyPro: 3.257 ± 0.052
3.357GlyGln: 3.357 ± 0.051
4.75GlyArg: 4.75 ± 0.067
4.687GlySer: 4.687 ± 0.066
4.553GlyThr: 4.553 ± 0.064
6.166GlyVal: 6.166 ± 0.072
1.379GlyTrp: 1.379 ± 0.036
2.393GlyTyr: 2.393 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.067HisAla: 2.067 ± 0.039
0.281HisCys: 0.281 ± 0.013
1.263HisAsp: 1.263 ± 0.034
1.004HisGlu: 1.004 ± 0.032
0.903HisPhe: 0.903 ± 0.028
1.86HisGly: 1.86 ± 0.042
0.592HisHis: 0.592 ± 0.021
1.123HisIle: 1.123 ± 0.03
0.616HisLys: 0.616 ± 0.019
2.234HisLeu: 2.234 ± 0.043
0.584HisMet: 0.584 ± 0.02
0.581HisAsn: 0.581 ± 0.021
1.359HisPro: 1.359 ± 0.035
0.814HisGln: 0.814 ± 0.024
1.284HisArg: 1.284 ± 0.031
1.228HisSer: 1.228 ± 0.031
0.907HisThr: 0.907 ± 0.025
1.479HisVal: 1.479 ± 0.032
0.372HisTrp: 0.372 ± 0.015
0.601HisTyr: 0.601 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.66IleAla: 6.66 ± 0.077
0.743IleCys: 0.743 ± 0.025
3.502IleAsp: 3.502 ± 0.05
3.546IleGlu: 3.546 ± 0.052
1.868IlePhe: 1.868 ± 0.039
5.007IleGly: 5.007 ± 0.059
1.007IleHis: 1.007 ± 0.024
2.542IleIle: 2.542 ± 0.048
1.727IleLys: 1.727 ± 0.036
5.121IleLeu: 5.121 ± 0.073
1.149IleMet: 1.149 ± 0.032
1.629IleAsn: 1.629 ± 0.036
2.45IlePro: 2.45 ± 0.034
1.525IleGln: 1.525 ± 0.029
3.105IleArg: 3.105 ± 0.045
3.782IleSer: 3.782 ± 0.061
3.101IleThr: 3.101 ± 0.052
3.692IleVal: 3.692 ± 0.052
0.839IleTrp: 0.839 ± 0.024
1.308IleTyr: 1.308 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.918LysAla: 3.918 ± 0.066
0.235LysCys: 0.235 ± 0.014
1.911LysAsp: 1.911 ± 0.042
1.663LysGlu: 1.663 ± 0.037
1.152LysPhe: 1.152 ± 0.027
2.801LysGly: 2.801 ± 0.051
0.74LysHis: 0.74 ± 0.022
2.081LysIle: 2.081 ± 0.04
1.437LysLys: 1.437 ± 0.043
3.418LysLeu: 3.418 ± 0.055
1.092LysMet: 1.092 ± 0.03
1.03LysAsn: 1.03 ± 0.03
1.96LysPro: 1.96 ± 0.039
1.186LysGln: 1.186 ± 0.032
2.279LysArg: 2.279 ± 0.042
2.208LysSer: 2.208 ± 0.046
2.245LysThr: 2.245 ± 0.041
2.483LysVal: 2.483 ± 0.046
0.455LysTrp: 0.455 ± 0.019
0.746LysTyr: 0.746 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
12.035LeuAla: 12.035 ± 0.115
1.009LeuCys: 1.009 ± 0.032
6.025LeuAsp: 6.025 ± 0.077
5.24LeuGlu: 5.24 ± 0.072
3.61LeuPhe: 3.61 ± 0.061
8.163LeuGly: 8.163 ± 0.094
1.95LeuHis: 1.95 ± 0.041
5.57LeuIle: 5.57 ± 0.076
3.672LeuLys: 3.672 ± 0.061
9.069LeuLeu: 9.069 ± 0.111
2.768LeuMet: 2.768 ± 0.052
3.151LeuAsn: 3.151 ± 0.043
5.468LeuPro: 5.468 ± 0.073
3.43LeuGln: 3.43 ± 0.052
6.392LeuArg: 6.392 ± 0.074
7.228LeuSer: 7.228 ± 0.079
6.33LeuThr: 6.33 ± 0.077
6.987LeuVal: 6.987 ± 0.072
1.274LeuTrp: 1.274 ± 0.034
2.031LeuTyr: 2.031 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
3.439MetAla: 3.439 ± 0.049
0.208MetCys: 0.208 ± 0.013
1.497MetAsp: 1.497 ± 0.033
1.312MetGlu: 1.312 ± 0.034
0.921MetPhe: 0.921 ± 0.03
2.29MetGly: 2.29 ± 0.043
0.49MetHis: 0.49 ± 0.019
1.627MetIle: 1.627 ± 0.034
1.085MetLys: 1.085 ± 0.029
2.667MetLeu: 2.667 ± 0.049
0.874MetMet: 0.874 ± 0.026
0.904MetAsn: 0.904 ± 0.029
1.502MetPro: 1.502 ± 0.032
1.181MetGln: 1.181 ± 0.03
1.819MetArg: 1.819 ± 0.036
1.957MetSer: 1.957 ± 0.036
2.085MetThr: 2.085 ± 0.038
2.017MetVal: 2.017 ± 0.04
0.274MetTrp: 0.274 ± 0.015
0.387MetTyr: 0.387 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.289AsnAla: 3.289 ± 0.055
0.33AsnCys: 0.33 ± 0.015
1.664AsnAsp: 1.664 ± 0.04
1.366AsnGlu: 1.366 ± 0.032
1.171AsnPhe: 1.171 ± 0.029
2.759AsnGly: 2.759 ± 0.056
0.602AsnHis: 0.602 ± 0.022
1.667AsnIle: 1.667 ± 0.038
0.907AsnLys: 0.907 ± 0.026
2.998AsnLeu: 2.998 ± 0.044
0.847AsnMet: 0.847 ± 0.025
0.916AsnAsn: 0.916 ± 0.027
1.934AsnPro: 1.934 ± 0.033
0.975AsnGln: 0.975 ± 0.027
1.838AsnArg: 1.838 ± 0.036
1.651AsnSer: 1.651 ± 0.035
1.748AsnThr: 1.748 ± 0.035
2.043AsnVal: 2.043 ± 0.04
0.58AsnTrp: 0.58 ± 0.021
0.783AsnTyr: 0.783 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
4.776ProAla: 4.776 ± 0.063
0.371ProCys: 0.371 ± 0.018
3.626ProAsp: 3.626 ± 0.057
3.66ProGlu: 3.66 ± 0.059
1.957ProPhe: 1.957 ± 0.038
4.043ProGly: 4.043 ± 0.053
1.028ProHis: 1.028 ± 0.03
2.335ProIle: 2.335 ± 0.037
1.891ProLys: 1.891 ± 0.037
4.489ProLeu: 4.489 ± 0.057
1.399ProMet: 1.399 ± 0.035
1.57ProAsn: 1.57 ± 0.036
1.904ProPro: 1.904 ± 0.038
1.799ProGln: 1.799 ± 0.038
2.301ProArg: 2.301 ± 0.041
2.801ProSer: 2.801 ± 0.049
2.511ProThr: 2.511 ± 0.046
4.013ProVal: 4.013 ± 0.061
0.626ProTrp: 0.626 ± 0.021
1.121ProTyr: 1.121 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
4.452GlnAla: 4.452 ± 0.059
0.267GlnCys: 0.267 ± 0.016
2.211GlnAsp: 2.211 ± 0.039
1.632GlnGlu: 1.632 ± 0.034
1.276GlnPhe: 1.276 ± 0.03
2.896GlnGly: 2.896 ± 0.049
0.762GlnHis: 0.762 ± 0.021
2.349GlnIle: 2.349 ± 0.041
1.314GlnLys: 1.314 ± 0.032
3.514GlnLeu: 3.514 ± 0.052
1.266GlnMet: 1.266 ± 0.031
1.237GlnAsn: 1.237 ± 0.032
1.751GlnPro: 1.751 ± 0.039
1.505GlnGln: 1.505 ± 0.037
2.392GlnArg: 2.392 ± 0.037
2.355GlnSer: 2.355 ± 0.041
2.073GlnThr: 2.073 ± 0.04
2.806GlnVal: 2.806 ± 0.046
0.45GlnTrp: 0.45 ± 0.019
0.683GlnTyr: 0.683 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
6.422ArgAla: 6.422 ± 0.074
0.519ArgCys: 0.519 ± 0.022
3.787ArgAsp: 3.787 ± 0.046
3.157ArgGlu: 3.157 ± 0.053
2.429ArgPhe: 2.429 ± 0.04
3.922ArgGly: 3.922 ± 0.05
1.406ArgHis: 1.406 ± 0.038
3.488ArgIle: 3.488 ± 0.053
2.257ArgLys: 2.257 ± 0.051
6.439ArgLeu: 6.439 ± 0.084
1.786ArgMet: 1.786 ± 0.036
1.915ArgAsn: 1.915 ± 0.043
2.813ArgPro: 2.813 ± 0.048
2.353ArgGln: 2.353 ± 0.043
4.091ArgArg: 4.091 ± 0.062
3.505ArgSer: 3.505 ± 0.055
2.71ArgThr: 2.71 ± 0.049
4.176ArgVal: 4.176 ± 0.055
0.851ArgTrp: 0.851 ± 0.023
1.468ArgTyr: 1.468 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.281SerAla: 6.281 ± 0.075
0.591SerCys: 0.591 ± 0.019
3.884SerAsp: 3.884 ± 0.06
3.201SerGlu: 3.201 ± 0.049
2.573SerPhe: 2.573 ± 0.047
5.755SerGly: 5.755 ± 0.069
1.246SerHis: 1.246 ± 0.028
3.004SerIle: 3.004 ± 0.051
2.041SerLys: 2.041 ± 0.039
5.743SerLeu: 5.743 ± 0.065
1.618SerMet: 1.618 ± 0.039
1.817SerAsn: 1.817 ± 0.037
2.853SerPro: 2.853 ± 0.048
2.164SerGln: 2.164 ± 0.041
3.314SerArg: 3.314 ± 0.048
3.257SerSer: 3.257 ± 0.059
3.039SerThr: 3.039 ± 0.052
4.185SerVal: 4.185 ± 0.062
0.805SerTrp: 0.805 ± 0.026
1.556SerTyr: 1.556 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.338ThrAla: 6.338 ± 0.075
0.546ThrCys: 0.546 ± 0.019
3.257ThrAsp: 3.257 ± 0.052
3.015ThrGlu: 3.015 ± 0.044
2.017ThrPhe: 2.017 ± 0.039
5.362ThrGly: 5.362 ± 0.066
1.213ThrHis: 1.213 ± 0.03
2.882ThrIle: 2.882 ± 0.045
1.772ThrLys: 1.772 ± 0.035
6.143ThrLeu: 6.143 ± 0.077
1.41ThrMet: 1.41 ± 0.035
1.503ThrAsn: 1.503 ± 0.038
3.296ThrPro: 3.296 ± 0.053
1.929ThrGln: 1.929 ± 0.038
3.188ThrArg: 3.188 ± 0.048
3.196ThrSer: 3.196 ± 0.048
2.996ThrThr: 2.996 ± 0.051
4.189ThrVal: 4.189 ± 0.059
0.709ThrTrp: 0.709 ± 0.02
1.349ThrTyr: 1.349 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.028ValAla: 8.028 ± 0.075
0.619ValCys: 0.619 ± 0.023
4.114ValAsp: 4.114 ± 0.058
4.379ValGlu: 4.379 ± 0.064
2.958ValPhe: 2.958 ± 0.055
5.178ValGly: 5.178 ± 0.063
1.329ValHis: 1.329 ± 0.033
4.294ValIle: 4.294 ± 0.058
2.316ValLys: 2.316 ± 0.045
7.555ValLeu: 7.555 ± 0.086
2.107ValMet: 2.107 ± 0.039
2.113ValAsn: 2.113 ± 0.038
3.326ValPro: 3.326 ± 0.053
2.516ValGln: 2.516 ± 0.039
3.759ValArg: 3.759 ± 0.053
4.748ValSer: 4.748 ± 0.062
4.676ValThr: 4.676 ± 0.06
5.454ValVal: 5.454 ± 0.077
0.897ValTrp: 0.897 ± 0.027
1.458ValTyr: 1.458 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.326TrpAla: 1.326 ± 0.031
0.144TrpCys: 0.144 ± 0.009
0.804TrpAsp: 0.804 ± 0.026
0.596TrpGlu: 0.596 ± 0.02
0.586TrpPhe: 0.586 ± 0.021
1.019TrpGly: 1.019 ± 0.031
0.349TrpHis: 0.349 ± 0.015
0.723TrpIle: 0.723 ± 0.023
0.481TrpLys: 0.481 ± 0.018
1.634TrpLeu: 1.634 ± 0.038
0.427TrpMet: 0.427 ± 0.019
0.42TrpAsn: 0.42 ± 0.016
0.664TrpPro: 0.664 ± 0.02
0.714TrpGln: 0.714 ± 0.025
0.955TrpArg: 0.955 ± 0.025
0.871TrpSer: 0.871 ± 0.026
0.766TrpThr: 0.766 ± 0.023
0.912TrpVal: 0.912 ± 0.025
0.22TrpTrp: 0.22 ± 0.011
0.279TrpTyr: 0.279 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.42TyrAla: 2.42 ± 0.042
0.275TyrCys: 0.275 ± 0.014
1.634TyrAsp: 1.634 ± 0.034
1.232TyrGlu: 1.232 ± 0.029
0.977TyrPhe: 0.977 ± 0.027
2.129TyrGly: 2.129 ± 0.044
0.584TyrHis: 0.584 ± 0.023
1.014TyrIle: 1.014 ± 0.028
0.662TyrLys: 0.662 ± 0.024
2.39TyrLeu: 2.39 ± 0.043
0.516TyrMet: 0.516 ± 0.019
0.669TyrAsn: 0.669 ± 0.021
1.088TyrPro: 1.088 ± 0.03
0.873TyrGln: 0.873 ± 0.026
1.47TyrArg: 1.47 ± 0.032
1.423TyrSer: 1.423 ± 0.031
1.214TyrThr: 1.214 ± 0.033
1.609TyrVal: 1.609 ± 0.034
0.387TyrTrp: 0.387 ± 0.015
0.641TyrTyr: 0.641 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4642 proteins (1420733 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski