Amino acid dipepetide frequency for Sphingobium fuliginis (strain ATCC 27551)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.041AlaAla: 19.041 ± 0.188	1.101AlaCys: 1.101 ± 0.031	7.728AlaAsp: 7.728 ± 0.083	7.454AlaGlu: 7.454 ± 0.093	4.308AlaPhe: 4.308 ± 0.064	11.452AlaGly: 11.452 ± 0.109	2.468AlaHis: 2.468 ± 0.039	6.638AlaIle: 6.638 ± 0.073	3.776AlaLys: 3.776 ± 0.071	14.333AlaLeu: 14.333 ± 0.148	4.06AlaMet: 4.06 ± 0.063	3.01AlaAsn: 3.01 ± 0.054	6.27AlaPro: 6.27 ± 0.083	4.719AlaGln: 4.719 ± 0.067	9.949AlaArg: 9.949 ± 0.106	6.515AlaSer: 6.515 ± 0.08	6.114AlaThr: 6.114 ± 0.073	8.707AlaVal: 8.707 ± 0.087	1.533AlaTrp: 1.533 ± 0.03	2.655AlaTyr: 2.655 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.046CysAla: 1.046 ± 0.031	0.089CysCys: 0.089 ± 0.007	0.493CysAsp: 0.493 ± 0.02	0.385CysGlu: 0.385 ± 0.017	0.271CysPhe: 0.271 ± 0.016	0.885CysGly: 0.885 ± 0.026	0.219CysHis: 0.219 ± 0.017	0.366CysIle: 0.366 ± 0.017	0.147CysLys: 0.147 ± 0.011	0.706CysLeu: 0.706 ± 0.022	0.158CysMet: 0.158 ± 0.012	0.198CysAsn: 0.198 ± 0.011	0.463CysPro: 0.463 ± 0.018	0.209CysGln: 0.209 ± 0.014	0.6CysArg: 0.6 ± 0.021	0.451CysSer: 0.451 ± 0.02	0.364CysThr: 0.364 ± 0.016	0.563CysVal: 0.563 ± 0.019	0.136CysTrp: 0.136 ± 0.01	0.165CysTyr: 0.165 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.66AspAla: 7.66 ± 0.078	0.463AspCys: 0.463 ± 0.019	3.166AspAsp: 3.166 ± 0.051	3.236AspGlu: 3.236 ± 0.051	2.182AspPhe: 2.182 ± 0.042	5.724AspGly: 5.724 ± 0.083	1.428AspHis: 1.428 ± 0.035	3.106AspIle: 3.106 ± 0.05	1.543AspLys: 1.543 ± 0.036	5.855AspLeu: 5.855 ± 0.072	1.611AspMet: 1.611 ± 0.036	1.41AspAsn: 1.41 ± 0.035	3.762AspPro: 3.762 ± 0.053	1.843AspGln: 1.843 ± 0.038	5.246AspArg: 5.246 ± 0.065	2.493AspSer: 2.493 ± 0.046	2.229AspThr: 2.229 ± 0.045	3.976AspVal: 3.976 ± 0.053	1.098AspTrp: 1.098 ± 0.032	1.679AspTyr: 1.679 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.653GluAla: 7.653 ± 0.106	0.317GluCys: 0.317 ± 0.015	2.762GluAsp: 2.762 ± 0.048	3.355GluGlu: 3.355 ± 0.066	1.394GluPhe: 1.394 ± 0.035	4.802GluGly: 4.802 ± 0.06	1.046GluHis: 1.046 ± 0.033	2.813GluIle: 2.813 ± 0.045	2.088GluLys: 2.088 ± 0.038	4.89GluLeu: 4.89 ± 0.066	1.46GluMet: 1.46 ± 0.033	1.353GluAsn: 1.353 ± 0.027	2.475GluPro: 2.475 ± 0.042	2.099GluGln: 2.099 ± 0.047	4.933GluArg: 4.933 ± 0.065	2.344GluSer: 2.344 ± 0.042	2.934GluThr: 2.934 ± 0.045	3.345GluVal: 3.345 ± 0.06	0.746GluTrp: 0.746 ± 0.027	0.939GluTyr: 0.939 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.761PheAla: 4.761 ± 0.063	0.355PheCys: 0.355 ± 0.017	2.601PheAsp: 2.601 ± 0.048	1.896PheGlu: 1.896 ± 0.038	1.245PhePhe: 1.245 ± 0.037	3.571PheGly: 3.571 ± 0.059	0.767PheHis: 0.767 ± 0.026	1.493PheIle: 1.493 ± 0.035	0.772PheLys: 0.772 ± 0.028	3.267PheLeu: 3.267 ± 0.057	0.747PheMet: 0.747 ± 0.026	1.011PheAsn: 1.011 ± 0.031	1.556PhePro: 1.556 ± 0.036	0.96PheGln: 0.96 ± 0.026	2.454PheArg: 2.454 ± 0.044	2.089PheSer: 2.089 ± 0.041	2.001PheThr: 2.001 ± 0.037	2.388PheVal: 2.388 ± 0.04	0.517PheTrp: 0.517 ± 0.022	0.924PheTyr: 0.924 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.144GlyAla: 10.144 ± 0.109	0.786GlyCys: 0.786 ± 0.026	4.941GlyAsp: 4.941 ± 0.064	4.902GlyGlu: 4.902 ± 0.064	3.66GlyPhe: 3.66 ± 0.051	8.338GlyGly: 8.338 ± 0.141	1.953GlyHis: 1.953 ± 0.041	4.52GlyIle: 4.52 ± 0.062	3.229GlyLys: 3.229 ± 0.058	8.963GlyLeu: 8.963 ± 0.091	2.45GlyMet: 2.45 ± 0.042	2.402GlyAsn: 2.402 ± 0.054	3.73GlyPro: 3.73 ± 0.057	3.21GlyGln: 3.21 ± 0.053	6.997GlyArg: 6.997 ± 0.073	4.982GlySer: 4.982 ± 0.072	4.682GlyThr: 4.682 ± 0.077	6.218GlyVal: 6.218 ± 0.077	1.699GlyTrp: 1.699 ± 0.038	2.355GlyTyr: 2.355 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.448HisAla: 2.448 ± 0.042	0.218HisCys: 0.218 ± 0.012	1.319HisAsp: 1.319 ± 0.03	1.002HisGlu: 1.002 ± 0.027	0.861HisPhe: 0.861 ± 0.026	2.14HisGly: 2.14 ± 0.05	0.615HisHis: 0.615 ± 0.025	0.959HisIle: 0.959 ± 0.027	0.424HisLys: 0.424 ± 0.017	1.96HisLeu: 1.96 ± 0.038	0.55HisMet: 0.55 ± 0.019	0.468HisAsn: 0.468 ± 0.02	1.302HisPro: 1.302 ± 0.035	0.553HisGln: 0.553 ± 0.02	1.589HisArg: 1.589 ± 0.038	0.973HisSer: 0.973 ± 0.028	0.534HisThr: 0.534 ± 0.02	1.663HisVal: 1.663 ± 0.037	0.386HisTrp: 0.386 ± 0.017	0.645HisTyr: 0.645 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.691IleAla: 7.691 ± 0.087	0.445IleCys: 0.445 ± 0.018	3.869IleAsp: 3.869 ± 0.055	3.16IleGlu: 3.16 ± 0.051	1.73IlePhe: 1.73 ± 0.035	5.072IleGly: 5.072 ± 0.068	0.921IleHis: 0.921 ± 0.025	1.993IleIle: 1.993 ± 0.048	1.125IleLys: 1.125 ± 0.027	4.185IleLeu: 4.185 ± 0.058	0.997IleMet: 0.997 ± 0.029	1.292IleAsn: 1.292 ± 0.03	2.233IlePro: 2.233 ± 0.041	1.189IleGln: 1.189 ± 0.034	3.388IleArg: 3.388 ± 0.057	2.685IleSer: 2.685 ± 0.048	2.312IleThr: 2.312 ± 0.056	4.104IleVal: 4.104 ± 0.058	0.64IleTrp: 0.64 ± 0.025	0.984IleTyr: 0.984 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.064LysAla: 4.064 ± 0.061	0.138LysCys: 0.138 ± 0.01	1.594LysAsp: 1.594 ± 0.042	1.289LysGlu: 1.289 ± 0.032	0.782LysPhe: 0.782 ± 0.026	2.721LysGly: 2.721 ± 0.049	0.449LysHis: 0.449 ± 0.019	1.412LysIle: 1.412 ± 0.037	0.986LysLys: 0.986 ± 0.033	3.042LysLeu: 3.042 ± 0.055	0.735LysMet: 0.735 ± 0.025	0.663LysAsn: 0.663 ± 0.024	1.909LysPro: 1.909 ± 0.044	0.842LysGln: 0.842 ± 0.028	2.113LysArg: 2.113 ± 0.04	1.48LysSer: 1.48 ± 0.034	1.478LysThr: 1.478 ± 0.033	2.158LysVal: 2.158 ± 0.04	0.389LysTrp: 0.389 ± 0.018	0.561LysTyr: 0.561 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.915LeuAla: 13.915 ± 0.125	0.919LeuCys: 0.919 ± 0.027	6.093LeuAsp: 6.093 ± 0.066	4.837LeuGlu: 4.837 ± 0.062	3.831LeuPhe: 3.831 ± 0.059	8.253LeuGly: 8.253 ± 0.096	1.938LeuHis: 1.938 ± 0.037	4.975LeuIle: 4.975 ± 0.064	3.056LeuLys: 3.056 ± 0.046	10.073LeuLeu: 10.073 ± 0.118	2.277LeuMet: 2.277 ± 0.051	2.501LeuAsn: 2.501 ± 0.04	5.771LeuPro: 5.771 ± 0.069	2.541LeuGln: 2.541 ± 0.046	7.158LeuArg: 7.158 ± 0.082	6.508LeuSer: 6.508 ± 0.083	5.553LeuThr: 5.553 ± 0.076	6.855LeuVal: 6.855 ± 0.087	1.308LeuTrp: 1.308 ± 0.033	2.039LeuTyr: 2.039 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.639MetAla: 3.639 ± 0.058	0.146MetCys: 0.146 ± 0.01	1.24MetAsp: 1.24 ± 0.032	1.252MetGlu: 1.252 ± 0.032	0.66MetPhe: 0.66 ± 0.02	2.037MetGly: 2.037 ± 0.046	0.447MetHis: 0.447 ± 0.016	1.324MetIle: 1.324 ± 0.028	0.957MetLys: 0.957 ± 0.027	2.777MetLeu: 2.777 ± 0.049	0.705MetMet: 0.705 ± 0.026	0.73MetAsn: 0.73 ± 0.025	1.583MetPro: 1.583 ± 0.037	0.801MetGln: 0.801 ± 0.029	1.911MetArg: 1.911 ± 0.046	1.471MetSer: 1.471 ± 0.033	1.766MetThr: 1.766 ± 0.039	1.638MetVal: 1.638 ± 0.041	0.211MetTrp: 0.211 ± 0.014	0.241MetTyr: 0.241 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.304AsnAla: 3.304 ± 0.06	0.237AsnCys: 0.237 ± 0.014	1.42AsnAsp: 1.42 ± 0.043	1.048AsnGlu: 1.048 ± 0.029	0.962AsnPhe: 0.962 ± 0.033	2.661AsnGly: 2.661 ± 0.051	0.46AsnHis: 0.46 ± 0.018	1.367AsnIle: 1.367 ± 0.033	0.572AsnLys: 0.572 ± 0.022	2.519AsnLeu: 2.519 ± 0.046	0.6AsnMet: 0.6 ± 0.022	0.685AsnAsn: 0.685 ± 0.027	1.745AsnPro: 1.745 ± 0.041	0.76AsnGln: 0.76 ± 0.027	1.938AsnArg: 1.938 ± 0.045	1.335AsnSer: 1.335 ± 0.039	0.899AsnThr: 0.899 ± 0.027	1.871AsnVal: 1.871 ± 0.043	0.449AsnTrp: 0.449 ± 0.018	0.658AsnTyr: 0.658 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.036ProAla: 7.036 ± 0.087	0.341ProCys: 0.341 ± 0.016	3.834ProAsp: 3.834 ± 0.062	3.407ProGlu: 3.407 ± 0.049	1.969ProPhe: 1.969 ± 0.038	4.922ProGly: 4.922 ± 0.061	1.127ProHis: 1.127 ± 0.028	2.345ProIle: 2.345 ± 0.04	1.374ProLys: 1.374 ± 0.033	5.115ProLeu: 5.115 ± 0.068	1.342ProMet: 1.342 ± 0.036	1.279ProAsn: 1.279 ± 0.031	2.852ProPro: 2.852 ± 0.071	1.767ProGln: 1.767 ± 0.04	3.147ProArg: 3.147 ± 0.051	2.786ProSer: 2.786 ± 0.044	2.487ProThr: 2.487 ± 0.044	4.479ProVal: 4.479 ± 0.067	0.727ProTrp: 0.727 ± 0.025	1.082ProTyr: 1.082 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.513GlnAla: 4.513 ± 0.071	0.237GlnCys: 0.237 ± 0.014	1.533GlnAsp: 1.533 ± 0.036	1.413GlnGlu: 1.413 ± 0.036	1.068GlnPhe: 1.068 ± 0.03	2.677GlnGly: 2.677 ± 0.043	0.588GlnHis: 0.588 ± 0.02	1.806GlnIle: 1.806 ± 0.043	0.937GlnLys: 0.937 ± 0.024	3.083GlnLeu: 3.083 ± 0.047	0.88GlnMet: 0.88 ± 0.025	0.801GlnAsn: 0.801 ± 0.027	1.943GlnPro: 1.943 ± 0.039	1.252GlnGln: 1.252 ± 0.036	2.606GlnArg: 2.606 ± 0.041	1.779GlnSer: 1.779 ± 0.036	1.542GlnThr: 1.542 ± 0.039	2.263GlnVal: 2.263 ± 0.041	0.516GlnTrp: 0.516 ± 0.019	0.646GlnTyr: 0.646 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.828ArgAla: 8.828 ± 0.109	0.501ArgCys: 0.501 ± 0.017	4.429ArgAsp: 4.429 ± 0.058	4.106ArgGlu: 4.106 ± 0.061	3.223ArgPhe: 3.223 ± 0.053	5.242ArgGly: 5.242 ± 0.072	1.91ArgHis: 1.91 ± 0.038	4.412ArgIle: 4.412 ± 0.054	2.176ArgLys: 2.176 ± 0.041	8.674ArgLeu: 8.674 ± 0.106	2.061ArgMet: 2.061 ± 0.044	1.932ArgAsn: 1.932 ± 0.039	4.041ArgPro: 4.041 ± 0.063	2.843ArgGln: 2.843 ± 0.04	6.15ArgArg: 6.15 ± 0.085	3.899ArgSer: 3.899 ± 0.058	3.572ArgThr: 3.572 ± 0.055	4.574ArgVal: 4.574 ± 0.065	1.282ArgTrp: 1.282 ± 0.031	1.904ArgTyr: 1.904 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.518SerAla: 6.518 ± 0.077	0.439SerCys: 0.439 ± 0.017	3.112SerAsp: 3.112 ± 0.054	2.451SerGlu: 2.451 ± 0.042	2.268SerPhe: 2.268 ± 0.043	5.638SerGly: 5.638 ± 0.071	1.064SerHis: 1.064 ± 0.029	2.781SerIle: 2.781 ± 0.049	1.294SerLys: 1.294 ± 0.033	5.313SerLeu: 5.313 ± 0.063	1.311SerMet: 1.311 ± 0.031	1.343SerAsn: 1.343 ± 0.035	2.875SerPro: 2.875 ± 0.045	1.554SerGln: 1.554 ± 0.037	3.777SerArg: 3.777 ± 0.05	2.851SerSer: 2.851 ± 0.058	2.553SerThr: 2.553 ± 0.051	3.69SerVal: 3.69 ± 0.047	0.803SerTrp: 0.803 ± 0.023	1.428SerTyr: 1.428 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.098ThrAla: 6.098 ± 0.082	0.364ThrCys: 0.364 ± 0.018	2.833ThrAsp: 2.833 ± 0.065	2.231ThrGlu: 2.231 ± 0.04	1.564ThrPhe: 1.564 ± 0.033	5.291ThrGly: 5.291 ± 0.074	0.945ThrHis: 0.945 ± 0.029	2.694ThrIle: 2.694 ± 0.05	1.132ThrLys: 1.132 ± 0.031	5.626ThrLeu: 5.626 ± 0.072	1.082ThrMet: 1.082 ± 0.027	1.193ThrAsn: 1.193 ± 0.036	3.251ThrPro: 3.251 ± 0.049	1.471ThrGln: 1.471 ± 0.03	3.234ThrArg: 3.234 ± 0.052	2.433ThrSer: 2.433 ± 0.046	2.449ThrThr: 2.449 ± 0.051	4.112ThrVal: 4.112 ± 0.08	0.522ThrTrp: 0.522 ± 0.019	1.076ThrTyr: 1.076 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.337ValAla: 9.337 ± 0.088	0.478ValCys: 0.478 ± 0.019	4.416ValAsp: 4.416 ± 0.057	4.575ValGlu: 4.575 ± 0.069	2.001ValPhe: 2.001 ± 0.038	5.56ValGly: 5.56 ± 0.071	1.389ValHis: 1.389 ± 0.032	3.486ValIle: 3.486 ± 0.064	2.164ValLys: 2.164 ± 0.045	6.197ValLeu: 6.197 ± 0.068	1.653ValMet: 1.653 ± 0.037	2.072ValAsn: 2.072 ± 0.047	3.897ValPro: 3.897 ± 0.056	2.207ValGln: 2.207 ± 0.048	5.124ValArg: 5.124 ± 0.064	3.844ValSer: 3.844 ± 0.067	4.382ValThr: 4.382 ± 0.073	4.975ValVal: 4.975 ± 0.069	0.762ValTrp: 0.762 ± 0.025	1.37ValTyr: 1.37 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.453TrpAla: 1.453 ± 0.035	0.11TrpCys: 0.11 ± 0.01	0.74TrpAsp: 0.74 ± 0.025	0.61TrpGlu: 0.61 ± 0.018	0.547TrpPhe: 0.547 ± 0.023	0.995TrpGly: 0.995 ± 0.025	0.34TrpHis: 0.34 ± 0.018	0.695TrpIle: 0.695 ± 0.023	0.503TrpLys: 0.503 ± 0.018	1.731TrpLeu: 1.731 ± 0.035	0.39TrpMet: 0.39 ± 0.018	0.497TrpAsn: 0.497 ± 0.019	0.709TrpPro: 0.709 ± 0.023	0.581TrpGln: 0.581 ± 0.022	1.392TrpArg: 1.392 ± 0.032	0.887TrpSer: 0.887 ± 0.028	0.836TrpThr: 0.836 ± 0.023	0.795TrpVal: 0.795 ± 0.028	0.24TrpTrp: 0.24 ± 0.014	0.277TrpTyr: 0.277 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.684TyrAla: 2.684 ± 0.049	0.229TyrCys: 0.229 ± 0.013	1.588TyrAsp: 1.588 ± 0.042	1.141TyrGlu: 1.141 ± 0.029	0.847TyrPhe: 0.847 ± 0.029	2.178TyrGly: 2.178 ± 0.043	0.539TyrHis: 0.539 ± 0.022	0.833TyrIle: 0.833 ± 0.026	0.548TyrLys: 0.548 ± 0.02	2.094TyrLeu: 2.094 ± 0.045	0.465TyrMet: 0.465 ± 0.018	0.65TyrAsn: 0.65 ± 0.027	1.051TyrPro: 1.051 ± 0.03	0.681TyrGln: 0.681 ± 0.025	2.053TyrArg: 2.053 ± 0.038	1.259TyrSer: 1.259 ± 0.029	0.915TyrThr: 0.915 ± 0.03	1.513TyrVal: 1.513 ± 0.039	0.361TyrTrp: 0.361 ± 0.016	0.64TyrTyr: 0.64 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4174 proteins (1366607 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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